HUE056799T2 - Módszer specifikus természetes kapszaicinoidok mikrobiális elõállítására - Google Patents

Módszer specifikus természetes kapszaicinoidok mikrobiális elõállítására

Info

Publication number
HUE056799T2
HUE056799T2 HUE17831838A HUE17831838A HUE056799T2 HU E056799 T2 HUE056799 T2 HU E056799T2 HU E17831838 A HUE17831838 A HU E17831838A HU E17831838 A HUE17831838 A HU E17831838A HU E056799 T2 HUE056799 T2 HU E056799T2
Authority
HU
Hungary
Prior art keywords
microbial production
specific natural
capsaicinoids
natural capsaicinoids
microbial
Prior art date
Application number
HUE17831838A
Other languages
English (en)
Inventor
Hui Chen
Xiaodan Yu
Lanlan Zhou
Hongxue Wang
Min Wang
Original Assignee
Conagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conagen Inc filed Critical Conagen Inc
Publication of HUE056799T2 publication Critical patent/HUE056799T2/hu

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/02Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/10Natural spices, flavouring agents or condiments; Extracts thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/70Fixation, conservation, or encapsulation of flavouring agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/20Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00Essential oils; Perfumes
    • C11B9/0061Essential oils; Perfumes compounds containing a six-membered aromatic ring not condensed with another ring
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01086Fatty-acyl-CoA synthase (2.3.1.86)
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Seasonings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HUE17831838A 2016-07-19 2017-07-19 Módszer specifikus természetes kapszaicinoidok mikrobiális elõállítására HUE056799T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662363951P 2016-07-19 2016-07-19

Publications (1)

Publication Number Publication Date
HUE056799T2 true HUE056799T2 (hu) 2022-03-28

Family

ID=60996099

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE17831838A HUE056799T2 (hu) 2016-07-19 2017-07-19 Módszer specifikus természetes kapszaicinoidok mikrobiális elõállítására

Country Status (13)

Country Link
US (2) US11459591B2 (hu)
EP (1) EP3487986B1 (hu)
JP (1) JP7053565B2 (hu)
KR (1) KR20190027830A (hu)
CN (1) CN109790513B (hu)
AU (1) AU2017299615A1 (hu)
BR (1) BR112019000895A2 (hu)
CA (1) CA3029246A1 (hu)
DK (1) DK3487986T3 (hu)
HU (1) HUE056799T2 (hu)
MX (1) MX2019000860A (hu)
PL (1) PL3487986T3 (hu)
WO (1) WO2018017772A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112018013539A2 (pt) 2016-01-07 2018-12-04 Conagen Inc métodos de preparar capsinoides por processos biossintéticos
KR20190027830A (ko) 2016-07-19 2019-03-15 코나겐 인크. 특정 자연 캡사이시노이드의 미생물 생산 방법
CN110305031B (zh) * 2019-07-03 2022-07-12 遂宁晶安科技有限公司 辣椒素的制备方法及利用该方法制备得到的辣椒素
CN112608247B (zh) * 2020-12-15 2023-04-07 遂宁晶安科技有限公司 辣椒素的制备方法及利用该方法制备得到的辣椒素
CN116837016B (zh) * 2023-08-29 2024-01-02 中国农业科学院北京畜牧兽医研究所 一种构建生产辣椒素香草壬酰胺的重组大肠杆菌工程菌株的方法及重组菌株和应用

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4493848A (en) 1983-07-14 1985-01-15 The Procter & Gamble Company Compositions and methods useful for producing analgesia
US5094782A (en) 1990-12-24 1992-03-10 National Science Council Of Republic Of China Synthesis of capsacin derivatives and their use as an analgesic drug and vessel dilation drug
US5958745A (en) 1996-03-13 1999-09-28 Monsanto Company Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants
JP4043605B2 (ja) 1998-07-02 2008-02-06 丸善製薬株式会社 カプサイシン類縁体の製造法
US20070244192A1 (en) 1999-01-14 2007-10-18 Martek Biosciences Corporation Plant seed oils containing polyunsaturated fatty acids
DE10000978A1 (de) 2000-01-12 2001-07-26 Gvs Ges Fuer Erwerb Und Verwer Verfahren zur Erhöhung des Gehalts an Fettsäuren in Pflanzen und Mikroorganismen
US20040010817A1 (en) 2000-07-21 2004-01-15 Washington State University Research Foundation Plant acyl-CoA synthetases
JP3951008B2 (ja) 2002-01-17 2007-08-01 国立大学法人 岡山大学 カプサイシン分解合成酵素及びその生産方法
WO2003087834A2 (en) 2002-04-08 2003-10-23 Affinium Pharmaceuticals, Inc. High throughput analysis of recombinant proteins in multi-well plates
JP2003310294A (ja) * 2002-04-23 2003-11-05 Sunnyhealth Co Ltd カプサイシン類の配糖体製造方法およびカプサイシン類配糖体組成物
CN100457904C (zh) * 2003-05-07 2009-02-04 财团法人Seoul大学校产学协力财团 针对胞质雄性不育辣椒的特异性dna片段及其应用
GB0421937D0 (en) 2004-10-02 2004-11-03 Univ York Acyl CoA synthetases
KR101246126B1 (ko) 2005-02-18 2013-03-25 아지노모토 가부시키가이샤 캡시노이드의 안정화 방법 및 캡시노이드 조성물의 제조방법
WO2006100680A2 (en) * 2005-03-22 2006-09-28 Hazera Genetics Ltd. Pepper plants having fruit with altered vitamin content
WO2007021020A1 (ja) 2005-08-16 2007-02-22 Ajinomoto Co., Inc. カプシノイド類含有組成物
JP2009529891A (ja) 2006-03-15 2009-08-27 マーテック バイオサイエンシーズ コーポレーション 多価不飽和脂肪酸を含む植物種子油
AU2007299219A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
JP2008048612A (ja) * 2006-08-22 2008-03-06 Bio Taxol:Kk 糖転移酵素遺伝子
ES2307420B1 (es) 2007-04-24 2009-10-20 Universidad De Cadiz Procedimiento de sintesis quimica de capsinoides.
EP2231864B1 (en) 2007-12-11 2017-05-24 Synthetic Genomics, Inc. Secretion of fatty acids by photosynthetic microorganisms
JP5594137B2 (ja) 2008-06-23 2014-09-24 味の素株式会社 カプシノイドを生合成する遺伝子改変植物
JP6177774B2 (ja) 2011-07-13 2017-08-16 ナショナル、リサーチ、カウンシル、オブ、カナダNational Research Council of Canada アルカノイル−coa合成のための遺伝子およびタンパク質
US8951762B2 (en) 2011-07-27 2015-02-10 Iowa State University Research Foundation, Inc. Materials and methods for using an acyl—acyl carrier protein thioesterase and mutants and chimeras thereof in fatty acid synthesis
JP6126597B2 (ja) 2011-08-08 2017-05-10 エヴォルヴァ エスアー.Evolva Sa. サフラン化合物の組換え生成のための方法および材料
EP2798063B1 (en) 2011-12-27 2022-03-30 Commonwealth Scientific and Industrial Research Organisation Production of dihydrosterculic acid and derivatives thereof
MY172692A (en) 2012-07-13 2019-12-10 Calysta Inc Biorefinery system, methods and compositions thereof
CN103087998B (zh) 2012-10-30 2014-09-03 浙江工业大学 冬虫夏草合成十六烷基-辅酶a的酶、基因及其应用
US10184140B2 (en) 2013-01-23 2019-01-22 Iowa State University Research Foundation, Inc. Materials and methods for production of bi-functional fatty acids in recombinant bacteria
CN103173444A (zh) * 2013-03-27 2013-06-26 广东省农业科学院蔬菜研究所 一种准确区分辣椒与甜椒的功能标记及其检测引物组和检测方法
JP2015034599A (ja) 2013-08-09 2015-02-19 トヨタ自動車株式会社 レリーズ機構
US10392643B2 (en) 2013-11-01 2019-08-27 Conagen Inc. Methods of using acyl-CoA synthetase for biosynthetic production of acyl-CoAs
JP6596009B2 (ja) 2013-11-04 2019-10-23 ビージーエヌ テック エルエルシー 植物デヒドロゲナーゼを用いるオイゲノールからのフェルラ酸の微生物発酵を介してバニリンを製造する方法
CN103725652B (zh) 2013-12-25 2016-06-29 无锡新和源发酵技术研究院有限公司 一种酰基辅酶a合成酶及其应用
WO2015109168A1 (en) 2014-01-17 2015-07-23 Conagen Inc. Methods of using capsaicin synthase for the microbial production of capsaicinoids
WO2015160842A1 (en) 2014-04-14 2015-10-22 Flex Pharma, Inc. Methods and formulatiions of capsaicinoids and capsinoids
EP3020819A1 (en) 2014-11-17 2016-05-18 Evonik Degussa GmbH Fatty acid and derivatives production
BR112018013539A2 (pt) 2016-01-07 2018-12-04 Conagen Inc métodos de preparar capsinoides por processos biossintéticos
KR20190027830A (ko) 2016-07-19 2019-03-15 코나겐 인크. 특정 자연 캡사이시노이드의 미생물 생산 방법
CN110291194A (zh) 2016-12-22 2019-09-27 科纳根公司 用于微生物生产8-甲基壬酸的方法

Also Published As

Publication number Publication date
US11946083B2 (en) 2024-04-02
WO2018017772A1 (en) 2018-01-25
CA3029246A1 (en) 2018-01-25
JP2019528685A (ja) 2019-10-17
DK3487986T3 (da) 2021-07-26
KR20190027830A (ko) 2019-03-15
CN109790513A (zh) 2019-05-21
EP3487986A4 (en) 2020-04-15
EP3487986A1 (en) 2019-05-29
US20220403427A1 (en) 2022-12-22
EP3487986B1 (en) 2021-06-30
MX2019000860A (es) 2019-06-03
US11459591B2 (en) 2022-10-04
BR112019000895A2 (pt) 2019-04-30
AU2017299615A1 (en) 2019-01-17
CN109790513B (zh) 2023-04-18
US20210317485A1 (en) 2021-10-14
JP7053565B2 (ja) 2022-04-12
PL3487986T3 (pl) 2021-11-08

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