DK1519908T3 - Sammensætning baseret på substituerede derivater af 1,3-dipenylprop-2-en-1-on, fremstilling af anvendelser deraf - Google Patents
Sammensætning baseret på substituerede derivater af 1,3-dipenylprop-2-en-1-on, fremstilling af anvendelser derafInfo
- Publication number
- DK1519908T3 DK1519908T3 DK03762750T DK03762750T DK1519908T3 DK 1519908 T3 DK1519908 T3 DK 1519908T3 DK 03762750 T DK03762750 T DK 03762750T DK 03762750 T DK03762750 T DK 03762750T DK 1519908 T3 DK1519908 T3 DK 1519908T3
- Authority
- DK
- Denmark
- Prior art keywords
- dipenylprop
- preparation
- composition based
- substituted derivatives
- preventing
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 230000032683 aging Effects 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000036542 oxidative stress Effects 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical class C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 abstract 1
- 230000037303 wrinkles Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/055—Phenols the aromatic ring being substituted by halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0208570A FR2841784B1 (fr) | 2002-07-08 | 2002-07-08 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations |
| PCT/FR2003/002128 WO2004005243A2 (fr) | 2002-07-08 | 2003-07-08 | Composition a base de derives de 1,3-diphenylprop-2-en-one substitues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1519908T3 true DK1519908T3 (da) | 2007-10-15 |
Family
ID=29725282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03762750T DK1519908T3 (da) | 2002-07-08 | 2003-07-08 | Sammensætning baseret på substituerede derivater af 1,3-dipenylprop-2-en-1-on, fremstilling af anvendelser deraf |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US7632870B2 (pt) |
| EP (1) | EP1519908B1 (pt) |
| JP (1) | JP4907083B2 (pt) |
| KR (1) | KR100947907B1 (pt) |
| CN (1) | CN1688532B (pt) |
| AT (1) | ATE364588T1 (pt) |
| AU (1) | AU2003264699B2 (pt) |
| BR (1) | BRPI0312399B8 (pt) |
| CA (1) | CA2490993C (pt) |
| CY (1) | CY1108051T1 (pt) |
| DE (1) | DE60314420T2 (pt) |
| DK (1) | DK1519908T3 (pt) |
| EA (1) | EA012699B1 (pt) |
| ES (1) | ES2287529T3 (pt) |
| FR (1) | FR2841784B1 (pt) |
| IL (1) | IL165454A (pt) |
| MX (1) | MXPA05000425A (pt) |
| NO (1) | NO334650B1 (pt) |
| NZ (1) | NZ538052A (pt) |
| PL (1) | PL207707B1 (pt) |
| PT (1) | PT1519908E (pt) |
| SI (1) | SI1519908T1 (pt) |
| WO (1) | WO2004005243A2 (pt) |
| ZA (1) | ZA200501081B (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2841900B1 (fr) | 2002-07-08 | 2007-03-02 | Genfit S A | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
| FR2841784B1 (fr) | 2002-07-08 | 2007-03-02 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations | |
| JP2007517841A (ja) * | 2004-01-08 | 2007-07-05 | ジェンフィット | １，３−ジフェニルプロプ−２−エン−１−オン誘導体化合物、その調製方法およびその使用 |
| CA2601028C (en) | 2005-03-11 | 2014-05-27 | Howard Florey Institute Of Experimental Physiology And Medecine | Flavonoid compounds and uses thereof |
| ES2681794T3 (es) * | 2009-11-26 | 2018-09-17 | Genfit | Uso de derivados de 1,3-difenilprop-2-en-1-ona para tratar trastornos hepáticos |
| WO2011080276A1 (en) | 2009-12-29 | 2011-07-07 | Genfit | Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative |
| MX2013000391A (es) | 2010-07-12 | 2013-03-08 | Hoffmann La Roche | 1-hidroxiimino-3-fenil-propanos. |
| EP3466418A1 (en) | 2011-07-15 | 2019-04-10 | NuSirt Sciences, Inc. | Compositions and methods for modulating metabolic pathways |
| RU2014119220A (ru) * | 2011-10-26 | 2015-12-10 | Ф. Хоффманн-Ля Рош Аг | 1-циклоалкил-или 1-гетероциклил-гидроксиимино-3-фенилпропаны |
| US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
| BR112015010947A2 (pt) | 2012-11-13 | 2018-06-05 | Nusirt Sciences Inc | composições e métodos para aumentar o metabolismo energético. |
| HUE042569T2 (hu) * | 2013-01-18 | 2019-07-29 | Genfit | Rákok és fibrózis kezelési eljárások |
| BR112015023310A2 (pt) | 2013-03-15 | 2017-07-18 | Nusirt Sciences Inc | composições, métodos e kits para redução de níveis lipídicos |
| WO2015131152A1 (en) | 2014-02-27 | 2015-09-03 | Nusirt Sciences Inc. | Compositions and methods for the reduction or prevention of hepatic steatosis |
| WO2017143038A1 (en) | 2016-02-16 | 2017-08-24 | Concert Pharmaceuticals, Inc. | Deuterated gft-505 |
| SG11201808192RA (en) * | 2016-03-30 | 2018-10-30 | Genfit | Non-invasive diagnostic of non-alcoholic steatohepatitis |
| MX2018012663A (es) * | 2016-04-16 | 2019-07-08 | Univ Florida | Metodos para aumentar la capacidad de actividad biológica del virus adenoasociado recombinante producido mediante el sistema baculovirus. |
| CN109316601B (zh) * | 2017-07-31 | 2021-11-09 | 武汉朗来科技发展有限公司 | 药物组合物及其用途 |
| CN108658908B (zh) | 2017-07-31 | 2019-05-10 | 广州必贝特医药技术有限公司 | 1，3-二取代烯酮类化合物及其应用 |
| JP7259850B2 (ja) | 2017-11-30 | 2023-04-18 | シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド | 芳香族化合物、薬学的組成物及びその使用 |
| WO2020025789A1 (en) | 2018-08-03 | 2020-02-06 | Genfit | Elafibranor salts |
| US11634387B2 (en) | 2019-09-26 | 2023-04-25 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
| JP2023513712A (ja) | 2020-02-10 | 2023-04-03 | ジェンフィット | エラフィブラノールの多形体 |
| WO2024029639A1 (ko) * | 2022-08-02 | 2024-02-08 | 제이투에이치바이오텍 주식회사 | 3성분 프로드럭, 이의 약학적 조성물 및 의약 용도 |
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| US3558612A (en) | 1968-05-22 | 1971-01-26 | Dow Chemical Co | Substituted phenoxyacetic acids |
| CH593224A5 (pt) * | 1973-10-30 | 1977-11-30 | Taisho Pharmaceutical Co Ltd | |
| US3994955A (en) * | 1975-01-20 | 1976-11-30 | G. D. Searle & Co. | Substituted phenoxydialkylacetic acids and esters |
| JPS5278856A (en) * | 1975-12-26 | 1977-07-02 | Taisho Pharmaceut Co Ltd | Preparation of chalcone ethers |
| US4190671A (en) * | 1977-03-17 | 1980-02-26 | Biorex Laboratories Limited | Chalcone derivatives |
| JPS5419947A (en) * | 1977-07-16 | 1979-02-15 | Taisho Pharmaceut Co Ltd | Chalcone derivatives |
| US4163859A (en) * | 1977-07-18 | 1979-08-07 | G. D. Searle & Co. | Phenoxyldialkyl acetic acids and esters |
| GB8426424D0 (en) * | 1984-10-19 | 1984-11-28 | Biorex Laboratories Ltd | Chalcone derivatives |
| JPS6310720A (ja) * | 1986-07-01 | 1988-01-18 | Nippon Kayaku Co Ltd | ５−リポキシゲナ−ゼ阻害剤および抗アレルギ−剤 |
| JPH023670A (ja) | 1988-06-22 | 1990-01-09 | Nippon Oil & Fats Co Ltd | アルキルチオカルコン誘導体 |
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| US5523302A (en) | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
| WO1998027970A2 (en) | 1996-12-24 | 1998-07-02 | National Research Council Of Canada | Treatment of diseases or prevention of cellular damage caused by oxygen-containing free radicals |
| EP0947511A1 (en) | 1998-03-30 | 1999-10-06 | F. Hoffmann-La Roche Ag | Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity |
| WO2000023073A1 (en) * | 1998-10-20 | 2000-04-27 | Korea Institute Of Science And Technology | Bioflavonoids as plasma high density lipoprotein level increasing agent |
| JP4249926B2 (ja) * | 2000-01-27 | 2009-04-08 | タカラバイオ株式会社 | 治療剤 |
| JP2004501147A (ja) | 2000-06-20 | 2004-01-15 | アセロジエニクス・インコーポレイテツド | １，３−ビス−（置換フェニル）−２−プロペン−１−オン類およびｖｃａｍ−１媒介障害を治療するためのそれらの使用 |
| EP1254759B1 (de) | 2001-05-03 | 2009-03-18 | Leister Process Technologies | Düse zum Schweissen von Kunststoffbahnen oder -folien |
| FR2841784B1 (fr) | 2002-07-08 | 2007-03-02 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations | |
| FR2841900B1 (fr) * | 2002-07-08 | 2007-03-02 | Genfit S A | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
| FR2857361B1 (fr) * | 2003-07-08 | 2005-09-09 | Genfit S A | PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one |
-
2002
- 2002-07-08 FR FR0208570A patent/FR2841784B1/fr not_active Expired - Fee Related
-
2003
- 2003-07-08 AU AU2003264699A patent/AU2003264699B2/en not_active Ceased
- 2003-07-08 US US10/520,078 patent/US7632870B2/en active Active
- 2003-07-08 AT AT03762750T patent/ATE364588T1/de active
- 2003-07-08 PL PL373465A patent/PL207707B1/pl unknown
- 2003-07-08 DK DK03762750T patent/DK1519908T3/da active
- 2003-07-08 SI SI200330841T patent/SI1519908T1/sl unknown
- 2003-07-08 ES ES03762750T patent/ES2287529T3/es not_active Expired - Lifetime
- 2003-07-08 MX MXPA05000425A patent/MXPA05000425A/es active IP Right Grant
- 2003-07-08 NZ NZ538052A patent/NZ538052A/en not_active IP Right Cessation
- 2003-07-08 JP JP2004518891A patent/JP4907083B2/ja not_active Expired - Lifetime
- 2003-07-08 PT PT03762750T patent/PT1519908E/pt unknown
- 2003-07-08 DE DE60314420T patent/DE60314420T2/de not_active Expired - Lifetime
- 2003-07-08 BR BRPI0312399A patent/BRPI0312399B8/pt not_active IP Right Cessation
- 2003-07-08 CA CA2490993A patent/CA2490993C/fr not_active Expired - Fee Related
- 2003-07-08 WO PCT/FR2003/002128 patent/WO2004005243A2/fr active IP Right Grant
- 2003-07-08 EA EA200500170A patent/EA012699B1/ru not_active IP Right Cessation
- 2003-07-08 CN CN038163519A patent/CN1688532B/zh not_active Expired - Lifetime
- 2003-07-08 EP EP03762750A patent/EP1519908B1/fr not_active Expired - Lifetime
- 2003-07-08 KR KR1020047021625A patent/KR100947907B1/ko active IP Right Grant
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2004
- 2004-11-22 NO NO20045082A patent/NO334650B1/no not_active IP Right Cessation
- 2004-11-29 IL IL165454A patent/IL165454A/en active IP Right Grant
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2005
- 2005-02-07 ZA ZA200501081A patent/ZA200501081B/en unknown
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2007
- 2007-07-03 CY CY20071100879T patent/CY1108051T1/el unknown
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2009
- 2009-10-30 US US12/609,270 patent/US8106097B2/en not_active Expired - Lifetime
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2012
- 2012-01-09 US US13/345,979 patent/US8461212B2/en not_active Expired - Lifetime
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