DK0745600T3 - Benzimidazolderivater, deres fremstilling og deres terapeutiske anvendelse - Google Patents

Benzimidazolderivater, deres fremstilling og deres terapeutiske anvendelse

Info

Publication number
DK0745600T3
DK0745600T3 DK96303940T DK96303940T DK0745600T3 DK 0745600 T3 DK0745600 T3 DK 0745600T3 DK 96303940 T DK96303940 T DK 96303940T DK 96303940 T DK96303940 T DK 96303940T DK 0745600 T3 DK0745600 T3 DK 0745600T3
Authority
DK
Denmark
Prior art keywords
ylmethyl
preparation
dioxothiazolidin
therapeutic use
benzimidazole derivatives
Prior art date
Application number
DK96303940T
Other languages
Danish (da)
English (en)
Inventor
Takashi Fujita
Kunio Wada
Minoru Oguchi
Hiroaki Yanagisawa
Koichi Fujimoto
Toshihiko Fujiwara
Hiroyoshi Horikoshi
Takao Yoshioka
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26385935&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0745600(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of DK0745600T3 publication Critical patent/DK0745600T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK96303940T 1995-06-01 1996-05-31 Benzimidazolderivater, deres fremstilling og deres terapeutiske anvendelse DK0745600T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP13509795 1995-06-01
JP4584596 1996-03-04

Publications (1)

Publication Number Publication Date
DK0745600T3 true DK0745600T3 (da) 2001-11-12

Family

ID=26385935

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96303940T DK0745600T3 (da) 1995-06-01 1996-05-31 Benzimidazolderivater, deres fremstilling og deres terapeutiske anvendelse

Country Status (20)

Country Link
US (1) US5886014A (cs)
EP (1) EP0745600B1 (cs)
JP (2) JP2976885B2 (cs)
KR (2) KR100485425B1 (cs)
CN (1) CN1066729C (cs)
AT (1) ATE207489T1 (cs)
AU (1) AU712390B2 (cs)
CA (1) CA2177858C (cs)
CZ (1) CZ293016B6 (cs)
DE (1) DE69616151T2 (cs)
DK (1) DK0745600T3 (cs)
ES (1) ES2164841T3 (cs)
HU (1) HU225778B1 (cs)
IL (1) IL118474A (cs)
MX (1) MX9602122A (cs)
NO (1) NO308744B1 (cs)
NZ (1) NZ286716A (cs)
PT (1) PT745600E (cs)
RU (1) RU2125048C1 (cs)
TW (1) TW449594B (cs)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
EP0783888A1 (en) * 1995-12-26 1997-07-16 Sankyo Company Limited Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis
IL120264A0 (en) * 1996-02-29 1997-06-10 Pfizer Method of reducing tissue damage associated with non-cardiac ischemia
ZA972152B (en) * 1996-03-18 1997-09-17 Sankyo Co Treatment and prophylaxis of pancreatitis.
IL120443A (en) * 1996-03-18 2000-07-16 Sankyo Co Use of an insulin sensitizer for the manufacture of a medicament for the treatment or prophylaxis of pancreatitis
US5889032A (en) * 1996-05-06 1999-03-30 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5801173A (en) * 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5889025A (en) * 1996-05-06 1999-03-30 Reddy's Research Foundation Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
CA2257284C (en) * 1996-05-31 2005-10-04 Sankyo Company Limited Remedy for autoimmune diseases
CZ388598A3 (cs) * 1996-05-31 1999-07-14 Sankyo Company, Limited Léčivo proti autoimunní nemoci
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
CZ298812B6 (cs) * 1996-07-01 2008-02-13 Dr. Reddy's Laboratories Limited Azolidindionové deriváty, způsob jejich přípravy, farmaceutické kompozice s jejich obsahem a jejich použití v léčbě diabetu a příbuzných nemocí
USRE39266E1 (en) 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6313113B1 (en) 1997-04-15 2001-11-06 Reddy-Cheminor, Inc. Heterocyclic compounds having antidiabetic, hypolipidemic and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
AU2823797A (en) * 1997-05-02 1997-11-19 Dr. Reddy's Research Foundation Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US6011031A (en) * 1997-05-30 2000-01-04 Dr. Reddy's Research Foundation Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them
AU740704B2 (en) * 1997-10-08 2001-11-15 Sankyo Company Limited Substituted fused heterocyclic compounds
HUP9902721A2 (hu) 1997-11-25 1999-12-28 The Procter & Gamble Co. Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület
AU1507799A (en) * 1997-12-16 1999-07-05 Sankyo Company Limited Leukemia remedy
WO2000028991A1 (fr) * 1998-11-13 2000-05-25 Fujisawa Pharmaceutical Co., Ltd. Remedes contre le syndrome des ovaires polykystiques
US6756360B1 (en) 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
WO2000043006A1 (fr) * 1999-01-19 2000-07-27 Sankyo Company, Limited Inhibiteur de la mort des cellules nerveuses imputable à la cytotoxicité de l'acide glutamique
WO2000059889A1 (en) * 1999-04-06 2000-10-12 Sankyo Company, Limited α-SUBSTITUTED CARBOXYLIC ACID DERIVATIVES
DE60044342D1 (de) 1999-04-07 2010-06-17 Daiichi Sankyo Co Ltd Aminderivate
AU3670900A (en) * 1999-04-08 2000-11-14 Sankyo Company Limited Substituted fused imidazole derivatives
TWI284533B (en) * 1999-05-24 2007-08-01 Sankyo Co Pharmaceutical composition for treating hyperglycemia, impaired glucose tolerance, diabetes complications and for improving insulin resistant
DE60030118T2 (de) 1999-06-28 2007-03-15 Sankyo Co., Ltd. Zwischenprodukte zur synthese von benzimidazolverbindungen und ein verfahren zu ihrer herstellung
JP2001072671A (ja) * 1999-06-28 2001-03-21 Sankyo Co Ltd ベンズイミダゾール化合物の合成中間体およびその製造方法
CA2379662A1 (en) 1999-07-19 2001-01-25 Sankyo Company Limited Preventive and therapeutic agents for cancer
AU7559200A (en) * 1999-10-12 2001-04-23 Japan Tobacco Inc. Hypertriglyceridemia remedies and antiobestics
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
EP1172356B1 (en) 2000-07-13 2004-10-06 Sumitomo Chemical Company, Limited Process for producing N-acylnitroaniline derivative
JP2002088048A (ja) * 2000-07-13 2002-03-27 Sumitomo Chem Co Ltd N−t−ブトキシカルボニルニトロアニリン誘導体の製造法
RU2205826C2 (ru) * 2000-12-21 2003-06-10 Национальная фармацевтическая академия Украины (±)-цис-3-(2'-бензимидазолил)-1,2,2-триметилциклопентанкарбоновая кислота, проявляющая сахароснижающее и антидиабетогенное действие
US6452014B1 (en) * 2000-12-22 2002-09-17 Geron Corporation Telomerase inhibitors and methods of their use
WO2002051441A1 (fr) * 2000-12-26 2002-07-04 Sankyo Company, Limited Compositions medicinales contenant un diuretique et un agent renforçant la resistance a l'insuline
GB0112363D0 (en) 2001-05-21 2001-07-11 Allied Therapeutics Ltd Method and apparatus for treating biological fluids
FR2829765A1 (fr) * 2001-09-14 2003-03-21 Lipha Derives imidazolylalkoxylarylalcanoiques leurs applications en therapeutique
JP2005538679A (ja) 2001-10-24 2005-12-22 ザ レジェンツ オブ ザ ユニバーシティー オブ カリフォルニア サン ディエゴ アテローム性動脈硬化症に寄与する主要遺伝子としての5−リポキシゲナーゼの同定
US20050119314A1 (en) * 2002-04-05 2005-06-02 Sankyo Company, Limited Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent
JP2004002365A (ja) * 2002-04-05 2004-01-08 Sankyo Co Ltd Acat阻害剤とインシュリン抵抗性改善剤とからなる医薬組成物
CA2481379A1 (en) * 2002-04-05 2003-10-16 Toshimori Inaba Medicinal composition comprising acat inhibitor and insuline resistance improving agent
JP2004083574A (ja) * 2002-06-25 2004-03-18 Sankyo Co Ltd 利尿剤及びペルオキシソーム増殖因子活性化受容体(PPAR)γ活性化剤を含有する医薬組成物
TW200403055A (en) * 2002-06-25 2004-03-01 Sankyo Co Pharmaceutical composition of a peroxisome proliferator-activated receptor (PPAR) gamma atcivetor and a diuretic
AU2003254795A1 (en) * 2002-08-02 2004-02-23 Sankyo Company, Limited Resorcinol derivative
US7232828B2 (en) * 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
WO2004035830A1 (ja) * 2002-10-18 2004-04-29 Sankyo Company,Limited β細胞機能不全改善剤の評価方法
US20040198800A1 (en) * 2002-12-19 2004-10-07 Geoffrey Allan Lipoxygenase inhibitors as hypolipidemic and anti-hypertensive agents
US6794401B2 (en) * 2003-01-17 2004-09-21 Bexel Pharmaceuticals, Inc. Amino acid phenoxy ethers
JP4217832B2 (ja) 2003-10-24 2009-02-04 参天製薬株式会社 角結膜障害の治療剤
WO2005039571A1 (ja) 2003-10-29 2005-05-06 Santen Pharmaceutical Co., Ltd. 角結膜障害治療剤
BRPI0509305A (pt) * 2004-03-29 2007-09-04 Sankyo Co uso de um sensibilizador insulìnico, composição farmecêutica, e , kit
RU2246945C1 (ru) * 2004-05-11 2005-02-27 Аверин Константин Михайлович Суппозитории притововоспалительного, антисептического и регенерационного действия
TW200608967A (en) * 2004-07-29 2006-03-16 Sankyo Co Pharmaceutical compositions containing with diabetic agent
WO2006022450A1 (ja) * 2004-08-26 2006-03-02 Santen Pharmaceutical Co., Ltd. 皮膚疾患治療剤
JP4789180B2 (ja) * 2004-09-28 2011-10-12 第一三共株式会社 6−置換−1−メチル−1−h−ベンズイミダゾール誘導体の製造方法及びその製造中間体
CA2580973C (en) 2004-09-28 2012-03-06 Sankyo Company Limited Intermediate of 6-substituted 1-methyl-1-h-benzimidazole derivative and method for producing same
US20060106014A1 (en) * 2004-10-14 2006-05-18 Sekhar Boddupalli Methods for treating diabetes
CN101048382B (zh) * 2004-10-27 2010-05-05 霍夫曼-拉罗奇有限公司 新型吲哚或苯并咪唑衍生物
EP1825854A1 (en) * 2004-12-15 2007-08-29 Daiichi Sankyo Company, Limited MEDICINAL COMPOSITION CONTAINING FBPase INHIBITOR
TW200637856A (en) * 2005-01-24 2006-11-01 Sankyo Co Process for producing thiazolidinedion compound and intermediate thereof
JP2006225382A (ja) * 2005-01-24 2006-08-31 Sankyo Co Ltd チアゾリジンジオン化合物の製造方法及びその製造中間体
US20090227493A1 (en) * 2005-05-27 2009-09-10 Daiichi Sankyo Company, Limited Combined drug for treating diabetes
TWI418350B (zh) * 2005-06-24 2013-12-11 Sankyo Co 含有ppar調節劑之醫藥組成物的用途
US20080262054A1 (en) * 2005-07-08 2008-10-23 Takao Kawasaki Pharmaceutical Composition Containing Thiazolidinedione Compound
JPWO2007007757A1 (ja) * 2005-07-12 2009-01-29 第一三共株式会社 PPARγアゴニストを含有する医薬組成物
TW200738266A (en) * 2005-09-29 2007-10-16 Sankyo Co Pharmaceutical agent containing insulin resistance improving agent
TW200730173A (en) * 2005-12-16 2007-08-16 Sankyo Co Pharmaceutical composition enhancing production of adiponectin
JP2008044932A (ja) * 2006-07-21 2008-02-28 Daiichi Sankyo Co Ltd チアゾリジンジオン化合物を含有する組成物
EP2063890A1 (en) 2006-09-07 2009-06-03 Nycomed GmbH Combination treatment for diabetes mellitus
KR100811100B1 (ko) * 2006-09-27 2008-03-06 한국생명공학연구원 벤즈아졸 유도체를 유효성분으로 함유하는 대사성 질환예방 및 치료용 약학적 조성물
EP2138484B1 (en) * 2007-04-05 2015-08-26 Daiichi Sankyo Company, Limited Fused bicyclic heteroaryl derivatives
JP5508258B2 (ja) 2007-06-04 2014-05-28 ベン グリオン ユニバーシティ オブ ザ ネガフ リサーチ アンド ディベロップメント オーソリティ トリアリール化合物および前記化合物を含む組成物
CA2716418A1 (en) 2008-02-25 2009-09-03 Santen Pharmaceutical Co., Ltd. Agent for enhancing corneal epithelial barrier function
BR112012012378A2 (pt) 2009-11-26 2019-09-24 Daiichi Sankyo Co Ltd método para fabricar um composto, e, composto
WO2013101911A2 (en) 2011-12-28 2013-07-04 Allergan, Inc. Benzimidazole derivatives as selective blockers of persistent sodium current
KR20160094956A (ko) 2013-11-05 2016-08-10 벤-구리온 유니버시티 오브 더 네게브 리서치 앤드 디벨럽먼트 어쏘러티 당뇨병 및 당뇨병으로부터 발생하는 합병증 질환의 치료를 위한 화합물
CN104086541B (zh) * 2014-07-18 2016-01-20 高中设 一种治疗小儿呼吸道感染的药物组合物
CN104083364B (zh) * 2014-07-18 2015-12-09 泰山医学院附属医院 一种治疗阴沟肠杆菌引起的小儿呼吸道感染的药物组合物

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
JPS6051189A (ja) * 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
JPS60226873A (ja) * 1984-03-28 1985-11-12 Sankyo Co Ltd 1,3−ベンゾオキサチオ−ル誘導体及びその製法
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物,其制备方法和用途
DK173350B1 (da) * 1985-02-26 2000-08-07 Sankyo Co Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
US4681940A (en) * 1985-11-19 1987-07-21 American Home Products Corporation 5-[3-[[2-quinolyl]methoxy]phenyl]-1,3-oxazoles
US4873255A (en) * 1987-02-04 1989-10-10 Sankyo Company Limited Thiazolidinone derivatives, their preparation and their use
ATE186724T1 (de) * 1987-09-04 1999-12-15 Beecham Group Plc Substituierte thiazolidindionderivate
GB8820389D0 (en) * 1988-08-26 1988-09-28 Beecham Group Plc Novel compounds
WO1991007107A1 (en) * 1989-11-13 1991-05-30 Pfizer Inc. Oxazolidinedione hypoglycemic agents
JP2826379B2 (ja) * 1990-01-22 1998-11-18 三共株式会社 チアゾリジン誘導体を有効成分とする肥満性高血圧症治療剤
US5143930A (en) * 1990-02-07 1992-09-01 Sankyo Company, Limited Thiazolidine derivatives with anti-diabetic activity, their preparation and their use
EP0839812A1 (en) * 1990-04-27 1998-05-06 Sankyo Company Limited Preparation of benzylthiazolidine derivatives
GB9017218D0 (en) * 1990-08-06 1990-09-19 Beecham Group Plc Novel compounds
WO1992003425A1 (en) * 1990-08-23 1992-03-05 Pfizer Inc. Hypoglycemic hydroxyurea derivatives
GB9023584D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
GB9023585D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
RU2066322C1 (ru) * 1991-06-28 1996-09-10 Киевский Государственный Университет Им.Т.Г.Шевченко 3-(4-метил-2-тиазолил)-6-пропил-7-(1-метил-1-этоксикарбонил)метоксихромон, обладающий гипогликемическим, гиполипидемическим действием и аналептическим действием
FR2680512B1 (fr) * 1991-08-20 1995-01-20 Adir Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
NO302519B1 (no) * 1991-12-26 1998-03-16 Sankyo Co Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat
US5614544A (en) * 1993-09-14 1997-03-25 Takeda Chemical Industries, Ltd. Oxazolidinedione derivatives and their use
NO303782B1 (no) * 1994-03-23 1998-08-31 Sankyo Co Tiazolidin- og oksazolidinderivater og farmas°ytiske preparater inneholdende slike, samt deres anvendelse til fremstilling av medikamenter
CA2146701A1 (en) * 1994-04-11 1995-10-12 Takashi Fujita Heterocyclic compounds having anti-diabetic activity, their preparation and their use
US5420146A (en) * 1994-05-10 1995-05-30 American Home Products Corporation Di-oxadiazolidine derivatives as antihyperglycemic agents
JPH08143556A (ja) * 1994-11-15 1996-06-04 Terumo Corp ジオキソチアゾリジン誘導体及びそれを含有する医薬組成物
JPH08143568A (ja) * 1994-11-22 1996-06-04 Terumo Corp ピリドピリミジン誘導体及びそれを含有する医薬組成物
JPH08143566A (ja) * 1994-11-25 1996-06-04 Terumo Corp キナゾリン誘導体及びそれを含有する医薬組成物
JP3929512B2 (ja) * 1995-06-02 2007-06-13 杏林製薬株式会社 N−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法
JP3144624B2 (ja) * 1995-06-02 2001-03-12 杏林製薬株式会社 N−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法

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IL118474A0 (en) 1996-09-12
EP0745600B1 (en) 2001-10-24
JP2000001487A (ja) 2000-01-07
ES2164841T3 (es) 2002-03-01
JP2976885B2 (ja) 1999-11-10
CN1157288A (zh) 1997-08-20
KR100485425B1 (ko) 2005-10-27
CA2177858C (en) 2010-07-06
NO962239D0 (no) 1996-05-31
NO308744B1 (no) 2000-10-23
JPH09295970A (ja) 1997-11-18
DE69616151D1 (de) 2001-11-29
JP3249490B2 (ja) 2002-01-21
HK1011683A1 (en) 1999-07-16
HU9601492D0 (en) 1996-07-29
DE69616151T2 (de) 2002-07-11
CZ293016B6 (cs) 2004-01-14
US5886014A (en) 1999-03-23
HUP9601492A3 (en) 1998-10-28
AU5462796A (en) 1996-12-12
CA2177858A1 (en) 1996-12-02
RU2125048C1 (ru) 1999-01-20
IL118474A (en) 2001-08-08
ATE207489T1 (de) 2001-11-15
AU712390B2 (en) 1999-11-04
TW449594B (en) 2001-08-11
HU225778B1 (en) 2007-08-28
CZ156796A3 (en) 1996-12-11
EP0745600A1 (en) 1996-12-04
KR100493772B1 (ko) 2005-06-08
HK1002280A1 (en) 1998-08-14
KR970001349A (ko) 1997-01-24
NO962239L (no) 1996-12-02
NZ286716A (en) 1997-08-22
HUP9601492A2 (hu) 1998-08-28
PT745600E (pt) 2002-02-28
CN1066729C (zh) 2001-06-06
MX9602122A (es) 1997-06-28

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