DE69820465T2 - Liposomen-umschlossene polynukleotidzusammensetzung sowie verfahren - Google Patents

Liposomen-umschlossene polynukleotidzusammensetzung sowie verfahren Download PDF

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Publication number
DE69820465T2
DE69820465T2 DE69820465T DE69820465T DE69820465T2 DE 69820465 T2 DE69820465 T2 DE 69820465T2 DE 69820465 T DE69820465 T DE 69820465T DE 69820465 T DE69820465 T DE 69820465T DE 69820465 T2 DE69820465 T2 DE 69820465T2
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DE
Germany
Prior art keywords
liposomes
polynucleotide
lipid
solvent
composition
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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DE69820465T
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German (de)
English (en)
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DE69820465D1 (de
Inventor
M. Theresa ALLEN
Darrin Stuart
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Alza Corp
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Alza Corp
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Publication of DE69820465T2 publication Critical patent/DE69820465T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69820465T 1997-06-23 1998-06-22 Liposomen-umschlossene polynukleotidzusammensetzung sowie verfahren Expired - Fee Related DE69820465T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5049097P 1997-06-23 1997-06-23
US50490P 1997-06-23
PCT/US1998/012937 WO1998058630A1 (en) 1997-06-23 1998-06-22 Liposome-entrapped polynucleotide composition and method

Publications (2)

Publication Number Publication Date
DE69820465D1 DE69820465D1 (de) 2004-01-22
DE69820465T2 true DE69820465T2 (de) 2004-09-16

Family

ID=21965541

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69820465T Expired - Fee Related DE69820465T2 (de) 1997-06-23 1998-06-22 Liposomen-umschlossene polynukleotidzusammensetzung sowie verfahren

Country Status (11)

Country Link
US (1) US6120798A (enExample)
EP (1) EP1017365B1 (enExample)
JP (1) JP2002508765A (enExample)
AT (1) ATE255882T1 (enExample)
AU (1) AU7983798A (enExample)
CA (1) CA2294579C (enExample)
DE (1) DE69820465T2 (enExample)
DK (1) DK1017365T3 (enExample)
ES (1) ES2212305T3 (enExample)
TW (1) TWI225412B (enExample)
WO (1) WO1998058630A1 (enExample)

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Also Published As

Publication number Publication date
US6120798A (en) 2000-09-19
WO1998058630A1 (en) 1998-12-30
HK1025906A1 (en) 2000-12-01
EP1017365B1 (en) 2003-12-10
DE69820465D1 (de) 2004-01-22
AU7983798A (en) 1999-01-04
TWI225412B (en) 2004-12-21
JP2002508765A (ja) 2002-03-19
CA2294579A1 (en) 1998-12-30
ATE255882T1 (de) 2003-12-15
CA2294579C (en) 2007-10-09
EP1017365A1 (en) 2000-07-12
DK1017365T3 (da) 2004-03-29
ES2212305T3 (es) 2004-07-16

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Owner name: ALZA CORP., MOUNTAIN VIEW, CALIF., US

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