UA109916C2 - 2-аміно-4-арилтіазольні сполуки як антагоністи trра1 - Google Patents

2-аміно-4-арилтіазольні сполуки як антагоністи trра1

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Publication number
UA109916C2
UA109916C2 UAA201306497A UAA201306497A UA109916C2 UA 109916 C2 UA109916 C2 UA 109916C2 UA A201306497 A UAA201306497 A UA A201306497A UA A201306497 A UAA201306497 A UA A201306497A UA 109916 C2 UA109916 C2 UA 109916C2
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UA
Ukraine
Prior art keywords
amino
trpa1
trpa1 antagonists
treating
arylthiazole
Prior art date
Application number
UAA201306497A
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English (en)
Russian (ru)
Inventor
Сукірті Кумар
Абрахам Томас
Сачін Сундарал Чаудхарі
Біпін Парсоттам Кансагра
Венката Рамана Еміредди
Нееліма Хаіраткар-Джоші
Індраніл Мукхопадхия
Гіріш Гуді
Original Assignee
Гленмарк Фармасьютікалс С.А.
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Application filed by Гленмарк Фармасьютікалс С.А. filed Critical Гленмарк Фармасьютікалс С.А.
Publication of UA109916C2 publication Critical patent/UA109916C2/uk

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
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  • Urology & Nephrology (AREA)
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  • Pain & Pain Management (AREA)
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  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Даний винахід належить до 2-аміно-4-арилтіазольних похідних як TRPA (підсімейство А тимчасового рецепторного потенціалу) модуляторів. Зокрема, сполуки, описані у цій заявці, корисні для лікування чи профілактики захворювань, станів та/або розладів, модульованих TRPA1 (підсімейство А тимчасового рецепторного потенціалу, член 1). Також у цій заявці представлені способи одержання сполук, описаних у цій заявці, проміжних сполук, використаних у їх синтезі, їх фармацевтичні композиції, та способи лікування чи профілактики захворювань, станів та/або розладів, модульованих TRPA1. EMBED ISISServer (І)
UAA201306497A 2010-12-20 2011-12-15 2-аміно-4-арилтіазольні сполуки як антагоністи trра1 UA109916C2 (uk)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
IN3451MU2010 2010-12-20
US201061428327P 2010-12-30 2010-12-30
IN748MU2011 2011-03-16
US201161466535P 2011-03-23 2011-03-23
IN1569MU2011 2011-05-25
US201161495002P 2011-06-09 2011-06-09
IN2741MU2011 2011-09-28
US201161552076P 2011-10-27 2011-10-27
PCT/IB2011/003224 WO2012085662A1 (en) 2010-12-20 2011-12-15 2-amino-4-arylthiazole compounds as trpa1 antagonists

Publications (1)

Publication Number Publication Date
UA109916C2 true UA109916C2 (uk) 2015-10-26

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UAA201306497A UA109916C2 (uk) 2010-12-20 2011-12-15 2-аміно-4-арилтіазольні сполуки як антагоністи trра1

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US (3) US8592398B2 (uk)
EP (1) EP2655377B1 (uk)
JP (1) JP5694560B2 (uk)
KR (1) KR101591153B1 (uk)
CN (1) CN103261201B (uk)
AP (1) AP3391A (uk)
AR (1) AR084294A1 (uk)
AU (1) AU2011346763B2 (uk)
BR (1) BR112013014692A2 (uk)
CA (1) CA2820448A1 (uk)
CL (1) CL2013001810A1 (uk)
EA (1) EA023141B1 (uk)
HK (1) HK1191008A1 (uk)
MX (1) MX336549B (uk)
MY (1) MY159059A (uk)
PE (1) PE20140234A1 (uk)
SG (1) SG191173A1 (uk)
TW (1) TWI515199B (uk)
UA (1) UA109916C2 (uk)
WO (1) WO2012085662A1 (uk)

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JP7354438B2 (ja) * 2019-10-15 2023-10-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｔｒｐａ１阻害剤としてのチエノピリミドン
JP7376706B2 (ja) * 2019-10-15 2023-11-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｔｒｐａ１阻害剤としてのチエノピリミドン
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