DK1337535T3 - Benzodiazepinderivater som GABA A-receptormodulatorer - Google Patents

Benzodiazepinderivater som GABA A-receptormodulatorer

Info

Publication number
DK1337535T3
DK1337535T3 DK01996541T DK01996541T DK1337535T3 DK 1337535 T3 DK1337535 T3 DK 1337535T3 DK 01996541 T DK01996541 T DK 01996541T DK 01996541 T DK01996541 T DK 01996541T DK 1337535 T3 DK1337535 T3 DK 1337535T3
Authority
DK
Denmark
Prior art keywords
gaba
receptor modulators
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
DK01996541T
Other languages
Danish (da)
English (en)
Inventor
Raffaello Masciadri
Andrew William Thomas
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1337535T3 publication Critical patent/DK1337535T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK01996541T 2000-11-16 2001-11-08 Benzodiazepinderivater som GABA A-receptormodulatorer DK1337535T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00124332 2000-11-16
PCT/EP2001/012887 WO2002040487A2 (en) 2000-11-16 2001-11-08 Benzodiazepine derivatives as gaba a receptor modulators

Publications (1)

Publication Number Publication Date
DK1337535T3 true DK1337535T3 (da) 2004-10-25

Family

ID=8170315

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01996541T DK1337535T3 (da) 2000-11-16 2001-11-08 Benzodiazepinderivater som GABA A-receptormodulatorer

Country Status (40)

Country Link
US (1) US6743789B2 (OSRAM)
EP (1) EP1337535B1 (OSRAM)
JP (1) JP4088151B2 (OSRAM)
KR (1) KR100504300B1 (OSRAM)
CN (1) CN1191255C (OSRAM)
AR (1) AR031345A1 (OSRAM)
AT (1) ATE268776T1 (OSRAM)
AU (2) AU1700702A (OSRAM)
BG (1) BG107817A (OSRAM)
BR (1) BR0115393A (OSRAM)
CA (1) CA2427576C (OSRAM)
CZ (1) CZ295256B6 (OSRAM)
DE (1) DE60103776T2 (OSRAM)
DK (1) DK1337535T3 (OSRAM)
EC (1) ECSP034607A (OSRAM)
ES (1) ES2220831T3 (OSRAM)
GC (1) GC0000375A (OSRAM)
GT (1) GT200100230A (OSRAM)
HR (1) HRP20030360A2 (OSRAM)
HU (1) HUP0303281A3 (OSRAM)
IL (1) IL155813A0 (OSRAM)
JO (1) JO2359B1 (OSRAM)
MA (1) MA26962A1 (OSRAM)
MX (1) MXPA03004251A (OSRAM)
MY (1) MY141675A (OSRAM)
NO (1) NO324706B1 (OSRAM)
NZ (1) NZ525413A (OSRAM)
PA (1) PA8532401A1 (OSRAM)
PE (1) PE20020583A1 (OSRAM)
PL (1) PL362925A1 (OSRAM)
PT (1) PT1337535E (OSRAM)
RU (1) RU2278865C2 (OSRAM)
SI (1) SI1337535T1 (OSRAM)
SK (1) SK7232003A3 (OSRAM)
TR (1) TR200402073T4 (OSRAM)
TW (1) TWI239333B (OSRAM)
UY (1) UY27026A1 (OSRAM)
WO (1) WO2002040487A2 (OSRAM)
YU (1) YU35603A (OSRAM)
ZA (1) ZA200303435B (OSRAM)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686352B2 (en) * 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
EP1634879A4 (en) * 2003-06-19 2007-09-05 Daiichi Seiyaku Co METHOD FOR THE SELECTIVE INTRODUCTION OF AN AMINO SUBSTITUENT
EP2343073A3 (en) 2003-12-11 2011-10-12 Sepracor Inc. Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
CA2577060A1 (en) 2004-08-13 2006-02-23 Amgen Inc. Substituted benzofused heterocycles
MX2007004250A (es) * 2004-10-12 2007-06-12 Hoffmann La Roche Derivados de imidazo[1,5-a]triazolo[1,5-d]benzodiazepina para el tratamiento de trastornos cognitivos.
CA2584757C (en) * 2004-10-20 2012-07-03 F. Hoffmann-La Roche Ag Halogen substituted benzodiazepine derivatives
RU2007112940A (ru) * 2004-10-20 2008-11-27 Ф.Хоффманн-Ля Рош Аг (Ch) Производные имидазобензодиазепина
KR100923393B1 (ko) * 2004-12-14 2009-10-23 에프. 호프만-라 로슈 아게 Ｇａｂａ 수용체 조절제로서 테트라사이클릭이미다조-벤조다이아제핀
EP1924712B1 (en) * 2005-08-03 2018-10-03 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
ATE477255T1 (de) * 2005-10-11 2010-08-15 Hoffmann La Roche Imidazobenzdiazepinderivate
JP2009513672A (ja) * 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
WO2009139916A1 (en) * 2008-05-16 2009-11-19 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate hsp90 activity
CA2739900C (en) * 2008-11-18 2016-11-08 F. Hoffmann-La Roche Ag Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
NZ592076A (en) * 2008-11-28 2012-06-29 Hoffmann La Roche Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin via receptor antagonists
CU20090172A6 (es) 2009-10-09 2011-10-05 Facultad De Quimica Universidad De La Habana Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
MX383953B (es) 2010-11-15 2025-03-14 Agenebio Inc Derivados de piridazina, composiciones y metodos para tratar deterioro cognitivo.
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
WO2014047413A1 (en) * 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma
MX381561B (es) * 2013-12-20 2025-03-12 Agenebio Inc Derivados de benzodiazepina, composiciones, y métodos para tratar el deterioro cognitivo.
US10815242B2 (en) * 2015-06-19 2020-10-27 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US10059718B2 (en) * 2016-01-04 2018-08-28 Tabomedex Biosciences, LLC Fused quadracyclic compounds, compositions and uses thereof
US10973479B2 (en) 2016-05-16 2021-04-13 Canon Medical Systems Corporation X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
CA3104478A1 (en) * 2018-06-19 2019-12-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102151969B1 (ko) * 2019-12-11 2020-09-04 주식회사 지투비 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK174086D0 (da) 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
TW201311B (OSRAM) 1991-06-17 1993-03-01 Hoffmann La Roche

Also Published As

Publication number Publication date
MY141675A (en) 2010-06-15
MXPA03004251A (es) 2003-09-22
AR031345A1 (es) 2003-09-17
BR0115393A (pt) 2004-07-06
SI1337535T1 (en) 2004-10-31
JP2004517070A (ja) 2004-06-10
DE60103776D1 (de) 2004-07-15
DE60103776T2 (de) 2005-07-14
IL155813A0 (en) 2003-12-23
TWI239333B (en) 2005-09-11
WO2002040487A2 (en) 2002-05-23
CN1191255C (zh) 2005-03-02
NO324706B1 (no) 2007-12-03
GT200100230A (es) 2002-07-04
YU35603A (sh) 2006-05-25
BG107817A (bg) 2004-07-30
SK7232003A3 (en) 2004-03-02
PT1337535E (pt) 2004-09-30
CZ295256B6 (cs) 2005-06-15
CA2427576A1 (en) 2002-05-23
ATE268776T1 (de) 2004-06-15
AU1700702A (en) 2002-05-27
HUP0303281A3 (en) 2005-05-30
HRP20030360A2 (en) 2005-04-30
KR20030045192A (ko) 2003-06-09
AU2002217007B2 (en) 2006-11-30
UY27026A1 (es) 2002-06-20
PA8532401A1 (es) 2002-08-26
JP4088151B2 (ja) 2008-05-21
HUP0303281A2 (hu) 2004-01-28
EP1337535B1 (en) 2004-06-09
CZ20031597A3 (cs) 2003-11-12
NO20032208L (no) 2003-05-15
ECSP034607A (es) 2003-06-25
JO2359B1 (en) 2006-12-12
NO20032208D0 (no) 2003-05-15
RU2003116895A (ru) 2005-02-20
WO2002040487A3 (en) 2002-09-26
US6743789B2 (en) 2004-06-01
CN1474820A (zh) 2004-02-11
HK1062442A1 (en) 2004-11-05
MA26962A1 (fr) 2004-12-20
CA2427576C (en) 2007-11-06
GC0000375A (en) 2007-03-31
ES2220831T3 (es) 2004-12-16
PE20020583A1 (es) 2002-07-06
EP1337535A2 (en) 2003-08-27
NZ525413A (en) 2005-02-25
TR200402073T4 (tr) 2004-10-21
RU2278865C2 (ru) 2006-06-27
US20020103371A1 (en) 2002-08-01
PL362925A1 (en) 2004-11-02
KR100504300B1 (ko) 2005-07-28
ZA200303435B (en) 2004-08-05

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