DK1560854T3 - Taxaner kovalent bundet til hyaluronsyre eller hyaluronsyrederivater - Google Patents

Taxaner kovalent bundet til hyaluronsyre eller hyaluronsyrederivater

Info

Publication number
DK1560854T3
DK1560854T3 DK03748126T DK03748126T DK1560854T3 DK 1560854 T3 DK1560854 T3 DK 1560854T3 DK 03748126 T DK03748126 T DK 03748126T DK 03748126 T DK03748126 T DK 03748126T DK 1560854 T3 DK1560854 T3 DK 1560854T3
Authority
DK
Denmark
Prior art keywords
hyaluronic acid
acid derivatives
covalently bound
taxanes covalently
derivatives
Prior art date
Application number
DK03748126T
Other languages
English (en)
Inventor
Luca Gilda De
Luisa Maria Migneco
Bettolo Rinaldo Marini
Original Assignee
Fidia Farmaceutici
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Farmaceutici filed Critical Fidia Farmaceutici
Application granted granted Critical
Publication of DK1560854T3 publication Critical patent/DK1560854T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
DK03748126T 2002-10-18 2003-10-10 Taxaner kovalent bundet til hyaluronsyre eller hyaluronsyrederivater DK1560854T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000271A ITPD20020271A1 (it) 2002-10-18 2002-10-18 Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati.
PCT/EP2003/011239 WO2004035629A2 (en) 2002-10-18 2003-10-10 Taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives

Publications (1)

Publication Number Publication Date
DK1560854T3 true DK1560854T3 (da) 2009-04-20

Family

ID=32104794

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03748126T DK1560854T3 (da) 2002-10-18 2003-10-10 Taxaner kovalent bundet til hyaluronsyre eller hyaluronsyrederivater

Country Status (23)

Country Link
US (2) US7897584B2 (da)
EP (2) EP2045270B1 (da)
JP (1) JP4704753B2 (da)
KR (1) KR101076414B1 (da)
CN (1) CN1705683B (da)
AT (1) ATE420117T1 (da)
AU (1) AU2003267441B2 (da)
BR (1) BR0315431A (da)
CA (2) CA2502531C (da)
DE (1) DE60325760D1 (da)
DK (1) DK1560854T3 (da)
ES (2) ES2320439T3 (da)
HK (1) HK1082753A1 (da)
HR (1) HRP20050416B1 (da)
IL (1) IL168086A (da)
IT (1) ITPD20020271A1 (da)
NO (1) NO333042B1 (da)
NZ (2) NZ547668A (da)
PL (2) PL216861B1 (da)
PT (1) PT1560854E (da)
RU (1) RU2384593C2 (da)
SI (1) SI1560854T1 (da)
WO (1) WO2004035629A2 (da)

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US9925209B2 (en) 2008-03-19 2018-03-27 The Board Of Regents Of The University Of Oklahoma Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same
US9687559B2 (en) 2008-03-19 2017-06-27 The Board Of Regents Of The University Of Oklahoma Heparosan polymers and methods of making and using same for the enhancement of therapeutics
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CN104491875A (zh) * 2014-12-22 2015-04-08 中国药科大学 一种基于透明质酸-难溶性药物前药的自聚纳米系统的制备方法
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CN108178803B (zh) * 2017-09-25 2020-03-10 温州医科大学 一种载药的肉桂醛-葡聚糖聚合物自组装纳米粒的制备及其抗肿瘤应用
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CN108219029A (zh) * 2018-03-22 2018-06-29 盐城师范学院 一种水溶性卡巴他赛抗癌药物的制备方法
CN108467439A (zh) * 2018-03-22 2018-08-31 盐城师范学院 一种水溶性紫杉醇抗癌药物的制备方法
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EP3812376A4 (en) * 2018-06-20 2022-08-17 Santolecan Pharmaceuticals LLC PACLITAXEL-LIPID-POLYSACCHARIDE DOUBLE-TYPE CONJUGATE, METHOD FOR PREPARING IT AND ITS USE
IT201800009731A1 (it) * 2018-10-25 2020-04-25 Fidia Farm Spa Coniugato paclitaxel - acido ialuronico nel trattamento del carcinoma vescicale non infiltrante
CN111588914A (zh) * 2019-12-31 2020-08-28 辽宁垠艺生物科技股份有限公司 介入或植入医疗器械的药物涂层及其制备方法
IT202000007747A1 (it) * 2020-04-10 2021-10-10 Fidia Farm Spa Coniugato acido ialuronico-paclitaxel nel trattamento del mesotelioma
IT202000008209A1 (it) * 2020-04-17 2021-10-17 Fidia Farm Spa Procedimento di sintesi di un coniugato acido ialuronico-paclitaxel
CN111892668B (zh) * 2020-07-03 2022-07-12 广东工业大学 一种化合物及其制备方法、荧光探针和抗肿瘤药物
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Also Published As

Publication number Publication date
CA2783175C (en) 2013-12-24
PT1560854E (pt) 2009-04-15
SI1560854T1 (sl) 2009-06-30
NZ540034A (en) 2007-11-30
BR0315431A (pt) 2005-08-16
US20060116346A1 (en) 2006-06-01
DE60325760D1 (de) 2009-02-26
HRP20050416B1 (hr) 2013-09-30
EP2045270A3 (en) 2009-06-03
EP1560854A2 (en) 2005-08-10
JP4704753B2 (ja) 2011-06-22
PL216861B1 (pl) 2014-05-30
WO2004035629A9 (en) 2005-07-07
US8034795B2 (en) 2011-10-11
NZ547668A (en) 2008-04-30
US20110159052A1 (en) 2011-06-30
CN1705683A (zh) 2005-12-07
JP2006504747A (ja) 2006-02-09
RU2384593C2 (ru) 2010-03-20
ITPD20020271A1 (it) 2004-04-19
ES2320439T3 (es) 2009-05-22
CN1705683B (zh) 2010-04-28
NO20052399D0 (no) 2005-05-18
NO20052399L (no) 2005-05-18
AU2003267441A1 (en) 2004-05-04
WO2004035629A8 (en) 2005-06-09
EP1560854B1 (en) 2009-01-07
WO2004035629A2 (en) 2004-04-29
RU2005115116A (ru) 2006-01-20
EP2045270B1 (en) 2015-05-06
ES2544481T3 (es) 2015-08-31
WO2004035629A3 (en) 2004-06-24
KR20050065595A (ko) 2005-06-29
IL168086A (en) 2010-11-30
EP2045270A2 (en) 2009-04-08
KR101076414B1 (ko) 2011-10-25
PL376349A1 (en) 2005-12-27
ATE420117T1 (de) 2009-01-15
HRP20050416A2 (en) 2006-02-28
HK1082753A1 (en) 2006-06-16
NO333042B1 (no) 2013-02-18
AU2003267441B2 (en) 2010-01-14
US7897584B2 (en) 2011-03-01
CA2502531C (en) 2012-10-02
CA2502531A1 (en) 2004-04-29
PL392566A1 (pl) 2010-11-22
CA2783175A1 (en) 2004-04-29

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