UA104861C2 - Похідні хроману як модулятори trpv3 - Google Patents

Похідні хроману як модулятори trpv3

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Publication number
UA104861C2
UA104861C2 UAA201012642A UAA201012642A UA104861C2 UA 104861 C2 UA104861 C2 UA 104861C2 UA A201012642 A UAA201012642 A UA A201012642A UA A201012642 A UAA201012642 A UA A201012642A UA 104861 C2 UA104861 C2 UA 104861C2
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UA
Ukraine
Prior art keywords
trpv3
chromane derivatives
modulators
treating
conditions
Prior art date
Application number
UAA201012642A
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English (en)
Russian (ru)
Inventor
В.С. Прасада Рао Лінгам
Абрахам Томас
Джавед Юсуф Хатік
Нііліма Хайраткар-Джоші
Від'я Ґанапаті Каттіге
Original Assignee
Гленмарк Фармас'Ютікалз С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гленмарк Фармас'Ютікалз С.А. filed Critical Гленмарк Фармас'Ютікалз С.А.
Publication of UA104861C2 publication Critical patent/UA104861C2/uk

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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Diabetes (AREA)
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  • Rheumatology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
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  • Child & Adolescent Psychology (AREA)
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  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)

Abstract

В даному винаході запропоновані похідні хроману як модулятори тимчасового потенціалу ванілоїдного рецептора (TRPV).Конкретно, описані в даному винаході сполуки є придатними для лікування або профілактики модульованих TRPV3 захворювань, етапів та/або розладів.Також запропоновані способи одержання описаних в даному винаході сполук, проміжні сполуки, які використовуються в їх синтезі, фармацевтичні композиції, що їх містять, і способи лікування або профілактики захворювань, станів та/або розладів, модульованих TRPV3.
UAA201012642A 2008-06-17 2009-05-19 Похідні хроману як модулятори trpv3 UA104861C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1274MU2008 2008-06-17
PCT/IB2009/005641 WO2010004379A2 (en) 2008-06-17 2009-05-19 Chromane derivatives as trpv3 modulators

Publications (1)

Publication Number Publication Date
UA104861C2 true UA104861C2 (uk) 2014-03-25

Family

ID=41507489

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201012642A UA104861C2 (uk) 2008-06-17 2009-05-19 Похідні хроману як модулятори trpv3

Country Status (11)

Country Link
US (1) US8492568B2 (uk)
EP (1) EP2285794A4 (uk)
JP (1) JP2011529855A (uk)
AU (1) AU2009269720A1 (uk)
CA (1) CA2728405A1 (uk)
EA (1) EA201071280A1 (uk)
GE (1) GEP20125709B (uk)
MX (1) MX2010011762A (uk)
NZ (1) NZ595780A (uk)
UA (1) UA104861C2 (uk)
WO (1) WO2010004379A2 (uk)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2013001612A (es) * 2010-08-10 2013-07-05 Abbvie Inc Moduladores de trpv3 novedosos.
WO2012129491A1 (en) 2011-03-24 2012-09-27 Abbott Laboratories Trpv3 modulators
EP2771322A2 (en) 2011-10-24 2014-09-03 AbbVie Inc. Novel trpv3 modulators
EP2919773A4 (en) * 2012-11-19 2016-11-02 Univ Columbia METHOD FOR THE TREATMENT OF KERATINOCYTE-MEDIATED LESIONS
CN112480018B (zh) * 2020-11-30 2023-06-20 中国药科大学 一种trpv3小分子变构抑制剂及其制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU553266B2 (en) 1982-02-04 1986-07-10 Farmitalia Carlo Erba S.P.A. Substituted 1,3,4-thiadiazolo(3,2-a) pyrimidines
US5418245A (en) 1990-04-16 1995-05-23 Rhone-Poulenc Rorer International (Holdings) Inc. Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit EGF receptor tyrosine kinase
JPH07242666A (ja) 1994-03-08 1995-09-19 Fujisawa Pharmaceut Co Ltd 複素環化合物
AU6959898A (en) 1997-04-11 1998-11-11 David J. Grainger Compounds and therapies for the prevention of vascular and non-vascular pathol ogies
US6797819B1 (en) 1998-06-11 2004-09-28 President And Fellows Of Harvard College Alkaloids
US6610749B2 (en) 2000-02-18 2003-08-26 Arch Development Corporation Polyhydroxylated benzene-containing compounds
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
DE10043791A1 (de) * 2000-09-06 2002-03-14 Bayer Ag Arzneimittel gegen virale Erkrankungen
US20040009537A1 (en) 2002-01-11 2004-01-15 Jack Roos Methods of modulating and of identifying agents that modulate intracellular calcium
AU2003205630A1 (en) 2002-01-18 2003-07-30 The Genetics Company Inc. Beta-secretase inhibitors
AU2004268621C1 (en) 2003-08-29 2011-08-18 Exelixis, Inc. c-Kit modulators and methods of use
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
US8192717B2 (en) 2004-11-26 2012-06-05 Nagasaki University Composition for diagnosing amyloid-related diseases
BRPI0519013A2 (pt) 2004-12-13 2009-11-03 Lilly Co Eli composto ou esteroisÈmeros únicos, misturas de esteroisÈmeros, sais, tautÈmeros ou pró-drogas destes farmaceuticamente aceitáveis, composição farmacêutica, e, uso de um composto
KR101136183B1 (ko) * 2005-07-22 2012-04-17 모찌다 세이야쿠 가부시끼가이샤 신규 헤테로시클리덴 아세트아미드 유도체
US7842703B2 (en) 2005-10-07 2010-11-30 Glenmark Pharmaceuticals S.A. Substituted benzofused derivatives and their use as vanilloid receptor ligands
EP1954283A2 (en) 2005-11-04 2008-08-13 Hydra Biosciences, Inc. Compounds for modulating trpv3 function
US7812703B2 (en) * 2006-03-23 2010-10-12 Innovative Micro Technology MEMS device using NiMn alloy and method of manufacture
US7998980B2 (en) * 2006-09-15 2011-08-16 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
PE20081692A1 (es) * 2007-01-24 2008-12-18 Mochida Pharm Co Ltd Nuevo derivado de heterocicliden acetamida

Also Published As

Publication number Publication date
AU2009269720A1 (en) 2012-01-19
WO2010004379A2 (en) 2010-01-14
WO2010004379A3 (en) 2011-11-17
US20110098316A1 (en) 2011-04-28
EA201071280A1 (ru) 2012-05-30
EP2285794A2 (en) 2011-02-23
AU2009269720A2 (en) 2012-05-31
EP2285794A4 (en) 2012-08-29
JP2011529855A (ja) 2011-12-15
US8492568B2 (en) 2013-07-23
GEP20125709B (en) 2012-12-10
NZ595780A (en) 2013-07-26
CA2728405A1 (en) 2010-01-14
MX2010011762A (es) 2011-02-03

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