DK1021432T3 - Halogensubstituerede tetracykliske tetrahydrofuranderivater - Google Patents

Halogensubstituerede tetracykliske tetrahydrofuranderivater

Info

Publication number
DK1021432T3
DK1021432T3 DK98950107T DK98950107T DK1021432T3 DK 1021432 T3 DK1021432 T3 DK 1021432T3 DK 98950107 T DK98950107 T DK 98950107T DK 98950107 T DK98950107 T DK 98950107T DK 1021432 T3 DK1021432 T3 DK 1021432T3
Authority
DK
Denmark
Prior art keywords
halogen
tetrahydrofuran derivatives
substituted tetracyclic
tetracyclic tetrahydrofuran
substituted
Prior art date
Application number
DK98950107T
Other languages
Danish (da)
English (en)
Inventor
Pilar Gil-Lopetegui
Jose Ignacio Andres-Gil
Francisco Javi Fernandez-Gadea
Adolfo Diaz-Martinez
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK1021432T3 publication Critical patent/DK1021432T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK98950107T 1997-10-10 1998-10-06 Halogensubstituerede tetracykliske tetrahydrofuranderivater DK1021432T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97203154 1997-10-10
PCT/EP1998/006352 WO1999019317A1 (en) 1997-10-10 1998-10-06 Halogen substituted tetracyclic tetrahydrofuran derivatives

Publications (1)

Publication Number Publication Date
DK1021432T3 true DK1021432T3 (da) 2003-07-14

Family

ID=8228817

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98950107T DK1021432T3 (da) 1997-10-10 1998-10-06 Halogensubstituerede tetracykliske tetrahydrofuranderivater

Country Status (35)

Country Link
US (2) US6511976B1 (cs)
EP (1) EP1021432B1 (cs)
JP (1) JP3248902B2 (cs)
KR (1) KR100366014B1 (cs)
CN (1) CN100340554C (cs)
AP (1) AP1239A (cs)
AR (1) AR017325A1 (cs)
AT (1) ATE235479T1 (cs)
AU (1) AU737334B2 (cs)
BG (1) BG64387B1 (cs)
BR (1) BR9812871A (cs)
CA (1) CA2305612C (cs)
CZ (1) CZ296928B6 (cs)
DE (1) DE69812668T2 (cs)
DK (1) DK1021432T3 (cs)
EA (1) EA003698B1 (cs)
EE (1) EE04526B1 (cs)
ES (1) ES2195403T3 (cs)
HR (1) HRP20000189A2 (cs)
HU (1) HU225161B1 (cs)
ID (1) ID23903A (cs)
IL (1) IL135538A (cs)
MY (1) MY117783A (cs)
NO (1) NO317159B1 (cs)
NZ (1) NZ503294A (cs)
OA (1) OA11898A (cs)
PL (1) PL339833A1 (cs)
PT (1) PT1021432E (cs)
SI (1) SI1021432T1 (cs)
SK (1) SK284028B6 (cs)
TR (1) TR200000918T2 (cs)
TW (1) TW567186B (cs)
UA (1) UA52778C2 (cs)
WO (1) WO1999019317A1 (cs)
ZA (1) ZA989204B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA79248C2 (en) * 2001-11-09 2007-06-11 Janssen Pharmaceutica Nv Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives
IL162349A0 (en) * 2001-12-07 2005-11-20 Janssen Pharmaceutica Nv Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo Ä3,4:6,7Ücyclohepta Ä1,2-bÜfuran derivatives
EP1463722A2 (en) 2001-12-07 2004-10-06 Janssen Pharmaceutica N.V. PREPARATION OF CIS-FUSED 3,3a,8,12b-TETRAHYDRO-2-H-DIBENZO[3,4:6,7]CYCLOHEPTA[1,2-b]FURAN DERIVATIVES
HRP20020305A8 (en) * 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020441A2 (en) * 2002-05-21 2003-12-31 Pliva D D 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20030160A2 (en) * 2003-03-06 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. 1-thiadibenzoazulene derivatives and biological action thereof
HRP20030885A2 (en) * 2003-11-03 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030958A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030959A2 (cs) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o.
HRP20030953A2 (en) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030954A2 (en) * 2003-11-21 2005-08-31 Pliva D.D. USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030955A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030956A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
HRP20030957A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) * 2004-01-30 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
PT1761514E (pt) * 2004-06-14 2008-10-28 Janssen Pharmaceutica Nv Novos derivados de tetra-hidrofurano tetracíclicos
JP4823221B2 (ja) * 2004-06-23 2011-11-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 新規な不飽和四環式テトラヒドロフラン誘導体
AU2005313325C1 (en) * 2004-12-07 2011-11-10 Janssen Pharmaceutica N.V. Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
AU2011202995B2 (en) * 2004-12-07 2012-02-02 Janssen Pharmaceutica N.V. Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
MX2007009092A (es) 2005-01-27 2007-09-12 Janssen Pharmaceutica Nv Derivados de tetrahidrofurano tetraciclicos heterociclicos como inhibidores de 5ht2 en el tratamiento de trastornos del sistema nervioso central.
WO2006122944A1 (en) 2005-05-19 2006-11-23 Janssen Pharmaceutica N.V. Selected tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain
CN101184759A (zh) * 2005-05-26 2008-05-21 詹森药业有限公司 新颖的取代四环四氢呋喃、吡咯烷和四氢噻吩衍生物以及它们作为药物的用途
AU2006259020C1 (en) * 2005-06-17 2012-01-19 Janssen Pharmaceutica N.V. Novel tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain
US9125866B1 (en) 2015-01-28 2015-09-08 King Saud University Antidepressant compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69520071T2 (de) * 1994-11-02 2001-09-13 Janssen Pharmaceutica N.V., Beerse Substituierte tetracyclische oxazepine- und thiazepinederivate mit 5-ht2 rezeptoraffinität
US5552399A (en) * 1994-11-02 1996-09-03 Janssen Pharmaceutica N.V. Substituted tetracyclic azepine derivatives
SI0892793T1 (en) * 1996-04-12 2003-10-31 Janssen Pharmaceutica N.V. Substituted tetracyclic tetrahydrofuran derivatives
YU10499A (sh) 1996-08-28 2001-03-07 Eli Lilly And Company Supstituisani 1,2,3,4-tetrahidro-2-dibenzofuranamini i 2-aminociklohepta /b/benzofurani

Also Published As

Publication number Publication date
HUP0003748A3 (en) 2002-02-28
HK1029106A1 (en) 2001-03-23
DE69812668D1 (de) 2003-04-30
EP1021432A1 (en) 2000-07-26
BG104287A (en) 2000-11-30
NO20001792D0 (no) 2000-04-06
ES2195403T3 (es) 2003-12-01
PL339833A1 (en) 2001-01-02
HU225161B1 (en) 2006-07-28
NZ503294A (en) 2001-08-31
MY117783A (en) 2004-08-30
PT1021432E (pt) 2003-08-29
BR9812871A (pt) 2000-08-08
SK284028B6 (sk) 2004-08-03
AU9629698A (en) 1999-05-03
EE200000161A (et) 2001-04-16
CN100340554C (zh) 2007-10-03
KR100366014B1 (ko) 2002-12-26
ATE235479T1 (de) 2003-04-15
TR200000918T2 (tr) 2000-07-21
EE04526B1 (et) 2005-08-15
CA2305612A1 (en) 1999-04-22
NO317159B1 (no) 2004-08-30
HUP0003748A2 (hu) 2002-01-28
EA003698B1 (ru) 2003-08-28
SI1021432T1 (en) 2003-08-31
EA200000400A1 (ru) 2000-10-30
TW567186B (en) 2003-12-21
AP2000001784A0 (en) 2000-06-30
ID23903A (id) 2000-05-25
WO1999019317A1 (en) 1999-04-22
JP3248902B2 (ja) 2002-01-21
AU737334B2 (en) 2001-08-16
US20030134852A1 (en) 2003-07-17
KR20010023292A (ko) 2001-03-26
ZA989204B (en) 2000-04-10
OA11898A (en) 2006-04-10
AP1239A (en) 2004-01-15
EP1021432B1 (en) 2003-03-26
DE69812668T2 (de) 2004-01-29
HRP20000189A2 (en) 2001-02-28
SK4712000A3 (en) 2000-10-09
CA2305612C (en) 2007-07-31
AR017325A1 (es) 2001-09-05
NO20001792L (no) 2000-04-06
US6511976B1 (en) 2003-01-28
IL135538A0 (en) 2001-05-20
CN1274353A (zh) 2000-11-22
US6699858B2 (en) 2004-03-02
UA52778C2 (uk) 2003-01-15
CZ296928B6 (cs) 2006-07-12
BG64387B1 (bg) 2004-12-30
CZ20001136A3 (cs) 2000-08-16
JP2001519425A (ja) 2001-10-23
IL135538A (en) 2005-07-25

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