ATE91689T1 - Geminale bisphosphonsaeuren und deren derivate als antiarthritische mittel. - Google Patents
Geminale bisphosphonsaeuren und deren derivate als antiarthritische mittel.Info
- Publication number
- ATE91689T1 ATE91689T1 AT90905160T AT90905160T ATE91689T1 AT E91689 T1 ATE91689 T1 AT E91689T1 AT 90905160 T AT90905160 T AT 90905160T AT 90905160 T AT90905160 T AT 90905160T AT E91689 T1 ATE91689 T1 AT E91689T1
- Authority
- AT
- Austria
- Prior art keywords
- geminal
- acids
- bisphosphone
- derivatives
- antiarthritic agents
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 229940124346 antiarthritic agent Drugs 0.000 title 1
- 239000003435 antirheumatic agent Substances 0.000 title 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33261889A | 1989-04-03 | 1989-04-03 | |
| PCT/US1990/001106 WO1990012017A1 (en) | 1989-04-03 | 1990-03-08 | Geminal bisphosphonic acids and derivatives as anti-arthritic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE91689T1 true ATE91689T1 (de) | 1993-08-15 |
Family
ID=23299047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90905160T ATE91689T1 (de) | 1989-04-03 | 1990-03-08 | Geminale bisphosphonsaeuren und deren derivate als antiarthritische mittel. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0466730B1 (de) |
| JP (1) | JPH04505011A (de) |
| KR (1) | KR920701216A (de) |
| AT (1) | ATE91689T1 (de) |
| AU (1) | AU628158B2 (de) |
| CA (1) | CA2046905A1 (de) |
| DE (1) | DE69002328T2 (de) |
| DK (1) | DK0466730T3 (de) |
| HU (1) | HU207095B (de) |
| WO (1) | WO1990012017A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0544812T3 (da) * | 1990-08-21 | 1995-08-21 | Upjohn Co | Bisphosphonsyrederivater som anti-arthritiske midler |
| US5391743A (en) * | 1992-05-29 | 1995-02-21 | Procter & Gamble Pharmaceuticals, Inc. | Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque |
| EP0642519B1 (de) * | 1992-05-29 | 2000-08-09 | Procter & Gamble Pharmaceuticals | Schwefel-enthaltende phosphonat-verbindungen zur behandlung von abnormalem calzium- und phosphat- metabolismus |
| US5753634A (en) * | 1992-05-29 | 1998-05-19 | The Procter & Gamble Company | Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism |
| AU666741B2 (en) * | 1992-05-29 | 1996-02-22 | Procter & Gamble Pharmaceuticals, Inc., The | Thio-substituted nitrogen-containing heterocyclic phosphonate compounds for treating abnormal calcium and phosphate metabolism |
| JPH07506569A (ja) * | 1992-05-29 | 1995-07-20 | プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド | 異常カルシウム及びリン酸代謝と歯石及び歯垢を治療するための四級窒素含有ホスホネート化合物 |
| US5763611A (en) * | 1992-05-29 | 1998-06-09 | The Procter & Gamble Company | Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| JPH07509241A (ja) * | 1992-07-16 | 1995-10-12 | ジ・アップジョン・カンパニー | 抗炎症および抗関節炎薬としてのホスホノ誘導体 |
| JPH08501794A (ja) * | 1992-09-23 | 1996-02-27 | ジ・アップジョン・カンパニー | 抗炎症剤として有用なアリールメチルホスホネートおよびホスホン酸 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4687768A (en) * | 1984-12-21 | 1987-08-18 | The Procter & Gamble Company | Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism |
| HU199151B (en) * | 1987-03-10 | 1990-01-29 | Yamanouchi Pharma Co Ltd | Process for producing bis-phosphonic acid derivatives |
| DE3719513A1 (de) * | 1987-06-11 | 1988-12-22 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
-
1990
- 1990-03-08 AT AT90905160T patent/ATE91689T1/de not_active IP Right Cessation
- 1990-03-08 DK DK90905160.9T patent/DK0466730T3/da active
- 1990-03-08 JP JP2505037A patent/JPH04505011A/ja active Pending
- 1990-03-08 AU AU53306/90A patent/AU628158B2/en not_active Ceased
- 1990-03-08 CA CA002046905A patent/CA2046905A1/en not_active Abandoned
- 1990-03-08 HU HU902754A patent/HU207095B/hu not_active IP Right Cessation
- 1990-03-08 DE DE90905160T patent/DE69002328T2/de not_active Expired - Fee Related
- 1990-03-08 EP EP90905160A patent/EP0466730B1/de not_active Expired - Lifetime
- 1990-03-08 KR KR1019910701244A patent/KR920701216A/ko not_active Withdrawn
- 1990-03-08 WO PCT/US1990/001106 patent/WO1990012017A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0466730B1 (de) | 1993-07-21 |
| CA2046905A1 (en) | 1990-10-04 |
| JPH04505011A (ja) | 1992-09-03 |
| AU5330690A (en) | 1990-11-05 |
| DE69002328D1 (de) | 1993-08-26 |
| WO1990012017A1 (en) | 1990-10-18 |
| HUT58751A (en) | 1992-03-30 |
| AU628158B2 (en) | 1992-09-10 |
| KR920701216A (ko) | 1992-08-11 |
| EP0466730A1 (de) | 1992-01-22 |
| HU207095B (en) | 1993-03-01 |
| DE69002328T2 (de) | 1993-12-09 |
| HU902754D0 (en) | 1991-12-30 |
| DK0466730T3 (da) | 1993-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |