MX2015015620A - Nuevos agonistas del receptor de somatostatina subtipo 4 (sstr4). - Google Patents

Nuevos agonistas del receptor de somatostatina subtipo 4 (sstr4).

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Publication number
MX2015015620A
MX2015015620A MX2015015620A MX2015015620A MX2015015620A MX 2015015620 A MX2015015620 A MX 2015015620A MX 2015015620 A MX2015015620 A MX 2015015620A MX 2015015620 A MX2015015620 A MX 2015015620A MX 2015015620 A MX2015015620 A MX 2015015620A
Authority
MX
Mexico
Prior art keywords
sstr4
agonists
receptor subtype
somatostatin receptor
processes
Prior art date
Application number
MX2015015620A
Other languages
English (en)
Other versions
MX369358B (es
Inventor
Klaus Rudolf
Henri Doods
Raimund Kuelzer
Riccardo Giovannini
Rocco Mazzaferro
Marco Ferrara
Iain Lingard
Yunhai Cui
Stefan Just
Original Assignee
Ct Xion Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Xion Therapeutics Corp filed Critical Ct Xion Therapeutics Corp
Publication of MX2015015620A publication Critical patent/MX2015015620A/es
Publication of MX369358B publication Critical patent/MX369358B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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Abstract

La invención se refiere a derivados de la amida del ácido 3-aza-biciclo[3.1.0]hexan-6-carboxílico de la Fórmula general (I), que son agonistas del receptor de somatostatina subtipo 4 (SSTR4), útiles para la prevención o el tratamiento de trastornos médicos relacionados con SSTR4. Además, la invención se refiere a procesos para preparar composiciones farmacéuticas, así como a procesos para la fabricación de compuestos de acuerdo con la invención.
MX2015015620A 2013-05-17 2014-05-15 Nuevos agonistas del receptor de somatostatina subtipo 4 (sstr4). MX369358B (es)

Applications Claiming Priority (2)

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EP13168224 2013-05-17
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