WO2009118596A3 - Phthalimide derivatives as trpa1 modulators - Google Patents
Phthalimide derivatives as trpa1 modulators Download PDFInfo
- Publication number
- WO2009118596A3 WO2009118596A3 PCT/IB2009/000523 IB2009000523W WO2009118596A3 WO 2009118596 A3 WO2009118596 A3 WO 2009118596A3 IB 2009000523 W IB2009000523 W IB 2009000523W WO 2009118596 A3 WO2009118596 A3 WO 2009118596A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- modulators
- phthalimide derivatives
- trpal
- treating
- conditions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
The present invention provides TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPAl (Transient Receptor Potential subfamily A, member 1) modulators. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPAl.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN645MU2008 | 2008-03-26 | ||
IN645/MUM/2008 | 2008-03-26 | ||
US4396608P | 2008-04-10 | 2008-04-10 | |
US61/043,966 | 2008-04-10 | ||
IN1669MU2008 | 2008-08-05 | ||
IN1669/MUM/2008 | 2008-08-05 | ||
US9231008P | 2008-08-27 | 2008-08-27 | |
US61/092,310 | 2008-08-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009118596A2 WO2009118596A2 (en) | 2009-10-01 |
WO2009118596A3 true WO2009118596A3 (en) | 2010-12-02 |
Family
ID=41114382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2009/000523 WO2009118596A2 (en) | 2008-03-26 | 2009-03-16 | Phthalimide derivatives as trpa1 modulators |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009118596A2 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011114184A1 (en) * | 2010-03-15 | 2011-09-22 | Glenmark Pharmaceuticals S.A. | Amides of heterocyclic compounds as trpa1 inhibitors |
MY159059A (en) | 2010-12-20 | 2016-12-15 | Glenmark Pharmaceuticals Sa | 2-amino-4-arylthiazole compounds as trpa1 antagonists |
EP2520566A1 (en) | 2011-05-06 | 2012-11-07 | Orion Corporation | New Pharmaceutical Compounds |
EP2903965B1 (en) | 2012-10-01 | 2017-03-01 | Orion Corporation | N-prop-2-ynyl carboxamide derivatives and their use as trpa1 antagonists |
ES2968371T3 (en) | 2013-10-10 | 2024-05-09 | Eastern Virginia Medical School | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as 12-lipoxygenase inhibitors |
GB201409783D0 (en) * | 2014-06-02 | 2014-07-16 | Agency Science Tech & Res | Phthalimide derivatives as modulators of WNT pathway |
SI3152199T1 (en) | 2014-06-03 | 2018-12-31 | Idorsia Pharmaceuticals Ltd | Pyrazole compounds and their use as t-type calcium channel blockers |
CN104926711B (en) * | 2015-06-01 | 2017-11-07 | 华南理工大学 | Utilize the method for carbonylation one pot process class TRPA1 conditioning agent precursors |
WO2017060488A1 (en) | 2015-10-09 | 2017-04-13 | Almirall, S.A. | New trpa1 antagonists |
WO2017064068A1 (en) | 2015-10-14 | 2017-04-20 | Almirall, S.A. | New trpa1 antagonists |
CN105434432B (en) * | 2015-12-04 | 2018-11-13 | 中国科学院昆明植物研究所 | N-Hydroxyphthalimide class compound application in preparation of anti-tumor drugs |
KR102296653B1 (en) | 2016-12-16 | 2021-09-01 | 이도르시아 파마슈티컬스 리미티드 | Pharmaceutical Combinations Comprising T-Type Calcium Channel Blockers |
TWI808960B (en) | 2017-02-06 | 2023-07-21 | 瑞士商愛杜西亞製藥有限公司 | A novel process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes |
KR20200030584A (en) | 2017-07-21 | 2020-03-20 | 앤타바이오 에스에이에스 | compound |
CN109867661B (en) * | 2017-12-05 | 2022-07-19 | 中国医学科学院药物研究所 | Amide compounds for regulating WNT signal pathway and application thereof |
CN112851564B (en) * | 2021-01-28 | 2022-03-11 | 山东海科新源材料科技股份有限公司 | Sulfonated group-containing phthalimide additive, electrolyte containing same and lithium ion battery |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006105796A1 (en) * | 2005-04-08 | 2006-10-12 | Leo Pharma A/S | Novel indolinone derivatives |
WO2007073505A2 (en) * | 2005-12-22 | 2007-06-28 | Hydra Biosciences, Inc. | Trpa1 inhibitors for treating pain |
-
2009
- 2009-03-16 WO PCT/IB2009/000523 patent/WO2009118596A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006105796A1 (en) * | 2005-04-08 | 2006-10-12 | Leo Pharma A/S | Novel indolinone derivatives |
WO2007073505A2 (en) * | 2005-12-22 | 2007-06-28 | Hydra Biosciences, Inc. | Trpa1 inhibitors for treating pain |
Also Published As
Publication number | Publication date |
---|---|
WO2009118596A2 (en) | 2009-10-01 |
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