GB1381860A - Tetrazole derivatives - Google Patents
Tetrazole derivativesInfo
- Publication number
- GB1381860A GB1381860A GB1876671A GB1876671A GB1381860A GB 1381860 A GB1381860 A GB 1381860A GB 1876671 A GB1876671 A GB 1876671A GB 1876671 A GB1876671 A GB 1876671A GB 1381860 A GB1381860 A GB 1381860A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- carbocyclic
- furan
- june
- substituent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1381860 Tetrazole derivatives JOHN WYETH & BROTHER Ltd 2 June 1972 [3 June 1971] 18766/71 Heading C2C The invention comprises compounds of formula wherein n is 0-2 and Het is either (1) an oxazole or thiazole residue containing as first substituent a carbocyclic or heterocyclic aryl, C 5-7 -ring- cycloalkyl or adamantyl group, and as optional second substituent one of these groups or an alkyl group, or (2) a furan, thiophene or pyrrole residue containing as substituents 1 or 2 carbocyclic and/or heterocyclic aryl groups. These compounds are prepared by tetrazole ring- formation. Intermediates prepared are the acid chloride, amide and nitrile of 2,5-di-(p-fluorophenyl)- furan-3-acetic acid; 2-(2-cyanoethyl)-4,5-diphenyloxazole; and 4-(p-chlorophenyl)-5-cyanomethyl-2-phenylthiazole. Therapeutic compositions having antiinflammatory activity comprise compounds of the above formula, which may be administered orally or parenterally.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1876671A GB1381860A (en) | 1971-06-03 | 1971-06-03 | Tetrazole derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1876671A GB1381860A (en) | 1971-06-03 | 1971-06-03 | Tetrazole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1381860A true GB1381860A (en) | 1975-01-29 |
Family
ID=10118050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1876671A Expired GB1381860A (en) | 1971-06-03 | 1971-06-03 | Tetrazole derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1381860A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2663331A1 (en) * | 1990-06-14 | 1991-12-20 | Bellon Labor Sa Roger | NEW OXAZOLE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
US5643932A (en) * | 1990-11-30 | 1997-07-01 | Otsuka Pharmaceutical Co., Ltd. | Superoxide radical inhibitor |
US5710140A (en) * | 1993-06-24 | 1998-01-20 | Merck Frosst Canada, Inc. | Phenyl heterocycles as COX-2 inhibitors |
WO1999018099A1 (en) * | 1997-10-03 | 1999-04-15 | Merck Frosst Canada & Co. | Aryl thiophene derivatives as pde iv inhibitors |
WO2006092059A1 (en) * | 2005-03-04 | 2006-09-08 | Fan Wu | Design and synthesis of novel antimicrobials |
US8354439B2 (en) | 1996-09-30 | 2013-01-15 | Otsuka Pharmaceutical Co., Ltd. | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion |
-
1971
- 1971-06-03 GB GB1876671A patent/GB1381860A/en not_active Expired
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2663331A1 (en) * | 1990-06-14 | 1991-12-20 | Bellon Labor Sa Roger | NEW OXAZOLE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
WO1991019714A1 (en) * | 1990-06-14 | 1991-12-26 | Laboratoire Roger Bellon | Novel oxazole derivatives, a preparation method therefor and pharmaceutical compositions containing same |
US5403852A (en) * | 1990-06-14 | 1995-04-04 | Laboratoire Roger Bellon | Oxazole derivatives, their preparation and pharmaceutical compositions containing them |
US5643932A (en) * | 1990-11-30 | 1997-07-01 | Otsuka Pharmaceutical Co., Ltd. | Superoxide radical inhibitor |
US5677319A (en) * | 1990-11-30 | 1997-10-14 | Otsuka Pharmaceutical Co., Ltd. | Superoxide radical inhibitor |
US6080764A (en) * | 1990-11-30 | 2000-06-27 | Otsuka Pharmaceutical Co., Ltd. | Superoxide radical inhibitor |
USRE37556E1 (en) | 1990-11-30 | 2002-02-19 | Otsuka Pharmaceutical Co., Ltd. | Superoxide radical inhibitor |
US5710140A (en) * | 1993-06-24 | 1998-01-20 | Merck Frosst Canada, Inc. | Phenyl heterocycles as COX-2 inhibitors |
US8354439B2 (en) | 1996-09-30 | 2013-01-15 | Otsuka Pharmaceutical Co., Ltd. | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion |
WO1999018099A1 (en) * | 1997-10-03 | 1999-04-15 | Merck Frosst Canada & Co. | Aryl thiophene derivatives as pde iv inhibitors |
WO2006092059A1 (en) * | 2005-03-04 | 2006-09-08 | Fan Wu | Design and synthesis of novel antimicrobials |
US8835476B2 (en) | 2005-03-04 | 2014-09-16 | Fan Wu | Synthesis of novel antimicrobials |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
746 | Register noted 'licences of right' (sect. 46/1977) |