JO3475B1 - ناهضات مستقبل سوماتوستاتين نوع فرعي 4 (sstr4) جديدة - Google Patents

ناهضات مستقبل سوماتوستاتين نوع فرعي 4 (sstr4) جديدة

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Publication number
JO3475B1
JO3475B1 JOP/2014/0165A JOP20140165A JO3475B1 JO 3475 B1 JO3475 B1 JO 3475B1 JO P20140165 A JOP20140165 A JO P20140165A JO 3475 B1 JO3475 B1 JO 3475B1
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JO
Jordan
Prior art keywords
sstr4
agonists
receptor subtype
somatostatin receptor
processes
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JOP/2014/0165A
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English (en)
Inventor
Kuelzer Raimund
Mazzaferro Rocco
Cui Yunhai
Giovannini Riccardo
Lingard Iain
Just Stefan
Doods Henri
Rudolf Klaus
Ferrara Marco
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Boehringer Ingelheim Int
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Publication of JO3475B1 publication Critical patent/JO3475B1/ar

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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Abstract

يتعلق الاختراع بمشتقات 3-أزا-ثنائي حلقي [3.1.0] هكسان-6-حمض الكربوكسيليك أميد ذو الصيغة العامة (I)، والتي تكون عبارة عن ناهضات لمستقبل السوماتوستاتين النوع 4 (SSTR4)، المفيدة في الوقاية من أو علاج الإضطرابات الطبية المتعلقة بـ SSTR4. بالإضافة إلى، يتعلق الاختراع بعمليات لتحضير التركيبات الصيدلانية وعمليات لتصنيع المركبات وفقا للاختراع.
JOP/2014/0165A 2013-05-17 2014-05-18 ناهضات مستقبل سوماتوستاتين نوع فرعي 4 (sstr4) جديدة JO3475B1 (ar)

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US20170014381A1 (en) 2017-01-19
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