DK0885242T3 - Peptider og forbindelser, der binder til en trombopoietinreceptor - Google Patents

Peptider og forbindelser, der binder til en trombopoietinreceptor

Info

Publication number
DK0885242T3
DK0885242T3 DK96919241T DK96919241T DK0885242T3 DK 0885242 T3 DK0885242 T3 DK 0885242T3 DK 96919241 T DK96919241 T DK 96919241T DK 96919241 T DK96919241 T DK 96919241T DK 0885242 T3 DK0885242 T3 DK 0885242T3
Authority
DK
Denmark
Prior art keywords
peptides
bind
compounds
thrombopoietin receptor
thrombopoietin
Prior art date
Application number
DK96919241T
Other languages
Danish (da)
English (en)
Inventor
Steven E Cwirla
Larry C Mattheakis
William J Dower
Ronald W Barret
David J Duffin
Christian M Gates
Sherril S Haselden
Peter J Schatz
Christopher R Wagstrom
Nicholas C Wrighton
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of DK0885242T3 publication Critical patent/DK0885242T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02Linear peptides containing at least one abnormal peptide link
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK96919241T 1995-06-07 1996-06-07 Peptider og forbindelser, der binder til en trombopoietinreceptor DK0885242T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47812895A 1995-06-07 1995-06-07
US48530195A 1995-06-07 1995-06-07
PCT/US1996/009623 WO1996040750A1 (en) 1995-06-07 1996-06-07 Peptides and compounds that bind to a thrombopoietin receptor

Publications (1)

Publication Number Publication Date
DK0885242T3 true DK0885242T3 (da) 2008-07-14

Family

ID=27045796

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96919241T DK0885242T3 (da) 1995-06-07 1996-06-07 Peptider og forbindelser, der binder til en trombopoietinreceptor

Country Status (27)

Country Link
US (2) US6083913A (pl)
EP (4) EP2055712A1 (pl)
JP (1) JP3059218B2 (pl)
KR (1) KR100436680B1 (pl)
CN (2) CN1966520B (pl)
AR (1) AR003431A1 (pl)
AT (1) ATE390439T1 (pl)
BR (1) BR9608587A (pl)
CA (2) CA2636432C (pl)
CZ (1) CZ291749B6 (pl)
DE (1) DE69637473T2 (pl)
DK (1) DK0885242T3 (pl)
EA (1) EA001220B1 (pl)
ES (1) ES2303338T3 (pl)
HK (1) HK1015380A1 (pl)
HU (1) HU227678B1 (pl)
IL (1) IL122102A (pl)
MX (1) MX9709315A (pl)
NO (2) NO317737B1 (pl)
NZ (1) NZ310778A (pl)
PE (1) PE7898A1 (pl)
PL (1) PL188795B1 (pl)
PT (1) PT885242E (pl)
TR (1) TR199701526T1 (pl)
TW (1) TW518341B (pl)
WO (1) WO1996040750A1 (pl)
ZA (1) ZA964814B (pl)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
EP2055712A1 (en) * 1995-06-07 2009-05-06 Glaxo Group Limited Peptides and compounds that bind to a thrombopoietin receptor
US6172210B1 (en) * 1996-04-02 2001-01-09 Blood Center Research Foundation DNA encoding phospholipid scramblase
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
US6930084B1 (en) 1996-11-06 2005-08-16 The Regents Of The University Of California Treating arthritis with TNF receptor releasing enzyme
US6593456B1 (en) * 1996-11-06 2003-07-15 The Regents Of The University Of California Tumor necrosis factor receptor releasing enzyme
US6420518B1 (en) 1997-04-04 2002-07-16 Genetech, Inc. Insulin-like growth factor agonist molecules
US6121416A (en) 1997-04-04 2000-09-19 Genentech, Inc. Insulin-like growth factor agonist molecules
WO1999052877A1 (en) * 1998-04-14 1999-10-21 Smithkline Beecham Corporation Receptor ligands
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
EP1124961B9 (en) 1998-10-23 2010-07-21 Kirin-Amgen Inc. Thrombopoietic compounds
AU762351B2 (en) 1999-01-06 2003-06-26 Genentech Inc. Insulin-like growth factor (IGF) I mutant variants
US6911314B2 (en) 1999-05-14 2005-06-28 The Regents Of The University Of California Screening for drugs that affect TNF receptor releasing enzyme
AU3885901A (en) 1999-09-21 2001-04-24 Emory University Methods and compositions for treating platelet-related disorders
TWI284639B (en) 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
ES2301547T3 (es) 2000-05-16 2008-07-01 Genentech, Inc. Tratamiento de trastornos del cartilago.
CY2010012I2 (el) 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
AU2001260661A1 (en) * 2000-05-30 2001-12-11 Chugai Seiyaku Kabushiki Kaisha Compounds exhibiting thrombopoietin-like activities
US7396917B2 (en) 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
DK1642910T3 (da) * 2000-12-05 2012-05-07 Alexion Pharma Inc Rationelt designede atistoffer
US6958213B2 (en) 2000-12-12 2005-10-25 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function
US7169931B2 (en) 2001-01-26 2007-01-30 Shionogi & Co., Ltd. Cyclic compounds exhibiting thrombopoietin receptor agonism
AU2002307062A1 (en) * 2001-04-02 2002-10-15 Purdue Pharma L.P. Thrombopoietin (tpo) synthebody for stimulation of platelet production
US7332474B2 (en) * 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
AU2002363522A1 (en) * 2001-11-06 2003-05-19 Ho Chris Meichung Wang System and method for improved computer drug design
EP1466912B1 (en) * 2002-01-18 2013-04-24 Astellas Pharma Inc. 2-acylaminothiazole derivative or salt thereof
US20040009944A1 (en) * 2002-05-10 2004-01-15 Inex Pharmaceuticals Corporation Methylated immunostimulatory oligonucleotides and methods of using the same
TWI280128B (en) 2002-05-22 2007-05-01 Smithkline Beecham Corp 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)
US20040028661A1 (en) * 2002-08-07 2004-02-12 Bartelmez Stephen H. Expansion of cells using thrombopoietin and anti-transforming growth factor-beta
EP1552828A4 (en) 2002-08-14 2007-01-24 Nissan Chemical Ind Ltd THROMBOPOIETIN RECEPTOR ACTIVATOR AND METHOD OF PRODUCTION
MXPA05003057A (es) 2002-09-18 2006-04-18 Johnson & Johnson Metodos para aumentar la produccion de celulas madre hematopoyeticas y plaquetas.
FI20021762A0 (fi) * 2002-10-03 2002-10-03 Karyon Oy Ab Ltd Uusia terapeuttisia aineita ja valmisteita
TWI324593B (en) 2002-10-09 2010-05-11 Nissan Chemical Ind Ltd Pyrazolone compounds and thrombopoietin receptor activator
US7736909B2 (en) * 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
EP1626983B8 (en) * 2003-05-12 2010-12-22 Affymax, Inc. Novel poly (ethylene glycol) modified erythropoietin agonists and uses thereof
CA2525399A1 (en) * 2003-05-12 2004-11-25 Affymax, Inc. Novel spacer moiety for poly(ethylene glycol)-modified peptide-based co mpounds
WO2004101611A2 (en) * 2003-05-12 2004-11-25 Affymax, Inc. Peptides that bind to the erythropoietin receptor
PT1629007E (pt) 2003-05-12 2009-05-06 Affymax Inc Péptidos novos que se ligam ao receptor da eritropoietina
WO2004108078A2 (en) * 2003-06-02 2004-12-16 Alexion Pharmaceuticals Inc. Rationally designed antibodies
CN1863783A (zh) 2003-08-12 2006-11-15 盐野义制药株式会社 具有血小板生成素受体激动作用的化合物
HUE032370T2 (en) * 2003-08-28 2017-09-28 Janssen Pharmaceuticals Inc Peptides and compounds that bind to thrombopoietin receptors
US7723295B2 (en) * 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
TW200526638A (en) 2003-10-22 2005-08-16 Smithkline Beecham Corp 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
US20060210542A1 (en) * 2004-08-16 2006-09-21 Yurkow Edward J Use of TPO mimetic compounds and pharmaceutical compositions in the treatment of anemia
CN100432102C (zh) * 2004-09-30 2008-11-12 百瑞全球有限公司 血小板增进蛋白及其应用
WO2006062685A2 (en) * 2004-11-11 2006-06-15 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
CA2587382A1 (en) * 2004-11-11 2006-06-08 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
NZ555466A (en) 2004-12-08 2010-08-27 Nissan Chemical Ind Ltd 3-ethylidenehydrazino substituted heterocyclic compounds as thrombopoietin receptor activators
WO2006064957A1 (ja) 2004-12-14 2006-06-22 Nissan Chemical Industries, Ltd. アミド化合物及びトロンボポエチンレセプター活性化剤
JP5517450B2 (ja) * 2005-03-10 2014-06-11 バイオンテック アーゲー 二量体または多量体のマイクロタンパク質
US8324159B2 (en) * 2005-06-03 2012-12-04 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US7919461B2 (en) 2005-06-03 2011-04-05 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US7550433B2 (en) 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
EP1907417A2 (en) * 2005-06-23 2008-04-09 AplaGen GmbH Supravalent compounds
TWI368617B (en) 2005-07-15 2012-07-21 Nissan Chemical Ind Ltd Thiophene compounds and thrombopoietin receptor activators
TWI330184B (en) 2005-07-20 2010-09-11 Nissan Chemical Ind Ltd Pyrazole compounds and thrombopoietin receptor activators
US8026368B2 (en) 2005-11-07 2011-09-27 Nissan Chemical Industries, Ltd. Hydrazide compounds and thrombopoietin receptor activators
US20070203153A1 (en) * 2005-11-08 2007-08-30 Astellas Pharma Inc. Compositions and methods for treating thrombocytopenia
US7879318B2 (en) 2006-01-23 2011-02-01 Mcw Research Foundation, Inc. Method of reducing the effects of ischemia by administration of a thrombopoietin receptor ligand
JP5157900B2 (ja) 2006-06-07 2013-03-06 日産化学工業株式会社 含窒素ヘテロ環化合物及びトロンボポエチンレセプター活性化剤
EP2452674B1 (en) * 2006-08-08 2014-03-26 Akarx, Inc. Compositions and methods for increasing blood platelet levels in humans
CA2676820A1 (en) * 2007-01-31 2008-08-07 Affymax, Inc. Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules
ECSP077628A (es) 2007-05-03 2008-12-30 Smithkline Beechman Corp Nueva composición farmacéutica
US20090054332A1 (en) * 2007-06-21 2009-02-26 Conjuchem Biotechnologies, Inc. Thombopoietin peptide conjugates
MX2010001082A (es) * 2007-07-31 2010-03-01 Shionogi & Co Composicion farmaceutica que contiene compuesto opticamente activo que tiene actividad agonista del receptor de trombopoyetina y compuesto intermedio para el mismo.
US20090088371A1 (en) * 2007-08-28 2009-04-02 Rigel Pharmaceuticals, Inc. Combination therapy with syk kinase inhibitor
US8278057B2 (en) * 2007-09-14 2012-10-02 Nestec S.A. Addressable antibody arrays and methods of use
US8637455B2 (en) * 2007-10-22 2014-01-28 Affinergy, Llc Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces
CN101481352A (zh) 2008-01-10 2009-07-15 上海恒瑞医药有限公司 双环取代吡唑酮偶氮类衍生物、其制备方法及其在医药上的应用
CN102428105B (zh) 2009-02-24 2015-09-30 阿雷克森制药公司 含有治疗性tpo/epo模拟肽的抗体
WO2010138797A1 (en) * 2009-05-29 2010-12-02 The Board Of Regents Of The University Of Texas System Peptoid ligands for isolation and treatment of autoimmune t-cells
CN102458120A (zh) 2009-05-29 2012-05-16 葛兰素史密斯克莱有限责任公司 给药血小板生成素激动剂化合物的方法
MX2011012933A (es) * 2009-06-02 2012-03-07 Univ Texas Identificacion de moleculas pequeñas reconocidas por los anticuerpos en sujetos con enfermedades neurodegerativas.
TW201124726A (en) * 2009-10-16 2011-07-16 Univ Texas Compositions and methods for producing coded peptoid libraries
EP2492262B1 (en) 2009-10-23 2016-04-20 Nissan Chemical Industries, Ltd. Fused heterocyclic compound and thrombopoietin receptor activator
WO2011098095A1 (en) 2010-02-09 2011-08-18 Aplagen Gmbh Peptides binding the tpo receptor
CN104045715B (zh) * 2013-03-15 2018-05-01 兰州大学 二聚体化融合蛋白的制备及应用
EP3191113B1 (en) * 2014-09-11 2019-11-06 Bristol-Myers Squibb Company Macrocyclic inhibitors of the pd-1/pd-l1 and cd80 (b7-1)/pd-l1 protein/protein interactions
EP3658191A1 (en) * 2017-07-26 2020-06-03 Janssen Pharmaceutica NV Methods of protecting vascular integrity induced by targeted radiation therapy
JPWO2021112249A1 (pl) 2019-12-06 2021-06-10

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3645090A (en) 1969-06-19 1972-02-29 Citizen Watch Co Ltd Day-date quick-adjuster for calender timepiece
US3940475A (en) 1970-06-11 1976-02-24 Biological Developments, Inc. Radioimmune method of assaying quantitatively for a hapten
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
NO812612L (no) 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4612132A (en) 1984-07-20 1986-09-16 Chevron Research Company Modified succinimides
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5326558A (en) 1989-08-08 1994-07-05 Genetics Institute, Inc. Megakaryocytopoietic factor
IL96477A0 (en) 1989-12-01 1991-08-16 Amgen Inc Megakaryocyte production
DK167813B1 (da) * 1989-12-07 1993-12-20 Carlbiotech Ltd As Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
US5571508A (en) 1989-12-18 1996-11-05 Amrad Corporation Limited Method for the treatment of thrombocytopenia and pharmaceutical compositions useful therefor
US5141851A (en) * 1990-04-18 1992-08-25 Board Of Regents, The University Of Texas System Isolated farnesyl protein transferase enzyme
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US5250732A (en) 1991-07-18 1993-10-05 Genentech, Inc. Ketamine analogues for treatment of thrombocytopenia
ATE148889T1 (de) 1991-09-18 1997-02-15 Affymax Tech Nv Verfahren zur synthese der verschiedenen sammlungen von oligomeren
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5359115A (en) 1992-03-26 1994-10-25 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
DK0644771T4 (da) 1992-06-11 2006-12-27 Alkermes Inc Lægemiddelsystem til levering af erythropoietin
US5420328A (en) 1992-09-11 1995-05-30 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
EP0673387B1 (en) * 1992-12-11 1999-09-22 University Of Florida Materials and methods for control of pests
US5354934A (en) 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
EP0722331A4 (en) 1993-08-25 1997-10-01 Systemix Inc METHOD FOR PRODUCING A POPULATION OF HIGHLY ENRICHED HEMATOPOIETIC STEM CELLS
WO1995011992A1 (en) 1993-10-27 1995-05-04 The Regents Of The University Of California Antiviral compounds
AU8124694A (en) 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
SG47030A1 (en) * 1994-01-03 1998-03-20 Genentech Inc Thrombopoietin
EP0668352A1 (en) 1994-02-14 1995-08-23 Kirin Brewery Company, Ltd. Protein having TPO activity
CA2169173C (en) 1994-02-14 2002-10-15 Kenneth Kaushansky Methods for stimulating erythropoiesis using thrombopoietin
WO1995021919A2 (en) * 1994-02-14 1995-08-17 Kirin Brewery Company, Limited Protein having tpo activity
WO1995021920A1 (en) 1994-02-14 1995-08-17 Zymogenetics, Inc. Hematopoietic protein and materials and methods for making it
TW565568B (en) 1994-03-31 2003-12-11 Amgen Inc Compositions and methods for stimulating megakaryocyte growth and differentiation
US5571686A (en) 1994-04-14 1996-11-05 Massachusetts Institute Of Technology Method of using megapoietin for prolonging the survival & viability of platlets
AU4163196A (en) * 1994-11-30 1996-06-19 Zymogenetics Inc. Low molecular weight thrombopoietin
US5641655A (en) 1994-11-30 1997-06-24 Zymogenetics, Inc. Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide
EP2055712A1 (en) * 1995-06-07 2009-05-06 Glaxo Group Limited Peptides and compounds that bind to a thrombopoietin receptor
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US5932546A (en) * 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
US8157793B2 (en) 2006-10-25 2012-04-17 Terumo Kabushiki Kaisha Manipulator for medical use
JP2023049441A (ja) 2021-09-29 2023-04-10 トヨタ紡織株式会社 乗物用シート

Also Published As

Publication number Publication date
CA2223449A1 (en) 1996-12-19
HU227678B1 (en) 2011-11-28
JP3059218B2 (ja) 2000-07-04
AR003431A1 (es) 1998-08-05
JPH10507776A (ja) 1998-07-28
CN1315870C (zh) 2007-05-16
EP0885242A4 (en) 2000-03-22
NO975705L (no) 1998-02-05
BR9608587A (pt) 1999-01-05
IL122102A0 (en) 1998-04-05
US6083913A (en) 2000-07-04
WO1996040750A1 (en) 1996-12-19
EA001220B1 (ru) 2000-12-25
DE69637473D1 (de) 2008-05-08
KR100436680B1 (ko) 2004-09-18
EP0885242B1 (en) 2008-03-26
PL188795B1 (pl) 2005-04-29
CZ291749B6 (cs) 2003-05-14
HUP9900921A2 (hu) 1999-07-28
DE69637473T2 (de) 2009-05-07
ES2303338T3 (es) 2008-08-01
CN1966520A (zh) 2007-05-23
HK1015380A1 (en) 1999-10-15
EA199700359A1 (ru) 1998-10-29
PL323917A1 (en) 1998-04-27
AU704215B2 (en) 1999-04-15
CA2636432A1 (en) 1996-12-19
NZ310778A (en) 1999-10-28
NO317737B1 (no) 2004-12-13
NO20041296L (no) 1998-02-05
TW518341B (en) 2003-01-21
EP0885242A1 (en) 1998-12-23
ZA964814B (en) 1998-02-09
EP2055712A1 (en) 2009-05-06
US6465430B1 (en) 2002-10-15
EP1961760A2 (en) 2008-08-27
TR199701526T1 (xx) 1998-03-21
ATE390439T1 (de) 2008-04-15
HUP9900921A3 (en) 1999-11-29
AU6163496A (en) 1996-12-30
PT885242E (pt) 2008-06-18
KR19990022576A (ko) 1999-03-25
PE7898A1 (es) 1998-03-05
CN1192749A (zh) 1998-09-09
CZ389797A3 (cs) 1998-06-17
EP1961760A3 (en) 2008-09-03
EP2338897A1 (en) 2011-06-29
CA2636432C (en) 2012-01-03
CA2223449C (en) 2008-10-07
NO975705D0 (no) 1997-12-05
CN1966520B (zh) 2012-07-11
NO331550B1 (no) 2012-01-23
MX9709315A (es) 1998-08-30
IL122102A (en) 2002-07-25

Similar Documents

Publication Publication Date Title
DK0885242T3 (da) Peptider og forbindelser, der binder til en trombopoietinreceptor
DE69425236D1 (de) Monatsbinde
FI963560A (fi) Sidontamääritys, jossa käytetään häntäryhmiä sisältäviä sidonta-aineita
ZA9711045B (en) Peptides and compounds that bind to a receptor
ATA1198A (de) Snowboard - einstiegsbindung
DE69410636T2 (de) Bindungsbestimmung
DE69611955D1 (de) Bindeelement
NO20015376D0 (no) Peptider fra TT-virus-sekvensen og monospesifikke antistoffer som binder til TT-viruset
DK0951459T3 (da) Bundet aggregatpræparat og bindere for samme
DK129293D0 (da) Carbonhydratholdige forbindelser, der kan binde sig til carbonhydratbindende receptorer
NO996209D0 (no) Peptider og forbindelser som bindes til IL-5 reseptoren
NO996210D0 (no) Peptider og forbindelser som bindes til IL-5-reseptorer
DK12793D0 (da) Binder
DE9320429U1 (de) Bindungsanordnung
KR950027698U (ko) 철근결속선 체결 갈고리
KR970023771U (ko) 철근결속장치
KR950012894U (ko) 트윈 전선결속밴드
KR960030752U (ko) 바인더용 결속판
DE59209588D1 (de) Monatsbinde
KR950017351U (ko) 바인더 화일용 내지
KR970016590U (ko) 서류제본물
KR970016591U (ko) 서류제본물
KR950017359U (ko) 바인더 화일용 내지의 정돈 구조
KR970058301U (ko) 반복 사용하는 결속 밴드
GB9712383D0 (en) Peptides and compounds that bind to the IL-5 receptor