ATE273715T1 - Alkyldextran-polyalcohol arzneimittel-komplexe - Google Patents
Alkyldextran-polyalcohol arzneimittel-komplexeInfo
- Publication number
- ATE273715T1 ATE273715T1 AT97924325T AT97924325T ATE273715T1 AT E273715 T1 ATE273715 T1 AT E273715T1 AT 97924325 T AT97924325 T AT 97924325T AT 97924325 T AT97924325 T AT 97924325T AT E273715 T1 ATE273715 T1 AT E273715T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyldextrane
- polyalcohol
- medicinal
- complexes
- spacer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14442196 | 1996-06-06 | ||
| PCT/JP1997/001914 WO1997046260A1 (en) | 1996-06-06 | 1997-06-05 | Drug complexes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE273715T1 true ATE273715T1 (de) | 2004-09-15 |
Family
ID=15361795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97924325T ATE273715T1 (de) | 1996-06-06 | 1997-06-05 | Alkyldextran-polyalcohol arzneimittel-komplexe |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6436912B1 (de) |
| EP (1) | EP0916348B1 (de) |
| JP (1) | JP4137183B2 (de) |
| KR (1) | KR20000016558A (de) |
| CN (1) | CN1227499A (de) |
| AT (1) | ATE273715T1 (de) |
| AU (1) | AU723392B2 (de) |
| CA (1) | CA2257245A1 (de) |
| DE (1) | DE69730332T2 (de) |
| DK (1) | DK0916348T3 (de) |
| EA (1) | EA001550B1 (de) |
| ES (1) | ES2229354T3 (de) |
| ID (1) | ID18298A (de) |
| NO (1) | NO985666L (de) |
| PT (1) | PT916348E (de) |
| TW (1) | TW527183B (de) |
| WO (1) | WO1997046260A1 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH071238U (ja) * | 1993-06-11 | 1995-01-10 | 株式会社大井製作所 | ドアロック操作用のロッド連結装置 |
| TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
| TW527183B (en) * | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
| CN1250293C (zh) * | 1998-05-22 | 2006-04-12 | 第一制药株式会社 | 药物复合物 |
| IL142842A0 (en) * | 1998-10-30 | 2002-03-10 | Daiichi Seiyaku Co | Dds compounds and method for assaying the same |
| US6677456B2 (en) | 1999-10-15 | 2004-01-13 | Daiichi Pharmaceutical Co., Ltd. | Pentacyclic taxan compound |
| AU774787B2 (en) * | 1999-10-15 | 2004-07-08 | Daiichi Sankyo Company, Limited | Pentacyclic taxane compounds |
| MXPA02012791A (es) * | 2000-06-29 | 2003-12-11 | Daiichi Seiyaku Co | Compuestos dds y metodo para prepararlo. |
| CA2415922A1 (en) * | 2000-07-13 | 2002-01-24 | Daiichi Pharmaceutical Co., Ltd. | Pharmaceutical compositions containing dds compound |
| US20030092608A1 (en) * | 2001-08-21 | 2003-05-15 | Takayuki Kawaguchi | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
| TWI313609B (en) * | 2001-08-21 | 2009-08-21 | Mitsubishi Tanabe Pharma Corp | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
| US7585491B2 (en) * | 2002-12-13 | 2009-09-08 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
| TW200306314A (en) * | 2002-04-16 | 2003-11-16 | Tanabe Seiyaku Co | Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation |
| KR101520209B1 (ko) * | 2003-11-06 | 2015-05-13 | 시애틀 지네틱스, 인크. | 리간드에 접합될 수 있는 모노메틸발린 화합물 |
| EP1854807A4 (de) * | 2005-02-18 | 2009-04-01 | Univ Tokushima | Eine polyoxyalkylenkette enthaltendes lipidderivat und eine lipidfilmstruktur, die ein solches derivat enthält |
| CN100516067C (zh) * | 2006-01-10 | 2009-07-22 | 上海恒瑞医药有限公司 | 具有抗肿瘤活性的紫杉酚衍生物 |
| EP3858385A3 (de) | 2010-05-25 | 2021-10-27 | Syndevrx, Inc. | Polymer-konjugierte metap2-hemmer und therapeutische verfahren zu ihrer verwendung |
| US9895449B2 (en) | 2010-05-25 | 2018-02-20 | Syndevrx, Inc. | Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof |
| HUE039000T2 (hu) | 2012-10-11 | 2018-12-28 | Daiichi Sankyo Co Ltd | Antitest-gyógyszer konjugát |
| EP2910573B1 (de) | 2012-10-19 | 2020-02-19 | Daiichi Sankyo Company, Limited | Durch bindung über einen linker mit hydrophiler struktur hergestelltes antikörper-wirkstoff-konjugat |
| BR112015025892A2 (pt) | 2013-04-10 | 2017-07-25 | Syndevrx Inc | inibidores de metap2 e métodos para tratar obesidade |
| WO2015071841A1 (en) | 2013-11-12 | 2015-05-21 | Druggability Technologies Holdings Limited | Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
| CA2933666C (en) | 2013-12-25 | 2021-08-03 | Sapporo Medical University | Anti-trop2 antibody-drug conjugate |
| DK3466976T3 (da) | 2014-01-31 | 2021-12-13 | Daiichi Sankyo Co Ltd | Anti-her2-antistof-lægemiddelkonjugat |
| KR102624244B1 (ko) | 2014-04-10 | 2024-01-11 | 다이이찌 산쿄 가부시키가이샤 | 항her3 항체-약물 콘주게이트 |
| US11185594B2 (en) * | 2014-04-10 | 2021-11-30 | Daiichi Sankyo Company, Limited | (Anti-HER2 antibody)-drug conjugate |
| IL290959B2 (en) | 2015-06-29 | 2023-04-01 | Daiichi Sankyo Co Ltd | Preparations containing antibody-drug conjugates and methods for their production |
| JP2019501898A (ja) | 2015-12-10 | 2019-01-24 | シンデブルックス，インコーポレイティド | フマギロール誘導体およびその多形体 |
| WO2017123603A1 (en) | 2016-01-11 | 2017-07-20 | Syndevrx, Inc. | Treatment for tumors driven by metabolic dysfunction |
| CA3036941C (en) | 2016-10-07 | 2023-02-21 | Daiichi Sankyo Company, Limited | Therapy for drug-resistant cancer by administration of anti-her2 antibody/drug conjugate |
| US11273155B2 (en) | 2016-12-12 | 2022-03-15 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and immune checkpoint inhibitor |
| WO2018135501A1 (ja) | 2017-01-17 | 2018-07-26 | 第一三共株式会社 | 抗ｇｐｒ２０抗体及び抗ｇｐｒ２０抗体－薬物コンジュゲート |
| TW202330036A (zh) | 2017-05-15 | 2023-08-01 | 日商第一三共股份有限公司 | 抗體-藥物結合物之製造方法 |
| CA3073924C (en) | 2017-08-31 | 2023-10-17 | Daiichi Sankyo Company, Limited | Improved method for producing antibody-drug conjugate |
| KR102630307B1 (ko) | 2017-08-31 | 2024-01-29 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트의 신규 제조 방법 |
| CA3100608A1 (en) | 2018-05-18 | 2019-11-21 | Daiichi Sankyo Co., Ltd. | Anti-muc1 antibody-drug conjugate |
| JP2022512826A (ja) | 2018-10-26 | 2022-02-07 | シンデブルックス，インコーポレイティド | ＭｅｔＡＰ２阻害剤のバイオマーカーとその応用 |
| MX2022000449A (es) | 2019-07-10 | 2022-04-25 | Cybrexa 2 Inc | Conjugados peptídicos de citotoxinas como terapéuticos. |
| EP3996749A1 (de) | 2019-07-10 | 2022-05-18 | Cybrexa 3, Inc. | Peptidkonjugate von auf mikrotubuli abzielenden mitteln als therapeutische wirkstoffe |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59220197A (ja) * | 1983-05-30 | 1984-12-11 | Snow Brand Milk Prod Co Ltd | 新規な含窒素多糖体およびその製造方法 |
| JP2604930B2 (ja) | 1990-12-14 | 1997-04-30 | 株式会社ディ・ディ・エス研究所 | ヒアルロン酸およびコンドロイチン誘導体 |
| DE69225542T2 (de) | 1991-02-21 | 1998-09-10 | Drug Delivery System Inst Ltd | Carboxymethylmannoglukan und derivate davon |
| JP3359955B2 (ja) | 1992-07-16 | 2002-12-24 | 第一製薬株式会社 | 抗腫瘍剤 |
| WO1994019376A1 (en) | 1993-02-26 | 1994-09-01 | Drug Delivery System Institute, Ltd. | Polysaccharide derivative and drug carrier |
| JPH0784481A (ja) | 1993-06-26 | 1995-03-31 | Ricoh Co Ltd | 画像形成装置 |
| US5811510A (en) * | 1995-04-14 | 1998-09-22 | General Hospital Corporation | Biodegradable polyacetal polymers and methods for their formation and use |
| SG50747A1 (en) | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
| TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
| TW527183B (en) * | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
| CN1250293C (zh) | 1998-05-22 | 2006-04-12 | 第一制药株式会社 | 药物复合物 |
| IL142842A0 (en) | 1998-10-30 | 2002-03-10 | Daiichi Seiyaku Co | Dds compounds and method for assaying the same |
-
1997
- 1997-05-31 TW TW086107455A patent/TW527183B/zh not_active IP Right Cessation
- 1997-06-05 WO PCT/JP1997/001914 patent/WO1997046260A1/ja active IP Right Grant
- 1997-06-05 CA CA002257245A patent/CA2257245A1/en not_active Abandoned
- 1997-06-05 ID IDP971928A patent/ID18298A/id unknown
- 1997-06-05 PT PT97924325T patent/PT916348E/pt unknown
- 1997-06-05 US US09/147,342 patent/US6436912B1/en not_active Expired - Fee Related
- 1997-06-05 DK DK97924325T patent/DK0916348T3/da active
- 1997-06-05 AT AT97924325T patent/ATE273715T1/de not_active IP Right Cessation
- 1997-06-05 DE DE69730332T patent/DE69730332T2/de not_active Expired - Lifetime
- 1997-06-05 ES ES97924325T patent/ES2229354T3/es not_active Expired - Lifetime
- 1997-06-05 KR KR1019980710148A patent/KR20000016558A/ko active IP Right Grant
- 1997-06-05 JP JP50042198A patent/JP4137183B2/ja not_active Expired - Fee Related
- 1997-06-05 EA EA199900004A patent/EA001550B1/ru not_active IP Right Cessation
- 1997-06-05 CN CN97197008A patent/CN1227499A/zh active Pending
- 1997-06-05 AU AU29787/97A patent/AU723392B2/en not_active Ceased
- 1997-06-05 EP EP97924325A patent/EP0916348B1/de not_active Expired - Lifetime
-
1998
- 1998-12-04 NO NO985666A patent/NO985666L/no not_active Application Discontinuation
-
2002
- 2002-05-28 US US10/155,170 patent/US6838450B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2978797A (en) | 1998-01-05 |
| EA001550B1 (ru) | 2001-04-23 |
| EA199900004A1 (ru) | 1999-06-24 |
| US6436912B1 (en) | 2002-08-20 |
| TW527183B (en) | 2003-04-11 |
| EP0916348B1 (de) | 2004-08-18 |
| EP0916348A4 (de) | 2000-11-29 |
| KR20000016558A (ko) | 2000-03-25 |
| CA2257245A1 (en) | 1997-12-11 |
| NO985666D0 (no) | 1998-12-04 |
| AU723392B2 (en) | 2000-08-24 |
| ID18298A (id) | 1998-03-26 |
| ES2229354T3 (es) | 2005-04-16 |
| EP0916348A1 (de) | 1999-05-19 |
| US6838450B2 (en) | 2005-01-04 |
| DE69730332T2 (de) | 2005-09-22 |
| CN1227499A (zh) | 1999-09-01 |
| PT916348E (pt) | 2004-10-29 |
| US20030171262A1 (en) | 2003-09-11 |
| DK0916348T3 (da) | 2004-12-06 |
| DE69730332D1 (de) | 2004-09-23 |
| JP4137183B2 (ja) | 2008-08-20 |
| NO985666L (no) | 1999-02-04 |
| WO1997046260A1 (en) | 1997-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0916348 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |