ES2115343T3 - Metodo de preparacion de liposomas y encapsulacion de material. - Google Patents

Metodo de preparacion de liposomas y encapsulacion de material.

Info

Publication number
ES2115343T3
ES2115343T3 ES95900452T ES95900452T ES2115343T3 ES 2115343 T3 ES2115343 T3 ES 2115343T3 ES 95900452 T ES95900452 T ES 95900452T ES 95900452 T ES95900452 T ES 95900452T ES 2115343 T3 ES2115343 T3 ES 2115343T3
Authority
ES
Spain
Prior art keywords
liposomes
lipid powder
liposome dispersion
dehydration
formation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95900452T
Other languages
English (en)
Inventor
David Sammuel Collins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ES2115343T3 publication Critical patent/ES2115343T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN METODO PARA LA PRODUCCION DE LIPOSOMAS UTILES PARA LA ENCAPSULACION Y SUMINISTRO DE UNA AMPLIA VARIEDAD DE MATERIALES BIOLOGICAMENTE ACTIVOS. EN LA INVENCION SE PRESENTAN LIPOSOMAS Y UN METODO PARA LA PRODUCCION DE LOS MISMOS QUE ES SENCILLO, FACTIBLE Y BARATO PARA LA FABRICACION COMERCIAL A GRAN ESCALA DE LIPOSOMAS Y DE MATERIALES ENCAPSULADOS. EL METODO CONSISTE EN FORMAR UNA DISPERSION DE LIPOSOMAS EN AUSENCIA DE UN SOLVENTE ORGANICO O DETERGENTE, EN UNO O VARIOS CICLOS DE CONGELACION Y DESCONGELACION DE LOS LIPOSOMAS Y EN UNA DESHIDRATACION DE LA DISPERSION DE LIPOSOMAS PARA FORMAR UN POLVO DE LIPIDOS. SI SE DESEA, EL POLVO DE LIPIDOS SE HIDRATA EN PRESENCIA DEL MATERIAL BIOLOGICAMENTE ACTIVO CON LO QUE EL MATERIAL SE ENCAPSULA A MODO DE LIPOSOMAS RECONSTITUIDOS. EL METODO PUEDE INCLUIR TAMBIEN UN PASO EN EL QUE SE COMBINA LA DISPERSION DE LIPOSOMAS CON UN AGENTE AUMENTADOR DEL VOLUMEN ANTES DE LA DESHIDRATACION Y LA FORMACION DEL POLVO DE LIPIDOS.LA ADICION DEL AGENTE AUMENTADOR DEL VOLUMEN FACILITA LA MANIPULACION DEL POLVO DE LIPIDOS ASI COMO SU RAPIDA DISPERSION TRAS LA HIDRATACION.
ES95900452T 1993-11-05 1994-11-03 Metodo de preparacion de liposomas y encapsulacion de material. Expired - Lifetime ES2115343T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14809993A 1993-11-05 1993-11-05

Publications (1)

Publication Number Publication Date
ES2115343T3 true ES2115343T3 (es) 1998-06-16

Family

ID=22524272

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95900452T Expired - Lifetime ES2115343T3 (es) 1993-11-05 1994-11-03 Metodo de preparacion de liposomas y encapsulacion de material.

Country Status (10)

Country Link
US (2) US5567433A (es)
EP (1) EP0678017B1 (es)
JP (1) JPH08505882A (es)
AT (1) ATE164515T1 (es)
AU (1) AU683957B2 (es)
CA (1) CA2153251C (es)
DE (1) DE69409361T2 (es)
DK (1) DK0678017T3 (es)
ES (1) ES2115343T3 (es)
WO (1) WO1995012387A1 (es)

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Also Published As

Publication number Publication date
AU683957B2 (en) 1997-11-27
ATE164515T1 (de) 1998-04-15
CA2153251A1 (en) 1995-05-11
DE69409361D1 (de) 1998-05-07
US6355267B1 (en) 2002-03-12
DK0678017T3 (da) 1998-10-19
WO1995012387A1 (en) 1995-05-11
EP0678017B1 (en) 1998-04-01
US5567433A (en) 1996-10-22
DE69409361T2 (de) 1998-11-12
EP0678017A1 (en) 1995-10-25
JPH08505882A (ja) 1996-06-25
AU8127394A (en) 1995-05-23
CA2153251C (en) 1998-09-01

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