DE69737990T2 - Neuer metabotropischer glutamat-rezeptor vom menschen - Google Patents

Neuer metabotropischer glutamat-rezeptor vom menschen Download PDF

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Publication number
DE69737990T2
DE69737990T2 DE69737990T DE69737990T DE69737990T2 DE 69737990 T2 DE69737990 T2 DE 69737990T2 DE 69737990 T DE69737990 T DE 69737990T DE 69737990 T DE69737990 T DE 69737990T DE 69737990 T2 DE69737990 T2 DE 69737990T2
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DE
Germany
Prior art keywords
nucleic acid
amino acid
metabotropic glutamate
receptor
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69737990T
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German (de)
English (en)
Other versions
DE69737990D1 (de
Inventor
Thomas M. Salt Lake City STORMANN
Rachel T. Salt Lake City SIMIN
Lance G. Bountiful HAMMERLAND
Forrest H. La Jolla Fuller
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AstraZeneca AB
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AstraZeneca AB
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Publication of DE69737990D1 publication Critical patent/DE69737990D1/de
Application granted granted Critical
Publication of DE69737990T2 publication Critical patent/DE69737990T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Psychology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyamides (AREA)
DE69737990T 1996-02-21 1997-02-20 Neuer metabotropischer glutamat-rezeptor vom menschen Expired - Fee Related DE69737990T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/604,298 US6084084A (en) 1996-02-21 1996-02-21 Human metabotropic glutamate receptor
PCT/US1997/009025 WO1997048724A2 (en) 1996-02-21 1997-02-20 Human metabotropic glutamate receptor
US604298 2000-06-26

Publications (2)

Publication Number Publication Date
DE69737990D1 DE69737990D1 (de) 2007-09-20
DE69737990T2 true DE69737990T2 (de) 2008-09-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE69737990T Expired - Fee Related DE69737990T2 (de) 1996-02-21 1997-02-20 Neuer metabotropischer glutamat-rezeptor vom menschen

Country Status (10)

Country Link
US (3) US6084084A (cg-RX-API-DMAC10.html)
EP (1) EP0882065B1 (cg-RX-API-DMAC10.html)
JP (1) JP2000506392A (cg-RX-API-DMAC10.html)
AT (1) ATE369385T1 (cg-RX-API-DMAC10.html)
AU (1) AU719841B2 (cg-RX-API-DMAC10.html)
CA (1) CA2246751A1 (cg-RX-API-DMAC10.html)
DE (1) DE69737990T2 (cg-RX-API-DMAC10.html)
ES (1) ES2292193T3 (cg-RX-API-DMAC10.html)
IL (2) IL125711A0 (cg-RX-API-DMAC10.html)
WO (1) WO1997048724A2 (cg-RX-API-DMAC10.html)

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US6620850B2 (en) * 2001-09-19 2003-09-16 University Of Florida Materials and methods for treatment of neurological disorders involving overactivation of glutamatergic ionotropic receptors
US20050233321A1 (en) * 2001-12-20 2005-10-20 Hess John W Identification of novel polymorphic sites in the human mglur8 gene and uses thereof
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Also Published As

Publication number Publication date
IL125711A0 (en) 1999-04-11
EP0882065B1 (en) 2007-08-08
WO1997048724A3 (en) 1998-03-26
JP2000506392A (ja) 2000-05-30
AU3715697A (en) 1998-01-07
EP0882065A2 (en) 1998-12-09
CA2246751A1 (en) 1997-12-24
DE69737990D1 (de) 2007-09-20
US6051688A (en) 2000-04-18
ATE369385T1 (de) 2007-08-15
AU719841B2 (en) 2000-05-18
WO1997048724A2 (en) 1997-12-24
US6084084A (en) 2000-07-04
IL125711A (en) 2006-09-05
US6077675A (en) 2000-06-20
ES2292193T3 (es) 2008-03-01

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