JO2359B1 - Benzathene derivatives as agents for modulation of GABA A receptor - Google Patents

Benzathene derivatives as agents for modulation of GABA A receptor

Info

Publication number
JO2359B1
JO2359B1 JO2001183A JOP20010183A JO2359B1 JO 2359 B1 JO2359 B1 JO 2359B1 JO 2001183 A JO2001183 A JO 2001183A JO P20010183 A JOP20010183 A JO P20010183A JO 2359 B1 JO2359 B1 JO 2359B1
Authority
JO
Jordan
Prior art keywords
gaba
receptor modulators
benzodiazepine derivatives
receptor
compounds
Prior art date
Application number
JO2001183A
Other languages
Arabic (ar)
English (en)
Inventor
ماسيادري رافيللو
ويليام ثوماس اندرو
ويتشمان جيورجن
Original Assignee
اف . هوفمان- لاروش أيه جي
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by اف . هوفمان- لاروش أيه جي filed Critical اف . هوفمان- لاروش أيه جي
Application granted granted Critical
Publication of JO2359B1 publication Critical patent/JO2359B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JO2001183A 2000-11-16 2001-11-12 Benzathene derivatives as agents for modulation of GABA A receptor JO2359B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00124332 2000-11-16

Publications (1)

Publication Number Publication Date
JO2359B1 true JO2359B1 (en) 2006-12-12

Family

ID=8170315

Family Applications (1)

Application Number Title Priority Date Filing Date
JO2001183A JO2359B1 (en) 2000-11-16 2001-11-12 Benzathene derivatives as agents for modulation of GABA A receptor

Country Status (40)

Country Link
US (1) US6743789B2 (OSRAM)
EP (1) EP1337535B1 (OSRAM)
JP (1) JP4088151B2 (OSRAM)
KR (1) KR100504300B1 (OSRAM)
CN (1) CN1191255C (OSRAM)
AR (1) AR031345A1 (OSRAM)
AT (1) ATE268776T1 (OSRAM)
AU (2) AU2002217007B2 (OSRAM)
BG (1) BG107817A (OSRAM)
BR (1) BR0115393A (OSRAM)
CA (1) CA2427576C (OSRAM)
CZ (1) CZ295256B6 (OSRAM)
DE (1) DE60103776T2 (OSRAM)
DK (1) DK1337535T3 (OSRAM)
EC (1) ECSP034607A (OSRAM)
ES (1) ES2220831T3 (OSRAM)
GC (1) GC0000375A (OSRAM)
GT (1) GT200100230A (OSRAM)
HR (1) HRP20030360A2 (OSRAM)
HU (1) HUP0303281A3 (OSRAM)
IL (1) IL155813A0 (OSRAM)
JO (1) JO2359B1 (OSRAM)
MA (1) MA26962A1 (OSRAM)
MX (1) MXPA03004251A (OSRAM)
MY (1) MY141675A (OSRAM)
NO (1) NO324706B1 (OSRAM)
NZ (1) NZ525413A (OSRAM)
PA (1) PA8532401A1 (OSRAM)
PE (1) PE20020583A1 (OSRAM)
PL (1) PL362925A1 (OSRAM)
PT (1) PT1337535E (OSRAM)
RU (1) RU2278865C2 (OSRAM)
SI (1) SI1337535T1 (OSRAM)
SK (1) SK7232003A3 (OSRAM)
TR (1) TR200402073T4 (OSRAM)
TW (1) TWI239333B (OSRAM)
UY (1) UY27026A1 (OSRAM)
WO (1) WO2002040487A2 (OSRAM)
YU (1) YU35603A (OSRAM)
ZA (1) ZA200303435B (OSRAM)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686352B2 (en) * 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
JP4616770B2 (ja) * 2003-06-19 2011-01-19 第一三共株式会社 選択的なアミノ置換基導入法
ES2515092T3 (es) 2003-12-11 2014-10-29 Sunovion Pharmaceuticals Inc. Combinación de un sedante y un modulador neurotransmisor y métodos de mejorar la calidad del sueño y de tratar la depresión
AU2005272627A1 (en) 2004-08-13 2006-02-23 Amgen Inc. Substituted benzofused heterocycles
WO2006040038A1 (en) 2004-10-12 2006-04-20 F.Hoffmann-La Roche Ag Imidazo [1, 5-a]triazolo[1, 5-d]benzodiazepine derivatives for the treatment of cognitive disorders
JP4783375B2 (ja) 2004-10-20 2011-09-28 エフ．ホフマン−ラ ロシュ アーゲー イミダゾベンゾジゼピン誘導体
CA2584757C (en) 2004-10-20 2012-07-03 F. Hoffmann-La Roche Ag Halogen substituted benzodiazepine derivatives
DE602005007265D1 (de) * 2004-12-14 2008-07-10 Hoffmann La Roche Tetrazyklische imidazobenzodiazepine als gaba-rezeptormodulatoren
WO2007019312A2 (en) * 2005-08-03 2007-02-15 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
JP4885967B2 (ja) * 2005-10-11 2012-02-29 エフ．ホフマン−ラ ロシュ アーゲー イミダゾベンゾジアゼピン誘導体
AU2006308889A1 (en) * 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US9156836B2 (en) * 2008-05-16 2015-10-13 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate HSP90 activity
MX2011005119A (es) 2008-11-18 2011-05-30 Hoffmann La Roche Alquilciclohexileteres de dihidrotetraazabenzoazulenos.
JP5452608B2 (ja) * 2008-11-28 2014-03-26 エフ．ホフマン−ラ ロシュ アーゲー バソプレシン介在受容体アンタゴニストとしての使用のためのジヒドロテトラアザベンゾアズレンのアリールシクロヘキシルエーテル
CU20090172A6 (es) 2009-10-09 2011-10-05 Facultad De Quimica Universidad De La Habana Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
DK2640391T3 (da) 2010-11-15 2016-02-15 Agenebio Inc Pyridazinderivater, sammensætninger og fremgangsmåder til behandling af kognitiv svækkelse
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CA2885148A1 (en) * 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma
EP4032889A1 (en) * 2013-12-20 2022-07-27 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
MA42624A (fr) * 2015-06-19 2021-04-28 Agenebio Inc Dérivés de benzodiazépine, compositions et méthodes de traitement de la déficience cognitive
US10059718B2 (en) * 2016-01-04 2018-08-28 Tabomedex Biosciences, LLC Fused quadracyclic compounds, compositions and uses thereof
US10973479B2 (en) 2016-05-16 2021-04-13 Canon Medical Systems Corporation X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
CN112601749B (zh) * 2018-06-19 2024-03-26 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法
KR102151969B1 (ko) * 2019-12-11 2020-09-04 주식회사 지투비 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK174086D0 (da) 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
TW201311B (OSRAM) 1991-06-17 1993-03-01 Hoffmann La Roche

Also Published As

Publication number Publication date
TWI239333B (en) 2005-09-11
PT1337535E (pt) 2004-09-30
MA26962A1 (fr) 2004-12-20
ES2220831T3 (es) 2004-12-16
AU2002217007B2 (en) 2006-11-30
YU35603A (sh) 2006-05-25
KR100504300B1 (ko) 2005-07-28
HUP0303281A3 (en) 2005-05-30
DE60103776T2 (de) 2005-07-14
PL362925A1 (en) 2004-11-02
MY141675A (en) 2010-06-15
GC0000375A (en) 2007-03-31
DE60103776D1 (de) 2004-07-15
WO2002040487A3 (en) 2002-09-26
GT200100230A (es) 2002-07-04
SI1337535T1 (en) 2004-10-31
RU2003116895A (ru) 2005-02-20
PA8532401A1 (es) 2002-08-26
AR031345A1 (es) 2003-09-17
ECSP034607A (es) 2003-06-25
JP2004517070A (ja) 2004-06-10
JP4088151B2 (ja) 2008-05-21
EP1337535A2 (en) 2003-08-27
NO20032208D0 (no) 2003-05-15
CZ20031597A3 (cs) 2003-11-12
HRP20030360A2 (en) 2005-04-30
HK1062442A1 (en) 2004-11-05
EP1337535B1 (en) 2004-06-09
ZA200303435B (en) 2004-08-05
BG107817A (bg) 2004-07-30
CA2427576C (en) 2007-11-06
BR0115393A (pt) 2004-07-06
ATE268776T1 (de) 2004-06-15
CA2427576A1 (en) 2002-05-23
NZ525413A (en) 2005-02-25
TR200402073T4 (tr) 2004-10-21
HUP0303281A2 (hu) 2004-01-28
CN1474820A (zh) 2004-02-11
DK1337535T3 (da) 2004-10-25
US6743789B2 (en) 2004-06-01
UY27026A1 (es) 2002-06-20
NO20032208L (no) 2003-05-15
WO2002040487A2 (en) 2002-05-23
KR20030045192A (ko) 2003-06-09
CN1191255C (zh) 2005-03-02
CZ295256B6 (cs) 2005-06-15
MXPA03004251A (es) 2003-09-22
PE20020583A1 (es) 2002-07-06
US20020103371A1 (en) 2002-08-01
SK7232003A3 (en) 2004-03-02
RU2278865C2 (ru) 2006-06-27
NO324706B1 (no) 2007-12-03
AU1700702A (en) 2002-05-27
IL155813A0 (en) 2003-12-23

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