UA108069C2 - Злиті піримідиндіонові похідні як модулятори trpa1 - Google Patents

Злиті піримідиндіонові похідні як модулятори trpa1

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Publication number
UA108069C2
UA108069C2 UAA201111147A UAA201111147A UA108069C2 UA 108069 C2 UA108069 C2 UA 108069C2 UA A201111147 A UAA201111147 A UA A201111147A UA A201111147 A UAA201111147 A UA A201111147A UA 108069 C2 UA108069 C2 UA 108069C2
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UA
Ukraine
Prior art keywords
trpa1
pyrimidinedione derivatives
modulators
subfamily
conditions
Prior art date
Application number
UAA201111147A
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English (en)
Russian (ru)
Inventor
Сачін Сундарал Чаудхарі
Сукірті Кумар
Абрахам Томас
Ніша Параг Патіл
Ашок Бхаусахеб Кадам
Вішал Говіндрао Дешмукх
Сачін Васантрао Дхоне
Раджендра Пракаш Чікхале
Нееліма Хаіраткар-Джоші
Індраніл Мукхопадхия
Original Assignee
Гленмарк Фармасьютікалс, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Гленмарк Фармасьютікалс, С.А. filed Critical Гленмарк Фармасьютікалс, С.А.
Publication of UA108069C2 publication Critical patent/UA108069C2/uk

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

Представлений винахід стосується нових злитих піримідиндіонових похідних формули (І), котрі є TRPA (перехідний рецепторний потенціал, підродина А) модуляторами. Зокрема, описані в даному документі сполуки корисні для лікування або попередження захворювань, станів та/або розладів, що модулюються TRPA1 (перехідним рецепторним потенціалом, підродина А, член 1). Даний винахід також стосується способів одержання описаних в даному документі сполук, проміжних сполук, що використовуються в їх синтезі, їх фармацевтичних композицій та способів лікування або попередження захворювань, станів та/або розладів, що модулюються TRPA1. EMBED ISISServer (І)
UAA201111147A 2009-03-23 2010-03-17 Злиті піримідиндіонові похідні як модулятори trpa1 UA108069C2 (uk)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
IN665MU2009 2009-03-23
US17135509P 2009-04-21 2009-04-21
IN2212MU2009 2009-09-23
IN2211MU2009 2009-09-23
US25194409P 2009-10-15 2009-10-15
US25326309P 2009-10-20 2009-10-20
IN2892MU2009 2009-12-15
IN2891MU2009 2009-12-15
US29446310P 2010-01-12 2010-01-12
US30024110P 2010-02-01 2010-02-01
PCT/IB2010/000553 WO2010109287A1 (en) 2009-03-23 2010-03-17 Fused pyrimidine-dione derivatives as trpa1 modulators

Publications (1)

Publication Number Publication Date
UA108069C2 true UA108069C2 (uk) 2015-03-25

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US (1) US9000159B2 (uk)
EP (2) EP2411393B1 (uk)
JP (1) JP5657638B2 (uk)
KR (1) KR20110132575A (uk)
CN (1) CN102361873B (uk)
AP (1) AP3280A (uk)
AU (1) AU2010227245B2 (uk)
BR (1) BRPI1013559A2 (uk)
CA (1) CA2756518A1 (uk)
CL (2) CL2011002315A1 (uk)
DK (1) DK2411393T3 (uk)
EA (1) EA023857B1 (uk)
ES (2) ES2456515T3 (uk)
HK (2) HK1166075A1 (uk)
IL (1) IL215178A (uk)
MX (1) MX2011009824A (uk)
PE (1) PE20120774A1 (uk)
PL (1) PL2411393T3 (uk)
PT (1) PT2411393E (uk)
SG (1) SG174402A1 (uk)
SI (1) SI2411393T1 (uk)
UA (1) UA108069C2 (uk)
WO (1) WO2010109287A1 (uk)
ZA (1) ZA201107648B (uk)

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