JP2002508765A - リポソーム被包ポリヌクレオチド組成物および方法 - Google Patents

リポソーム被包ポリヌクレオチド組成物および方法

Info

Publication number
JP2002508765A
JP2002508765A JP50493699A JP50493699A JP2002508765A JP 2002508765 A JP2002508765 A JP 2002508765A JP 50493699 A JP50493699 A JP 50493699A JP 50493699 A JP50493699 A JP 50493699A JP 2002508765 A JP2002508765 A JP 2002508765A
Authority
JP
Japan
Prior art keywords
lipid
liposome
polynucleotide
composition
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP50493699A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002508765A5 (enExample
Inventor
エム． アレン，テレサ
スチュアート，ダリン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of JP2002508765A publication Critical patent/JP2002508765A/ja
Publication of JP2002508765A5 publication Critical patent/JP2002508765A5/ja
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP50493699A 1997-06-23 1998-06-22 リポソーム被包ポリヌクレオチド組成物および方法 Abandoned JP2002508765A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5049097P 1997-06-23 1997-06-23
US60/050,490 1997-06-23
PCT/US1998/012937 WO1998058630A1 (en) 1997-06-23 1998-06-22 Liposome-entrapped polynucleotide composition and method

Publications (2)

Publication Number Publication Date
JP2002508765A true JP2002508765A (ja) 2002-03-19
JP2002508765A5 JP2002508765A5 (enExample) 2005-12-22

Family

ID=21965541

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50493699A Abandoned JP2002508765A (ja) 1997-06-23 1998-06-22 リポソーム被包ポリヌクレオチド組成物および方法

Country Status (11)

Country Link
US (1) US6120798A (enExample)
EP (1) EP1017365B1 (enExample)
JP (1) JP2002508765A (enExample)
AT (1) ATE255882T1 (enExample)
AU (1) AU7983798A (enExample)
CA (1) CA2294579C (enExample)
DE (1) DE69820465T2 (enExample)
DK (1) DK1017365T3 (enExample)
ES (1) ES2212305T3 (enExample)
TW (1) TWI225412B (enExample)
WO (1) WO1998058630A1 (enExample)

Cited By (16)

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JP2002536316A (ja) * 1999-02-08 2002-10-29 アルザ・コーポレーション リポソームサイズを調節する方法
JP2005535730A (ja) * 2002-06-26 2005-11-24 メディゲーネ オンコロギー ゲゼルシャフト ミット ベシュレンクテル ハフツング 脂肪親和性化合物から成る陽イオン性リポソームの製法
WO2007080902A1 (ja) 2006-01-11 2007-07-19 Kyowa Hakko Kogyo Co., Ltd. 眼球において標的遺伝子の発現を抑制する組成物および眼球における疾患の治療剤
WO2010013815A1 (ja) 2008-08-01 2010-02-04 協和発酵キリン株式会社 標的遺伝子の発現を抑制する組成物
WO2011136368A1 (ja) 2010-04-28 2011-11-03 協和発酵キリン株式会社 カチオン性脂質
WO2011136369A1 (ja) 2010-04-28 2011-11-03 協和発酵キリン株式会社 カチオン性脂質
WO2012098692A1 (ja) 2011-01-19 2012-07-26 協和発酵キリン株式会社 標的遺伝子の発現を抑制する組成物
WO2013065825A1 (ja) 2011-11-02 2013-05-10 協和発酵キリン株式会社 カチオン性脂質
WO2013089151A1 (ja) 2011-12-12 2013-06-20 協和発酵キリン株式会社 カチオン性脂質を含有するドラッグデリバリーシステムのための脂質ナノ粒子
WO2013089152A1 (ja) 2011-12-12 2013-06-20 協和発酵キリン株式会社 カチオン性脂質の組み合わせを含有する脂質ナノ粒子
WO2014007398A1 (ja) 2012-07-06 2014-01-09 協和発酵キリン株式会社 カチオン性脂質
WO2014013995A1 (ja) 2012-07-16 2014-01-23 協和発酵キリン株式会社 KRAS遺伝子発現抑制RNAi医薬組成物
JP2014058468A (ja) * 2012-09-18 2014-04-03 Kyoto Univ 内包物質に耐熱性を与えたリポソーム及びその製造方法
JP2015518472A (ja) * 2012-03-29 2015-07-02 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド 脂質誘導される中性ナノ粒子
JP2016172778A (ja) * 2002-06-28 2016-09-29 プロティバ バイオセラピューティクス， インコーポレイテッド リポソーム製造方法および装置
WO2017111172A1 (ja) 2015-12-25 2017-06-29 協和発酵キリン株式会社 カチオン性脂質としての化合物

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US7309692B1 (en) * 1996-07-08 2007-12-18 Board Of Regents, The University Of Texas System Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1
US6977244B2 (en) 1996-10-04 2005-12-20 Board Of Regents, The University Of Texas Systems Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US6056973A (en) * 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
US6126965A (en) * 1997-03-21 2000-10-03 Georgetown University School Of Medicine Liposomes containing oligonucleotides
US7262173B2 (en) * 1997-03-21 2007-08-28 Georgetown University Chemosensitizing with liposomes containing oligonucleotides
US20030229040A1 (en) * 1997-03-21 2003-12-11 Georgetown University Cationic liposomal delivery system and therapeutic use thereof
US6559129B1 (en) * 1997-03-21 2003-05-06 Georgetown University Cationic liposomal delivery system and therapeutic use thereof
US7285288B1 (en) 1997-10-03 2007-10-23 Board Of Regents, The University Of Texas System Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US7704962B1 (en) 1997-10-03 2010-04-27 Board Of Regents, The University Of Texas System Small oligonucleotides with anti-tumor activity
US7223406B2 (en) * 2000-07-21 2007-05-29 The Regents Of The University Of California Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder
US6852323B2 (en) 2000-07-21 2005-02-08 The Regents Of The University Of California Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder
US20020146829A1 (en) * 2000-11-29 2002-10-10 Aventis Pharmaceuticals Products Inc. Neutral and anionic colloidal particles for gene delivery
US6610322B1 (en) * 2000-12-20 2003-08-26 Brian Charles Keller Self forming, thermodynamically stable liposomes and their applications
WO2002087541A1 (en) * 2001-04-30 2002-11-07 Protiva Biotherapeutics Inc. Lipid-based formulations for gene transfer
KR100411234B1 (ko) * 2001-08-14 2003-12-18 한국과학기술원 올리고뉴클레오티드 혼성화 미셀 및 그의 제조방법
CA2471967A1 (en) * 2002-01-03 2003-07-31 Board Of Regents, The University Of Texas System Wt1 antisense oligos for the inhibition of breast cancer
KR100466254B1 (ko) * 2002-02-25 2005-01-14 한국과학기술원 세포내 전달을 위한 올리고뉴클레오티드와 친수성 고분자로 구성되는 유전자 전달용 접합체, 고분자 전해질 복합 미셀 및 그의 제조방법
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US20070178066A1 (en) 2003-04-21 2007-08-02 Hall Frederick L Pathotropic targeted gene delivery system for cancer and other disorders
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US20090209621A1 (en) 2005-06-03 2009-08-20 The Johns Hopkins University Compositions and methods for decreasing microrna expression for the treatment of neoplasia
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US20110091377A1 (en) 2007-05-11 2011-04-21 The Johns Hopkins University Biomarkers for melanoma
PL208054B1 (pl) * 2007-09-06 2011-03-31 Akademia Medyczna Im Piastow Śląskich We Wrocławiu Kompozycja lipidowa do wytwarzania lipidowego nośnika dla leków genetycznych i jej zastosowanie
US20110038941A1 (en) * 2007-12-27 2011-02-17 The Ohio State University Research Foundation Lipid Nanoparticle Compositions and Methods of Making and Using the Same
US20110229498A1 (en) 2008-05-08 2011-09-22 The Johns Hopkins University Compositions and methods for modulating an immune response
US20120035247A1 (en) 2009-03-19 2012-02-09 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 6 (STAT6) Gene Expression Using Short Interfering Nucleic Acid (siNA)
US20120029054A1 (en) 2009-03-19 2012-02-02 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of GATA Binding Protein 3 (GATA3) Gene Expression Using Short Intefering Nucleic Acid (siNA)
JP2012520683A (ja) 2009-03-19 2012-09-10 メルク・シャープ・エンド・ドーム・コーポレイション 低分子干渉核酸（ｓｉＮＡ）を用いた結合組織増殖因子（ＣＴＧＦ）遺伝子発現のＲＮＡ干渉媒介性阻害
AU2010226604A1 (en) 2009-03-19 2011-10-13 Merck Sharp & Dohme Corp. RNA interference mediated inhibition of BTB and CNC homology 1, basic leucine zipper transcription factor 1 (Bach 1) gene expression using short interfering nucleic acid (siNA) sequence listing
WO2010111468A2 (en) 2009-03-27 2010-09-30 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF THE NERVE GROWTH FACTOR BETA CHAIN (NGFß) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)
US20120010272A1 (en) 2009-03-27 2012-01-12 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of Apoptosis Signal-Regulating Kinase 1 (ASK1) Gene Expression Using Short Interfering Nucleic Acid (siNA)
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JP2002536316A (ja) * 1999-02-08 2002-10-29 アルザ・コーポレーション リポソームサイズを調節する方法
US8663606B2 (en) 2002-06-26 2014-03-04 Medigene Ag Method of producing a cationic liposomal preparation comprising a lipophilic compound
JP2005535730A (ja) * 2002-06-26 2005-11-24 メディゲーネ オンコロギー ゲゼルシャフト ミット ベシュレンクテル ハフツング 脂肪親和性化合物から成る陽イオン性リポソームの製法
US9238021B2 (en) 2002-06-26 2016-01-19 Medigene Ag Method of producing a cationic liposomal preparation comprising a lipophilic compound
US11318098B2 (en) 2002-06-28 2022-05-03 Arbutus Biopharma Corporation Liposomal apparatus and manufacturing methods
US11298320B2 (en) 2002-06-28 2022-04-12 Arbutus Biopharma Corporation Liposomal apparatus and manufacturing methods
JP2016172778A (ja) * 2002-06-28 2016-09-29 プロティバ バイオセラピューティクス， インコーポレイテッド リポソーム製造方法および装置
WO2007080902A1 (ja) 2006-01-11 2007-07-19 Kyowa Hakko Kogyo Co., Ltd. 眼球において標的遺伝子の発現を抑制する組成物および眼球における疾患の治療剤
WO2010013815A1 (ja) 2008-08-01 2010-02-04 協和発酵キリン株式会社 標的遺伝子の発現を抑制する組成物
KR20110042294A (ko) 2008-08-01 2011-04-26 교와 핫꼬 기린 가부시키가이샤 표적 유전자의 발현을 억제하는 조성물
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WO2011136369A1 (ja) 2010-04-28 2011-11-03 協和発酵キリン株式会社 カチオン性脂質
WO2011136368A1 (ja) 2010-04-28 2011-11-03 協和発酵キリン株式会社 カチオン性脂質
WO2012098692A1 (ja) 2011-01-19 2012-07-26 協和発酵キリン株式会社 標的遺伝子の発現を抑制する組成物
WO2013065825A1 (ja) 2011-11-02 2013-05-10 協和発酵キリン株式会社 カチオン性脂質
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EP1017365B1 (en) 2003-12-10
DE69820465D1 (de) 2004-01-22
AU7983798A (en) 1999-01-04
DE69820465T2 (de) 2004-09-16
TWI225412B (en) 2004-12-21
CA2294579A1 (en) 1998-12-30
ATE255882T1 (de) 2003-12-15
CA2294579C (en) 2007-10-09
EP1017365A1 (en) 2000-07-12
DK1017365T3 (da) 2004-03-29
ES2212305T3 (es) 2004-07-16

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