ES2115343T3 - Metodo de preparacion de liposomas y encapsulacion de material. - Google Patents
Metodo de preparacion de liposomas y encapsulacion de material.Info
- Publication number
- ES2115343T3 ES2115343T3 ES95900452T ES95900452T ES2115343T3 ES 2115343 T3 ES2115343 T3 ES 2115343T3 ES 95900452 T ES95900452 T ES 95900452T ES 95900452 T ES95900452 T ES 95900452T ES 2115343 T3 ES2115343 T3 ES 2115343T3
- Authority
- ES
- Spain
- Prior art keywords
- liposomes
- lipid powder
- liposome dispersion
- dehydration
- formation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UN METODO PARA LA PRODUCCION DE LIPOSOMAS UTILES PARA LA ENCAPSULACION Y SUMINISTRO DE UNA AMPLIA VARIEDAD DE MATERIALES BIOLOGICAMENTE ACTIVOS. EN LA INVENCION SE PRESENTAN LIPOSOMAS Y UN METODO PARA LA PRODUCCION DE LOS MISMOS QUE ES SENCILLO, FACTIBLE Y BARATO PARA LA FABRICACION COMERCIAL A GRAN ESCALA DE LIPOSOMAS Y DE MATERIALES ENCAPSULADOS. EL METODO CONSISTE EN FORMAR UNA DISPERSION DE LIPOSOMAS EN AUSENCIA DE UN SOLVENTE ORGANICO O DETERGENTE, EN UNO O VARIOS CICLOS DE CONGELACION Y DESCONGELACION DE LOS LIPOSOMAS Y EN UNA DESHIDRATACION DE LA DISPERSION DE LIPOSOMAS PARA FORMAR UN POLVO DE LIPIDOS. SI SE DESEA, EL POLVO DE LIPIDOS SE HIDRATA EN PRESENCIA DEL MATERIAL BIOLOGICAMENTE ACTIVO CON LO QUE EL MATERIAL SE ENCAPSULA A MODO DE LIPOSOMAS RECONSTITUIDOS. EL METODO PUEDE INCLUIR TAMBIEN UN PASO EN EL QUE SE COMBINA LA DISPERSION DE LIPOSOMAS CON UN AGENTE AUMENTADOR DEL VOLUMEN ANTES DE LA DESHIDRATACION Y LA FORMACION DEL POLVO DE LIPIDOS.LA ADICION DEL AGENTE AUMENTADOR DEL VOLUMEN FACILITA LA MANIPULACION DEL POLVO DE LIPIDOS ASI COMO SU RAPIDA DISPERSION TRAS LA HIDRATACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14809993A | 1993-11-05 | 1993-11-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2115343T3 true ES2115343T3 (es) | 1998-06-16 |
Family
ID=22524272
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95900452T Expired - Lifetime ES2115343T3 (es) | 1993-11-05 | 1994-11-03 | Metodo de preparacion de liposomas y encapsulacion de material. |
Country Status (10)
Country | Link |
---|---|
US (2) | US5567433A (es) |
EP (1) | EP0678017B1 (es) |
JP (1) | JPH08505882A (es) |
AT (1) | ATE164515T1 (es) |
AU (1) | AU683957B2 (es) |
CA (1) | CA2153251C (es) |
DE (1) | DE69409361T2 (es) |
DK (1) | DK0678017T3 (es) |
ES (1) | ES2115343T3 (es) |
WO (1) | WO1995012387A1 (es) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5994314A (en) * | 1993-04-07 | 1999-11-30 | Inhale Therapeutic Systems, Inc. | Compositions and methods for nucleic acid delivery to the lung |
US20020132787A1 (en) * | 1993-04-07 | 2002-09-19 | Mohammed Eljamal | Compositions and methods for nucleic acid delivery to the lung |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US5981501A (en) * | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
US7422902B1 (en) * | 1995-06-07 | 2008-09-09 | The University Of British Columbia | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
US5855911A (en) * | 1995-08-29 | 1999-01-05 | Board Of Regents, The University Of Texas System | Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides |
US6096336A (en) * | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
AU3130597A (en) | 1996-05-16 | 1997-12-05 | Duke University | Tristetraprolin |
US7384923B2 (en) * | 1999-05-14 | 2008-06-10 | Lipoxen Technologies Limited | Liposomes |
DE69717661T2 (de) * | 1996-09-13 | 2003-09-25 | Lipoxen Technologies Ltd | Liposomenzusammensetzung |
US6264996B1 (en) | 1996-12-11 | 2001-07-24 | A. Glenn Braswell | Composition for inhibiting production of dihydrotestosterone to treat benign prostate hyperplasia |
IT1289938B1 (it) * | 1997-02-20 | 1998-10-19 | Angelini Ricerche Spa | Preparazione farmaceutica comprendente liposomi liofilizzati in cui e' incapsulato un principio attivo altamente insolubile in acqua e |
WO1998051278A2 (en) * | 1997-05-14 | 1998-11-19 | Inex Pharmaceuticals Corporation | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
CA2309548A1 (en) * | 1997-11-14 | 1999-05-27 | Skyepharma Inc. | Production of multivesicular liposomes |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
GB9813100D0 (en) * | 1998-06-18 | 1998-08-19 | Secr Defence | Method of forming liposomes |
US6352996B1 (en) | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
US20030129251A1 (en) | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
US7129222B2 (en) * | 2000-03-10 | 2006-10-31 | Dynavax Technologies Corporation | Immunomodulatory formulations and methods for use thereof |
US20040057988A1 (en) * | 2000-11-10 | 2004-03-25 | Eishun Tsuchida | Method for preparing microsome dispersion |
US20030077829A1 (en) * | 2001-04-30 | 2003-04-24 | Protiva Biotherapeutics Inc.. | Lipid-based formulations |
US6676958B2 (en) | 2001-06-19 | 2004-01-13 | Advanced Bioadjuvants, Llc | Adjuvant composition for mucosal and injection delivered vaccines |
CA2472055A1 (en) * | 2001-11-07 | 2003-05-15 | Inex Pharmaceuticals Corporation | Improved mucosal vaccines and methods for using the same |
US20040082521A1 (en) * | 2002-03-29 | 2004-04-29 | Azaya Therapeutics Inc. | Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases |
US20060093661A1 (en) * | 2002-05-07 | 2006-05-04 | Kapac, Llc | Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs |
US20030212046A1 (en) * | 2002-05-07 | 2003-11-13 | Kapac, Llc | Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs |
US20040009944A1 (en) * | 2002-05-10 | 2004-01-15 | Inex Pharmaceuticals Corporation | Methylated immunostimulatory oligonucleotides and methods of using the same |
WO2004032789A2 (en) * | 2002-10-09 | 2004-04-22 | The Azza Co., Ltd. | Liposomal hgh composition and method for administration thereof |
US7179484B2 (en) * | 2002-11-06 | 2007-02-20 | Azaya Therapeutics, Inc. | Protein-stabilized liposomal formulations of pharmaceutical agents |
US20040092102A1 (en) * | 2002-11-12 | 2004-05-13 | Sachem, Inc. | Chemical mechanical polishing composition and method |
US20040204435A1 (en) * | 2003-04-09 | 2004-10-14 | Joachim Liehr | Alternating treatment with topoisomerase I and topoisomerase II inhibitors |
WO2005002546A1 (en) * | 2003-06-27 | 2005-01-13 | Smithkline Beecham Corporation | Stabilized topotecan liposomal composition and methods |
US20050123596A1 (en) * | 2003-09-23 | 2005-06-09 | Kohane Daniel S. | pH-triggered microparticles |
US7943179B2 (en) | 2003-09-23 | 2011-05-17 | Massachusetts Institute Of Technology | pH triggerable polymeric particles |
WO2005034979A2 (en) * | 2003-10-11 | 2005-04-21 | Inex Pharmaceuticals Corporation | Methods and compositions for enhancing innate immunity and antibody dependent cellular cytotoxicity |
JP2005162702A (ja) * | 2003-12-04 | 2005-06-23 | Konica Minolta Medical & Graphic Inc | リポソーム製剤の製造方法、リポソーム製剤およびその製造装置 |
US20050169978A1 (en) * | 2004-01-29 | 2005-08-04 | Shu-Wen Fu | Wet-micro grinding |
EP1750673B1 (en) * | 2004-05-17 | 2009-12-02 | Tekmira Pharmaceuticals Corporation | Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof |
PT1962805T (pt) | 2005-12-08 | 2016-10-05 | Insmed Inc | Composições de anti-infeciosos baseadas em lípidos para tratamento de infeções pulmonares |
US8119156B2 (en) | 2006-10-24 | 2012-02-21 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
US8268347B1 (en) | 2006-10-24 | 2012-09-18 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
US8071127B2 (en) * | 2006-10-24 | 2011-12-06 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
AU2007329193A1 (en) * | 2006-12-08 | 2008-06-12 | Protech Research Pty Ltd | Liposome production |
US8088887B2 (en) * | 2007-02-13 | 2012-01-03 | Academia Sinica | Peptide-conjugates that bind to VEGF-stimulated or tumor vasculature and methods of treatment |
US8415453B2 (en) * | 2007-02-13 | 2013-04-09 | Academia Sinica | Lung cancer-targeted peptides and applications thereof |
US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
US20080292663A1 (en) * | 2007-05-22 | 2008-11-27 | Gerber Jay D | Adjuvant compositions and methods for delivering vaccines |
US8541543B2 (en) * | 2007-11-20 | 2013-09-24 | Academia Sinica | Peptides specific for hepatocellular carcinoma cells and applications thereof |
ES2538468T3 (es) | 2008-05-20 | 2015-06-22 | Eos Neuroscience, Inc. | Vectores para la administración de proteínas sensibles a la luz y métodos para su utilización |
US9445975B2 (en) | 2008-10-03 | 2016-09-20 | Access Business Group International, Llc | Composition and method for preparing stable unilamellar liposomal suspension |
GB201116248D0 (en) * | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
EP2825196A4 (en) | 2012-03-12 | 2015-08-26 | Advanced Bioadjuvants Llc | ADJUVANT AND VACCINE COMPOSITIONS |
MX2015006681A (es) | 2012-11-29 | 2016-04-06 | Insmed Inc | Formulaciones de vancomicina estabilizadas. |
AU2014340568B2 (en) | 2013-10-22 | 2017-02-02 | Aradigm Corporation | Inhaled surfactant-modified liposomal formulations providing both an immediate and sustained release profile |
HUE052968T2 (hu) | 2014-04-30 | 2021-05-28 | Fujifilm Corp | Liposzóma kompozíció és annak elõállítási eljárása |
WO2015175939A1 (en) | 2014-05-15 | 2015-11-19 | Insmed Incorporated | Methods for treating pulmonary non-tuberculous mycobacterial infections |
CN113289034A (zh) | 2014-12-31 | 2021-08-24 | 蓝瑟斯医学影像公司 | 脂质封装的气体微球组合物及相关方法 |
BR112018007611A2 (pt) | 2015-10-14 | 2018-10-23 | Bio Path Holding Inc | ácidos nucleicos p-etóxi para formulação lipossômica |
IL262647B2 (en) | 2016-05-04 | 2023-03-01 | Lantheus Medical Imaging Inc | Methods and devices for preparing sharpness factors for ultrasound |
US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
CN109963571A (zh) | 2016-09-16 | 2019-07-02 | 拜奥-帕斯控股股份有限公司 | 含有脂质体反义寡核苷酸的组合疗法 |
AU2018255352B2 (en) | 2017-04-19 | 2023-11-16 | Bio-Path Holdings, Inc. | P-ethoxy nucleic acids for STAT3 inhibition |
EP3773505A4 (en) | 2018-03-30 | 2021-12-22 | Insmed Incorporated | PROCESS FOR THE CONTINUOUS MANUFACTURING OF LIPOSOMAL MEDICINAL PRODUCTS |
US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
CN114916651B (zh) * | 2022-05-19 | 2024-03-29 | 成都科建生物医药有限公司 | 一种芥末精油脂质体及其制备方法与应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1575343A (en) * | 1977-05-10 | 1980-09-17 | Ici Ltd | Method for preparing liposome compositions containing biologically active compounds |
CH621479A5 (es) * | 1977-08-05 | 1981-02-13 | Battelle Memorial Institute | |
US4241046A (en) * | 1978-11-30 | 1980-12-23 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
JPS5782311A (en) * | 1980-11-11 | 1982-05-22 | Tanabe Seiyaku Co Ltd | Production of liposome preparation |
US4515736A (en) * | 1983-05-12 | 1985-05-07 | The Regents Of The University Of California | Method for encapsulating materials into liposomes |
US4744989A (en) * | 1984-02-08 | 1988-05-17 | E. R. Squibb & Sons, Inc. | Method of preparing liposomes and products produced thereby |
JPH0753661B2 (ja) * | 1984-03-08 | 1995-06-07 | フアレス フアーマスーチカル リサーチ エヌブイ | プロ―リポソーム組成物及びリポソームの水性分散物を作る方法 |
US5077056A (en) * | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
EP0172007B1 (en) * | 1984-08-10 | 1991-05-22 | Syntex (U.S.A.) Inc. | Stable liposomes with aqueous-soluble medicaments and methods for their preparation |
US4857319A (en) * | 1985-01-11 | 1989-08-15 | The Regents Of The University Of California | Method for preserving liposomes |
US5104661A (en) * | 1989-08-14 | 1992-04-14 | Technology Unlimited, Inc. | Reverse loading of liposomes |
-
1994
- 1994-11-03 DK DK95900452T patent/DK0678017T3/da active
- 1994-11-03 JP JP7513303A patent/JPH08505882A/ja active Pending
- 1994-11-03 CA CA002153251A patent/CA2153251C/en not_active Expired - Fee Related
- 1994-11-03 EP EP95900452A patent/EP0678017B1/en not_active Expired - Lifetime
- 1994-11-03 AT AT95900452T patent/ATE164515T1/de not_active IP Right Cessation
- 1994-11-03 ES ES95900452T patent/ES2115343T3/es not_active Expired - Lifetime
- 1994-11-03 DE DE69409361T patent/DE69409361T2/de not_active Expired - Fee Related
- 1994-11-03 WO PCT/US1994/012350 patent/WO1995012387A1/en active IP Right Grant
- 1994-11-03 AU AU81273/94A patent/AU683957B2/en not_active Ceased
-
1995
- 1995-01-30 US US08/381,613 patent/US5567433A/en not_active Expired - Lifetime
-
1997
- 1997-06-03 US US08/868,019 patent/US6355267B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2153251C (en) | 1998-09-01 |
DK0678017T3 (da) | 1998-10-19 |
CA2153251A1 (en) | 1995-05-11 |
EP0678017A1 (en) | 1995-10-25 |
JPH08505882A (ja) | 1996-06-25 |
AU8127394A (en) | 1995-05-23 |
ATE164515T1 (de) | 1998-04-15 |
DE69409361T2 (de) | 1998-11-12 |
US5567433A (en) | 1996-10-22 |
US6355267B1 (en) | 2002-03-12 |
DE69409361D1 (de) | 1998-05-07 |
AU683957B2 (en) | 1997-11-27 |
WO1995012387A1 (en) | 1995-05-11 |
EP0678017B1 (en) | 1998-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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