PL3138555T3 - Kompozycja liposomowa i sposób jej wytwarzania - Google Patents

Kompozycja liposomowa i sposób jej wytwarzania

Info

Publication number
PL3138555T3
PL3138555T3 PL15785362T PL15785362T PL3138555T3 PL 3138555 T3 PL3138555 T3 PL 3138555T3 PL 15785362 T PL15785362 T PL 15785362T PL 15785362 T PL15785362 T PL 15785362T PL 3138555 T3 PL3138555 T3 PL 3138555T3
Authority
PL
Poland
Prior art keywords
production
liposomal composition
liposomal
composition
Prior art date
Application number
PL15785362T
Other languages
English (en)
Inventor
Makoto Ono
Kohei Ono
Takeshi Matsumoto
Mikinaga Mori
Original Assignee
Fujifilm Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Corporation filed Critical Fujifilm Corporation
Publication of PL3138555T3 publication Critical patent/PL3138555T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y10S977/907—Liposome

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
PL15785362T 2014-04-30 2015-04-30 Kompozycja liposomowa i sposób jej wytwarzania PL3138555T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014094140 2014-04-30
PCT/JP2015/062983 WO2015166986A1 (ja) 2014-04-30 2015-04-30 リポソーム組成物及びその製造方法
EP15785362.3A EP3138555B1 (en) 2014-04-30 2015-04-30 Liposome composition and production method therefor

Publications (1)

Publication Number Publication Date
PL3138555T3 true PL3138555T3 (pl) 2021-04-06

Family

ID=54358710

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15785362T PL3138555T3 (pl) 2014-04-30 2015-04-30 Kompozycja liposomowa i sposób jej wytwarzania

Country Status (15)

Country Link
US (3) US10391057B2 (pl)
EP (1) EP3138555B1 (pl)
JP (1) JP6251385B2 (pl)
CY (1) CY1123731T1 (pl)
DK (1) DK3138555T3 (pl)
ES (1) ES2836772T3 (pl)
HR (1) HRP20202030T1 (pl)
HU (1) HUE052968T2 (pl)
LT (1) LT3138555T (pl)
PL (1) PL3138555T3 (pl)
PT (1) PT3138555T (pl)
RS (1) RS61273B1 (pl)
SI (1) SI3138555T1 (pl)
SM (1) SMT202000687T1 (pl)
WO (1) WO2015166986A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015166985A1 (ja) * 2014-04-30 2015-11-05 富士フイルム株式会社 リポソーム組成物及びその製造方法
HUE052968T2 (hu) 2014-04-30 2021-05-28 Fujifilm Corp Liposzóma kompozíció és annak elõállítási eljárása
EP3372223B1 (en) * 2015-11-02 2024-04-17 FUJIFILM Corporation Liposome composition and method for producing same
AU2019288048B2 (en) 2018-06-20 2022-08-11 Fujifilm Corporation Combined medicine comprising gemcitabine-encapsulated liposome composition and immune checkpoint blockade
HUE069834T2 (hu) 2020-04-03 2025-04-28 Fujifilm Corp Tumorellenes szer
JP7657627B2 (ja) * 2021-03-25 2025-04-07 富士フイルム株式会社 化粧料用リポソーム組成物

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5077056A (en) 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US4970074A (en) 1987-06-29 1990-11-13 Abbott Laboratories Fluorophores for encapsulation into liposomes
US5328678A (en) 1987-11-04 1994-07-12 Vestar, Inc. Composition and method of use for liposome encapsulated compounds for neutron capture tumor therapy
JP2931981B2 (ja) 1988-03-04 1999-08-09 武田薬品工業株式会社 リポソーム製剤およびその製造法
EP0331504B1 (en) 1988-03-04 1992-06-10 Takeda Chemical Industries, Ltd. Liposome composition
US5049392A (en) 1989-01-18 1991-09-17 The Liposome Company, Inc. Osmotically dependent vesicles
US5227170A (en) 1989-06-22 1993-07-13 Vestar, Inc. Encapsulation process
IS1685B (is) 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
JPH069374A (ja) * 1992-04-07 1994-01-18 Banyu Pharmaceut Co Ltd リポソ−ム製剤およびその製造法
CA2093381A1 (en) * 1992-04-07 1993-10-08 Hideyuki Sawahara Liposome formulation and process for production thereof
AU683957B2 (en) * 1993-11-05 1997-11-27 Amgen, Inc. Liposome preparation and material encapsulation method
US5540935A (en) 1993-12-06 1996-07-30 Nof Corporation Reactive vesicle and functional substance-fixed vesicle
US6261597B1 (en) 1995-08-31 2001-07-17 Seymour J. Kurtz Method for treating periodontal disease
US6132789A (en) * 1995-12-15 2000-10-17 National Research Council Of Canada Archaeosomes, archaeosomes containing coenzyme Q10, and other types of liposomes containing coenzyme Q10 as adjuvants and as delivery vehicles
US6056973A (en) 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
US20050118250A1 (en) * 2001-11-13 2005-06-02 Paul Tardi Lipid carrier compositions with enhanced blood stability
WO2004017944A1 (en) * 2002-08-23 2004-03-04 Neopharm, Inc. Liposomal gemcitabine compositions for better drug delivery
EP1585504A4 (en) 2002-11-06 2009-07-15 Azaya Therapeutics Inc Protein stabilized liposomal formulations of pharmaceutical active ingredients
CA2536612A1 (en) 2003-04-02 2004-10-14 Celator Pharmaceuticals, Inc. Combination compositions of camptothecins and fluoropyrimidines
EP1643971A2 (en) 2003-05-22 2006-04-12 Neopharm, Inc. Liposomal formulations comprising a combination of two or more active agents
WO2005021012A1 (ja) * 2003-08-29 2005-03-10 Terumo Kabushiki Kaisha ゲムシタビン封入薬剤担体
ES2967961T3 (es) 2004-05-03 2024-05-06 Ipsen Biopharm Ltd Liposomas útiles en la administración de fármacos
AU2005249205A1 (en) 2004-06-03 2005-12-15 F. Hoffmann-La Roche Ag Treatment with gemcitabine and an EGFR-inhibitor
WO2006032136A1 (en) * 2004-09-20 2006-03-30 British Columbia Cancer Agency Branch Free or liposomal gemcitabine alone or in combination with free or liposomal idarubicin
EP2418278A3 (en) 2005-05-09 2012-07-04 Ono Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
JPWO2006137377A1 (ja) * 2005-06-22 2009-01-22 独立行政法人理化学研究所 神経再生促進剤
WO2007005754A2 (en) * 2005-07-01 2007-01-11 Alza Corporation Liposomal delivery vehicle for hydrophobic drugs
EP2007355A2 (en) 2005-12-08 2008-12-31 Wyeth a Corporation of the State of Delaware Liposomal compositions
US8119156B2 (en) 2006-10-24 2012-02-21 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
JP5080779B2 (ja) 2006-10-25 2012-11-21 テルモ株式会社 リポソーム製剤の製造方法
CN101209243B (zh) * 2006-12-29 2010-12-08 石药集团中奇制药技术（石家庄）有限公司 一种脂质体药物及其制备方法
CN100496609C (zh) 2006-12-30 2009-06-10 上海艾力斯医药科技有限公司 一种稳定的脂质体组合物
AU2008303466A1 (en) 2007-09-28 2009-04-02 Universitatsspital Basel Immunoliposomes for treatment of cancer
CN102056607B (zh) 2008-04-17 2014-07-30 约翰·霍普金斯大学 On01910.na促进在抗药性肿瘤中化学治疗剂的活性
US8231895B2 (en) 2008-05-22 2012-07-31 Universidade De Coimbra Targeted delivery to human diseases and disorders
CN101444485B (zh) * 2008-12-25 2011-11-23 中国医药集团总公司四川抗菌素工业研究所 吉西他滨脂质体及其制备方法
PL387296A1 (pl) * 2009-02-17 2010-08-30 Instytut Farmaceutyczny Sposób aktywnego zamykania amfifilowych substancji czynnych w strukturach liposomowych
DK177529B1 (en) * 2009-10-23 2013-09-08 Bio Bedst Aps Liposomes with improved storage stability
AU2010322516A1 (en) 2009-11-20 2012-05-17 Clavis Pharma Asa Parenteral formulations of gemcitabine derivatives
DK2508170T3 (en) 2009-12-03 2015-09-21 Jiangsu Hengrui Medicine Co LIPOSOM OF IRINOTECAN OR ITS HYDROCHLORIDE AND ITS PROCEDURE
JP2013126953A (ja) * 2010-03-31 2013-06-27 Terumo Corp リポソーム製剤の製造方法
CN101822669B (zh) 2010-04-23 2012-06-13 海南美兰史克制药有限公司 一种阿莫西林钠舒巴坦钠药物组合物脂质体注射剂
EP2394640A1 (en) 2010-05-21 2011-12-14 MediGene AG Improved liposomal formulations of lipophilic compounds
CN101926779A (zh) 2010-08-19 2010-12-29 苏州特瑞药业有限公司 一种吉西他滨固体脂质纳米粒及其制备方法与用途
JP5889279B2 (ja) 2011-03-25 2016-03-22 テルモ株式会社 持続徐放性リポソーム組成物およびその製造方法
JP5853453B2 (ja) 2011-07-15 2016-02-09 コニカミノルタ株式会社 リポソームを製造する方法
US8987224B2 (en) 2011-08-05 2015-03-24 Baylor College Of Medicine MicroRNA-198 as a tumor suppressor in pancreatic cancer
EP3424564A1 (en) 2011-10-31 2019-01-09 Mallinckrodt LLC Combinational liposome compositions for cancer therapy
EP2604253A1 (en) 2011-12-13 2013-06-19 Otto Glatter Water-in-oil emulsions and methods for their preparation
JP6042527B2 (ja) 2012-04-04 2016-12-14 ハロザイム インコーポレイテッド 抗ヒアルロナン剤と腫瘍標的タキサンの組み合わせ治療
CN102784107B (zh) * 2012-05-17 2015-04-22 江苏豪森药业股份有限公司 一种吉西他滨或其盐脂质体及其制备方法和用途
CN102716089B (zh) * 2012-06-29 2013-12-11 海南灵康制药有限公司 一种盐酸吉西他滨脂质体注射剂
KR20150095809A (ko) 2012-12-12 2015-08-21 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 암 치료용 조성물 및 방법
WO2014110555A1 (en) 2013-01-14 2014-07-17 Chemo-Enchanced Llc Compositions and methods for treating cancer
EP2964201B1 (en) 2013-03-05 2024-02-14 The Regents of the University of California Lipid bilayer coated mesoporous silica nanoparticles with a high loading capacity for one or more anticancer agents
TWI660739B (zh) 2013-10-25 2019-06-01 製藥公司 使用布魯頓氏酪胺酸激酶抑制劑之治療及免疫療法
EP3138558B1 (en) 2014-04-30 2023-06-07 FUJIFILM Corporation Liposome composition and production method therefor
WO2015166988A1 (ja) 2014-04-30 2015-11-05 富士フイルム株式会社 リポソームの製造方法
WO2015166985A1 (ja) * 2014-04-30 2015-11-05 富士フイルム株式会社 リポソーム組成物及びその製造方法
HUE052968T2 (hu) * 2014-04-30 2021-05-28 Fujifilm Corp Liposzóma kompozíció és annak elõállítási eljárása
CN115590953A (zh) 2014-05-15 2023-01-13 百时美施贵宝公司（Us） 使用抗pd-1抗体和另一种抗癌剂的组合治疗肺癌
WO2016172494A2 (en) 2015-04-23 2016-10-27 The Johns Hopkins University Combination of immunotherapy with local chemotherapy for the treatment of malignancies
BR112017028287A2 (pt) 2015-06-29 2018-09-04 Syndax Pharmaceuticals Inc Combinação do inibidor hdac e anticorpido anti-pd- l1 para o tratamento do câncer
CN105012966B (zh) 2015-07-01 2018-11-02 南通厚元生物科技有限公司 吉西他滨-磷脂复合物的制备方法及其应用
EP3372223B1 (en) 2015-11-02 2024-04-17 FUJIFILM Corporation Liposome composition and method for producing same
CN111632030B (zh) 2015-11-02 2023-01-17 富士胶片株式会社 包含吉西他滨或其盐的脂质体组合物的制造方法
CN106955354B (zh) 2016-01-11 2020-06-19 中国科学院分子细胞科学卓越创新中心 用于肿瘤免疫治疗的联合用药物组合
US10940112B2 (en) 2016-05-04 2021-03-09 L.E.A.F. Holdings Group Llc Targeted liposomal gemcitabine compositions and methods thereof
SG11201903283UA (en) 2016-10-12 2019-05-30 Univ Texas Methods and compositions for tusc2 immunotherapy
KR20240023677A (ko) 2016-12-05 2024-02-22 쥐원 쎄라퓨틱스, 인크. 화학요법 레지멘 동안의 면역 반응의 보존

Also Published As

Publication number Publication date
EP3138555A4 (en) 2017-03-08
US20190336447A1 (en) 2019-11-07
SMT202000687T1 (it) 2021-01-05
PT3138555T (pt) 2020-12-15
EP3138555A1 (en) 2017-03-08
JPWO2015166986A1 (ja) 2017-04-20
RS61273B1 (sr) 2021-01-29
LT3138555T (lt) 2021-03-25
JP6251385B2 (ja) 2017-12-20
EP3138555B1 (en) 2020-10-28
US10898435B2 (en) 2021-01-26
US11684575B2 (en) 2023-06-27
DK3138555T3 (da) 2020-12-14
US10391057B2 (en) 2019-08-27
HUE052968T2 (hu) 2021-05-28
SI3138555T1 (sl) 2021-06-30
HRP20202030T1 (hr) 2021-02-19
ES2836772T3 (es) 2021-06-28
CY1123731T1 (el) 2022-05-27
US20210100745A1 (en) 2021-04-08
US20170042811A1 (en) 2017-02-16
WO2015166986A1 (ja) 2015-11-05

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