DE69732428D1 - Thiazolderivate für die inhibierung der zytokinproduktion beziehungsweise der zelladhäsion - Google Patents

Thiazolderivate für die inhibierung der zytokinproduktion beziehungsweise der zelladhäsion

Info

Publication number
DE69732428D1
DE69732428D1 DE69732428T DE69732428T DE69732428D1 DE 69732428 D1 DE69732428 D1 DE 69732428D1 DE 69732428 T DE69732428 T DE 69732428T DE 69732428 T DE69732428 T DE 69732428T DE 69732428 D1 DE69732428 D1 DE 69732428D1
Authority
DE
Germany
Prior art keywords
inhibition
cell adhesion
cytokine production
production relationship
thiazol derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69732428T
Other languages
English (en)
Other versions
DE69732428T2 (de
Inventor
Masatoshi Chihiro
Takayuki Matsuzaki
Hisashi Nagamoto
Goro Miyakoda
Shinobu Sueyoshi
Toyoki Mori
Kazuyoshi Kitano
Isao Takemura
Hiroshi Yamashita
Muneaki Kurimura
Fujio Tabusa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69732428D1 publication Critical patent/DE69732428D1/de
Publication of DE69732428T2 publication Critical patent/DE69732428T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69732428T 1996-09-30 1997-09-29 Thiazolderivate für die inhibierung der zytokinproduktion beziehungsweise der zelladhäsion Expired - Lifetime DE69732428T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP25853396 1996-09-30
JP25853396 1996-09-30
PCT/JP1997/003466 WO1998014191A1 (en) 1996-09-30 1997-09-29 Agent for inhibition of cytokine production and agent for inhibition of cell adhesion

Publications (2)

Publication Number Publication Date
DE69732428D1 true DE69732428D1 (de) 2005-03-10
DE69732428T2 DE69732428T2 (de) 2005-12-29

Family

ID=17321550

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69732428T Expired - Lifetime DE69732428T2 (de) 1996-09-30 1997-09-29 Thiazolderivate für die inhibierung der zytokinproduktion beziehungsweise der zelladhäsion

Country Status (18)

Country Link
US (5) US6291487B1 (de)
EP (1) EP0957915B1 (de)
KR (2) KR20000048603A (de)
CN (2) CN1190193C (de)
AR (2) AR009376A1 (de)
AT (1) ATE288267T1 (de)
AU (1) AU714349B2 (de)
BR (1) BR9712140A (de)
CA (1) CA2265746C (de)
DE (1) DE69732428T2 (de)
EG (1) EG24160A (de)
ES (1) ES2237803T3 (de)
HK (2) HK1022419A1 (de)
ID (1) ID21933A (de)
MY (1) MY128323A (de)
PT (1) PT957915E (de)
TW (1) TW529950B (de)
WO (1) WO1998014191A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY128323A (en) * 1996-09-30 2007-01-31 Otsuka Pharma Co Ltd Thiazole derivatives for inhibition of cytokine production and of cell adhesion
US7101899B1 (en) * 1999-04-23 2006-09-05 Takeda Pharmaceutical Company Limited 5-pyridyl-1,3-azole compounds, process for producing the same and use thereof
BR0208719A (pt) * 2001-07-24 2004-07-20 Otsuka Pharma Co Ltd Uso de um composto
JP3836019B2 (ja) * 2001-11-21 2006-10-18 松下電器産業株式会社 受信装置、送信装置及び送信方法
TW200503700A (en) * 2003-07-17 2005-02-01 Otsuka Pharma Co Ltd Enema preparation
EP3067053A1 (de) * 2004-10-13 2016-09-14 PTC Therapeutics, Inc. Verbindungen zur nonsense-unterdrückung und verfahren zu deren verwendung
JP5800451B2 (ja) * 2005-04-08 2015-10-28 ピーティーシー セラピューティクス，インコーポレーテッド ナンセンス突然変異抑制治療用の、経口的に活性な１，２，４−オキサジアゾール組成物
AU2006244203B2 (en) * 2005-05-09 2012-05-03 Achillion Pharmaceuticals, Inc. Thiazole compounds and methods of use
EP1983980A4 (de) * 2006-01-25 2010-05-05 Synta Pharmaceuticals Corp Thiazol- und thiadiazol-verbindungen für verwendungen in verbindung mit entzündung und immunität
TWI394753B (zh) 2006-03-17 2013-05-01 Otsuka Pharma Co Ltd 新穎替妥牟拉（ｔｅｔｏｍｉｌａｓｔ）晶體
TWI436761B (zh) 2006-06-19 2014-05-11 Otsuka Pharma Co Ltd 使用噻唑衍生物之方法
US9187485B2 (en) 2007-02-02 2015-11-17 Baylor College Of Medicine Methods and compositions for the treatment of cancer and related hyperproliferative disorders
CN101674730B (zh) 2007-02-02 2014-09-10 贝勒医学院 用于治疗代谢疾病的组合物和方法
US9212179B2 (en) 2007-02-02 2015-12-15 Baylor College Of Medicine Compositions and methods for the treatment of metabolic disorders
US9085566B2 (en) 2007-02-02 2015-07-21 Baylor College Of Medicine Compositions and methods for the treatment of metabolic and related disorders
US9233941B2 (en) 2007-02-02 2016-01-12 Baylor College Of Medicine Methods and compositions for the treatment of body weight related disorders
EP2164846A2 (de) * 2007-05-22 2010-03-24 Achillion Pharmaceuticals, Inc. Heteroaryl substituerte thiazole und ihre verwendung als antiviralen wirkstoffe.
JP2011513203A (ja) * 2008-03-14 2011-04-28 大塚製薬株式会社 Ｍｍｐ−２及び／又はｍｍｐ−９阻害剤
WO2022128051A1 (en) 2020-12-14 2022-06-23 Symrise Ag Medicament for fighting inflammatory conditions of human skin (ii)

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE204094C (de)
FR8018E (de)
US1970656A (en) 1931-11-04 1934-08-21 Winthrop Chem Co Inc Thiazole compound and process of producing the same
BE623714A (de) 1961-10-19
JPS3910130B1 (de) 1962-05-10 1964-06-10
US3320270A (en) 1963-10-08 1967-05-16 Tri Kem Corp Certain 2-acylimidothiazole compounds
US3401120A (en) 1965-10-23 1968-09-10 Gaf Corp Corrosion inhibitors
DE1670383A1 (de) 1966-09-14 1970-10-29 Ciba Geigy Neue Tetrahydroimidazole und Verfahren zu ihrer Herstellung
US3462448A (en) 1966-10-27 1969-08-19 Dow Chemical Co Substituted phenyl thiazole compounds
IL28803A (en) 1966-11-18 1974-05-16 Wyeth John & Brother Ltd Oxazole and thiazole compounds,their preparation and pharmaceutical compositions containing them
FI53314C (fi) 1967-06-14 1978-04-10 Wyeth John & Brother Ltd Foerfarande foer framstaellning av farmaceutiskt anvaendbar 2-(fenyleller p-klorfenyl) oxazol-4-yl (aettiksyra -acetatsalt eller -acetamid)
GB1226548A (de) 1967-06-14 1971-03-31 Wyeth John & Brother Ltd
GB1245087A (en) 1967-10-26 1971-09-02 Wyeth John & Brother Ltd Heterocyclic compounds
US3625999A (en) 1968-02-19 1971-12-07 Lever Brothers Ltd Process for the preparation of phosphonium sulfonate salts
GB1262292A (en) 1968-04-09 1972-02-02 Wyeth John & Brother Ltd Novel thiazoline derivatives, the preparation thereof and compositions containing the same
US4001420A (en) 1968-12-12 1977-01-04 Science Union Et Cie, Societe Francaise De Recherche Medical Thiazolyl benzoic acid compounds
GB1248070A (en) 1968-12-16 1971-09-29 Science Union & Cie Thiazolyl-benzoic acid derivatives and process for preparing them
US3635999A (en) 1969-03-25 1972-01-18 Aquitaine Petrole Synthesis of oxazoles
US3705153A (en) 1969-05-14 1972-12-05 Sumitomo Chemical Co Novel thiazolyacetic acids and salts thereof
FR2082164A5 (en) 1970-03-05 1971-12-10 Aries Robert Phenylalkyl esters of oxazolyl and thiazolyl carboxylic - acids - analgesics, antiinflammatories, tranquilisers
GB1308028A (en) 1970-06-12 1973-02-21 Science Union & Cie Thiazolylbenzoic acid derivatives and a process for their manufactur
DE2048272C3 (de) 1970-10-01 1974-10-17 Dynamit Nobel Ag, 5210 Troisdorf Verfahren zur Herstellung von 1,1,2-Trimethoxyäthanund o-Essigsäuremethylester
CA962269A (en) 1971-05-05 1975-02-04 Robert E. Grahame (Jr.) Thiazoles, and their use as insecticides
GB1381860A (en) 1971-06-03 1975-01-29 Wyeth John & Brother Ltd Tetrazole derivatives
JPS471469A (de) 1971-06-22 1972-01-25
DE2152367C2 (de) 1971-10-21 1985-01-03 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von 4- Methyl-oxazolen
BE791087A (fr) 1971-11-15 1973-03-01 Lepetit Spa Oxazoles 2,4,5-trisubstitues et leur preparation
JPS4938268A (de) 1972-08-16 1974-04-09
JPS4938267A (de) 1972-08-18 1974-04-09
JPS5327586B2 (de) 1972-08-23 1978-08-09
JPS503315A (de) 1973-05-10 1975-01-14
US4072689A (en) 1973-02-22 1978-02-07 Gruppo Lepetit S.P.A. Monoamino 2,4,5-trisubstituted oxazoles
JPS5030619A (de) 1973-07-23 1975-03-26
HU168036B (de) 1973-11-09 1976-02-28
DE2711655A1 (de) 1977-03-17 1978-09-21 Basf Ag Pyridinyl-aminoalkylaether
US4259341A (en) 1977-06-01 1981-03-31 Merck & Co., Inc. Di- and tri-substituted thiazoles
US4153703A (en) 1977-06-30 1979-05-08 Uniroyal, Inc. Method of controlling insects and acarids with certain aryl-substituted thiazoles
JPS5461936A (en) 1977-10-26 1979-05-18 Ricoh Co Ltd Photoreceptor for electrophotography
JPS6051475B2 (ja) 1977-11-08 1985-11-14 久光製薬株式会社 新規なフエニル酢酸誘導体
GB1574583A (en) 1978-02-09 1980-09-10 Wyeth John & Brother Ltd Process for preparing thiazoles
US4267179A (en) 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4221584A (en) 1979-02-09 1980-09-09 Chevron Research Company Herbicidal and plant-growth-regulating N-(heterocyclyl)-methylacetanilides
JPS55111418A (en) 1979-02-21 1980-08-28 Santen Pharmaceut Co Ltd Remedy for eye disease and its preparation
NZ193011A (en) 1979-03-19 1983-03-15 Ici Australia Ltd Diarylamine derivatives intermediates herbicidal compositions
AU534093B2 (en) 1979-03-19 1984-01-05 Ici Australia Limited Thiazoles,benzthiazoles, benzoxazoles and benzimidazoles
JPS55133366A (en) * 1979-04-05 1980-10-17 Otsuka Pharmaceut Factory Inc Thiazole derivative
US4298743A (en) 1979-09-11 1981-11-03 Merck & Co., Inc. 4-(Substituted phenyl thiazolyl)-3-hydroxy-3-pyrroline-2,5-diones
JPS56123544A (en) 1980-03-03 1981-09-28 Hitachi Ltd Composite type electrophotographic plate and electrophotographic method using it
US4322428A (en) 1980-04-02 1982-03-30 Eli Lilly And Company 2(4-Fluorophenyl)-4,5,-bis(4-methoxyphenyl)thiazole and method of use
ZA811691B (en) 1980-04-03 1982-10-27 Wyeth John & Brother Ltd Thiazoles
US4329459A (en) 1980-05-05 1982-05-11 The Upjohn Company Tetrahydrobenzopyran derivatives
US4282364A (en) 1980-05-22 1981-08-04 Merck & Co., Inc. Process for the preparation of thiazoles
JPS58120257A (ja) 1982-01-12 1983-07-18 Hitachi Chem Co Ltd 電子写真感光体
JPS58201771A (ja) 1982-05-19 1983-11-24 Tanabe Seiyaku Co Ltd アルキルオキサゾリル酢酸誘導体
JPS58219169A (ja) 1982-06-15 1983-12-20 Takeda Chem Ind Ltd オキサゾ−ル酢酸誘導体
JPS5925381A (ja) 1982-06-30 1984-02-09 Hisamitsu Pharmaceut Co Inc 新規なフエニル酢酸誘導体
JPS5925380A (ja) 1982-06-30 1984-02-09 Hisamitsu Pharmaceut Co Inc 新規なフエニル酢酸誘導体
US4659657A (en) 1982-12-24 1987-04-21 Bayer Aktiengesellschaft Chromogenic and fluorogenic esters for photometric or fluorimetric determination of phosphatases or sulphatases
JPS6058981A (ja) 1983-09-09 1985-04-05 Takeda Chem Ind Ltd ５−ピリジル−１，３−チアゾ−ル誘導体，その製造法およびそれを含んでなる医薬組成物
JPS6051111A (ja) 1983-08-30 1985-03-22 Tanabe Seiyaku Co Ltd 抗脂血剤
DE3406329A1 (de) 1984-02-22 1985-08-22 Merck Patent Gmbh, 6100 Darmstadt Pyridone
US4659726A (en) 1984-04-19 1987-04-21 Kanebo, Ltd. Novel 4,5-Bis (4-methoxyphenyl)-2-(pyrrol-2-yl) thiazoles and pharmaceutical composition containing the same
JPS60222481A (ja) 1984-04-19 1985-11-07 Kanebo Ltd 新規なジフエニルピロリルチアゾ−ル誘導体、その製造法およびそれを有効成分とする医薬組成物
JPS60230147A (ja) 1984-04-27 1985-11-15 Ricoh Co Ltd 電子写真製版用印刷原版
DE3425118A1 (de) 1984-07-07 1986-01-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue redox-indikatoren
JPS6123790A (ja) 1984-07-12 1986-02-01 Hitachi Cable Ltd ＮｉまたはＮｉ合金表面へのメツキ方法
DK402785D0 (da) 1985-09-03 1985-09-03 Syn Tek Ab Fremgangsmaade til fremstilling af et enzym
DE3601411A1 (de) 1986-01-20 1987-07-23 Nattermann A & Cie 3-amino-1-(2-thiazolyl)-2-pyrazoline, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4833155A (en) * 1986-11-25 1989-05-23 Syntex (U.S.A.) Inc. 3-(ω-(3,5,-di-t-butyl-4-hydroxyphenyl)-alkanoyl)pyrroles, and anti-inflammatory uses thereof
US4791200A (en) 1987-06-22 1988-12-13 Ortho Pharmaceutical Corporation 2-substituted-4-aryl-substituted thiazoles
MY104933A (en) 1987-09-30 1994-07-30 Pfizer Ltd Platelet activating factor antagonists
US5149814A (en) 1987-09-30 1992-09-22 Pfizer Inc Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters as intermediate compounds
US4826990A (en) 1987-09-30 1989-05-02 American Home Products Corporation 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents
DE3929233A1 (de) 1989-09-02 1991-03-07 Bayer Ag 5-heterocyclyl-pyridin-3-carbon-benzylamide und -anilide
US5370870A (en) 1989-10-06 1994-12-06 Genentech, Inc. Method for protection against reactive oxygen species
AU621245B2 (en) 1989-10-17 1992-03-05 Boehringer Mannheim Gmbh Hydrolase substrates, a process for the preparation thereof and agents containing them
ES2245660T3 (es) * 1990-11-30 2006-01-16 Otsuka Pharmaceutical Co., Ltd. Derivados de azol y su utilizacion como inhibidores de los radicales superoxidos.
JP2719742B2 (ja) * 1991-04-30 1998-02-25 株式会社大塚製薬工場 フェニルチアゾール誘導体
US5476944A (en) * 1991-11-18 1995-12-19 G. D. Searle & Co. Derivatives of cyclic phenolic thioethers
US5194434A (en) * 1991-12-03 1993-03-16 Texas A&M University System Use of OB-101 to treat ocular inflammation
US5441951A (en) * 1994-06-15 1995-08-15 Brigham & Women's Hospital Lipoxin compounds
US5629322A (en) * 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
MY128323A (en) * 1996-09-30 2007-01-31 Otsuka Pharma Co Ltd Thiazole derivatives for inhibition of cytokine production and of cell adhesion
US6069908A (en) 1998-02-09 2000-05-30 Hewlwtt-Packard Company N-drive or P-drive VCSEL array
WO2001071280A2 (en) 2000-03-23 2001-09-27 Snap-On Technologies, Inc. Self-calibrating, multi-camera machine vision measuring system
JP3910130B2 (ja) 2002-09-30 2007-04-25 ファナック株式会社 ロボットシステム
US7550924B2 (en) 2003-02-27 2009-06-23 Koninklijke Philips Electronics N.V. High-pressure discharge lamp having a metal exhaust tube
JP4624696B2 (ja) 2004-03-10 2011-02-02 オリンパス株式会社 外科用処置具
JP4615935B2 (ja) 2004-08-26 2011-01-19 オリンパス株式会社 内視鏡可撓管およびその製造方法
KR100818522B1 (ko) 2004-08-31 2008-03-31 삼성전기주식회사 레이저 다이오드의 제조방법
JP4639856B2 (ja) 2005-03-07 2011-02-23 トヨタ自動車株式会社 車輌の摩擦制動装置
JP4938268B2 (ja) 2005-08-30 2012-05-23 株式会社ノーリツ 熱回収装置、並びに、コージェネレーションシステム
JP5030619B2 (ja) 2007-02-28 2012-09-19 株式会社サクラクレパス イーゼル
JP4939262B2 (ja) 2007-03-09 2012-05-23 本田技研工業株式会社 加工システム
JP4641542B2 (ja) 2007-11-30 2011-03-02 サミー株式会社 弾球遊技機

Also Published As

Publication number Publication date
US6583163B2 (en) 2003-06-24
ID21933A (id) 1999-08-12
PT957915E (pt) 2005-04-29
BR9712140A (pt) 1999-08-31
AU4322197A (en) 1998-04-24
CN1236769C (zh) 2006-01-18
MY128323A (en) 2007-01-31
ES2237803T3 (es) 2005-08-01
US20070105911A1 (en) 2007-05-10
DE69732428T2 (de) 2005-12-29
US20070238758A1 (en) 2007-10-11
AR009376A1 (es) 2000-04-12
KR100503704B1 (ko) 2005-07-25
CA2265746A1 (en) 1998-04-09
US20040014792A1 (en) 2004-01-22
TW529950B (en) 2003-05-01
KR20000048603A (ko) 2000-07-25
CA2265746C (en) 2004-04-20
AR068695A2 (es) 2009-12-02
KR20050042829A (ko) 2005-05-11
EP0957915A1 (de) 1999-11-24
ATE288267T1 (de) 2005-02-15
EG24160A (en) 2008-08-20
WO1998014191A1 (en) 1998-04-09
HK1022419A1 (en) 2000-08-11
AU714349B2 (en) 1999-12-23
US6291487B1 (en) 2001-09-18
CN1494904A (zh) 2004-05-12
CN1190193C (zh) 2005-02-23
US20020013469A1 (en) 2002-01-31
HK1064038A1 (en) 2005-01-21
CN1232396A (zh) 1999-10-20
US8354439B2 (en) 2013-01-15
EP0957915B1 (de) 2005-02-02

Similar Documents

Publication Publication Date Title
DE69732428D1 (de) Thiazolderivate für die inhibierung der zytokinproduktion beziehungsweise der zelladhäsion
DE69932032D1 (de) Inhibitoren der alpha4 vermittelten zelladhäsion
FI951001A0 (fi) Sulfatoituja alfa-glykolipidijohdannaisia soluadheesioinhibiittoreina
ATE307117T1 (de) Succinoylaminolactamderivate als inhibitoren der a beta protein produktion
AU8147198A (en) Use of ppargamma agonists for inhibition of inflammatory cytokine production
DE69937076D1 (de) Zwischenprodukte für die Herstellung von Imidazo-Pyridin-Derivate
PL345817A1 (en) Amide derivatives useful as inhibitors of the production of cytokines
EE9700362A (et) Rakuadhesiooni inhibiitorid
NO20006157D0 (no) Celleadhesjons-inhiberende anti-inflammatoriske forbindelser
ID27037A (id) Gen untuk desaturasa untuk mengubah profil lipida pada jagung
EP0743951A4 (de) Substituierte laktosederivate als zelladhäsionsinhibitoren
NO985966D0 (no) Celleadhesjonsinhiberende forbindelser
DE69909274D1 (de) Mechanisches hilfsherz für die wiederherstellung der herzfunktion
IT1295072B1 (it) Procedimento per la produzione di stirene
IT1298535B1 (it) Procedimento per la produzione di gamma-butirrolattone
ID26478A (id) Penggambaran kelima macam langkah produksi
IS4980A (is) Aðferðir og milliefni við framleiðslu á setnum krómanól afleiðum
FI951002A0 (fi) Sulfatoituja beta-glykolipidijohdannaisia soluadheesioinhibiittoreina
EE03958B1 (et) Valuvorm pingebetoonelementide valmistamiseks
DE69315721D1 (de) Oligosaccharidderivate für die Alpha-Amylasebestimmung
IT1283301B1 (it) Macchina per la produzione,mediante colata continua,di nastri metallici,particolarmente per la produzione di nastri metallici
NO301870B1 (no) Produksjonslinje for forming av stålstrimler
TR199801514A3 (tr) N-Piruvil-L-Prolin üretimi için yöntem.
IT1286224B1 (it) Stampo per la fabbricazione di piastrelle ceramiche
LV12205A (lv) Buvelementu razosanas panemiens

Legal Events

Date Code Title Description
8364 No opposition during term of opposition