DK0771794T3 - Oxygenholdige heterocykliske forbindelser - Google Patents

Oxygenholdige heterocykliske forbindelser

Info

Publication number
DK0771794T3
DK0771794T3 DK96915194T DK96915194T DK0771794T3 DK 0771794 T3 DK0771794 T3 DK 0771794T3 DK 96915194 T DK96915194 T DK 96915194T DK 96915194 T DK96915194 T DK 96915194T DK 0771794 T3 DK0771794 T3 DK 0771794T3
Authority
DK
Denmark
Prior art keywords
bond
oxygen
containing heterocyclic
cyano
combined
Prior art date
Application number
DK96915194T
Other languages
Danish (da)
English (en)
Inventor
Fumio Suzuki
Takashi Kawakita
Etsuo Ohshima
Koji Yanagawa
Kyoichiro Iida
Rie Koike
Michio Ichimura
Haruhiko Manabe
Kenji Ohmori
Yoshisuke Nakasato
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Application granted granted Critical
Publication of DK0771794T3 publication Critical patent/DK0771794T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK96915194T 1995-05-19 1996-05-20 Oxygenholdige heterocykliske forbindelser DK0771794T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12153795 1995-05-19
JP25865195 1995-10-05

Publications (1)

Publication Number Publication Date
DK0771794T3 true DK0771794T3 (da) 2006-09-11

Family

ID=26458881

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96915194T DK0771794T3 (da) 1995-05-19 1996-05-20 Oxygenholdige heterocykliske forbindelser

Country Status (14)

Country Link
EP (1) EP0771794B1 (zh)
JP (1) JP4172817B2 (zh)
KR (1) KR100445356B1 (zh)
CN (1) CN1163493C (zh)
AT (1) ATE325110T1 (zh)
AU (1) AU705690B2 (zh)
CA (1) CA2195755A1 (zh)
DE (1) DE69636086T2 (zh)
DK (1) DK0771794T3 (zh)
ES (1) ES2258775T3 (zh)
HK (1) HK1000785A1 (zh)
NO (1) NO317631B1 (zh)
PT (1) PT771794E (zh)
WO (1) WO1996036624A1 (zh)

Families Citing this family (45)

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Publication number Priority date Publication date Assignee Title
US5902824A (en) * 1995-05-18 1999-05-11 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenyldihydrobenzofuranes
WO1996036626A1 (de) * 1995-05-18 1996-11-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Cyclohexyldihydrobenzofurane
JP2000501411A (ja) * 1995-12-05 2000-02-08 ダーウィン・ディスカバリー・リミテッド ベンゾフランカルボキサミドおよびスルホンアミド
IL126558A (en) * 1996-05-20 2002-07-25 Darwin Discovery Ltd Benzofuran carboxamides and pharmaceutical compositions containing them
EP0923568B9 (en) * 1996-08-19 2003-08-13 ALTANA Pharma AG Novel benzofuran-4-carboxamides
CA2272327A1 (en) * 1996-11-19 1998-05-28 Kyowa Hakko Kogyo Co., Ltd. Oxygen-containing heterocyclic compounds
ATE237612T1 (de) * 1997-10-01 2003-05-15 Kyowa Hakko Kogyo Kk Benzofuranderivate
CN1290266A (zh) * 1998-02-09 2001-04-04 达尔文发现有限公司 苯并呋喃－4－甲酰胺和其治疗用途
PT1095040E (pt) * 1998-07-06 2004-08-31 Altana Pharma Ag Novos benzoxazoles com actividade inibidora da pde
CA2341890C (en) 1998-09-03 2006-07-18 Kyowa Hakko Kogyo Co., Ltd. Oxygen-containing heterocyclic compounds
WO2000040714A2 (en) * 1998-12-30 2000-07-13 Oligos Etc. Inc. Therapeutic phosphodiesterase inhibitors
WO2001007031A1 (fr) * 1999-07-26 2001-02-01 Shionogi & Co., Ltd. Derives de benzene, compositions immunostimulantes ou agents de retablissement de la pharmacosensibilite les contenant
WO2003000697A1 (fr) * 2001-06-22 2003-01-03 Takeda Chemical Industries, Ltd. Derive de furo-isoquinoline, procede de production de ce compose et utilisation de ce compose
DE10205274A1 (de) * 2002-02-08 2003-08-21 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen enthaltend neben Anticholinergika heterocyclische Verbindungen
DE10216427A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Arzneimittelkompositionen enthaltend heterocyclische Verbindungen und ein neues Anticholinergikum
EP1535920A4 (en) * 2002-07-03 2007-03-21 Kyowa Hakko Kogyo Kk PROCESS FOR THE PREPARATION OF 1,3-BENZODIOXOLE-2-SPIRO-CYCLOALCAN DERIVATIVES
RU2005131943A (ru) * 2003-03-17 2006-03-20 Киова Хакко Когио Ко., Лтд. (Jp) Лечебные и/или профилактические средства для хронических болезней кожи
WO2004087150A1 (ja) * 2003-03-31 2004-10-14 Kyowa Hakko Kogyo Co. Ltd. 医薬組成物
JPWO2004087148A1 (ja) * 2003-03-31 2006-06-29 協和醗酵工業株式会社 肺疾患の治療および／または予防剤
JPWO2004087151A1 (ja) * 2003-03-31 2006-06-29 協和醗酵工業株式会社 医薬組成物
EP1634606A1 (en) * 2003-03-31 2006-03-15 Kyowa Hakko Kogyo Co., Ltd. Drug for airway administration
WO2004087149A1 (ja) * 2003-03-31 2004-10-14 Kyowa Hakko Kogyo Co. Ltd. 医薬組成物
JPWO2004087147A1 (ja) * 2003-03-31 2006-06-29 協和醗酵工業株式会社 肺疾患の治療および／または予防剤
WO2004087146A1 (ja) * 2003-03-31 2004-10-14 Kyowa Hakko Kogyo Co., Ltd. 微粒子混合物の製造方法
JPWO2004112791A1 (ja) * 2003-06-23 2006-07-27 協和醗酵工業株式会社 肺疾患の治療および／または予防剤
EP1504756A1 (en) * 2003-08-06 2005-02-09 Kyowa Hakko Kogyo Co., Ltd Medicament compositions comprising a heterocyclic compound and an anticholinergic
CA2584169A1 (en) * 2004-10-13 2006-04-20 Kyowa Hakko Kogyo Co., Ltd. Remedies/preventives for chronic skin disease
CA2584261A1 (en) * 2004-10-13 2006-04-20 Kyowa Hakko Kogyo Co., Ltd. Pharmaceutical composition
WO2006123726A1 (ja) * 2005-05-18 2006-11-23 Kyowa Hakko Kogyo Co., Ltd. 医薬組成物
US20100056791A1 (en) * 2006-09-01 2010-03-04 Yasushi Kohno Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same
CA2661992A1 (en) * 2006-09-06 2008-03-13 Kyorin Pharmaceutical Co., Ltd. Pyrazolopyridine derivative and phosphodiesterase (pde) inhibitor containing the same as active ingredient
CA2673370C (en) * 2006-12-22 2015-11-17 Leo Pharma A/S Substituted acetophenones useful as pde4 inhibitors
KR101571654B1 (ko) * 2007-02-28 2015-11-25 레오 파마 에이/에스 신규한 포스포디에스테라제 억제제
CN101679428A (zh) 2007-04-16 2010-03-24 利奥制药有限公司 用于治疗皮肤疾病的作为磷酸二酯酶抑制剂的三唑并吡啶类
EP2379548B1 (en) 2008-12-19 2016-03-09 Leo Pharma A/S Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases
EP2585469B1 (en) 2010-06-24 2016-05-25 Leo Pharma A/S Benzodioxole or benzodioxepine heterocyclic compounds as phosphodiesterase inhibitors
CA2858123A1 (en) 2011-12-21 2013-06-27 Leo Pharma A/S [1,2,4]triazolopyridines and their use as phosphodiesterase inhibitors
JP6785666B2 (ja) * 2014-06-23 2020-11-18 レオ ファーマ アクティーゼルスカブ １，３−ベンゾジオキソール複素環化合物の調製方法
CN106588841B (zh) * 2015-10-19 2019-01-25 富乐马鸿凯（大连）医药有限公司 合成2,3-二氢-1-苯并呋喃-4-甲醛的方法
CN106588900A (zh) * 2015-10-20 2017-04-26 北京康辰医药科技有限公司 一种苯并双环化合物或其药学上可接受的盐、药物组合物及其应用
CN106905336B (zh) * 2017-01-22 2019-04-09 浙江工业大学 一种手性吡唑螺呋喃类化合物的不对称合成方法
CN107325067B (zh) * 2017-05-03 2020-05-12 广州中医药大学 磷酸二酯酶4抑制剂桑辛素m衍生物及其用途
CN109721580B (zh) * 2017-10-27 2022-11-04 中国医学科学院药物研究所 3-苯基-7,8-脱氢葡萄藤戊素衍生物、其制法和药物组合物与用途
CN109721579B (zh) * 2017-10-27 2022-11-04 中国医学科学院药物研究所 7,8-脱氢葡萄藤戊素衍生物、其制法和药物组合物与用途
CN114478413B (zh) * 2022-01-14 2023-06-23 北京富盛嘉华医药科技有限公司 2-(2′-羟基-3′-甲代烯丙基-5′-甲基苯基)苯并三氮唑的制备方法及应用

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Also Published As

Publication number Publication date
WO1996036624A1 (fr) 1996-11-21
ATE325110T1 (de) 2006-06-15
AU5702996A (en) 1996-11-29
DE69636086T2 (de) 2006-11-30
PT771794E (pt) 2006-09-29
JP4172817B2 (ja) 2008-10-29
EP0771794A4 (en) 1998-09-02
CA2195755A1 (en) 1996-11-21
ES2258775T3 (es) 2006-09-01
NO970151D0 (no) 1997-01-14
EP0771794A1 (en) 1997-05-07
KR970704724A (ko) 1997-09-06
AU705690B2 (en) 1999-05-27
HK1000785A1 (en) 2006-06-30
NO317631B1 (no) 2004-11-29
KR100445356B1 (ko) 2004-11-12
NO970151L (no) 1997-03-06
CN1154697A (zh) 1997-07-16
EP0771794B1 (en) 2006-05-03
DE69636086D1 (de) 2006-06-08
CN1163493C (zh) 2004-08-25

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