DE69409361T2 - Herstellung von liposomen und verfahren zur substanzverkapselung - Google Patents

Herstellung von liposomen und verfahren zur substanzverkapselung

Info

Publication number
DE69409361T2
DE69409361T2 DE69409361T DE69409361T DE69409361T2 DE 69409361 T2 DE69409361 T2 DE 69409361T2 DE 69409361 T DE69409361 T DE 69409361T DE 69409361 T DE69409361 T DE 69409361T DE 69409361 T2 DE69409361 T2 DE 69409361T2
Authority
DE
Germany
Prior art keywords
liposomes
lipid powder
liposome dispersion
dehydration
formation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69409361T
Other languages
English (en)
Other versions
DE69409361D1 (de
Inventor
David Sammuel Collins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of DE69409361D1 publication Critical patent/DE69409361D1/de
Application granted granted Critical
Publication of DE69409361T2 publication Critical patent/DE69409361T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69409361T 1993-11-05 1994-11-03 Herstellung von liposomen und verfahren zur substanzverkapselung Expired - Fee Related DE69409361T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14809993A 1993-11-05 1993-11-05
PCT/US1994/012350 WO1995012387A1 (en) 1993-11-05 1994-11-03 Liposome preparation and material encapsulation method

Publications (2)

Publication Number Publication Date
DE69409361D1 DE69409361D1 (de) 1998-05-07
DE69409361T2 true DE69409361T2 (de) 1998-11-12

Family

ID=22524272

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69409361T Expired - Fee Related DE69409361T2 (de) 1993-11-05 1994-11-03 Herstellung von liposomen und verfahren zur substanzverkapselung

Country Status (10)

Country Link
US (2) US5567433A (de)
EP (1) EP0678017B1 (de)
JP (1) JPH08505882A (de)
AT (1) ATE164515T1 (de)
AU (1) AU683957B2 (de)
CA (1) CA2153251C (de)
DE (1) DE69409361T2 (de)
DK (1) DK0678017T3 (de)
ES (1) ES2115343T3 (de)
WO (1) WO1995012387A1 (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994314A (en) * 1993-04-07 1999-11-30 Inhale Therapeutic Systems, Inc. Compositions and methods for nucleic acid delivery to the lung
US20020132787A1 (en) * 1993-04-07 2002-09-19 Mohammed Eljamal Compositions and methods for nucleic acid delivery to the lung
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US5981501A (en) * 1995-06-07 1999-11-09 Inex Pharmaceuticals Corp. Methods for encapsulating plasmids in lipid bilayers
US7422902B1 (en) * 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US5855911A (en) * 1995-08-29 1999-01-05 Board Of Regents, The University Of Texas System Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
WO1997042820A1 (en) * 1996-05-16 1997-11-20 Duke University Tristetraprolin
US7384923B2 (en) * 1999-05-14 2008-06-10 Lipoxen Technologies Limited Liposomes
WO1998010748A1 (en) * 1996-09-13 1998-03-19 The School Of Pharmacy Liposomes
US6264996B1 (en) 1996-12-11 2001-07-24 A. Glenn Braswell Composition for inhibiting production of dihydrotestosterone to treat benign prostate hyperplasia
IT1289938B1 (it) * 1997-02-20 1998-10-19 Angelini Ricerche Spa Preparazione farmaceutica comprendente liposomi liofilizzati in cui e' incapsulato un principio attivo altamente insolubile in acqua e
US6287591B1 (en) * 1997-05-14 2001-09-11 Inex Pharmaceuticals Corp. Charged therapeutic agents encapsulated in lipid particles containing four lipid components
ES2384094T3 (es) * 1997-11-14 2012-06-29 Pacira Pharmaceuticals, Inc. Producción de liposomas multivesiculares
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
GB9813100D0 (en) * 1998-06-18 1998-08-19 Secr Defence Method of forming liposomes
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US20030129251A1 (en) 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
US7129222B2 (en) * 2000-03-10 2006-10-31 Dynavax Technologies Corporation Immunomodulatory formulations and methods for use thereof
WO2002038128A1 (fr) * 2000-11-10 2002-05-16 Japan Science And Technology Corporation Procede de preparation d'une dispersion de microsome
US20030077829A1 (en) * 2001-04-30 2003-04-24 Protiva Biotherapeutics Inc.. Lipid-based formulations
US6676958B2 (en) * 2001-06-19 2004-01-13 Advanced Bioadjuvants, Llc Adjuvant composition for mucosal and injection delivered vaccines
AU2002340662B2 (en) * 2001-11-07 2008-07-03 Tekmira Pharmaceuticals Corporation Mucosal adjuvants comprising an oligonucleotide and a cationic lipid
US20040082521A1 (en) * 2002-03-29 2004-04-29 Azaya Therapeutics Inc. Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases
US20030212046A1 (en) * 2002-05-07 2003-11-13 Kapac, Llc Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs
US20060093661A1 (en) 2002-05-07 2006-05-04 Kapac, Llc Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs
US20040009944A1 (en) * 2002-05-10 2004-01-15 Inex Pharmaceuticals Corporation Methylated immunostimulatory oligonucleotides and methods of using the same
WO2004032789A2 (en) * 2002-10-09 2004-04-22 The Azza Co., Ltd. Liposomal hgh composition and method for administration thereof
EP1585504A4 (de) * 2002-11-06 2009-07-15 Azaya Therapeutics Inc Proteinstabilisierte liposomale formulierungen pharmazeutischer wirkstoffe
US20040092102A1 (en) * 2002-11-12 2004-05-13 Sachem, Inc. Chemical mechanical polishing composition and method
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
EP1643972A4 (de) * 2003-06-27 2010-01-20 Smithkline Beecham Corp Stabilisierte liposomale topotecan-zusammensetzung und verfahren
US20050123596A1 (en) * 2003-09-23 2005-06-09 Kohane Daniel S. pH-triggered microparticles
US7943179B2 (en) 2003-09-23 2011-05-17 Massachusetts Institute Of Technology pH triggerable polymeric particles
CA2542099A1 (en) * 2003-10-11 2005-04-21 Inex Pharmaceuticals Corporation Methods and compositions for enhancing innate immunity and antibody dependent cellular cytotoxicity
JP2005162702A (ja) * 2003-12-04 2005-06-23 Konica Minolta Medical & Graphic Inc リポソーム製剤の製造方法、リポソーム製剤およびその製造装置
US20050169978A1 (en) * 2004-01-29 2005-08-04 Shu-Wen Fu Wet-micro grinding
CA2566559C (en) * 2004-05-17 2014-05-06 Inex Pharmaceuticals Corporation Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof
US8226975B2 (en) 2005-12-08 2012-07-24 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof
US8071127B2 (en) * 2006-10-24 2011-12-06 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8119156B2 (en) 2006-10-24 2012-02-21 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
AU2007329193A1 (en) * 2006-12-08 2008-06-12 Protech Research Pty Ltd Liposome production
US8088887B2 (en) * 2007-02-13 2012-01-03 Academia Sinica Peptide-conjugates that bind to VEGF-stimulated or tumor vasculature and methods of treatment
US8415453B2 (en) * 2007-02-13 2013-04-09 Academia Sinica Lung cancer-targeted peptides and applications thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US20080292663A1 (en) * 2007-05-22 2008-11-27 Gerber Jay D Adjuvant compositions and methods for delivering vaccines
US8541543B2 (en) * 2007-11-20 2013-09-24 Academia Sinica Peptides specific for hepatocellular carcinoma cells and applications thereof
MX2010012592A (es) 2008-05-20 2011-05-05 Eos Neuroscience Inc Vectores para la administracion de proteinas sensibles a la luz y metodos de uso de las mismas.
US9445975B2 (en) 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
GB201116248D0 (en) * 2011-09-20 2011-11-02 Glaxosmithkline Biolog Sa Liposome production using isopropanol
CA2866170A1 (en) 2012-03-12 2013-09-19 Advanced Bioadjuvants, Llc Adjuvant and vaccine compositions
ES2743039T3 (es) 2012-11-29 2020-02-18 Insmed Inc Formulaciones de vancomicina estabilizada
WO2015061025A1 (en) 2013-10-22 2015-04-30 Aradigm Corporation Inhaled surfactant-modified liposomal formulations providing both an immediate and sustained release profile
PL3138555T3 (pl) 2014-04-30 2021-04-06 Fujifilm Corporation Kompozycja liposomowa i sposób jej wytwarzania
SI3142643T1 (sl) 2014-05-15 2019-11-29 Insmed Inc Postopki za zdravljenje pljučnih netuberkuloznih mikobakterijskih infekcij
ES2928401T3 (es) 2014-12-31 2022-11-17 Lantheus Medical Imaging Inc Composiciones de microesferas de gas encapsuladas en lípidos y métodos relacionados
KR20180091816A (ko) 2015-10-14 2018-08-16 바이오-패쓰 홀딩스 인크. 리포좀 제제를 위한 p-에톡시 핵산
EP3452108A4 (de) 2016-05-04 2019-12-25 Lantheus Medical Imaging, Inc. Verfahren und vorrichtungen zur herstellung von ultraschallkontrastmitteln
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
MX2019003070A (es) 2016-09-16 2019-10-14 Bio Path Holdings Inc Terapia de combinacion con oligonucleotidos antisentido liposomales.
CA3058018A1 (en) 2017-04-19 2018-10-25 Bio-Path Holdings, Inc. P-ethoxy nucleic acids for stat3 inhibition
US11571386B2 (en) 2018-03-30 2023-02-07 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
CN114916651B (zh) * 2022-05-19 2024-03-29 成都科建生物医药有限公司 一种芥末精油脂质体及其制备方法与应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
CH621479A5 (de) * 1977-08-05 1981-02-13 Battelle Memorial Institute
US4241046A (en) * 1978-11-30 1980-12-23 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
JPS5782311A (en) * 1980-11-11 1982-05-22 Tanabe Seiyaku Co Ltd Production of liposome preparation
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
EP0158441B2 (de) * 1984-03-08 2001-04-04 Phares Pharmaceutical Research N.V. Liposombildende Zusammensetzung
US5077056A (en) * 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
DE3582905D1 (de) * 1984-08-10 1991-06-27 Syntex Inc Stabile liposome mit wasserloeslichen arzneimitteln.
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US5104661A (en) * 1989-08-14 1992-04-14 Technology Unlimited, Inc. Reverse loading of liposomes

Also Published As

Publication number Publication date
ES2115343T3 (es) 1998-06-16
AU683957B2 (en) 1997-11-27
DE69409361D1 (de) 1998-05-07
US6355267B1 (en) 2002-03-12
EP0678017A1 (de) 1995-10-25
AU8127394A (en) 1995-05-23
CA2153251C (en) 1998-09-01
WO1995012387A1 (en) 1995-05-11
US5567433A (en) 1996-10-22
JPH08505882A (ja) 1996-06-25
DK0678017T3 (da) 1998-10-19
EP0678017B1 (de) 1998-04-01
CA2153251A1 (en) 1995-05-11
ATE164515T1 (de) 1998-04-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee