DK0916348T3 - Alkyldextranpolyalkohollægemiddelkomplekser - Google Patents
AlkyldextranpolyalkohollægemiddelkomplekserInfo
- Publication number
- DK0916348T3 DK0916348T3 DK97924325T DK97924325T DK0916348T3 DK 0916348 T3 DK0916348 T3 DK 0916348T3 DK 97924325 T DK97924325 T DK 97924325T DK 97924325 T DK97924325 T DK 97924325T DK 0916348 T3 DK0916348 T3 DK 0916348T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyldextran polyalcohol
- spacer
- drug complexes
- drug
- complex
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14442196 | 1996-06-06 | ||
| EP97924325A EP0916348B1 (en) | 1996-06-06 | 1997-06-05 | alkyldextran-polyalcohol drug complexes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0916348T3 true DK0916348T3 (da) | 2004-12-06 |
Family
ID=15361795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97924325T DK0916348T3 (da) | 1996-06-06 | 1997-06-05 | Alkyldextranpolyalkohollægemiddelkomplekser |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6436912B1 (id) |
| EP (1) | EP0916348B1 (id) |
| JP (1) | JP4137183B2 (id) |
| KR (1) | KR20000016558A (id) |
| CN (1) | CN1227499A (id) |
| AT (1) | ATE273715T1 (id) |
| AU (1) | AU723392B2 (id) |
| CA (1) | CA2257245A1 (id) |
| DE (1) | DE69730332T2 (id) |
| DK (1) | DK0916348T3 (id) |
| EA (1) | EA001550B1 (id) |
| ES (1) | ES2229354T3 (id) |
| ID (1) | ID18298A (id) |
| NO (1) | NO985666L (id) |
| PT (1) | PT916348E (id) |
| TW (1) | TW527183B (id) |
| WO (1) | WO1997046260A1 (id) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH071238U (ja) * | 1993-06-11 | 1995-01-10 | 株式会社大井製作所 | ドアロック操作用のロッド連結装置 |
| TW527183B (en) * | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
| TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
| KR100581443B1 (ko) * | 1998-05-22 | 2006-05-23 | 다이이찌 세이야꾸 가부시기가이샤 | 약물복합체 |
| EA003790B1 (ru) * | 1998-10-30 | 2003-10-30 | Дайити Фармасьютикал Ко., Лтд. | Соединение сдлс и способ его измерения |
| US6677456B2 (en) | 1999-10-15 | 2004-01-13 | Daiichi Pharmaceutical Co., Ltd. | Pentacyclic taxan compound |
| ES2311473T3 (es) * | 1999-10-15 | 2009-02-16 | Daiichi Sankyo Company, Limited | Compuestos de taxano pentaciclico. |
| AU2001267831A1 (en) * | 2000-06-29 | 2002-01-08 | Daiichi Pharmaceutical Co., Ltd. | DDS compound and process for the preparation thereof |
| EP1308171A1 (en) * | 2000-07-13 | 2003-05-07 | Daiichi Pharmaceutical Co., Ltd. | Pharmaceutical compositions containing dds compounds |
| US20030092608A1 (en) * | 2001-08-21 | 2003-05-15 | Takayuki Kawaguchi | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
| TWI313609B (en) * | 2001-08-21 | 2009-08-21 | Mitsubishi Tanabe Pharma Corp | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
| TW200306314A (en) * | 2002-04-16 | 2003-11-16 | Tanabe Seiyaku Co | Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation |
| JP4959136B2 (ja) * | 2002-12-13 | 2012-06-20 | イミューノメディクス、インコーポレイテッド | 細胞内で開裂可能な結合を有する免疫接合体 |
| BR122018071808B8 (pt) * | 2003-11-06 | 2020-06-30 | Seattle Genetics Inc | conjugado |
| WO2006088245A1 (ja) * | 2005-02-18 | 2006-08-24 | The University Of Tokushima | ポリオキシアルキレン鎖含有脂質誘導体及び該誘導体を含有する脂質膜構造体 |
| CN100516067C (zh) * | 2006-01-10 | 2009-07-22 | 上海恒瑞医药有限公司 | 具有抗肿瘤活性的紫杉酚衍生物 |
| US9895449B2 (en) | 2010-05-25 | 2018-02-20 | Syndevrx, Inc. | Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof |
| CA2828605C (en) | 2010-05-25 | 2019-01-15 | Syndevrx, Inc. | Polymer-conjugated metap2 inhibitors, and therapeutic methods of use thereof |
| NZ740948A (en) | 2012-10-11 | 2019-11-29 | Daiichi Sankyo Co Ltd | Glycinamide derivatives and production methods thereof |
| ES2782248T3 (es) | 2012-10-19 | 2020-09-11 | Daiichi Sankyo Co Ltd | Conjugado de anticuerpo y fármaco producido por la unión a través de un enlazador que tiene estructura hidrófila |
| BR112015025892A2 (pt) | 2013-04-10 | 2017-07-25 | Syndevrx Inc | inibidores de metap2 e métodos para tratar obesidade |
| WO2015071841A1 (en) | 2013-11-12 | 2015-05-21 | Druggability Technologies Holdings Limited | Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
| SG11201605215YA (en) | 2013-12-25 | 2016-08-30 | Daiichi Sankyo Co Ltd | Anti-trop2 antibody-drug conjugate |
| KR102275925B1 (ko) | 2014-01-31 | 2021-07-12 | 다이이찌 산쿄 가부시키가이샤 | 항-her2 항체-약물 접합체 |
| CN111228511B (zh) | 2014-04-10 | 2024-06-18 | 第一三共株式会社 | 抗her3抗体-药物偶联物 |
| US11185594B2 (en) * | 2014-04-10 | 2021-11-30 | Daiichi Sankyo Company, Limited | (Anti-HER2 antibody)-drug conjugate |
| CN116059395A (zh) | 2015-06-29 | 2023-05-05 | 第一三共株式会社 | 用于选择性制造抗体-药物缀合物的方法 |
| ES2893749T3 (es) | 2015-12-10 | 2022-02-10 | Syndevrx Inc | Derivados de fumagilol y polimorfos de los mismos |
| CA3008960A1 (en) | 2016-01-11 | 2017-07-20 | Syndevrx, Inc. | Treatment for tumors driven by metabolic dysfunction |
| CA3036941C (en) | 2016-10-07 | 2023-02-21 | Daiichi Sankyo Company, Limited | Therapy for drug-resistant cancer by administration of anti-her2 antibody/drug conjugate |
| TW201828993A (zh) | 2016-12-12 | 2018-08-16 | 日商第一三共股份有限公司 | 抗體－藥物結合物與免疫檢查點抑制劑之組合 |
| BR112019012847A2 (pt) | 2017-01-17 | 2019-12-10 | Daiichi Sankyo Co Ltd | anticorpo ou fragmento funcional do anticorpo, polinucleotídeo, vetor de expressão, células hospedeiras, método para produção de um anticorpo de interesse ou de um fragmento funcional do anticorpo e para produção de um conjugado de anticorpo-fármaco, conjugado de anticorpo-fármaco, composição farmacêutica, fármaco antitumoral, e, método de tratamento de um tumor. |
| TWI794230B (zh) | 2017-05-15 | 2023-03-01 | 日商第一三共股份有限公司 | 抗ｃｄｈ６抗體及抗ｃｄｈ６抗體-藥物結合物、以及其製造方法 |
| JP7366745B2 (ja) | 2017-08-31 | 2023-10-23 | 第一三共株式会社 | 抗体－薬物コンジュゲートの改良製造方法 |
| KR102422860B1 (ko) | 2017-08-31 | 2022-07-19 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트의 신규 제조 방법 |
| TWI825098B (zh) | 2018-05-18 | 2023-12-11 | 德商葛萊高托普公司 | 抗ｍｕｃ１抗體 |
| CN113453721A (zh) | 2018-10-26 | 2021-09-28 | 辛德弗雷克斯公司 | Metap2抑制剂的生物标志物及其应用 |
| EP3997093A1 (en) | 2019-07-10 | 2022-05-18 | Cybrexa 2, Inc. | Peptide conjugates of cytotoxins as therapeutics |
| CA3146385A1 (en) | 2019-07-10 | 2021-01-14 | Cybrexa 3, Inc. | Peptide conjugates of microtubule-targeting agents as therapeutics |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59220197A (ja) | 1983-05-30 | 1984-12-11 | Snow Brand Milk Prod Co Ltd | 新規な含窒素多糖体およびその製造方法 |
| JP2604930B2 (ja) * | 1990-12-14 | 1997-04-30 | 株式会社ディ・ディ・エス研究所 | ヒアルロン酸およびコンドロイチン誘導体 |
| DK0526649T3 (da) | 1991-02-21 | 1998-10-07 | Drug Delivery System Inst Ltd | Carboxymethylmannoglucan og derivater deraf. |
| JP3359955B2 (ja) | 1992-07-16 | 2002-12-24 | 第一製薬株式会社 | 抗腫瘍剤 |
| DE69425464T2 (de) * | 1993-02-26 | 2001-05-23 | Drug Delivery System Institute, Ltd. | Polysaccharidderivat und wirkstoffträger |
| JPH0784481A (ja) | 1993-06-26 | 1995-03-31 | Ricoh Co Ltd | 画像形成装置 |
| US5811510A (en) * | 1995-04-14 | 1998-09-22 | General Hospital Corporation | Biodegradable polyacetal polymers and methods for their formation and use |
| SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
| TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
| TW527183B (en) * | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
| KR100581443B1 (ko) | 1998-05-22 | 2006-05-23 | 다이이찌 세이야꾸 가부시기가이샤 | 약물복합체 |
| EA003790B1 (ru) | 1998-10-30 | 2003-10-30 | Дайити Фармасьютикал Ко., Лтд. | Соединение сдлс и способ его измерения |
-
1997
- 1997-05-31 TW TW086107455A patent/TW527183B/zh not_active IP Right Cessation
- 1997-06-05 PT PT97924325T patent/PT916348E/pt unknown
- 1997-06-05 WO PCT/JP1997/001914 patent/WO1997046260A1/ja active IP Right Grant
- 1997-06-05 DK DK97924325T patent/DK0916348T3/da active
- 1997-06-05 US US09/147,342 patent/US6436912B1/en not_active Expired - Fee Related
- 1997-06-05 EP EP97924325A patent/EP0916348B1/en not_active Expired - Lifetime
- 1997-06-05 JP JP50042198A patent/JP4137183B2/ja not_active Expired - Fee Related
- 1997-06-05 ES ES97924325T patent/ES2229354T3/es not_active Expired - Lifetime
- 1997-06-05 ID IDP971928A patent/ID18298A/id unknown
- 1997-06-05 CA CA002257245A patent/CA2257245A1/en not_active Abandoned
- 1997-06-05 EA EA199900004A patent/EA001550B1/ru not_active IP Right Cessation
- 1997-06-05 AT AT97924325T patent/ATE273715T1/de not_active IP Right Cessation
- 1997-06-05 DE DE69730332T patent/DE69730332T2/de not_active Expired - Lifetime
- 1997-06-05 AU AU29787/97A patent/AU723392B2/en not_active Ceased
- 1997-06-05 CN CN97197008A patent/CN1227499A/zh active Pending
- 1997-06-05 KR KR1019980710148A patent/KR20000016558A/ko active IP Right Grant
-
1998
- 1998-12-04 NO NO985666A patent/NO985666L/no not_active Application Discontinuation
-
2002
- 2002-05-28 US US10/155,170 patent/US6838450B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1227499A (zh) | 1999-09-01 |
| NO985666L (no) | 1999-02-04 |
| EA001550B1 (ru) | 2001-04-23 |
| EP0916348B1 (en) | 2004-08-18 |
| NO985666D0 (no) | 1998-12-04 |
| JP4137183B2 (ja) | 2008-08-20 |
| AU2978797A (en) | 1998-01-05 |
| TW527183B (en) | 2003-04-11 |
| DE69730332T2 (de) | 2005-09-22 |
| KR20000016558A (ko) | 2000-03-25 |
| US6436912B1 (en) | 2002-08-20 |
| DE69730332D1 (de) | 2004-09-23 |
| EP0916348A1 (en) | 1999-05-19 |
| CA2257245A1 (en) | 1997-12-11 |
| ATE273715T1 (de) | 2004-09-15 |
| US20030171262A1 (en) | 2003-09-11 |
| AU723392B2 (en) | 2000-08-24 |
| ID18298A (id) | 1998-03-26 |
| EP0916348A4 (en) | 2000-11-29 |
| PT916348E (pt) | 2004-10-29 |
| ES2229354T3 (es) | 2005-04-16 |
| US6838450B2 (en) | 2005-01-04 |
| EA199900004A1 (ru) | 1999-06-24 |
| WO1997046260A1 (en) | 1997-12-11 |
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