ATE78828T1 - Verfahren und zwischenverbindungen fuer n-(s-3alkyl-heptanoyl)-d-gamma-glutamyl-glycyl-dalanine. - Google Patents

Verfahren und zwischenverbindungen fuer n-(s-3alkyl-heptanoyl)-d-gamma-glutamyl-glycyl-dalanine.

Info

Publication number
ATE78828T1
ATE78828T1 AT87307492T AT87307492T ATE78828T1 AT E78828 T1 ATE78828 T1 AT E78828T1 AT 87307492 T AT87307492 T AT 87307492T AT 87307492 T AT87307492 T AT 87307492T AT E78828 T1 ATE78828 T1 AT E78828T1
Authority
AT
Austria
Prior art keywords
glycyl
glutamyl
gamma
dalanine
3alkyl
Prior art date
Application number
AT87307492T
Other languages
English (en)
Inventor
Charles William Murtiashaw
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE78828T1 publication Critical patent/ATE78828T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/36—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/62—Preparation of carboxylic acid halides by reactions not involving the carboxylic acid halide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/27—Preparation of carboxylic acid esters from ortho-esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/303—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/533—Monocarboxylic acid esters having only one carbon-to-carbon double bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT87307492T 1986-08-27 1987-08-25 Verfahren und zwischenverbindungen fuer n-(s-3alkyl-heptanoyl)-d-gamma-glutamyl-glycyl-dalanine. ATE78828T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1986/001772 WO1988001612A1 (en) 1986-08-27 1986-08-27 Processes and intermediates for n-(s-3-alkyl-heptanoyl)-d-gamma-glutamyl-glycyl-d-alanine
EP87307492A EP0258032B1 (de) 1986-08-27 1987-08-25 Verfahren und Zwischenverbindungen für N-(S-3-Alkyl-heptanoyl)-D-gamma-glutamyl-glycyl-D-alanine

Publications (1)

Publication Number Publication Date
ATE78828T1 true ATE78828T1 (de) 1992-08-15

Family

ID=22195617

Family Applications (2)

Application Number Title Priority Date Filing Date
AT87307492T ATE78828T1 (de) 1986-08-27 1987-08-25 Verfahren und zwischenverbindungen fuer n-(s-3alkyl-heptanoyl)-d-gamma-glutamyl-glycyl-dalanine.
AT0262887A AT387380B (de) 1986-08-27 1987-10-08 Verfahren und zwischenprodukte fuer n-(s-3alkyl-heptanoyl)-d-gamma-glutamyl-glycyl-dalanin

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT0262887A AT387380B (de) 1986-08-27 1987-10-08 Verfahren und zwischenprodukte fuer n-(s-3alkyl-heptanoyl)-d-gamma-glutamyl-glycyl-dalanin

Country Status (11)

Country Link
EP (1) EP0258032B1 (de)
AT (2) ATE78828T1 (de)
AU (1) AU589543B2 (de)
DE (1) DE3780726T2 (de)
ES (1) ES2042572T3 (de)
FI (1) FI890885A0 (de)
GR (1) GR3005495T3 (de)
IE (1) IE60040B1 (de)
NO (1) NO881811L (de)
WO (1) WO1988001612A1 (de)
ZA (1) ZA876354B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1295784C (en) * 1985-11-25 1992-02-11 James Patrick Rizzi Peptide immunostimulants

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US45475A (en) * 1864-12-20 Improved submarine port-hole
US3985722A (en) * 1973-12-12 1976-10-12 Ajinomoto Co., Inc. Process for preparing N-higher aliphatic acyl derivatives of amino acids, peptides or proteins
US4113968A (en) * 1974-10-03 1978-09-12 Kuraray Co., Ltd. Process for preparation of substituted cyclopropane carboxylic acids and esters thereof and intermediates of said acids and esters
US4374264A (en) * 1980-06-02 1983-02-15 Ici Australia Limited Process for the preparation of γ-unsaturated carboxylates
FR2496654A1 (fr) * 1980-12-19 1982-06-25 Rhone Poulenc Sante Nouveaux tri-, tetra- et pentapeptides, leur preparation et les medicaments qui les contiennent
JPS57144276A (en) * 1981-03-03 1982-09-06 Toray Ind Inc 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative
US4565653A (en) * 1984-03-30 1986-01-21 Pfizer Inc. Acyltripeptide immunostimulants
DE3568879D1 (en) * 1984-08-29 1989-04-20 Rodenstock Optik G Projection system for a guide beam
ATE46347T1 (de) * 1985-11-25 1989-09-15 Pfizer Immunostimulierende peptide.
WO1988001613A1 (en) * 1986-08-27 1988-03-10 Pfizer Inc. Crystalline n-(s-3-methylheptanoyl)-d-gamma-glutamyl-glycyl-d-alanine, and processes and intermediates therefor

Also Published As

Publication number Publication date
ES2042572T3 (es) 1993-12-16
NO881811D0 (no) 1988-04-26
AU589543B2 (en) 1989-10-12
AU7746287A (en) 1988-03-03
DE3780726D1 (de) 1992-09-03
ZA876354B (en) 1989-03-29
FI890885A (fi) 1989-02-24
IE60040B1 (en) 1994-05-18
EP0258032B1 (de) 1992-07-29
GR3005495T3 (de) 1993-05-24
WO1988001612A1 (en) 1988-03-10
ATA262887A (de) 1988-06-15
EP0258032A3 (en) 1989-10-11
EP0258032A2 (de) 1988-03-02
FI890885A0 (fi) 1989-02-24
AT387380B (de) 1989-01-10
NO881811L (no) 1988-04-26
IE872278L (en) 1988-02-27
DE3780726T2 (de) 1992-12-17

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee