DE60325760D1 - Kovalent an hyaluronsäure oder dessen derivate gebundene taxane - Google Patents
Kovalent an hyaluronsäure oder dessen derivate gebundene taxaneInfo
- Publication number
- DE60325760D1 DE60325760D1 DE60325760T DE60325760T DE60325760D1 DE 60325760 D1 DE60325760 D1 DE 60325760D1 DE 60325760 T DE60325760 T DE 60325760T DE 60325760 T DE60325760 T DE 60325760T DE 60325760 D1 DE60325760 D1 DE 60325760D1
- Authority
- DE
- Germany
- Prior art keywords
- hyaluronic acid
- taxane
- derivatives
- covalent
- relates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000271A ITPD20020271A1 (it) | 2002-10-18 | 2002-10-18 | Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati. |
PCT/EP2003/011239 WO2004035629A2 (en) | 2002-10-18 | 2003-10-10 | Taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60325760D1 true DE60325760D1 (de) | 2009-02-26 |
Family
ID=32104794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60325760T Expired - Lifetime DE60325760D1 (de) | 2002-10-18 | 2003-10-10 | Kovalent an hyaluronsäure oder dessen derivate gebundene taxane |
Country Status (23)
Country | Link |
---|---|
US (2) | US7897584B2 (de) |
EP (2) | EP2045270B1 (de) |
JP (1) | JP4704753B2 (de) |
KR (1) | KR101076414B1 (de) |
CN (1) | CN1705683B (de) |
AT (1) | ATE420117T1 (de) |
AU (1) | AU2003267441B2 (de) |
BR (1) | BR0315431A (de) |
CA (2) | CA2502531C (de) |
DE (1) | DE60325760D1 (de) |
DK (1) | DK1560854T3 (de) |
ES (2) | ES2320439T3 (de) |
HK (1) | HK1082753A1 (de) |
HR (1) | HRP20050416B1 (de) |
IL (1) | IL168086A (de) |
IT (1) | ITPD20020271A1 (de) |
NO (1) | NO333042B1 (de) |
NZ (2) | NZ547668A (de) |
PL (2) | PL376349A1 (de) |
PT (1) | PT1560854E (de) |
RU (1) | RU2384593C2 (de) |
SI (1) | SI1560854T1 (de) |
WO (1) | WO2004035629A2 (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7923431B2 (en) | 2001-12-21 | 2011-04-12 | Ferrosan Medical Devices A/S | Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis |
EP2286795B1 (de) * | 2002-06-26 | 2016-10-26 | SynCore Biotechnology CO., LTD | Herstellungsmethode von diagnostischen und therapeutischen Stoffen in einen kationischen Trägersystem |
KR20070046093A (ko) | 2004-07-09 | 2007-05-02 | 훼로산 아크티에 셀스카브 | 히알루론산을 포함하는 지혈 조성물 |
WO2007004675A1 (ja) * | 2005-07-06 | 2007-01-11 | Seikagaku Corporation | 薬剤導入光架橋ヒアルロン酸誘導体ゲル |
ITPD20050242A1 (it) * | 2005-08-03 | 2007-02-04 | Fidia Farmaceutici | Bioconiugati antitumorali dell'acido ialuronico o dei suoi derivati, ottenibili per coniugazione chimica diretta o indiretta, e loro impiego in campo farmaceutico |
EP1973952A4 (de) * | 2006-01-23 | 2010-09-01 | Kwangju Inst Sci & Tech | Konjugat, umfassend eine kovalent an ein mucoadhäsives polymer gebundene pharmazeutisch wirksame verbindung, und transmucosale verabreichungsmethode für eine pharmazeutisch wirksame verbindung unter anwendung davon |
IE20060049A1 (en) * | 2006-01-25 | 2007-08-08 | Eurand Pharmaceuticals Ltd | A novel drug delivery system: use of hyaluronic acid as a carrier moleclue for different classes of therapeutic active agents |
CN101501075B (zh) * | 2006-08-04 | 2013-07-10 | 诺维信生物制药丹麦公司 | 支化透明质酸和制造方法 |
WO2008089256A2 (en) * | 2007-01-16 | 2008-07-24 | Cappella, Inc. | Polymeric therapeutics |
ITMI20071267A1 (it) * | 2007-06-22 | 2008-12-23 | Fidia Farmaceutici | Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative |
ITMI20071341A1 (it) | 2007-07-05 | 2009-01-06 | Fidia Farmaceutici | Derivati di acido ialuronico contenenti gruppi in grado di rilasciare no |
IE20070900A1 (en) * | 2007-12-12 | 2009-06-24 | Eurand Pharmaceuticals Ltd | New anticancer conjugates |
CA2713813C (en) * | 2008-01-30 | 2017-12-05 | University Of Kansas | Intralymphatic chemotherapy drug carriers |
EP2259803B2 (de) | 2008-02-29 | 2019-03-13 | Ferrosan Medical Devices A/S | Vorrichtung zur förderung von hämostase und/oder wundheilung |
US9687559B2 (en) | 2008-03-19 | 2017-06-27 | The Board Of Regents Of The University Of Oklahoma | Heparosan polymers and methods of making and using same for the enhancement of therapeutics |
US9925209B2 (en) | 2008-03-19 | 2018-03-27 | The Board Of Regents Of The University Of Oklahoma | Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same |
KR101584384B1 (ko) | 2008-04-22 | 2016-01-12 | 피디아 파마슈티치 에스.피.에이. | 종양 형성의 치료에서 히알루론산에 결합된 항종양 약물을 포함하는 신규한 제약학적 조제물의 치료적 용도 |
IT1391006B1 (it) * | 2008-10-08 | 2011-10-27 | Fidia Farmaceutici | Uso terapeutico di nuove preparazioni farmaceutiche contenenti farmaci antitumorali legati all'acido ialuronico nel trattamento delle neoplasie |
WO2010030342A2 (en) * | 2008-09-09 | 2010-03-18 | The Board Of Regents Of The University Of Oklahoma | Heparosan polymers and methods of making and using same for the enhancement of therapeutics |
WO2010053140A1 (ja) | 2008-11-05 | 2010-05-14 | 国立大学法人 東京医科歯科大学 | ヒアルロン酸誘導体、およびその医薬組成物 |
IT1397247B1 (it) * | 2009-05-14 | 2013-01-04 | Fidia Farmaceutici | Nuovi agenti regolatori dell'attivita' citochinica |
IT1399351B1 (it) * | 2009-06-16 | 2013-04-16 | Fidia Farmaceutici | Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi |
KR20110032561A (ko) * | 2009-09-23 | 2011-03-30 | 포항공과대학교 산학협력단 | 약물 전달체의 표적 특이성 조절 방법, 표적 특이적 약물 전달체, 및 표적-비특이적 약효 장기 지속성 약물 전달체 |
US8722644B2 (en) | 2010-01-04 | 2014-05-13 | Holy Stone Healthcare Co., Ltd. | Mixture of hyaluronic acid for treating and preventing peptic ulcer and duodenal ulcer |
WO2012086857A1 (ko) * | 2010-12-21 | 2012-06-28 | (주)파낙스이엠 | 광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법 |
IN2014DN08122A (de) | 2012-03-06 | 2015-05-01 | Ferrosan Medical Devices As | |
JP6104232B2 (ja) * | 2012-03-27 | 2017-03-29 | テルモ株式会社 | コーティング組成物および医療機器 |
EP2977066A3 (de) | 2012-06-12 | 2016-07-27 | Ferrosan Medical Devices A/S | Trockene blutstillende zusammensetzung |
BR112015004501B1 (pt) | 2012-09-05 | 2021-04-13 | Chugai Seiyaku Kabushiki Kaisha | Derivado de ácido hialurônico tendo aminoácidos e grupos esterila introduzidos no mesmo e composição farmacêutica que o compreende |
US9635795B2 (en) | 2012-10-23 | 2017-04-25 | International Business Machines Corporation | Multiple expansion card insertion and extraction tool |
CN103641925B (zh) * | 2012-11-27 | 2016-08-17 | 王晖 | 水溶性多聚糖与紫杉烷类化合物的共价聚化合物,其制备方法及医药用途 |
BR112015030612B1 (pt) | 2013-06-21 | 2020-07-21 | Ferrosan Medical Devices A/S | método para preparar uma composição seca |
JP6453214B2 (ja) * | 2013-07-10 | 2019-01-16 | 生化学工業株式会社 | グリコサミノグリカン誘導体及びその製造方法 |
US10675354B2 (en) | 2013-07-10 | 2020-06-09 | Seikagaku Corporation | Glycosaminoglycan derivative and method for producing same |
EP3079731B1 (de) | 2013-12-11 | 2018-08-08 | Ferrosan Medical Devices A/S | Trockenzusammensetzung mit extrusionsverstärker |
CN103861116A (zh) * | 2014-03-06 | 2014-06-18 | 沈阳药大制剂新技术有限公司 | 一种抗肿瘤药物的前体药物及其制备和应用 |
KR102394087B1 (ko) * | 2014-07-31 | 2022-05-03 | 콘시글리오 나치오날레 델레 리체르체 | 히알루론산 및 카르노신으로부터 수득된 유도체 |
CN104198707B (zh) * | 2014-09-12 | 2016-09-14 | 范飞舟 | N-乙酰氨基葡萄糖在制备检测肿瘤的试剂盒中的应用 |
US11046818B2 (en) | 2014-10-13 | 2021-06-29 | Ferrosan Medical Devices A/S | Dry composition for use in haemostasis and wound healing |
CN104491875A (zh) * | 2014-12-22 | 2015-04-08 | 中国药科大学 | 一种基于透明质酸-难溶性药物前药的自聚纳米系统的制备方法 |
CN107206165B (zh) | 2014-12-24 | 2020-10-23 | 弗罗桑医疗设备公司 | 用于保持并混合第一和第二物质的注射器 |
EP3243841B1 (de) * | 2015-01-09 | 2020-09-30 | Seikagaku Corporation | Chondroitinschwefelsäurederivat und arzneimittel zur behandlung von blasenerkrankungen |
KR20180014042A (ko) * | 2015-05-29 | 2018-02-07 | 알바트로스 테크놀로지스 리미티드 | 약물을 전달하기 위한 가교된 히알루론산 및 이를 이용한 약학적 제제 |
US10918796B2 (en) | 2015-07-03 | 2021-02-16 | Ferrosan Medical Devices A/S | Syringe for mixing two components and for retaining a vacuum in a storage condition |
CN108178803B (zh) * | 2017-09-25 | 2020-03-10 | 温州医科大学 | 一种载药的肉桂醛-葡聚糖聚合物自组装纳米粒的制备及其抗肿瘤应用 |
EP3712181B1 (de) | 2017-11-15 | 2022-10-26 | Chugai Seiyaku Kabushiki Kaisha | Mit polyethylenglykol modifiziertes hyaluronsäurederivat |
CN108219029A (zh) * | 2018-03-22 | 2018-06-29 | 盐城师范学院 | 一种水溶性卡巴他赛抗癌药物的制备方法 |
CN108467439A (zh) * | 2018-03-22 | 2018-08-31 | 盐城师范学院 | 一种水溶性紫杉醇抗癌药物的制备方法 |
KR20210008479A (ko) | 2018-05-09 | 2021-01-22 | 훼로산 메디칼 디바이스 에이/에스 | 지혈 조성물을 제조하는 방법 |
US20210228530A1 (en) * | 2018-06-20 | 2021-07-29 | Santolecan Pharmaceuticals Llc | Taxane-lipid-polysaccharide dual conjugates, preparation methods thereof and uses thereof |
IT201800009731A1 (it) * | 2018-10-25 | 2020-04-25 | Fidia Farm Spa | Coniugato paclitaxel - acido ialuronico nel trattamento del carcinoma vescicale non infiltrante |
CN111588914A (zh) * | 2019-12-31 | 2020-08-28 | 辽宁垠艺生物科技股份有限公司 | 介入或植入医疗器械的药物涂层及其制备方法 |
IT202000007747A1 (it) | 2020-04-10 | 2021-10-10 | Fidia Farm Spa | Coniugato acido ialuronico-paclitaxel nel trattamento del mesotelioma |
IT202000008209A1 (it) * | 2020-04-17 | 2021-10-17 | Fidia Farm Spa | Procedimento di sintesi di un coniugato acido ialuronico-paclitaxel |
CN111892668B (zh) * | 2020-07-03 | 2022-07-12 | 广东工业大学 | 一种化合物及其制备方法、荧光探针和抗肿瘤药物 |
IL297377A (en) * | 2020-07-15 | 2022-12-01 | Coval Biopharma Shanghai Co Ltd | Drug administration system for local administration of therapeutic substances and its uses |
CN114870031B (zh) * | 2022-05-20 | 2023-07-07 | 四川大学 | 一种cd44靶向的紫杉烷类纳米晶体及其制备方法与应用 |
WO2024038088A1 (en) * | 2022-08-16 | 2024-02-22 | Synartro Ab | Liquid formulations |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
GB8713662D0 (en) * | 1987-06-11 | 1987-07-15 | Skandigen Ab | Hyaluronic acid derivatives |
IT1219587B (it) | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
US5356883A (en) * | 1989-08-01 | 1994-10-18 | Research Foundation Of State University Of N.Y. | Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use |
EP0506976B1 (de) * | 1990-10-18 | 1997-04-09 | Shiseido Company Limited | Kombination von hyaluronsäure mit einem medizinischen bestandteil, und seine herstellung |
JP2604930B2 (ja) * | 1990-12-14 | 1997-04-30 | 株式会社ディ・ディ・エス研究所 | ヒアルロン酸およびコンドロイチン誘導体 |
WO1993024476A1 (en) * | 1992-06-04 | 1993-12-09 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
DE69425464T2 (de) * | 1993-02-26 | 2001-05-23 | Drug Delivery System Institute, Ltd. | Polysaccharidderivat und wirkstoffträger |
US5616568A (en) | 1993-11-30 | 1997-04-01 | The Research Foundation Of State University Of New York | Functionalized derivatives of hyaluronic acid |
ITPD940054A1 (it) | 1994-03-23 | 1995-09-23 | Fidia Advanced Biopolymers Srl | Polisaccaridi solfatati |
BR9710646A (pt) * | 1996-03-12 | 2000-01-11 | Pg Txl Co Lp | Pródrogas de paclitaxel solúveis em água. |
CA2175282A1 (en) | 1996-04-29 | 1997-10-30 | Rudolf Edgar Falk | Use of forms of hyaluronic acid (ha) for the treatment of cancer |
CA2208924A1 (en) | 1997-07-09 | 1999-01-09 | Hyal Pharmaceutical Corporation | Sparing paclitaxel by the use of hyaluronan |
EP1082963A4 (de) * | 1998-05-20 | 2004-03-17 | Chugai Pharmaceutical Co Ltd | Arzneimittel für hyaluronsäure-assozierte gelenkkrankheiten |
ITPD980169A1 (it) * | 1998-07-06 | 2000-01-06 | Fidia Advanced Biopolymers Srl | Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione. |
JP2002523407A (ja) | 1998-08-21 | 2002-07-30 | ファルマヘミー ベー.フェー. | パクリタキセルの水溶性類似体およびプロドラッグ |
CN100374163C (zh) | 1999-01-13 | 2008-03-12 | 阿尔凯米亚肿瘤学私人有限公司 | 增强药物功效的组合物 |
JP2001081103A (ja) * | 1999-09-13 | 2001-03-27 | Denki Kagaku Kogyo Kk | ヒアルロン酸結合薬剤 |
US6593308B2 (en) | 1999-12-03 | 2003-07-15 | The Regents Of The University Of California | Targeted drug delivery with a hyaluronan ligand |
WO2001047561A1 (en) | 1999-12-28 | 2001-07-05 | Bioniche Life Sciences Inc. | Hyaluronic acid in the treatment of cancer |
IT1317358B1 (it) | 2000-08-31 | 2003-06-16 | Fidia Advanced Biopolymers Srl | Derivati cross-linkati dell'acido ialuronico. |
IT1317359B1 (it) | 2000-08-31 | 2003-06-16 | Fidia Advanced Biopolymers Srl | Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e |
-
2002
- 2002-10-18 IT IT000271A patent/ITPD20020271A1/it unknown
-
2003
- 2003-10-10 AT AT03748126T patent/ATE420117T1/de active
- 2003-10-10 CN CN200380101570XA patent/CN1705683B/zh not_active Expired - Lifetime
- 2003-10-10 DK DK03748126T patent/DK1560854T3/da active
- 2003-10-10 US US10/531,853 patent/US7897584B2/en active Active
- 2003-10-10 ES ES03748126T patent/ES2320439T3/es not_active Expired - Lifetime
- 2003-10-10 KR KR1020057006412A patent/KR101076414B1/ko active IP Right Grant
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2005
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2006
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