MX369358B - Nuevos agonistas del receptor de somatostatina subtipo 4 (sstr4). - Google Patents
Nuevos agonistas del receptor de somatostatina subtipo 4 (sstr4).Info
- Publication number
- MX369358B MX369358B MX2015015620A MX2015015620A MX369358B MX 369358 B MX369358 B MX 369358B MX 2015015620 A MX2015015620 A MX 2015015620A MX 2015015620 A MX2015015620 A MX 2015015620A MX 369358 B MX369358 B MX 369358B
- Authority
- MX
- Mexico
- Prior art keywords
- sstr4
- agonists
- receptor subtype
- somatostatin receptor
- processes
- Prior art date
Links
- 108010064556 somatostatin receptor subtype-4 Proteins 0.000 title abstract 4
- 239000000556 agonist Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- GLEUKLIFNNEVEM-UHFFFAOYSA-N 3-azabicyclo[3.1.0]hexane-6-carboxamide Chemical class C1NCC2C(C(=O)N)C21 GLEUKLIFNNEVEM-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
La invención se refiere a derivados de la amida del ácido 3-aza-biciclo[3.1.0]hexan-6-carboxílico de la Fórmula general (I), que son agonistas del receptor de somatostatina subtipo 4 (SSTR4), útiles para la prevención o el tratamiento de trastornos médicos relacionados con SSTR4. Además, la invención se refiere a procesos para preparar composiciones farmacéuticas, así como a procesos para la fabricación de compuestos de acuerdo con la invención.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13168224 | 2013-05-17 | ||
PCT/EP2014/059905 WO2014184275A1 (en) | 2013-05-17 | 2014-05-15 | New somatostatin receptor subtype 4 (sstr4) agonists |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015015620A MX2015015620A (es) | 2016-03-07 |
MX369358B true MX369358B (es) | 2019-11-06 |
Family
ID=48428384
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015015620A MX369358B (es) | 2013-05-17 | 2014-05-15 | Nuevos agonistas del receptor de somatostatina subtipo 4 (sstr4). |
Country Status (25)
Country | Link |
---|---|
US (4) | US9371282B2 (es) |
EP (1) | EP2997021B1 (es) |
JP (1) | JP6387086B2 (es) |
KR (1) | KR102286196B1 (es) |
CN (1) | CN105473574B (es) |
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JP2017526728A (ja) | 2014-09-15 | 2017-09-14 | インフラマトリー・レスポンス・リサーチ・インコーポレイテッド | 炎症介在性状態の治療におけるレボセチリジン及びモンテルカスト |
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US11912687B2 (en) | 2017-05-12 | 2024-02-27 | Board of Trustees of the Southern Illinois University | 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof |
US11136312B2 (en) | 2017-05-12 | 2021-10-05 | Board of Trustees of the Southern Illinois University | 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof |
US10865163B2 (en) | 2017-12-20 | 2020-12-15 | The University Of Toledo | Carbon dioxide as a directing group for C—H functionalization reactions involving Lewis basic amines, alcohols, thiols, and phosphines for the synthesis of compounds |
WO2019161098A1 (en) | 2018-02-16 | 2019-08-22 | Incyte Corporation | Jak1 pathway inhibitors for the treatment of cytokine-related disorders |
TWI834637B (zh) | 2018-03-01 | 2024-03-11 | 日商武田藥品工業有限公司 | 六氫吡啶基-3-(芳氧基)丙醯胺及丙酸酯 |
JP2021519775A (ja) | 2018-03-30 | 2021-08-12 | インサイト・コーポレイションIncyte Corporation | Jak阻害剤を用いる化膿性汗腺炎の治療 |
US11668295B2 (en) | 2018-12-28 | 2023-06-06 | Avent, Inc. | Pump head for a peristaltic pump |
CN112979655A (zh) | 2019-12-16 | 2021-06-18 | 上海赛默罗生物科技有限公司 | 三唑并哒嗪类衍生物、其制备方法、药物组合物和用途 |
EP4153178A4 (en) * | 2020-05-19 | 2024-06-05 | Irr, Inc. | LEVOCETIRIZINE AND MONTELUKAST IN THE TREATMENT OF SEPSIS AND SYMPTOMS THEREOF |
TW202146403A (zh) * | 2020-05-21 | 2021-12-16 | 大陸商廣州費米子科技有限責任公司 | 含氮飽和雜環化合物及其製備方法、藥物組合物和應用 |
US20230192683A1 (en) | 2020-05-21 | 2023-06-22 | Guangzhou Fermion Technology Co., Ltd. | Fused ring compounds, preparation method therefor, pharmaceutical compositions and use thereof |
EP4157831A1 (en) | 2020-06-02 | 2023-04-05 | Incyte Corporation | Processes of preparing a jak1 inhibitor |
CN113929693B (zh) * | 2020-07-13 | 2023-05-09 | 广州费米子科技有限责任公司 | 含氮杂环化合物、药物组合物和应用 |
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