DK1309677T3 - Baxillustransformation, transformanter og mutantbiblioteker - Google Patents

Baxillustransformation, transformanter og mutantbiblioteker

Info

Publication number
DK1309677T3
DK1309677T3 DK01957519T DK01957519T DK1309677T3 DK 1309677 T3 DK1309677 T3 DK 1309677T3 DK 01957519 T DK01957519 T DK 01957519T DK 01957519 T DK01957519 T DK 01957519T DK 1309677 T3 DK1309677 T3 DK 1309677T3
Authority
DK
Denmark
Prior art keywords
bax
transformants
illustration
mutant libraries
constructs
Prior art date
Application number
DK01957519T
Other languages
English (en)
Other versions
DK1309677T4 (da
Inventor
Volker Schellenberger
Maria R Diaz-Torres
Olga V Selifonova
Thomas B Morrison
Edwin W Lee
Original Assignee
Genencor Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22842887&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1309677(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genencor Int filed Critical Genencor Int
Application granted granted Critical
Publication of DK1309677T3 publication Critical patent/DK1309677T3/da
Publication of DK1309677T4 publication Critical patent/DK1309677T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
DK01957519.0T 2000-08-11 2001-08-10 Bacillustransformation, transformanter og mutantbiblioteker DK1309677T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22494800P 2000-08-11 2000-08-11
PCT/US2001/025166 WO2002014490A2 (en) 2000-08-11 2001-08-10 Bacillus transformation, transformants and mutant libraries

Publications (2)

Publication Number Publication Date
DK1309677T3 true DK1309677T3 (da) 2008-11-03
DK1309677T4 DK1309677T4 (da) 2012-06-25

Family

ID=22842887

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01957519.0T DK1309677T4 (da) 2000-08-11 2001-08-10 Bacillustransformation, transformanter og mutantbiblioteker

Country Status (8)

Country Link
US (2) US20020182734A1 (da)
EP (1) EP1309677B2 (da)
AT (1) ATE400648T1 (da)
AU (1) AU2001279254A1 (da)
CA (1) CA2418317A1 (da)
DE (1) DE60134752D1 (da)
DK (1) DK1309677T4 (da)
WO (1) WO2002014490A2 (da)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6936289B2 (en) 1995-06-07 2005-08-30 Danisco A/S Method of improving the properties of a flour dough, a flour dough improving composition and improved food products
GB0112226D0 (en) * 2001-05-18 2001-07-11 Danisco Method of improving dough and bread quality
ATE231186T1 (de) 1998-07-21 2003-02-15 Danisco Lebensmittel
DE60234523D1 (de) 2001-05-15 2010-01-07 Novozymes As Alpha-amylasevariante mit veränderten eigenschaften
BR0209154A (pt) 2001-05-18 2004-07-20 Danisco Processo de preparação de uma massa com uma enzima
EP2339017A3 (en) 2002-03-29 2011-10-12 Genencor International, Inc. Enhanced protein expression in bacillus
AU2003223928A1 (en) * 2002-05-07 2003-11-11 Novozymes A/S Homologous recombination into bacterium for the generation of polynucleotide libraries
US20050196766A1 (en) 2003-12-24 2005-09-08 Soe Jorn B. Proteins
MXPA05007654A (es) 2003-01-17 2005-09-30 Danisco Metodo.
US7955814B2 (en) 2003-01-17 2011-06-07 Danisco A/S Method
CN103421760A (zh) 2003-11-19 2013-12-04 金克克国际有限公司 丝氨酸蛋白酶、编码丝氨酸酶的核酸以及包含它们的载体和宿主细胞
US7985569B2 (en) 2003-11-19 2011-07-26 Danisco Us Inc. Cellulomonas 69B4 serine protease variants
WO2005066347A1 (en) 2003-12-24 2005-07-21 Danisco A/S Proteins
US7718408B2 (en) * 2003-12-24 2010-05-18 Danisco A/S Method
GB0716126D0 (en) * 2007-08-17 2007-09-26 Danisco Process
GB0405637D0 (en) 2004-03-12 2004-04-21 Danisco Protein
BRPI0509671A (pt) * 2004-04-08 2007-10-30 Genencor Internation Inc alfa-amilases mutante
DK1776455T3 (da) 2004-07-16 2015-06-22 Dupont Nutrition Biosci Aps Lipolytisk enzym, anvendelser deraf i fødevareindustrien
ZA200706858B (en) 2005-02-18 2008-10-29 Genencor Int Polypeptides having alpha-amylase and granular starch hydrolyzing activity
DK2390321T3 (da) 2005-10-12 2015-02-23 Procter & Gamble Anvendelse og fremstilling af en opbevaringsstabil neutral metalloprotease
EP1989309B1 (en) 2006-01-24 2011-08-31 PURAC Biochem BV Genetic modification of homolactic thermophilic bacilli
US7968691B2 (en) * 2006-08-23 2011-06-28 Danisco Us Inc. Pullulanase variants with increased productivity
WO2008045489A2 (en) 2006-10-10 2008-04-17 Danisco Us, Inc. Genencor Division Glucoamylase variants with altered properties
CN105950523A (zh) * 2006-12-21 2016-09-21 诺维信股份有限公司 在芽孢杆菌属细胞中获得遗传感受态的方法
CN101657538A (zh) 2006-12-21 2010-02-24 诺维信股份有限公司 在芽孢杆菌属细胞中获得遗传感受态的方法
BRPI0720801A2 (pt) 2007-01-25 2014-09-16 Dupont Nutrition Biosci Aps Produção de um lipídio aciltranfersase a partir de células transformadas de bacillus licheniformis.
KR20100028031A (ko) 2007-06-06 2010-03-11 다니스코 유에스 인크. 단백질 특성의 개선 방법
EP3031919B1 (en) * 2007-07-31 2018-09-19 BASF Enzymes LLC Tailored multi-site combinational assembly
JP5594898B2 (ja) 2007-10-09 2014-09-24 ダニスコ・ユーエス・インク 性質が変えられたグルコアミラーゼ変異種
US8592194B2 (en) 2007-10-09 2013-11-26 Danisco Us Inc. Glucoamylase variants with altered properties
BRPI0818144A2 (pt) 2007-11-01 2014-10-14 Danisco Us Inc Produção de termolisin e variantes deste, e uso em detergentes líquidos
MX2010004670A (es) 2007-11-05 2010-05-20 Danisco Us Inc Variantes de alfa-amilasa ts-23 de bacillus sp. con propiedades alteradas.
AR069168A1 (es) 2007-11-05 2010-01-06 Danisco Us Inc Genencor Div Variantes de alfa -amilasas con propiedades alteradas
JP5594899B2 (ja) 2007-11-20 2014-09-24 ダニスコ・ユーエス・インク 変更された性質を有するグルコアミラーゼ変異体
EA020035B1 (ru) 2007-12-21 2014-08-29 ДюПон НЬЮТРИШН БАЙОСАЙЕНСИЗ АпС Способы
WO2009100102A2 (en) 2008-02-04 2009-08-13 Danisco Us Inc., Genencor Division Ts23 alpha-amylase variants with altered properties
DK2257629T3 (da) 2008-03-28 2016-06-13 Danisco Us Inc Fremgangsmåde til locusamplifikation i en bakteriecelle
GB0807161D0 (en) * 2008-04-18 2008-05-21 Danisco Process
WO2009149130A2 (en) 2008-06-06 2009-12-10 Danisco Us Inc. Geobacillus stearothermophilus alpha-amylase (amys) variants with improved properties
JP5647976B2 (ja) 2008-06-06 2015-01-07 ダニスコ・ユーエス・インク 変異体微生物プロテアーゼを含む組成物及び方法
MX2011003178A (es) 2008-09-25 2011-04-21 Danisco Inc Mezclas de alfa-amilasa y metodos para usar esas mezclas.
EP2362902B1 (en) 2008-11-11 2012-10-24 Danisco US, Inc., Genencor Division Compositions and methods comprising a subtilisin variant
EP2647692A3 (en) 2008-11-11 2014-01-22 The Procter and Gamble Company Compositions and methods comprising serine protease variants
AR074106A1 (es) 2008-11-11 2010-12-22 Danisco Us Inc Composiciones y metodos que comprenden una variante de subtilisina
RU2560978C2 (ru) 2008-11-11 2015-08-20 ДАНИСКО ЮЭс ИНК. Протеазы, содержащие одну или несколько комбинируемых мутаций
US20120172275A1 (en) 2009-03-10 2012-07-05 Danisco Us Inc. Bacillus Megaterium Strain DSM90-Related Alpha-Amylases, and Methods of Use, Thereof
RU2011143721A (ru) 2009-04-01 2013-05-10 ДАНИСКО ЮЭс ИНК. Система очистки, содержащая альфа-амилазу и протеазу
WO2010117511A1 (en) 2009-04-08 2010-10-14 Danisco Us Inc. Halomonas strain wdg195-related alpha-amylases, and methods of use, thereof
AR076941A1 (es) 2009-06-11 2011-07-20 Danisco Us Inc Cepa de bacillus para una mayor produccion de proteina
PE20121504A1 (es) 2009-08-19 2012-11-05 Dupont Nutrition Biosci Aps Variantes de glucoamilasa
EP2467475A1 (en) 2009-08-19 2012-06-27 Danisco US Inc. Combinatorial variants of glucoamylase with improved specific activity and/or thermostability
CN102656264A (zh) 2009-10-15 2012-09-05 丹尼斯科公司 脂质酰基转移酶蛋白及其制备方法
GB0920089D0 (en) 2009-11-17 2009-12-30 Danisco Method
US8815559B2 (en) 2010-02-18 2014-08-26 Danisco Us Inc. Amylase from nesterenkonia and methods of use, thereof
US20120067373A1 (en) 2010-04-15 2012-03-22 Philip Frank Souter Automatic Dishwashing Detergent Composition
JP6018044B2 (ja) 2010-04-15 2016-11-02 ダニスコ・ユーエス・インク プロテアーゼ変異体を含む組成物及び方法
CN105925556B (zh) 2010-05-06 2020-11-13 丹尼斯科美国公司 包含枯草杆菌蛋白酶变体的组合物和方法
CA3111256C (en) 2011-05-05 2023-05-09 Danisco Us Inc. Compositions and methods comprising serine protease variants
KR20140056237A (ko) 2011-06-30 2014-05-09 노보자임스 에이/에스 알파-아밀라제 변이체
EP3246404B1 (en) 2011-10-28 2019-02-27 Danisco US Inc. Variant maltohexaose-forming alpha-amylase variants
CA2858252A1 (en) 2011-12-22 2013-06-27 Danisco Us Inc. Variant alpha-amylases and methods of use, thereof
HUE057894T2 (hu) 2012-06-08 2022-06-28 Danisco Us Inc Alfa-amiláz változatok javított aktivitással keményítõpolimereken
MX2015002099A (es) 2012-08-22 2015-05-11 Dupont Nutrition Biosci Aps Variantes que tienen actividad glucoamilasa.
EP3354728B1 (en) 2012-12-21 2020-04-22 Danisco US Inc. Alpha-amylase variants
BR112015021647B1 (pt) 2013-03-11 2023-04-25 Danisco Us Inc Variantes recombinantes de alfa-amilase e composições de detergente compreendendo as mesmas
WO2014204596A1 (en) 2013-06-17 2014-12-24 Danisco Us Inc. Alpha-amylase from bacillaceae family member
US20160186102A1 (en) 2013-10-03 2016-06-30 Danisco Us Inc. Alpha-amylases from exiguobacterium, and methods of use, thereof
US20160160199A1 (en) 2013-10-03 2016-06-09 Danisco Us Inc. Alpha-amylases from exiguobacterium, and methods of use, thereof
WO2015092013A1 (en) * 2013-12-20 2015-06-25 Deinove Is-targeting system for gene insertion and genetic engineering in deinococcus bacteria
EP3495482B1 (en) * 2014-01-21 2020-09-02 Synplogen Co., Ltd. Method for preparing dna unit composition, and method for creating concatenated dna
US9416393B2 (en) 2014-10-13 2016-08-16 American Sterilizer Company Biological indicator
EP3805384A1 (en) 2015-05-22 2021-04-14 DuPont Nutrition Biosciences ApS Aldc production methods
US20180171323A1 (en) 2015-05-22 2018-06-21 Dupont Nutrition Biosciences Aps Acetolactate decarboxylase
CA3012445C (en) 2016-01-25 2024-01-23 American Sterilizer Company Capacitor for detecting viable microorganisms
DK3419991T3 (da) 2016-03-04 2023-01-16 Danisco Us Inc Modificerede ribosomale genpromotorer til proteinproduktion i mikroorganismer
CN105861405A (zh) * 2016-05-06 2016-08-17 中国科学院上海高等研究院 一种高转化率的枯草芽孢杆菌及其构建方法
WO2018050649A1 (en) 2016-09-16 2018-03-22 Dupont Nutrition Biosciences Aps Acetolactate decarboxylase variants having improved specific activity
CN110381746B (zh) 2016-12-21 2023-12-01 杜邦营养生物科学有限公司 使用热稳定丝氨酸蛋白酶的方法
EP3571217B1 (en) 2017-01-23 2023-06-21 Danisco US Inc. Methods and compositions for obtaining natural competence in bacillus host cells
US11866713B2 (en) 2017-02-24 2024-01-09 Danisco Us Inc. Compositions and methods for increased protein production in bacillus licheniformis
WO2018169780A1 (en) 2017-03-15 2018-09-20 Dupont Nutrition Biosciences Aps Methods of using an archaeal serine protease
WO2018169750A1 (en) 2017-03-15 2018-09-20 Danisco Us Inc Trypsin-like serine proteases and uses thereof
BR112019018969A2 (pt) 2017-03-15 2020-04-22 Dupont Nutrition Biosci Aps serina proteases similar à tripsina e usos das mesmas
DK3607097T3 (da) 2017-04-07 2023-09-18 Dupont Nutrition Biosci Aps Bacillus-værtsceller, der danner beta-galactosidaser og lactaser i fravær af p-nitrobenzylesterase-sideaktivitet
US10889848B2 (en) 2017-07-14 2021-01-12 American Sterilizer Company Process for determining viability of test microorganisms of biological indicator and sterilization detection device for determining same
US10876144B2 (en) 2017-07-14 2020-12-29 American Sterilizer Company Process for determining viability of test microorganisms of biological indicator and sterilization detection device for determining same
US10900062B2 (en) 2017-07-14 2021-01-26 American Sterilizer Company Process for determining viability of test microorganisms of biological indicator and sterilization detection device for determining same
EP3655537A1 (en) 2017-08-23 2020-05-27 Danisco US Inc. Methods and compositions for efficient genetic modifications of bacillus licheniformis strains
CN111094576A (zh) 2017-09-13 2020-05-01 丹尼斯科美国公司 用于增加芽胞杆菌属中蛋白质产生的经修饰的5′-非翻译区(utr)序列
AU2018386002A1 (en) 2017-12-15 2020-05-28 Danisco Us Inc CAS9 variants and methods of use
KR20200105879A (ko) 2018-01-03 2020-09-09 다니스코 유에스 인크. 증가된 단백질 생산을 위한 돌연변이체 및 유전자 변형된 바실러스 세포 및 이의 방법
US20210277374A1 (en) 2018-07-06 2021-09-09 Dupont Nutrition Biosciences Aps Xylanase-containing feed additives for cereal-based animal feed
US11781147B2 (en) 2018-11-28 2023-10-10 Danisco Us Inc. Promoter sequences and methods thereof for enhanced protein production in Bacillus cells
JP2022526982A (ja) 2019-04-05 2022-05-27 ダニスコ・ユーエス・インク 線状組換えＤＮＡコンストラクトを使用してバチルス（Ｂａｃｉｌｌｕｓ）のゲノムにドナーＤＮＡ配列を組み込むための方法及びその組成物
US20220162621A1 (en) 2019-04-05 2022-05-26 Danisco Us Inc Methods For Polynucleotide Integration Into The Genome Of Bacillus Using Dual Circular Recombinant DNA Constructs And Compositions Thereof
EP4031560A1 (en) 2019-08-14 2022-07-27 Danisco US Inc Compositions and methods for increased protein production in bacillus licheniformis
CN114729346A (zh) 2019-09-13 2022-07-08 丹尼斯科美国公司 热稳定的葡萄糖异构酶变体
EP4051793A1 (en) 2019-10-28 2022-09-07 Danisco US Inc Microbial host cells for the production of heterologous cyanuric acid hydrolases and biuret hydrolases
CN115335503A (zh) 2019-11-11 2022-11-11 丹尼斯科美国公司 用于增强芽孢杆菌属细胞中蛋白质产生的组合物和方法
KR20220098245A (ko) 2019-11-19 2022-07-11 다니스코 유에스 인크. 바실러스 게놈 및 이의 조성물을 변형시키기 위한 선택 마커-부재 방법
JP2023524334A (ja) 2020-01-15 2023-06-12 ダニスコ・ユーエス・インク バチルス・リケニフォルミス（ｂａｃｉｌｌｕｓ ｌｉｃｈｅｎｉｆｏｒｍｉｓ）における強化したタンパク質産生のための組成物及び方法
US20240101611A1 (en) 2021-02-22 2024-03-28 Danisco Us Inc. Methods and compositions for producing proteins of interest in pigment deficient bacillus cells
CN117769597A (zh) 2021-05-24 2024-03-26 丹尼斯科美国公司 用于增强芽孢杆菌属细胞中蛋白质产生的组合物和方法
WO2023274923A1 (en) 2021-06-30 2023-01-05 Henkel Ag & Co. Kgaa Composition with improved moisture management performance
CN117616120A (zh) 2021-06-30 2024-02-27 丹尼斯科美国公司 变体脂肪酶及其用途
KR20240027617A (ko) 2021-06-30 2024-03-04 헨켈 아게 운트 코. 카게아아 폴리에스테라제 활성을 갖는 지질분해 효소를 포함하는 세정 조성물
CN117580939A (zh) 2021-06-30 2024-02-20 汉高股份有限及两合公司 具有改善的抗灰化性能和/或抗起球性能的清洁组合物
WO2023023642A2 (en) 2021-08-20 2023-02-23 Danisco Us Inc. Methods and compositions for enhanced protein production in bacillus cells
WO2023091878A1 (en) 2021-11-16 2023-05-25 Danisco Us Inc. Compositions and methods for enhanced protein production in bacillus cells
WO2023183865A1 (en) 2022-03-24 2023-09-28 Danisco Us Inc. Compositions and methods for industrial scale production and recovery of lectins
WO2023192953A1 (en) 2022-04-01 2023-10-05 Danisco Us Inc. Pro-region mutations enhancing protein production in gram-positive bacterial cells
CN114990035A (zh) * 2022-04-08 2022-09-02 华南农业大学 一株枯草芽孢杆菌bs168感受态工程菌株及其应用
WO2024040043A1 (en) 2022-08-16 2024-02-22 International N&H Denmark Aps Expression systems for phosphatases
WO2024050503A1 (en) 2022-09-02 2024-03-07 Danisco Us Inc. Novel promoter and 5'-untranslated region mutations enhancing protein production in gram-positive cells
WO2024064653A1 (en) 2022-09-20 2024-03-28 Dupont Nutrition Biosciences Aps Variant anti-viral polypeptides
WO2024091804A1 (en) 2022-10-24 2024-05-02 Danisco Us Inc. Compositions and methods for enhanced protein production in bacillus cells

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5624829A (en) * 1984-07-03 1997-04-29 Gist-Brocades, B.V. Transformed industrial bacillus strains and methods for making and using them
US4828994A (en) * 1984-09-21 1989-05-09 Genex Corporation Bacillus strains with reduced extracellular protease levels
DE69631118T2 (de) * 1995-01-23 2004-07-01 Novozymes A/S Dna-integration durch transposition
US5827515A (en) * 1995-08-30 1998-10-27 Sandoz Ltd. Bacillus thuringiensis sporulation gene
US5756316A (en) † 1995-11-02 1998-05-26 Genencor International, Inc. Molecular cloning by multimerization of plasmids
US6326204B1 (en) * 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination

Also Published As

Publication number Publication date
WO2002014490A2 (en) 2002-02-21
CA2418317A1 (en) 2002-02-21
ATE400648T1 (de) 2008-07-15
EP1309677A2 (en) 2003-05-14
DE60134752D1 (de) 2008-08-21
AU2001279254A1 (en) 2002-02-25
DK1309677T4 (da) 2012-06-25
EP1309677B2 (en) 2012-04-11
EP1309677B1 (en) 2008-07-09
US20020182734A1 (en) 2002-12-05
US20060199222A1 (en) 2006-09-07
WO2002014490A3 (en) 2003-02-06

Similar Documents

Publication Publication Date Title
DK1309677T3 (da) Baxillustransformation, transformanter og mutantbiblioteker
MY127434A (en) Method for producing substance utilizing microorganism
GB0003146D0 (en) A support member for a busbar assembly,a method of making a support member for a busbar assembly,a busbar assembly,& a support member & a spacer member for a
DK1012298T3 (da) Gærstammer til fremstilling af mælkesyre
NZ513153A (en) Selection of proteins using RNA-protein fusions
MXPA02006614A (es) Promotor mutante apre.
EA200700329A1 (ru) Биохимический синтез 1,4-бутандиамина
HK1084151A1 (en) Interleukin-18 mutants, their production and use
EP1154020A3 (en) Arginine repressor deficient strain of coryneform bacterium and method for producing L-arginine
TWI266837B (en) Friction damper
GR1004334B (el) Αιωρουμενη ηλιακη καμιναδα
MXPA02008151A (es) Metodo para la fabricacion de un electrodo y electrodo producido.
PL331942A1 (en) Method of biologically transforming colchicinoid compounds into their correcponding 3-glycoside derivatives
ATE510017T1 (de) 2,5-dkg-permeasen
EP1591520A3 (en) Microorganism producing L-threonine having inactivated tyR gene, method of producing the same and method of producing L-threonine using the microorganism
AU2003287945A8 (en) Mutant protein and refolding method
AU2002230579A1 (en) Calcilytic compounds
DK1002122T3 (da) Fremgangsmåde til fremstilling af amider
PT1294622E (pt) Lata metalica que e uma embalagem metalica estanque a pressao e metodo para a sua producao
MXPA04004526A (es) N-metil-homocisteinas, su uso y metodo para su produccion.
EP1334176A4 (en) L-GLUTAMATE-PRODUCING MICRO-ORGANISMS AND METHOD FOR THE PREPARATION OF L-GLUTAMATE USING THE SAME
AU2002364384A1 (en) Articular implant and method for the production thereof
DK1268950T3 (da) Anvendelse af en forbindelsesanordning til forbindelse og lydisolering mellem to panelformede vægenheder
HUP9700615A2 (hu) Akarviozil-transzferáz, eljárás az előállítására, valamint az enzim alkalmazása akarbóz-melléktermékek akarbózzá való átalakítására és akarbóz-homológok előállítására
CA2414988A1 (en) Equipment and method for enhancing combustion and heat transfer in a boiler by using sound