PL3487986T3 - Sposób produkcji mikrobiologicznej określonych naturalnych kapsaicynoidów - Google Patents
Sposób produkcji mikrobiologicznej określonych naturalnych kapsaicynoidówInfo
- Publication number
- PL3487986T3 PL3487986T3 PL17831838T PL17831838T PL3487986T3 PL 3487986 T3 PL3487986 T3 PL 3487986T3 PL 17831838 T PL17831838 T PL 17831838T PL 17831838 T PL17831838 T PL 17831838T PL 3487986 T3 PL3487986 T3 PL 3487986T3
- Authority
- PL
- Poland
- Prior art keywords
- microbial production
- specific natural
- capsaicinoids
- natural capsaicinoids
- microbial
- Prior art date
Links
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 title 1
- 230000000813 microbial effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/10—Natural spices, flavouring agents or condiments; Extracts thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/20—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0061—Essential oils; Perfumes compounds containing a six-membered aromatic ring not condensed with another ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01086—Fatty-acyl-CoA synthase (2.3.1.86)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Seasonings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662363951P | 2016-07-19 | 2016-07-19 | |
EP17831838.2A EP3487986B1 (en) | 2016-07-19 | 2017-07-19 | Method for the microbial production of specific natural capsaicinoids |
PCT/US2017/042944 WO2018017772A1 (en) | 2016-07-19 | 2017-07-19 | Method for the microbial production of specific natural capsaicinoids |
Publications (1)
Publication Number | Publication Date |
---|---|
PL3487986T3 true PL3487986T3 (pl) | 2021-11-08 |
Family
ID=60996099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL17831838T PL3487986T3 (pl) | 2016-07-19 | 2017-07-19 | Sposób produkcji mikrobiologicznej określonych naturalnych kapsaicynoidów |
Country Status (13)
Country | Link |
---|---|
US (2) | US11459591B2 (pl) |
EP (1) | EP3487986B1 (pl) |
JP (1) | JP7053565B2 (pl) |
KR (1) | KR20190027830A (pl) |
CN (1) | CN109790513B (pl) |
AU (1) | AU2017299615A1 (pl) |
BR (1) | BR112019000895A2 (pl) |
CA (1) | CA3029246A1 (pl) |
DK (1) | DK3487986T3 (pl) |
HU (1) | HUE056799T2 (pl) |
MX (1) | MX2019000860A (pl) |
PL (1) | PL3487986T3 (pl) |
WO (1) | WO2018017772A1 (pl) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019500877A (ja) | 2016-01-07 | 2019-01-17 | コナゲン インコーポレイテッド | 生合成プロセスによりカプシノイドを調製する方法 |
JP7053565B2 (ja) | 2016-07-19 | 2022-04-12 | コナジェン・インコーポレイテッド | 特定の天然カプサイシノイドの微生物生成のための方法 |
CN110305031B (zh) * | 2019-07-03 | 2022-07-12 | 遂宁晶安科技有限公司 | 辣椒素的制备方法及利用该方法制备得到的辣椒素 |
CN112608247B (zh) * | 2020-12-15 | 2023-04-07 | 遂宁晶安科技有限公司 | 辣椒素的制备方法及利用该方法制备得到的辣椒素 |
CN116837016B (zh) * | 2023-08-29 | 2024-01-02 | 中国农业科学院北京畜牧兽医研究所 | 一种构建生产辣椒素香草壬酰胺的重组大肠杆菌工程菌株的方法及重组菌株和应用 |
Family Cites Families (39)
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US4493848A (en) | 1983-07-14 | 1985-01-15 | The Procter & Gamble Company | Compositions and methods useful for producing analgesia |
US5094782A (en) | 1990-12-24 | 1992-03-10 | National Science Council Of Republic Of China | Synthesis of capsacin derivatives and their use as an analgesic drug and vessel dilation drug |
US5958745A (en) | 1996-03-13 | 1999-09-28 | Monsanto Company | Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants |
JP4043605B2 (ja) | 1998-07-02 | 2008-02-06 | 丸善製薬株式会社 | カプサイシン類縁体の製造法 |
US20070244192A1 (en) | 1999-01-14 | 2007-10-18 | Martek Biosciences Corporation | Plant seed oils containing polyunsaturated fatty acids |
DE10000978A1 (de) | 2000-01-12 | 2001-07-26 | Gvs Ges Fuer Erwerb Und Verwer | Verfahren zur Erhöhung des Gehalts an Fettsäuren in Pflanzen und Mikroorganismen |
US20040010817A1 (en) | 2000-07-21 | 2004-01-15 | Washington State University Research Foundation | Plant acyl-CoA synthetases |
JP3951008B2 (ja) | 2002-01-17 | 2007-08-01 | 国立大学法人 岡山大学 | カプサイシン分解合成酵素及びその生産方法 |
WO2003087834A2 (en) | 2002-04-08 | 2003-10-23 | Affinium Pharmaceuticals, Inc. | High throughput analysis of recombinant proteins in multi-well plates |
JP2003310294A (ja) * | 2002-04-23 | 2003-11-05 | Sunnyhealth Co Ltd | カプサイシン類の配糖体製造方法およびカプサイシン類配糖体組成物 |
CN100457904C (zh) * | 2003-05-07 | 2009-02-04 | 财团法人Seoul大学校产学协力财团 | 针对胞质雄性不育辣椒的特异性dna片段及其应用 |
GB0421937D0 (en) | 2004-10-02 | 2004-11-03 | Univ York | Acyl CoA synthetases |
CN101137613B (zh) | 2005-02-18 | 2012-03-28 | 味之素株式会社 | 通过脱水缩合制备辣椒素酯类物质的方法、辣椒素酯类物质的稳定方法和辣椒素酯类物质组合物 |
EP1860933A4 (en) * | 2005-03-22 | 2010-01-06 | Hazera Genetics Ltd | PEPPERS WITH VITAMIN FRUIT CONTENT HAS BEEN MODIFIED |
EP1917961A1 (en) | 2005-08-16 | 2008-05-07 | Ajinomoto Co., Inc. | Capsinoid containing composition |
JP2009529891A (ja) | 2006-03-15 | 2009-08-27 | マーテック バイオサイエンシーズ コーポレーション | 多価不飽和脂肪酸を含む植物種子油 |
EP2090662A3 (en) | 2006-04-05 | 2012-10-31 | Metanomics GmbH | Process for the production of a fine chemical |
JP2008048612A (ja) * | 2006-08-22 | 2008-03-06 | Bio Taxol:Kk | 糖転移酵素遺伝子 |
ES2307420B1 (es) | 2007-04-24 | 2009-10-20 | Universidad De Cadiz | Procedimiento de sintesis quimica de capsinoides. |
BRPI0821508B1 (pt) | 2007-12-11 | 2018-12-26 | Synthetic Genomics Inc | cultura celular compreendendo uma cianobactéria recombinante da espécie synechococcus elongatus e método para converter carbono inorgânico em ácidos graxos. |
CN102065680B (zh) | 2008-06-23 | 2014-12-24 | 味之素株式会社 | 能生物合成辣椒素酯类物质的基因修饰植物 |
CN103842509B (zh) | 2011-07-13 | 2016-06-08 | 加拿大国家研究委员会 | 用于烷酰基辅酶a合成的基因和蛋白质 |
US8951762B2 (en) | 2011-07-27 | 2015-02-10 | Iowa State University Research Foundation, Inc. | Materials and methods for using an acyl—acyl carrier protein thioesterase and mutants and chimeras thereof in fatty acid synthesis |
IN2014CN01129A (pl) * | 2011-08-08 | 2015-04-10 | Evolva Sa | |
WO2013096991A1 (en) * | 2011-12-27 | 2013-07-04 | Commonwealth Scientific And Industrial Research Organisation | Production of dihydrosterculic acid and derivatives thereof |
IN2015DN00919A (pl) | 2012-07-13 | 2015-06-12 | Calysta Inc | |
CN103710315B (zh) | 2012-10-30 | 2016-03-23 | 浙江工业大学 | 来自冬虫夏草的长链-酰基-辅酶a合成酶、基因及应用 |
US10184140B2 (en) | 2013-01-23 | 2019-01-22 | Iowa State University Research Foundation, Inc. | Materials and methods for production of bi-functional fatty acids in recombinant bacteria |
CN103173444A (zh) * | 2013-03-27 | 2013-06-26 | 广东省农业科学院蔬菜研究所 | 一种准确区分辣椒与甜椒的功能标记及其检测引物组和检测方法 |
JP2015034599A (ja) | 2013-08-09 | 2015-02-19 | トヨタ自動車株式会社 | レリーズ機構 |
CN105916991A (zh) | 2013-11-01 | 2016-08-31 | 康纳根有限公司 | 使用酰基-CoA合成酶生物合成生成酰基-CoA的方法 |
US9932610B2 (en) | 2013-11-04 | 2018-04-03 | Bgn Tech Llc | Methods of making vanillin via the microbial fermentation of ferulic acid from eugenol using a plant dehydrogenase |
CN103725652B (zh) | 2013-12-25 | 2016-06-29 | 无锡新和源发酵技术研究院有限公司 | 一种酰基辅酶a合成酶及其应用 |
WO2015109168A1 (en) | 2014-01-17 | 2015-07-23 | Conagen Inc. | Methods of using capsaicin synthase for the microbial production of capsaicinoids |
WO2015160842A1 (en) | 2014-04-14 | 2015-10-22 | Flex Pharma, Inc. | Methods and formulatiions of capsaicinoids and capsinoids |
EP3020819A1 (en) | 2014-11-17 | 2016-05-18 | Evonik Degussa GmbH | Fatty acid and derivatives production |
JP2019500877A (ja) | 2016-01-07 | 2019-01-17 | コナゲン インコーポレイテッド | 生合成プロセスによりカプシノイドを調製する方法 |
JP7053565B2 (ja) | 2016-07-19 | 2022-04-12 | コナジェン・インコーポレイテッド | 特定の天然カプサイシノイドの微生物生成のための方法 |
EP3559219A4 (en) | 2016-12-22 | 2020-09-09 | Conagen Inc. | PROCESS FOR THE MICROBIAL PRODUCTION OF 8-METHYL-NONANOIC ACID |
-
2017
- 2017-07-19 JP JP2019503221A patent/JP7053565B2/ja active Active
- 2017-07-19 US US16/317,844 patent/US11459591B2/en active Active
- 2017-07-19 WO PCT/US2017/042944 patent/WO2018017772A1/en unknown
- 2017-07-19 BR BR112019000895-0A patent/BR112019000895A2/pt not_active Application Discontinuation
- 2017-07-19 MX MX2019000860A patent/MX2019000860A/es unknown
- 2017-07-19 PL PL17831838T patent/PL3487986T3/pl unknown
- 2017-07-19 KR KR1020197001710A patent/KR20190027830A/ko unknown
- 2017-07-19 DK DK17831838.2T patent/DK3487986T3/da active
- 2017-07-19 AU AU2017299615A patent/AU2017299615A1/en not_active Abandoned
- 2017-07-19 CA CA3029246A patent/CA3029246A1/en not_active Abandoned
- 2017-07-19 CN CN201780044873.4A patent/CN109790513B/zh active Active
- 2017-07-19 EP EP17831838.2A patent/EP3487986B1/en active Active
- 2017-07-19 HU HUE17831838A patent/HUE056799T2/hu unknown
-
2022
- 2022-08-24 US US17/821,810 patent/US11946083B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US11459591B2 (en) | 2022-10-04 |
HUE056799T2 (hu) | 2022-03-28 |
JP7053565B2 (ja) | 2022-04-12 |
DK3487986T3 (da) | 2021-07-26 |
US20210317485A1 (en) | 2021-10-14 |
AU2017299615A1 (en) | 2019-01-17 |
CN109790513A (zh) | 2019-05-21 |
BR112019000895A2 (pt) | 2019-04-30 |
CN109790513B (zh) | 2023-04-18 |
WO2018017772A1 (en) | 2018-01-25 |
MX2019000860A (es) | 2019-06-03 |
JP2019528685A (ja) | 2019-10-17 |
CA3029246A1 (en) | 2018-01-25 |
KR20190027830A (ko) | 2019-03-15 |
EP3487986A1 (en) | 2019-05-29 |
US20220403427A1 (en) | 2022-12-22 |
EP3487986A4 (en) | 2020-04-15 |
EP3487986B1 (en) | 2021-06-30 |
US11946083B2 (en) | 2024-04-02 |
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