ATE510017T1 - 2,5-dkg-permeasen - Google Patents

2,5-dkg-permeasen

Info

Publication number
ATE510017T1
ATE510017T1 AT01959520T AT01959520T ATE510017T1 AT E510017 T1 ATE510017 T1 AT E510017T1 AT 01959520 T AT01959520 T AT 01959520T AT 01959520 T AT01959520 T AT 01959520T AT E510017 T1 ATE510017 T1 AT E510017T1
Authority
AT
Austria
Prior art keywords
host cell
dkg
klg
transport
produce
Prior art date
Application number
AT01959520T
Other languages
English (en)
Inventor
Veronique Dartois
James Hoch
Fernando Valle
Manoj Kumar
Original Assignee
Microgenomics Inc
Danisco Us Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microgenomics Inc, Danisco Us Inc filed Critical Microgenomics Inc
Application granted granted Critical
Publication of ATE510017T1 publication Critical patent/ATE510017T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/26—Klebsiella (G)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Laminated Bodies (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Production Of Multi-Layered Print Wiring Board (AREA)
AT01959520T 2000-08-04 2001-08-03 2,5-dkg-permeasen ATE510017T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63329400A 2000-08-04 2000-08-04
US67703200A 2000-09-29 2000-09-29
PCT/US2001/024507 WO2002012468A2 (en) 2000-08-04 2001-08-03 2,5-dkg permeases

Publications (1)

Publication Number Publication Date
ATE510017T1 true ATE510017T1 (de) 2011-06-15

Family

ID=27091840

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01959465T ATE318907T1 (de) 2000-08-04 2001-08-03 Erhöhte herstellung von 2-keto-l-gulonsäure
AT01959520T ATE510017T1 (de) 2000-08-04 2001-08-03 2,5-dkg-permeasen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT01959465T ATE318907T1 (de) 2000-08-04 2001-08-03 Erhöhte herstellung von 2-keto-l-gulonsäure

Country Status (12)

Country Link
US (1) US20040029234A1 (de)
EP (3) EP1305423A2 (de)
JP (3) JP4975937B2 (de)
CN (3) CN100547073C (de)
AT (2) ATE318907T1 (de)
AU (3) AU2001283132A1 (de)
BR (3) BR0113032A (de)
CA (4) CA2417970C (de)
DE (1) DE60117566T2 (de)
DK (1) DK1305421T3 (de)
MX (3) MXPA03001025A (de)
WO (3) WO2002012481A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6720168B2 (en) 2000-08-04 2004-04-13 Genencor International, Inc. 2,5-DKG permeases
ATE318907T1 (de) * 2000-08-04 2006-03-15 Genencor Int Erhöhte herstellung von 2-keto-l-gulonsäure
US7229811B2 (en) 2001-08-03 2007-06-12 Genencor International, Inc. 2,5-diketo-D-gluconic acid (2,5-DKG) permeases
CA2852159A1 (en) 2003-05-22 2005-02-24 Timothy C. Dodge Metabolically engineered bacterial strains having non-functional endogenous gluconate transporters
ATE531803T1 (de) 2003-06-05 2011-11-15 Ajinomoto Kk Fermentierungsverfahren mittels veränderter bakterien mit einer erhöhten aufnahme von nebenprodukten
JP4742521B2 (ja) * 2003-06-05 2011-08-10 味の素株式会社 目的物質の製造法
WO2006084725A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Novel gene sts 16
JP4980651B2 (ja) * 2006-06-09 2012-07-18 Ｊｘ日鉱日石エネルギー株式会社 菌体温度を制御する能力を有する細菌
KR20160018568A (ko) * 2013-06-05 2016-02-17 란자테크 뉴질랜드 리미티드 발효 경로를 통한 플럭스의 증가를 나타내는 재조합 미생물
CN114045243B (zh) * 2021-12-03 2023-12-26 山东天力药业有限公司 一种缩短生黑葡萄糖酸杆菌发酵周期的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757012A (en) * 1983-06-28 1988-07-12 Genentech, Inc. Ascorbic acid intermediates and process enzymes
US5047340A (en) * 1985-06-05 1991-09-10 The University Of Kentucky Research Foundation LAC+ saccharomyces cerevisiae
US5032514A (en) * 1988-08-08 1991-07-16 Genentech, Inc. Metabolic pathway engineering to increase production of ascorbic acid intermediates
US5376544A (en) * 1992-09-08 1994-12-27 Rutgers The State University Of New Jersey Enzymes for the production of 2-keto-L-gulonic acid
ATE257515T1 (de) * 1993-10-08 2004-01-15 Lonza Ag Gene für den butyrobetain/crotonobetain-l- carnitin-stoffwechsel und ihre verwendung zur mikrobiologischen herstellung von l-carnitin
US5795716A (en) * 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
DE19523279A1 (de) * 1995-06-27 1997-01-09 Forschungszentrum Juelich Gmbh Verfahren zur mikrobiellen Herstellung von Aminosäuren mittels rekombinanter Mikroorganismen mit erhöhter Sekretionsrate
FR2736652B1 (fr) * 1995-07-13 1997-08-14 Univ Bourgogne Levures et bacteries transformees pour operer la fermentation malolactique dans les vins
US5958672A (en) * 1995-07-18 1999-09-28 Diversa Corporation Protein activity screening of clones having DNA from uncultivated microorganisms
US5795761A (en) * 1996-01-11 1998-08-18 Rutgers, The State University Of New Jersey Mutants of 2,5-diketo-D-gluconic acid (2,5-DKG) reductase A
US5783431A (en) * 1996-04-24 1998-07-21 Chromaxome Corporation Methods for generating and screening novel metabolic pathways
US5817490A (en) * 1996-05-17 1998-10-06 Eastman Chemical Company Enzymatic process for the manufacture of ascorbic acid 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid
CN1180747A (zh) * 1996-10-18 1998-05-06 中国科学院上海生物工程研究中心 从葡萄糖发酵制备2－酮基－l－古龙酸的新方法
US5834231A (en) * 1996-10-24 1998-11-10 Archer Daniels Midland Co. Bacterial strains and use thereof in fermentation process for 2-keto-L-gulonic acid production
DE19644566A1 (de) * 1996-10-26 1998-04-30 Forschungszentrum Juelich Gmbh Mikrobielle Herstellung von Substanzen aus dem aromatischen Stoffwechsel / I
EP0839909A1 (de) * 1996-10-29 1998-05-06 Rijksuniversiteit te Groningen Nukleinsäuresequenzen die für Citrat-Transporterproteine Kodieren
CN1119414C (zh) * 1997-12-30 2003-08-27 中国科学院上海生物工程研究中心 突变的2,5二酮基－d－葡萄糖酸还原酶及其基因工程表达
US6368793B1 (en) * 1998-10-14 2002-04-09 Microgenomics, Inc. Metabolic selection methods
US6720168B2 (en) * 2000-08-04 2004-04-13 Genencor International, Inc. 2,5-DKG permeases
ATE318907T1 (de) * 2000-08-04 2006-03-15 Genencor Int Erhöhte herstellung von 2-keto-l-gulonsäure

Also Published As

Publication number Publication date
WO2002012468A3 (en) 2002-12-05
DE60117566D1 (de) 2006-04-27
MXPA03001030A (es) 2003-11-25
CN1469927A (zh) 2004-01-21
DE60117566T2 (de) 2007-01-11
AU2001281018A1 (en) 2002-02-18
JP2004519213A (ja) 2004-07-02
MXPA03001026A (es) 2003-09-22
CA2417871A1 (en) 2002-02-14
CN100378222C (zh) 2008-04-02
BR0113034A (pt) 2005-08-16
EP1305421A2 (de) 2003-05-02
CN1458976A (zh) 2003-11-26
JP2004519214A (ja) 2004-07-02
EP1305422A2 (de) 2003-05-02
CA2417969A1 (en) 2002-02-14
BR0113032A (pt) 2006-02-21
JP4975937B2 (ja) 2012-07-11
WO2002012528A3 (en) 2003-02-06
DK1305421T3 (da) 2006-07-10
CN1527880A (zh) 2004-09-08
WO2002012481A3 (en) 2002-10-10
EP1305421B1 (de) 2006-03-01
AU2001281068A1 (en) 2002-02-18
WO2002012528A2 (en) 2002-02-14
CN100547073C (zh) 2009-10-07
EP1305422B1 (de) 2011-05-18
ATE318907T1 (de) 2006-03-15
WO2002012481A2 (en) 2002-02-14
BR0113034B1 (pt) 2014-09-16
CA2820132A1 (en) 2002-02-14
BR0113036A (pt) 2006-02-21
EP1305423A2 (de) 2003-05-02
CA2417871C (en) 2011-11-15
MXPA03001025A (es) 2003-11-25
US20040029234A1 (en) 2004-02-12
JP2004514421A (ja) 2004-05-20
JP4975938B2 (ja) 2012-07-11
WO2002012468A2 (en) 2002-02-14
AU2001283132A1 (en) 2002-02-18
CA2417970A1 (en) 2002-02-14
CA2417970C (en) 2013-09-24

Similar Documents

Publication Publication Date Title
MXPA05012230A (es) Codificacion de longitud de cuadro variable optimizada en fidelidad.
BR0200452A (pt) Método para produzir ácido l-glut mico pela fermentação
EP1180371A4 (de) WIRKSTOFFE ZUR FöRDERUNG DER AUSBILDUNG EINER MEMBRAN ALS HAUTGRUNDLAGE, WIRKSTOFFE ZUR FöRDERUNG DER AUSBILDUNG VON KüNSTLICHER HAUT UND VERFAHREN ZUR HERSTELLUNG VON KüNSTLICHER HAUT
EP0913466A3 (de) Verfahren zur Herstellung von L-Leucin
DK1032686T3 (da) Cellulase dannet af Actinomyceter og fremgangsmåde til frembringelse heraf
DK1283265T3 (da) Fremgangsmåde til fremstilling af protein med reduktion af mannosephosphat i sukkerkæden og glycoprotein fremstillet derved
AUPR063400A0 (en) Xml encoding scheme
BR0012712A (pt) Métodos de produção de l-aminoácidos aumentando-se o nadph celular
ATE510017T1 (de) 2,5-dkg-permeasen
CY1110827T1 (el) Μια μεθοδος παραγωγης ηλεκτρικου οξεος απο ακατεργαστα υδρολυματα
ATE338471T1 (de) Nicht-lebensfähigen lactobacillus enthaltendes lebensmittelprodukt
DK1311670T3 (da) Fremgangsmåde til massiv dirigeret mutagenese
ATE445426T1 (de) Portsystem für einen perkutan implantierten port
DK1476029T3 (da) Bakterielt autolysat
LV12319A (lv) Phaffia rhodozyma celmi kuros augsta intracelulara astaksanina koncentracija un zema intracelulara hdco koncentracija
AU2003273521A1 (en) Production method of iturin a and its homologues
FR2815640B1 (fr) Procede de production de proteines par electropulsation de levures
BR0114238A (pt) Sistema, método e equipamento de comunicação
BR9903603A (pt) Processo para produzir um produto fermentativo utilizando um microorganismo, e, microorganismo
GEP20063918B (en) Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrro-lizin-5-ylacetic acid
TWI316091B (de)
RU2076527C1 (ru) Штамм вируса скручивания листьев картофеля для получения антигена, используемого при производстве иммуноферментных диагностикумов
FR2803484B1 (fr) Procede d'obtention de plantes a teneur enrichie en cysteine et glutathion
ATE364082T1 (de) Verfahren zur herstellung von pflanzen mit erhöhter resistenz gegen wasserstress
DE60332667D1 (de) Verfahren zur herstellung von streptokinase durch kultivierung von genetisch veränderten escherichia coli

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties