DK0763032T3 - Palladiumkatalyseret ringlukning af triazolyltryptamin - Google Patents
Palladiumkatalyseret ringlukning af triazolyltryptaminInfo
- Publication number
- DK0763032T3 DK0763032T3 DK95918939T DK95918939T DK0763032T3 DK 0763032 T3 DK0763032 T3 DK 0763032T3 DK 95918939 T DK95918939 T DK 95918939T DK 95918939 T DK95918939 T DK 95918939T DK 0763032 T3 DK0763032 T3 DK 0763032T3
- Authority
- DK
- Denmark
- Prior art keywords
- palladium
- ring closure
- catalyzed ring
- triazolyltryptamine
- tryptamine
- Prior art date
Links
- 238000006798 ring closing metathesis reaction Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- -1 triazolyl tryptamine Chemical compound 0.000 abstract 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- APJYDQYYACXCRM-UHFFFAOYSA-N Tryptamine Natural products C1=CC=C2C(CCN)=CNC2=C1 APJYDQYYACXCRM-UHFFFAOYSA-N 0.000 abstract 2
- 101710138068 5-hydroxytryptamine receptor 1D Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002460 anti-migrenic effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 235000017550 sodium carbonate Nutrition 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 125000005270 trialkylamine group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Inorganic Insulating Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/248,288 US5567824A (en) | 1994-05-24 | 1994-05-24 | Palladium catalyzed ring closure of triazolyltryptamine |
| PCT/US1995/005506 WO1995032197A1 (en) | 1994-05-24 | 1995-05-19 | Palladium catalyzed ring closure of triazolyl tryptamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0763032T3 true DK0763032T3 (da) | 2004-02-09 |
Family
ID=22938473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95918939T DK0763032T3 (da) | 1994-05-24 | 1995-05-19 | Palladiumkatalyseret ringlukning af triazolyltryptamin |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5567824A (en:Method) |
| EP (1) | EP0763032B1 (en:Method) |
| JP (1) | JP3947216B2 (en:Method) |
| KR (1) | KR100385027B1 (en:Method) |
| CN (2) | CN1157390C (en:Method) |
| AT (1) | ATE252095T1 (en:Method) |
| AU (1) | AU688505B2 (en:Method) |
| DE (1) | DE69531939T2 (en:Method) |
| DK (1) | DK0763032T3 (en:Method) |
| ES (1) | ES2207648T3 (en:Method) |
| FI (1) | FI116899B (en:Method) |
| HK (1) | HK1041262B (en:Method) |
| HR (1) | HRP950304B1 (en:Method) |
| HU (1) | HU226460B1 (en:Method) |
| MX (1) | MX9605838A (en:Method) |
| NZ (1) | NZ285539A (en:Method) |
| PT (1) | PT763032E (en:Method) |
| RO (1) | RO118586B1 (en:Method) |
| RU (1) | RU2138496C1 (en:Method) |
| SK (1) | SK284495B6 (en:Method) |
| TW (1) | TW300221B (en:Method) |
| UA (1) | UA52586C2 (en:Method) |
| WO (1) | WO1995032197A1 (en:Method) |
| YU (1) | YU49345B (en:Method) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA965837B (en) * | 1995-07-11 | 1997-01-31 | Merck & Co Inc | A triazolylmethyl-indole ethylamine bisulfate salt |
| EP0840733B1 (en) * | 1995-07-11 | 2001-10-24 | Merck & Co., Inc. | A triazolylmethyl-indole ethylamine bisulfate salt |
| US5877329A (en) * | 1996-08-13 | 1999-03-02 | Merck & Co., Inc. | Palladium catalyzed indolization |
| US5811551A (en) * | 1996-08-13 | 1998-09-22 | Merck & Co., Inc. | Palladium catalyzed indolization |
| AU4053497A (en) * | 1996-08-13 | 1998-03-06 | Merck & Co., Inc. | Palladium catalyzed indolization |
| US5808064A (en) * | 1996-08-13 | 1998-09-15 | Merck & Co., Inc. | Palladium catalyzed indolization |
| EP1400519B1 (en) * | 1999-06-28 | 2007-03-07 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
| ES2204303B2 (es) * | 2002-08-07 | 2004-12-16 | Laboratorios Vita, S.A. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo. |
| EP1709032A2 (en) | 2004-01-09 | 2006-10-11 | Ratiopharm GmbH | Crystalline forms of rizatriptan benzoate |
| ATE461916T1 (de) * | 2004-01-28 | 2010-04-15 | Ratiopharm Gmbh | Syntheseverfahren und zwischenprodukte zur herstellung von rizatriptan |
| PA8626701A1 (es) * | 2004-03-26 | 2006-05-16 | Wyeth Corp | Procedimientos para la preparacion de compuestos aminoarilos yodados |
| WO2006082598A2 (en) * | 2005-02-01 | 2006-08-10 | Natco Pharma Limited | Novel crystalline forms of rizatriptan benzoate |
| WO2006137083A1 (en) * | 2005-06-20 | 2006-12-28 | Natco Pharma Limited | Improved process for the preparation of rizatriptan benzoate |
| EP1951713A1 (en) * | 2005-11-14 | 2008-08-06 | Matrix Laboratories Ltd | Process for the large scale production of rizatriptan benzoate |
| US20110313171A1 (en) * | 2006-01-19 | 2011-12-22 | Chandra Purna Ray | Conversion of aromatic diazonium salt to aryl hydrazine |
| AU2008259518A1 (en) * | 2007-06-04 | 2008-12-11 | Generics [Uk] Limited | Novel process |
| CA3010568C (en) | 2016-01-27 | 2023-10-17 | Instar Technologies A.S. | Oromucosal nanofiber carriers for therapeutic treatment |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK278998B6 (sk) * | 1991-02-01 | 1998-05-06 | Merck Sharp & Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu, spôsob i |
| CA2084531A1 (en) * | 1991-12-19 | 1993-06-20 | David W. Smith | Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines |
| GB9215526D0 (en) * | 1992-07-22 | 1992-09-02 | Merck Sharp & Dohme | Chemical process |
-
1994
- 1994-05-24 US US08/248,288 patent/US5567824A/en not_active Expired - Lifetime
-
1995
- 1995-05-16 TW TW084104806A patent/TW300221B/zh not_active IP Right Cessation
- 1995-05-19 PT PT95918939T patent/PT763032E/pt unknown
- 1995-05-19 RO RO96-02190A patent/RO118586B1/ro unknown
- 1995-05-19 MX MX9605838A patent/MX9605838A/es unknown
- 1995-05-19 EP EP95918939A patent/EP0763032B1/en not_active Expired - Lifetime
- 1995-05-19 CN CNB011034440A patent/CN1157390C/zh not_active Expired - Lifetime
- 1995-05-19 JP JP53030995A patent/JP3947216B2/ja not_active Expired - Lifetime
- 1995-05-19 WO PCT/US1995/005506 patent/WO1995032197A1/en not_active Ceased
- 1995-05-19 AT AT95918939T patent/ATE252095T1/de active
- 1995-05-19 DE DE69531939T patent/DE69531939T2/de not_active Expired - Lifetime
- 1995-05-19 ES ES95918939T patent/ES2207648T3/es not_active Expired - Lifetime
- 1995-05-19 NZ NZ285539A patent/NZ285539A/en not_active IP Right Cessation
- 1995-05-19 UA UA96124773A patent/UA52586C2/uk unknown
- 1995-05-19 AU AU24671/95A patent/AU688505B2/en not_active Expired
- 1995-05-19 CN CN95194106A patent/CN1077104C/zh not_active Expired - Lifetime
- 1995-05-19 KR KR1019960706634A patent/KR100385027B1/ko not_active Expired - Lifetime
- 1995-05-19 RU RU96124486A patent/RU2138496C1/ru active
- 1995-05-19 HU HU9603236A patent/HU226460B1/hu unknown
- 1995-05-19 DK DK95918939T patent/DK0763032T3/da active
- 1995-05-19 SK SK1498-96A patent/SK284495B6/sk not_active IP Right Cessation
- 1995-05-23 YU YU33495A patent/YU49345B/sh unknown
- 1995-05-23 HR HR08/248,288 patent/HRP950304B1/xx not_active IP Right Cessation
-
1996
- 1996-11-22 FI FI964669A patent/FI116899B/fi not_active IP Right Cessation
-
2002
- 2002-04-15 HK HK02102830.8A patent/HK1041262B/zh not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI964669A0 (fi) | Triatsolyylitryptamiinin palladiumkatalysoitu renkaanmuodostus | |
| EA200000393A1 (ru) | Химические соединения | |
| DK156719C (da) | Analogifremgangsmaade til fremstilling af 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphanforbindelser eller syreadditionssalte deraf | |
| DK129282A (da) | Fremgangsmaade til fremstilling af indolylethylderivater | |
| PT98768A (pt) | Processo de preparacao de derivados de piperazinilo e de composicoes farmaceuticas que os contem | |
| ES485064A1 (es) | Un procedimiento para preparar derivados de acido acetico | |
| ES521124A0 (es) | Procedimiento para preparar espino (piperidino-oxobenzo-xazinas) substituidas en posicion 1 anti-hipertensivas. | |
| ATE48835T1 (de) | Chinolylglycinamidderivate, verfahren zu ihrer herstellung und therapeutische verwendung als psychotrope. | |
| YU217181A (en) | Process for preparing 2-(1,4-benzodioxane-2-ylalkyl)-imidazoles | |
| GB9306899D0 (en) | Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation | |
| FI913658A0 (fi) | 4-amino-d4,6-steroider och deras anvaendning som 5a-reduktas-inhibitorer. | |
| DK432086D0 (da) | Fremgangsmaade til fremstilling af beta-lactamforbindelser eller saltederaf | |
| DK501480A (da) | Fremgangsmaade til fremstilling af substituerede 2-phenylamino-imidazoliner-(2). | |
| KR840001974A (ko) | 1-[3-(6-플루오로-1,2-벤즈이속사졸-3-일)프로필]-4-(치환된)-피페라진 및-피레리딘의 제조방법 | |
| DK0779895T3 (da) | Forbedret fremgangsmåde til fremstilling af sidekædederivater af cyclohexapeptidyl-lipopeptider | |
| CA2190851A1 (en) | Palladium catalyzed ring closure of triazolyl tryptamine | |
| ES8407042A1 (es) | Procedimiento para la obtencion de un nuevo derivado del sulpiride. | |
| EP0030620A3 (en) | Substituted 2-phenylamino-2-imidazolines, acid addition salts thereof, medicaments containing them and process for preparing them | |
| JPH0356452A (ja) | 安息香酸誘導体の製造方法 | |
| DK0614890T3 (da) | Fremgangsmåde til fremstilling af eventuelt 2-substituerede 5-chlorimidazoler. | |
| BR8203989A (pt) | Processo para a preparacao de hidrazidinas | |
| HU9302786D0 (en) | New thiophene-2-carboxylic acid derivatives and process for preparing them | |
| JPS5640677A (en) | Catechol derivative and its preparation | |
| KR970042548A (ko) | 이미다조 피리딘 유도체,이의 제조방법 및 이를 함유한 약제학적 조성물 | |
| JPS62212359A (ja) | ジアリ−ルオキシアルカンの製法 |