WO2009118596A3 - Phthalimide derivatives as trpa1 modulators - Google Patents

Phthalimide derivatives as trpa1 modulators Download PDF

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Publication number
WO2009118596A3
WO2009118596A3 PCT/IB2009/000523 IB2009000523W WO2009118596A3 WO 2009118596 A3 WO2009118596 A3 WO 2009118596A3 IB 2009000523 W IB2009000523 W IB 2009000523W WO 2009118596 A3 WO2009118596 A3 WO 2009118596A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulators
phthalimide derivatives
trpal
treating
conditions
Prior art date
Application number
PCT/IB2009/000523
Other languages
French (fr)
Other versions
WO2009118596A2 (en
Inventor
Meyyappan Muthuppalniappan
Sukeerthi Kumar
Abraham Thomas
Neelima Khairatkar-Joshi
Indranil Mukhopadhyay
Original Assignee
Glenmark Pharmaceuticals, S. A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals, S. A. filed Critical Glenmark Pharmaceuticals, S. A.
Publication of WO2009118596A2 publication Critical patent/WO2009118596A2/en
Publication of WO2009118596A3 publication Critical patent/WO2009118596A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

The present invention provides TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPAl (Transient Receptor Potential subfamily A, member 1) modulators. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPAl.
PCT/IB2009/000523 2008-03-26 2009-03-16 Phthalimide derivatives as trpa1 modulators WO2009118596A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
IN645MU2008 2008-03-26
IN645/MUM/2008 2008-03-26
US4396608P 2008-04-10 2008-04-10
US61/043,966 2008-04-10
IN1669MU2008 2008-08-05
IN1669/MUM/2008 2008-08-05
US9231008P 2008-08-27 2008-08-27
US61/092,310 2008-08-27

Publications (2)

Publication Number Publication Date
WO2009118596A2 WO2009118596A2 (en) 2009-10-01
WO2009118596A3 true WO2009118596A3 (en) 2010-12-02

Family

ID=41114382

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/000523 WO2009118596A2 (en) 2008-03-26 2009-03-16 Phthalimide derivatives as trpa1 modulators

Country Status (1)

Country Link
WO (1) WO2009118596A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011114184A1 (en) * 2010-03-15 2011-09-22 Glenmark Pharmaceuticals S.A. Amides of heterocyclic compounds as trpa1 inhibitors
MY159059A (en) 2010-12-20 2016-12-15 Glenmark Pharmaceuticals Sa 2-amino-4-arylthiazole compounds as trpa1 antagonists
EP2520566A1 (en) 2011-05-06 2012-11-07 Orion Corporation New Pharmaceutical Compounds
EP2903965B1 (en) 2012-10-01 2017-03-01 Orion Corporation N-prop-2-ynyl carboxamide derivatives and their use as trpa1 antagonists
ES2968371T3 (en) 2013-10-10 2024-05-09 Eastern Virginia Medical School 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as 12-lipoxygenase inhibitors
GB201409783D0 (en) * 2014-06-02 2014-07-16 Agency Science Tech & Res Phthalimide derivatives as modulators of WNT pathway
SI3152199T1 (en) 2014-06-03 2018-12-31 Idorsia Pharmaceuticals Ltd Pyrazole compounds and their use as t-type calcium channel blockers
CN104926711B (en) * 2015-06-01 2017-11-07 华南理工大学 Utilize the method for carbonylation one pot process class TRPA1 conditioning agent precursors
WO2017060488A1 (en) 2015-10-09 2017-04-13 Almirall, S.A. New trpa1 antagonists
WO2017064068A1 (en) 2015-10-14 2017-04-20 Almirall, S.A. New trpa1 antagonists
CN105434432B (en) * 2015-12-04 2018-11-13 中国科学院昆明植物研究所 N-Hydroxyphthalimide class compound application in preparation of anti-tumor drugs
KR102296653B1 (en) 2016-12-16 2021-09-01 이도르시아 파마슈티컬스 리미티드 Pharmaceutical Combinations Comprising T-Type Calcium Channel Blockers
TWI808960B (en) 2017-02-06 2023-07-21 瑞士商愛杜西亞製藥有限公司 A novel process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes
KR20200030584A (en) 2017-07-21 2020-03-20 앤타바이오 에스에이에스 compound
CN109867661B (en) * 2017-12-05 2022-07-19 中国医学科学院药物研究所 Amide compounds for regulating WNT signal pathway and application thereof
CN112851564B (en) * 2021-01-28 2022-03-11 山东海科新源材料科技股份有限公司 Sulfonated group-containing phthalimide additive, electrolyte containing same and lithium ion battery

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006105796A1 (en) * 2005-04-08 2006-10-12 Leo Pharma A/S Novel indolinone derivatives
WO2007073505A2 (en) * 2005-12-22 2007-06-28 Hydra Biosciences, Inc. Trpa1 inhibitors for treating pain

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006105796A1 (en) * 2005-04-08 2006-10-12 Leo Pharma A/S Novel indolinone derivatives
WO2007073505A2 (en) * 2005-12-22 2007-06-28 Hydra Biosciences, Inc. Trpa1 inhibitors for treating pain

Also Published As

Publication number Publication date
WO2009118596A2 (en) 2009-10-01

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