DK0402644T3 - N-(Aryloxyalkyl)-heteroarylpiperidiner og -heteroarylpiperaziner, fremgangsmåde til deres fremstilli ng samt deres anvendelse som medikamenter - Google Patents

N-(Aryloxyalkyl)-heteroarylpiperidiner og -heteroarylpiperaziner, fremgangsmåde til deres fremstilli ng samt deres anvendelse som medikamenter

Info

Publication number
DK0402644T3
DK0402644T3 DK90109208.0T DK90109208T DK0402644T3 DK 0402644 T3 DK0402644 T3 DK 0402644T3 DK 90109208 T DK90109208 T DK 90109208T DK 0402644 T3 DK0402644 T3 DK 0402644T3
Authority
DK
Denmark
Prior art keywords
lower alkyl
alkyl
heteroaryl
chem
alkoxy
Prior art date
Application number
DK90109208.0T
Other languages
Danish (da)
English (en)
Inventor
Joseph T Strupczewski
Grover C Helsley
Yulin Chiang
Kenneth J Bordeau
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of DK0402644T3 publication Critical patent/DK0402644T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
DK90109208.0T 1989-05-19 1990-05-16 N-(Aryloxyalkyl)-heteroarylpiperidiner og -heteroarylpiperaziner, fremgangsmåde til deres fremstilli ng samt deres anvendelse som medikamenter DK0402644T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35441189A 1989-05-19 1989-05-19
US45679089A 1989-12-29 1989-12-29

Publications (1)

Publication Number Publication Date
DK0402644T3 true DK0402644T3 (da) 1996-01-02

Family

ID=26998389

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90109208.0T DK0402644T3 (da) 1989-05-19 1990-05-16 N-(Aryloxyalkyl)-heteroarylpiperidiner og -heteroarylpiperaziner, fremgangsmåde til deres fremstilli ng samt deres anvendelse som medikamenter

Country Status (24)

Country Link
EP (1) EP0402644B1 (ja)
JP (1) JPH0662580B2 (ja)
KR (1) KR0157308B1 (ja)
CN (2) CN1086387C (ja)
AT (1) ATE126512T1 (ja)
AU (1) AU640653B2 (ja)
CA (1) CA2017193C (ja)
CZ (1) CZ282385B6 (ja)
DD (1) DD300433A5 (ja)
DE (1) DE69021645T2 (ja)
DK (1) DK0402644T3 (ja)
ES (1) ES2076253T3 (ja)
FI (2) FI104072B (ja)
GR (1) GR3017447T3 (ja)
HK (2) HK1006710A1 (ja)
HU (2) HU218200B (ja)
IE (1) IE68431B1 (ja)
IL (1) IL94425A (ja)
NO (1) NO177301C (ja)
NZ (1) NZ233710A (ja)
PL (1) PL163965B1 (ja)
PT (1) PT94084B (ja)
RU (3) RU2062776C1 (ja)
SK (1) SK242590A3 (ja)

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US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
US5177088A (en) * 1991-04-17 1993-01-05 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 3-(pyridinylamino)-indoles
TW241263B (ja) * 1991-08-22 1995-02-21 Hoechst Roussel Pharma
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
US5378714A (en) * 1991-11-27 1995-01-03 Novo Nordisk A/S Antipsychotic piperidine derivatives
JPH07502268A (ja) * 1991-11-27 1995-03-09 ノボ　ノルディスク　アクティーゼルスカブ 化学化合物、それらの製法および使用
WO1993013068A1 (en) * 1991-12-25 1993-07-08 Zeria Pharmaceutical Co., Ltd. Tricyclic compound and medicine containing the same
CA2146018A1 (en) * 1992-10-23 1994-05-11 Paul David Leeson Dopamine receptor subtype ligands
DE69325662T2 (de) * 1992-10-23 2000-02-10 Merck Sharp & Dohme Ltd., Hoddesdon Dopamin rezeptor subtyp liganden
DK60593D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
DK60793D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
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JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
ES2101646B1 (es) * 1995-04-12 1998-04-01 Ferrer Int Nuevo compuesto derivado del cromeno.
US5668148A (en) * 1995-04-20 1997-09-16 Merck & Co., Inc. Alpha1a adrenergic receptor antagonists
JP3122469B2 (ja) * 1995-06-06 2001-01-09 ヘキスト・マリオン・ルセル・インコーポレイテツド 抗精神病剤としてのピリジンイミニル−１，２−ベイゾイソオキサゾール類及び−ベンゾイソチアゾール類
WO1997025317A1 (en) * 1996-01-05 1997-07-17 Hoechst Marion Roussel, Inc. 4,5-dihydronaphth[1,2-c]isoxazoles and derivatives thereof having cns activity
US5880121A (en) * 1996-01-05 1999-03-09 Hoechst Marion Roussel Inc. 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
ES2144355B1 (es) * 1997-12-30 2001-01-01 Ferrer Int Compuestos derivados del cromeno.
WO2001017993A1 (en) * 1999-09-09 2001-03-15 EGIS Gyógyszergyár Rt. Alkylpiperidi nylbenzo [d] isoxazole derivatives having psychotropic activity, pharmaceutical compositions containing the same, and a process for the preparation of the active ingredient
AU2006201188B2 (en) * 2001-02-05 2007-11-15 Novartis Ag New use of iloperidone
GB0102841D0 (en) * 2001-02-05 2001-03-21 Novartis Ag Organic compounds
US20050020632A1 (en) * 2001-08-31 2005-01-27 Dominique Grimler Optical isomers of an iloperidone metabolite
JP5067998B2 (ja) 2001-10-30 2012-11-07 ノバルティス アーゲー イロペリドンおよび星形ポリマーのデポー製剤
US6995144B2 (en) * 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
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MXPA05004273A (es) * 2002-11-08 2005-10-18 Warner Lambert Co Derivados de fenilalquil y piridilalquil piperazina.
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
GB0322994D0 (en) * 2003-10-01 2003-11-05 Novartis Ag Organic compounds
JP2010519171A (ja) 2006-02-17 2010-06-03 メモリー・ファーマシューティカルズ・コーポレイション ５−ｈｔ６受容体親和性を有する化合物
WO2008066750A1 (en) 2006-11-22 2008-06-05 Seaside Therapeutics, Llc Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism
WO2008128166A1 (en) * 2007-04-13 2008-10-23 Concert Pharmaceuticals Inc. Deuterated derivatives of 4-(6-fluoro-1, 2-benzisoxazol-3-yl) piperidine compounds
CN101824030B (zh) * 2009-03-04 2014-06-18 北京德众万全药物技术开发有限公司 一种伊潘立酮的制备方法
PL2445502T5 (pl) 2009-06-25 2023-03-13 Alkermes Pharma Ireland Limited Związki heterocykliczne do leczenia zaburzeń neurologicznych i psychologicznych
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Also Published As

Publication number Publication date
IE901809L (en) 1990-11-19
CN1086387C (zh) 2002-06-19
DD300433A5 (de) 1992-06-11
PL163965B1 (pl) 1994-05-31
AU640653B2 (en) 1993-09-02
ES2076253T3 (es) 1995-11-01
CN1223348C (zh) 2005-10-19
EP0402644A1 (en) 1990-12-19
IL94425A0 (en) 1991-03-10
NO902214L (no) 1990-11-20
HU218200B (hu) 2000-06-28
RU2062776C1 (ru) 1996-06-27
ATE126512T1 (de) 1995-09-15
CA2017193C (en) 2000-06-27
IE68431B1 (en) 1996-06-12
HK1038316A1 (en) 2002-03-15
NO902214D0 (no) 1990-05-18
HU903090D0 (en) 1990-09-28
FI104072B1 (fi) 1999-11-15
KR900018070A (ko) 1990-12-20
FI19991869A (fi) 1999-09-02
HU211853A9 (en) 1995-12-28
JPH0363263A (ja) 1991-03-19
SK279474B6 (sk) 1998-11-04
SK242590A3 (en) 1998-11-04
DE69021645D1 (de) 1995-09-21
HUT58720A (en) 1992-03-30
PL285247A1 (en) 1991-02-11
IL94425A (en) 1994-02-27
NO177301B (no) 1995-05-15
FI104072B (fi) 1999-11-15
CN1048037A (zh) 1990-12-26
RU2239434C2 (ru) 2004-11-10
JPH0662580B2 (ja) 1994-08-17
CZ282385B6 (cs) 1997-07-16
CN1305812A (zh) 2001-08-01
FI902449A0 (fi) 1990-05-17
DE69021645T2 (de) 1996-02-22
KR0157308B1 (ko) 1998-11-16
PT94084A (pt) 1991-01-08
RU2147583C1 (ru) 2000-04-20
CA2017193A1 (en) 1990-11-19
NO177301C (no) 1995-08-23
PT94084B (pt) 1996-12-31
GR3017447T3 (en) 1995-12-31
NZ233710A (en) 1992-05-26
HK1006710A1 (en) 1999-03-12
EP0402644B1 (en) 1995-08-16
AU5577090A (en) 1990-11-22
CZ242590A3 (en) 1997-03-12

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