DK129282A - Fremgangsmaade til fremstilling af indolylethylderivater - Google Patents

Fremgangsmaade til fremstilling af indolylethylderivater Download PDF

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Publication number
DK129282A
DK129282A DK129282A DK129282A DK129282A DK 129282 A DK129282 A DK 129282A DK 129282 A DK129282 A DK 129282A DK 129282 A DK129282 A DK 129282A DK 129282 A DK129282 A DK 129282A
Authority
DK
Denmark
Prior art keywords
carbon atoms
indolylet
shelter
derivatives
procedure
Prior art date
Application number
DK129282A
Other languages
English (en)
Inventor
R D Clark
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of DK129282A publication Critical patent/DK129282A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
DK129282A 1981-03-23 1982-03-22 Fremgangsmaade til fremstilling af indolylethylderivater DK129282A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/246,459 US4332804A (en) 1981-03-23 1981-03-23 9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones

Publications (1)

Publication Number Publication Date
DK129282A true DK129282A (da) 1982-09-24

Family

ID=22930776

Family Applications (1)

Application Number Title Priority Date Filing Date
DK129282A DK129282A (da) 1981-03-23 1982-03-22 Fremgangsmaade til fremstilling af indolylethylderivater

Country Status (19)

Country Link
US (1) US4332804A (da)
EP (1) EP0061333B1 (da)
JP (1) JPS57169485A (da)
KR (1) KR830009094A (da)
AT (1) ATE17249T1 (da)
AU (1) AU557094B2 (da)
BR (1) BR8201589A (da)
DE (1) DE3268225D1 (da)
DK (1) DK129282A (da)
ES (1) ES8306373A1 (da)
FI (1) FI820998L (da)
IE (1) IE52652B1 (da)
IL (1) IL65310A (da)
NO (1) NO820937L (da)
NZ (1) NZ200085A (da)
PH (1) PH17233A (da)
PL (1) PL235561A1 (da)
PT (1) PT74626B (da)
ZA (1) ZA821929B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861880A (en) * 1982-09-20 1989-08-29 Pfizer Inc. 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents
US4879391A (en) * 1982-09-20 1989-11-07 Pfizer Inc. 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents
US4977178A (en) * 1982-09-20 1990-12-11 Pfizer Inc. Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents
GB8808433D0 (en) * 1988-04-11 1988-05-11 Merck Sharp & Dohme Therapeutic agents
JP4664564B2 (ja) 2000-03-06 2011-04-06 アカディア ファーマシューティカルズ，インコーポレーテッド セロトニン関連疾患の治療に使用する含窒素環式化合物
NZ571695A (en) * 2001-12-28 2010-02-26 Acadia Pharm Inc Spiroazacyclic compounds as monoamine receptor for modulating 5-HT2A receptor-mediated events
CA2490397A1 (en) * 2002-06-24 2003-12-31 Acadia Pharmaceuticals Inc. N-substituted piperidine derivatives as serotonin receptor agents
US7253186B2 (en) * 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
US7538222B2 (en) * 2002-06-24 2009-05-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
US7601740B2 (en) 2003-01-16 2009-10-13 Acadia Pharmaceuticals, Inc. Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases
US20050261278A1 (en) * 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
US7820695B2 (en) * 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
US7790899B2 (en) * 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
SG161221A1 (en) * 2004-09-27 2010-05-27 Acadia Pharm Inc Synthesis of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-næ-(4-(2- methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
AU2008228833B9 (en) 2007-03-19 2013-10-24 Acadia Pharmaceuticals Inc. Combinations of 5-HT2A inverse agonists and antagonists with antipsychotics
CA2700331A1 (en) * 2007-09-21 2009-03-26 Acadia Pharmaceuticals, Inc. Co-administration of pimavanserin with other agents
TWI685497B (zh) * 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物
WO2017015272A1 (en) 2015-07-20 2017-01-26 Acadia Pharmaceuticals Inc. Methods for preparing n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c
ES2932000T3 (es) 2015-11-16 2023-01-09 Esteve Pharmaceuticals Sa Compuestos de oxadiazaspiro para el tratamiento del abuso de drogas y adicciones
WO2017165635A1 (en) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome p450 modulators
US10953000B2 (en) 2016-03-25 2021-03-23 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome P450 modulators
EP3558311A1 (en) 2016-12-20 2019-10-30 Acadia Pharmaceuticals Inc. Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis
EP3615028A1 (en) 2017-04-28 2020-03-04 Acadia Pharmaceuticals Inc. Pimavanserin for treating impulse control disorder
WO2019046167A1 (en) 2017-08-30 2019-03-07 Acadia Pharmaceuticals Inc. PIMAVANSERIN FORMULATIONS
CA3076765A1 (en) 2017-10-17 2019-04-25 Esteve Pharmaceuticals, S.A. Salts of (r)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3481942A (en) * 1968-09-06 1969-12-02 Smithkline Corp Oxa-diazaspiro(4.5)decane compounds
US3574204A (en) * 1969-07-03 1971-04-06 Yoshitomi Pharmaceutical Piperidine spiro compounds
CA952908A (en) * 1970-02-27 1974-08-13 Yoshitomi Pharmaceutical Industries Benzodioxane derivatives
US3723442A (en) * 1970-12-31 1973-03-27 Yoshitomi Pharmaceutical 3-oxo-1-oxa-4,8-diazaspiro(4.5)decanes
US4255432A (en) * 1979-09-06 1981-03-10 Syntex (U.S.A.) Inc. 8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof

Also Published As

Publication number Publication date
ES510649A0 (es) 1983-06-01
ATE17249T1 (de) 1986-01-15
IL65310A (en) 1985-03-31
PH17233A (en) 1984-07-03
PL235561A1 (da) 1982-10-25
PT74626A (en) 1982-04-01
AU8176982A (en) 1982-09-30
AU557094B2 (en) 1986-12-04
DE3268225D1 (de) 1986-02-13
PT74626B (en) 1983-12-19
FI820998L (fi) 1982-09-24
KR830009094A (ko) 1983-12-17
IE52652B1 (en) 1988-01-06
EP0061333B1 (en) 1986-01-02
NO820937L (no) 1982-09-24
NZ200085A (en) 1985-07-12
IE820648L (en) 1982-09-23
ES8306373A1 (es) 1983-06-01
US4332804A (en) 1982-06-01
JPS57169485A (en) 1982-10-19
ZA821929B (en) 1983-11-30
BR8201589A (pt) 1983-02-08
IL65310A0 (en) 1982-05-31
EP0061333A1 (en) 1982-09-29

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment