EA201190003A1 - Производные хроменона в качестве trpv3 антагонистов - Google Patents

Производные хроменона в качестве trpv3 антагонистов

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Publication number
EA201190003A1
EA201190003A1 EA201190003A EA201190003A EA201190003A1 EA 201190003 A1 EA201190003 A1 EA 201190003A1 EA 201190003 A EA201190003 A EA 201190003A EA 201190003 A EA201190003 A EA 201190003A EA 201190003 A1 EA201190003 A1 EA 201190003A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diseases
chromenon
derivatives
trpv3
trpv3 antagonists
Prior art date
Application number
EA201190003A
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English (en)
Inventor
Сачин Сундарлал Чаудхари
Абрахам Томас
Ашок Бхаусахеб Кадам
Сачин Васантрао Дхоне
Неелима Кхайраткар-Джоши
Видийа Ганапати Каттиге
Бхарат Гангадхар Адик
Original Assignee
Гленмарк Фармасьютикалс, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Гленмарк Фармасьютикалс, С.А. filed Critical Гленмарк Фармасьютикалс, С.А.
Publication of EA201190003A1 publication Critical patent/EA201190003A1/ru

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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
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Abstract

Настоящее изобретение обеспечивает потенциальный ванилоидный транзиторный рецептор (TRPV) в качестве модулятора формулы (I). В частности, соединения, раскрытые в описании, пригодные для лечения или профилактики заболеваний, расстройств или болезней, модулируемых TRPV3. Также обеспечиваются процессы получения соединений, раскрытых в описании, промежуточных соединений, используемых в синтезе, фармацевтических композиций и способов лечения или профилактики заболеваний, расстройств или болезней, модулируемых TRPV3.
EA201190003A 2008-11-17 2009-11-06 Производные хроменона в качестве trpv3 антагонистов EA201190003A1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN2420MU2008 2008-11-17
US13845608P 2008-12-17 2008-12-17
IN664MU2009 2009-03-23
US17126509P 2009-04-21 2009-04-21
PCT/IB2009/007353 WO2010055384A1 (en) 2008-11-17 2009-11-06 Chromenone derivatives as trpv3 antagonists

Publications (1)

Publication Number Publication Date
EA201190003A1 true EA201190003A1 (ru) 2012-05-30

Family

ID=42169675

Family Applications (1)

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EA201190003A EA201190003A1 (ru) 2008-11-17 2009-11-06 Производные хроменона в качестве trpv3 антагонистов

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US (1) US20110237659A1 (ru)
EP (1) EP2367810A4 (ru)
JP (1) JP2012508790A (ru)
AU (1) AU2009315363A1 (ru)
CA (1) CA2743276A1 (ru)
EA (1) EA201190003A1 (ru)
GE (1) GEP20146025B (ru)
MX (1) MX2011005147A (ru)
NZ (1) NZ595779A (ru)
WO (1) WO2010055384A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106232116B (zh) 2014-03-20 2020-05-01 日本脏器制药株式会社 含有香豆素衍生物作为有效成分的治疗或预防剂
CN112694392B (zh) * 2020-12-21 2022-11-22 青岛大学 一种trpv3抑制剂及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4033845A (en) * 1975-11-20 1977-07-05 Warner-Lambert Company [2-(4-Oxo-4H-1-benzopyran-2-yl)ethenyl]benzonitriles and benzoic acids
US4183945A (en) * 1976-06-16 1980-01-15 Carlo Erba S.P.A. Substituted 2-vinyl-chromones and process for their preparation
AU508350B2 (en) * 1976-06-16 1980-03-20 Farmitalia Carlo Erba S.P.A. Substicuted 2-vinyl-chromones
WO1997027177A2 (en) * 1996-01-29 1997-07-31 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Dihydropyridine-, pyridine-, benzopyran-4-one- and triazoloquinazoline derivatives, their preparation and their use as adenosine receptor antagonists
DE10031809A1 (de) * 2000-07-04 2002-01-17 Basf Ag Neue Flavonoide und ihre Verwendung in kosmetischen und dermatologischen Zubereitungen
US20040009537A1 (en) * 2002-01-11 2004-01-15 Jack Roos Methods of modulating and of identifying agents that modulate intracellular calcium
GB0412768D0 (en) * 2004-06-08 2004-07-07 Novartis Ag Organic compounds
CN101233132A (zh) * 2005-05-09 2008-07-30 海德拉生物科学公司 调节trpv3功能的化合物
AU2006311883A1 (en) * 2005-11-04 2007-05-18 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
CA2652307A1 (en) * 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels

Also Published As

Publication number Publication date
EP2367810A1 (en) 2011-09-28
NZ595779A (en) 2013-08-30
JP2012508790A (ja) 2012-04-12
AU2009315363A1 (en) 2012-01-19
GEP20146025B (en) 2014-01-27
AU2009315363A2 (en) 2012-04-12
MX2011005147A (es) 2011-08-29
US20110237659A1 (en) 2011-09-29
WO2010055384A1 (en) 2010-05-20
CA2743276A1 (en) 2010-05-20
EP2367810A4 (en) 2012-06-13

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