PT3138555T - Composição lipossómica e método de produção da mesma - Google Patents

Composição lipossómica e método de produção da mesma

Info

Publication number
PT3138555T
PT3138555T PT157853623T PT15785362T PT3138555T PT 3138555 T PT3138555 T PT 3138555T PT 157853623 T PT157853623 T PT 157853623T PT 15785362 T PT15785362 T PT 15785362T PT 3138555 T PT3138555 T PT 3138555T
Authority
PT
Portugal
Prior art keywords
production method
method therefor
liposome composition
liposome
composition
Prior art date
Application number
PT157853623T
Other languages
English (en)
Original Assignee
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Corp filed Critical Fujifilm Corp
Publication of PT3138555T publication Critical patent/PT3138555T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y10S977/907—Liposome

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
PT157853623T 2014-04-30 2015-04-30 Composição lipossómica e método de produção da mesma PT3138555T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2014094140 2014-04-30

Publications (1)

Publication Number Publication Date
PT3138555T true PT3138555T (pt) 2020-12-15

Family

ID=54358710

Family Applications (1)

Application Number Title Priority Date Filing Date
PT157853623T PT3138555T (pt) 2014-04-30 2015-04-30 Composição lipossómica e método de produção da mesma

Country Status (14)

Country Link
US (3) US10391057B2 (pt)
EP (1) EP3138555B1 (pt)
JP (1) JP6251385B2 (pt)
CY (1) CY1123731T1 (pt)
DK (1) DK3138555T3 (pt)
ES (1) ES2836772T3 (pt)
HR (1) HRP20202030T1 (pt)
HU (1) HUE052968T2 (pt)
LT (1) LT3138555T (pt)
PL (1) PL3138555T3 (pt)
PT (1) PT3138555T (pt)
RS (1) RS61273B1 (pt)
SI (1) SI3138555T1 (pt)
WO (1) WO2015166986A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015166985A1 (ja) * 2014-04-30 2015-11-05 富士フイルム株式会社 リポソーム組成物及びその製造方法
LT3138555T (lt) 2014-04-30 2021-03-25 Fujifilm Corporation Liposomų kompozicija ir jų gamybos būdas
EP3372223B1 (en) * 2015-11-02 2024-04-17 FUJIFILM Corporation Liposome composition and method for producing same
WO2019244978A1 (ja) 2018-06-20 2019-12-26 富士フイルム株式会社 ゲムシタビンを内包するリポソーム組成物および免疫チェックポイント阻害剤を含む組合せ医薬
CA3173715A1 (en) 2020-04-03 2021-10-07 Takeshi Matsumoto Anti-tumor agent comprising a liposome encompassing gemcitabine,and usesthereof

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5077056A (en) 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US4970074A (en) 1987-06-29 1990-11-13 Abbott Laboratories Fluorophores for encapsulation into liposomes
US5328678A (en) 1987-11-04 1994-07-12 Vestar, Inc. Composition and method of use for liposome encapsulated compounds for neutron capture tumor therapy
JP2931981B2 (ja) 1988-03-04 1999-08-09 武田薬品工業株式会社 リポソーム製剤およびその製造法
ATE77051T1 (de) 1988-03-04 1992-06-15 Takeda Chemical Industries Ltd Liposom-zusammensetzung.
US5049392A (en) 1989-01-18 1991-09-17 The Liposome Company, Inc. Osmotically dependent vesicles
US5227170A (en) 1989-06-22 1993-07-13 Vestar, Inc. Encapsulation process
IS1685B (is) 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
CA2093381A1 (en) * 1992-04-07 1993-10-08 Hideyuki Sawahara Liposome formulation and process for production thereof
JPH069374A (ja) * 1992-04-07 1994-01-18 Banyu Pharmaceut Co Ltd リポソ−ム製剤およびその製造法
DE69409361T2 (de) * 1993-11-05 1998-11-12 Amgen Inc Herstellung von liposomen und verfahren zur substanzverkapselung
CA2137297C (en) 1993-12-06 2000-04-18 Tsuyoshi Miyazaki Reactive vesicle and functional substance-fixed vesicle
US6261597B1 (en) 1995-08-31 2001-07-17 Seymour J. Kurtz Method for treating periodontal disease
EP0869773B1 (en) * 1995-12-15 2004-03-24 National Research Council Of Canada Archaeosomes, archaeosomes containing coenzyme q 10, and other types of liposomes containing coenzyme q 10 as adjuvants and as delivery vehicles
US6056973A (en) 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
WO2003041681A2 (en) * 2001-11-13 2003-05-22 Celator Technologies, Inc. Lipid carrier compositions with enhanced blood stability
AU2003268087A1 (en) * 2002-08-23 2004-03-11 Ian Ma Liposomal gemcitabine compositions for better drug delivery
EP1585504A4 (en) 2002-11-06 2009-07-15 Azaya Therapeutics Inc LIPOSOMAL PREPARATIONS OF PHARMACEUTICAL AGENTS STABILIZED BY PROTEINS
US20060240090A1 (en) 2003-04-02 2006-10-26 Lawrence Mayer Combination compositions of camptothecins and fluoropyrimidines
EP1643971A2 (en) 2003-05-22 2006-04-12 Neopharm, Inc. Liposomal formulations comprising a combination of two or more active agents
WO2005021012A1 (ja) 2003-08-29 2005-03-10 Terumo Kabushiki Kaisha ゲムシタビン封入薬剤担体
UA86063C2 (ru) 2004-05-03 2009-03-25 Хермес Біосайенсез, Інк. Липосомы для снабжения лекарств
KR100986945B1 (ko) 2004-06-03 2010-10-12 에프. 호프만-라 로슈 아게 젬시타빈 및 ｅｇｆｒ-억제제로의 치료
US20080213183A1 (en) * 2004-09-20 2008-09-04 Marcel Bally Free or Liposomal Gemcitabine Alone or in Combination with Free or Liposomal Idarubicin
PT2161336E (pt) 2005-05-09 2013-10-03 Ono Pharmaceutical Co Anticorpos monoclonais humanos para morte programada 1 (pd-1) e métodos de tratamento do cancro utilizando anticorpos anti- pd-1 sozinhos ou em combinação com outros agentes imunoterapêuticos¿
JPWO2006137377A1 (ja) * 2005-06-22 2009-01-22 独立行政法人理化学研究所 神経再生促進剤
US20070014845A1 (en) * 2005-07-01 2007-01-18 Yuanpeng Zhang Liposomal delivery vehicle for hydrophobic drugs
WO2007067784A2 (en) 2005-12-08 2007-06-14 Wyeth Liposomal compositions
US8119156B2 (en) 2006-10-24 2012-02-21 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
JP5080779B2 (ja) 2006-10-25 2012-11-21 テルモ株式会社 リポソーム製剤の製造方法
CN101209243B (zh) 2006-12-29 2010-12-08 石药集团中奇制药技术（石家庄）有限公司 一种脂质体药物及其制备方法
CN100496609C (zh) 2006-12-30 2009-06-10 上海艾力斯医药科技有限公司 一种稳定的脂质体组合物
WO2009040426A1 (en) 2007-09-28 2009-04-02 Universitätsspital Basel Immunoliposomes for treatment of cancer
CN102056607B (zh) 2008-04-17 2014-07-30 约翰·霍普金斯大学 On01910.na促进在抗药性肿瘤中化学治疗剂的活性
US8231895B2 (en) 2008-05-22 2012-07-31 Universidade De Coimbra Targeted delivery to human diseases and disorders
CN101444485B (zh) * 2008-12-25 2011-11-23 中国医药集团总公司四川抗菌素工业研究所 吉西他滨脂质体及其制备方法
PL387296A1 (pl) * 2009-02-17 2010-08-30 Instytut Farmaceutyczny Sposób aktywnego zamykania amfifilowych substancji czynnych w strukturach liposomowych
DK177529B1 (en) 2009-10-23 2013-09-08 Bio Bedst Aps Liposomes with improved storage stability
BR112012011784A2 (pt) 2009-11-20 2019-09-24 Clavis Pharma Asa "formulações parenterais de derivados de gencitabina".
KR101780915B1 (ko) 2009-12-03 2017-09-21 지앙수 헨그루이 메디슨 컴퍼니 리미티드 이리노테칸 또는 그의 하이드로클로라이드의 리포좀 및 그의 제조 방법
JP2013126953A (ja) * 2010-03-31 2013-06-27 Terumo Corp リポソーム製剤の製造方法
CN101822669B (zh) 2010-04-23 2012-06-13 海南美兰史克制药有限公司 一种阿莫西林钠舒巴坦钠药物组合物脂质体注射剂
EP2394640A1 (en) 2010-05-21 2011-12-14 MediGene AG Improved liposomal formulations of lipophilic compounds
CN101926779A (zh) 2010-08-19 2010-12-29 苏州特瑞药业有限公司 一种吉西他滨固体脂质纳米粒及其制备方法与用途
JP5889279B2 (ja) 2011-03-25 2016-03-22 テルモ株式会社 持続徐放性リポソーム組成物およびその製造方法
JP5853453B2 (ja) 2011-07-15 2016-02-09 コニカミノルタ株式会社 リポソームを製造する方法
US8987224B2 (en) 2011-08-05 2015-03-24 Baylor College Of Medicine MicroRNA-198 as a tumor suppressor in pancreatic cancer
EP2773426B1 (en) 2011-10-31 2018-08-22 Mallinckrodt LLC Combinational liposome compositions for cancer therapy
EP2604253A1 (en) 2011-12-13 2013-06-19 Otto Glatter Water-in-oil emulsions and methods for their preparation
PT2833905T (pt) 2012-04-04 2018-08-06 Halozyme Inc Terapia de combinação com hialuronidase e um taxano dirigido a tumor
CN102784107B (zh) * 2012-05-17 2015-04-22 江苏豪森药业股份有限公司 一种吉西他滨或其盐脂质体及其制备方法和用途
CN102716089B (zh) * 2012-06-29 2013-12-11 海南灵康制药有限公司 一种盐酸吉西他滨脂质体注射剂
CA2894846A1 (en) 2012-12-12 2014-06-19 Temple University - Of The Commonwealth System Of Higher Education Compositions and methods for treatment of cancer
US9968570B2 (en) 2013-01-14 2018-05-15 Chemo-Enhanced Llc Compositions and methods for treating cancer
WO2014138278A1 (en) 2013-03-05 2014-09-12 The Regents Of The University Of California Lipid bilayer coated mesoporous silica nanoparticles with a high loading capacity for one or more anticancer agents
EP3060251A4 (en) 2013-10-25 2017-12-06 Pharmacyclics LLC Treatment using bruton's tyrosine kinase inhibitors and immunotherapy
EP3138558B1 (en) 2014-04-30 2023-06-07 FUJIFILM Corporation Liposome composition and production method therefor
LT3138555T (lt) 2014-04-30 2021-03-25 Fujifilm Corporation Liposomų kompozicija ir jų gamybos būdas
PL3138556T3 (pl) 2014-04-30 2022-05-16 Fujifilm Corporation Sposób wytwarzania liposomu
WO2015166985A1 (ja) * 2014-04-30 2015-11-05 富士フイルム株式会社 リポソーム組成物及びその製造方法
EP3760229A3 (en) 2014-05-15 2021-04-07 Bristol-Myers Squibb Company Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent
WO2016172494A2 (en) 2015-04-23 2016-10-27 The Johns Hopkins University Combination of immunotherapy with local chemotherapy for the treatment of malignancies
US20180353602A1 (en) 2015-06-29 2018-12-13 Syndax Pharmaceuticals, Inc. Combination of hdac inhibitor and anti-pd-l1 antibody for treatment of cancer
CN105012966B (zh) 2015-07-01 2018-11-02 南通厚元生物科技有限公司 吉西他滨-磷脂复合物的制备方法及其应用
ES2869283T3 (es) 2015-11-02 2021-10-25 Fujifilm Corp Agente terapéutico antitumoral que contiene composición de liposoma de gemcitabina y kit
EP3372223B1 (en) 2015-11-02 2024-04-17 FUJIFILM Corporation Liposome composition and method for producing same
CN106955354B (zh) 2016-01-11 2020-06-19 中国科学院分子细胞科学卓越创新中心 用于肿瘤免疫治疗的联合用药物组合
WO2017192863A1 (en) 2016-05-04 2017-11-09 L.E.A.F. Holdings Group Llc Targeted liposomal gemcitabine compositions and methods thereof
JP7041136B2 (ja) 2016-10-12 2022-03-23 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム Ｔｕｓｃ２免疫療法のための方法および組成物
WO2018106729A1 (en) 2016-12-05 2018-06-14 G1 Therapeutics, Inc. Preservation of immune response during chemotherapy regimens

Also Published As

Publication number Publication date
SI3138555T1 (sl) 2021-06-30
EP3138555A4 (en) 2017-03-08
HRP20202030T1 (hr) 2021-02-19
JPWO2015166986A1 (ja) 2017-04-20
ES2836772T3 (es) 2021-06-28
CY1123731T1 (el) 2022-05-27
EP3138555A1 (en) 2017-03-08
HUE052968T2 (hu) 2021-05-28
US10391057B2 (en) 2019-08-27
PL3138555T3 (pl) 2021-04-06
EP3138555B1 (en) 2020-10-28
RS61273B1 (sr) 2021-01-29
JP6251385B2 (ja) 2017-12-20
LT3138555T (lt) 2021-03-25
WO2015166986A1 (ja) 2015-11-05
US10898435B2 (en) 2021-01-26
DK3138555T3 (da) 2020-12-14
US20190336447A1 (en) 2019-11-07
US11684575B2 (en) 2023-06-27
US20210100745A1 (en) 2021-04-08
US20170042811A1 (en) 2017-02-16

Similar Documents

Publication Publication Date Title
IL247963A0 (en) Solid forms of ibrutinib and process for their preparation
GB201410262D0 (en) Novel method
EP3103633B8 (en) Molded object and production method therefor
HK1208435A1 (en) Cement and manufacturing method thereof
SG11201507206TA (en) Formed material manufacturing method
EP3206263A4 (en) Terminal and production method therefor
GB2522923B (en) Insoles and production methods
PL3175539T3 (pl) Pakiet lamelek oraz sposób ich wytwarzania
HK1256241A1 (zh) 形象物以及形象物的製造方法
EP3235562C0 (en) METHOD AND DEVICE FOR MANUFACTURING LIPOSOMES
EP3138558A4 (en) Liposome composition and production method therefor
EP3138557A4 (en) Liposome composition and method for producing same
PT3138555T (pt) Composição lipossómica e método de produção da mesma
PL3235561T3 (pl) Sposób wytwarzania liposomów i urządzenie do wytwarzania liposomów
HK1243995A1 (zh) α-細辛醇酯及其製備方法與應用
SG11201609688QA (en) Formed material manufacturing method and formed material
GB201705822D0 (en) Proppant composition and method
SG11201507205UA (en) Formed material manufacturing method and formed material
IL246831B (en) A method for the production of 1-indanols and 1-indanamines
EP3085819A4 (en) Fabric production method and fabric
EP3132790A4 (en) Exenatide-containing composition and preparation method therefor
EP3109243A4 (en) GAMMA BUTYLOLACTONE COMPOSITION AND METHOD OF PREPARING THEREOF
GB201501762D0 (en) Composite component and method for its production
GB201416082D0 (en) Method and uses
PL2995872T3 (pl) Przekładka oraz sposób jej wytwarzania