DE69715888D1 - Pyridylalken- und pyridylalkin-säureamide als cytostatika und immunosuppressive arzneimittel - Google Patents
Pyridylalken- und pyridylalkin-säureamide als cytostatika und immunosuppressive arzneimittelInfo
- Publication number
- DE69715888D1 DE69715888D1 DE69715888T DE69715888T DE69715888D1 DE 69715888 D1 DE69715888 D1 DE 69715888D1 DE 69715888 T DE69715888 T DE 69715888T DE 69715888 T DE69715888 T DE 69715888T DE 69715888 D1 DE69715888 D1 DE 69715888D1
- Authority
- DE
- Germany
- Prior art keywords
- acid amides
- pyridylalkine
- pyridylalken
- cytostatics
- medicinal products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catalysts (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE69715888T DE69715888T2 (de) | 1996-06-20 | 1997-06-20 | Pyridylalken- und pyridylalkin-säureamide als cytostatika und immunosuppressive arzneimittel |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19624659A DE19624659A1 (de) | 1996-06-20 | 1996-06-20 | Neue Pyridylalken- und Pyridylalkinsäureamide |
| DE69715888T DE69715888T2 (de) | 1996-06-20 | 1997-06-20 | Pyridylalken- und pyridylalkin-säureamide als cytostatika und immunosuppressive arzneimittel |
| PCT/EP1997/003245 WO1997048696A1 (en) | 1996-06-20 | 1997-06-20 | Pyridyl alkene- and pyridyl alkine- acid amides as cytostatics and immunosuppressives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69715888D1 true DE69715888D1 (de) | 2002-10-31 |
| DE69715888T2 DE69715888T2 (de) | 2003-07-31 |
Family
ID=7797501
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19624659A Ceased DE19624659A1 (de) | 1996-06-20 | 1996-06-20 | Neue Pyridylalken- und Pyridylalkinsäureamide |
| DE69715888T Expired - Lifetime DE69715888T2 (de) | 1996-06-20 | 1997-06-20 | Pyridylalken- und pyridylalkin-säureamide als cytostatika und immunosuppressive arzneimittel |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19624659A Ceased DE19624659A1 (de) | 1996-06-20 | 1996-06-20 | Neue Pyridylalken- und Pyridylalkinsäureamide |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7241745B2 (de) |
| EP (1) | EP0923570B1 (de) |
| JP (1) | JP4225572B2 (de) |
| CN (2) | CN1546472A (de) |
| AT (1) | ATE224888T1 (de) |
| AU (1) | AU736206B2 (de) |
| BR (1) | BR9709823B1 (de) |
| CA (1) | CA2257448C (de) |
| CZ (1) | CZ291791B6 (de) |
| DE (2) | DE19624659A1 (de) |
| DK (1) | DK0923570T3 (de) |
| ES (1) | ES2179351T3 (de) |
| HK (1) | HK1021974A1 (de) |
| HU (1) | HU225715B1 (de) |
| IL (1) | IL127352A (de) |
| PT (1) | PT923570E (de) |
| RU (1) | RU2200734C2 (de) |
| TR (1) | TR199802651T2 (de) |
| WO (1) | WO1997048696A1 (de) |
| ZA (1) | ZA975437B (de) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19624659A1 (de) * | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
| DE19756236A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue piperazinylsubstituierte Pyridylalkan-, alken- und -alkincarbonsäureamide |
| DE19756235A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide |
| DE19756212A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide |
| DE19756261A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide |
| DE19818044A1 (de) * | 1998-04-22 | 1999-10-28 | Klinge Co Chem Pharm Fab | Verwendung von Vitamin-PP-Verbindungen |
| CA2350722A1 (en) * | 1998-11-17 | 2000-05-25 | Leyi Gong | 4-aroyl-piperidin-ccr-3 receptor antagonists iii |
| EP1031564A1 (de) * | 1999-02-26 | 2000-08-30 | Klinge Pharma GmbH | Hemmer der Nicotinamidmonononukleotide-Bildung und deren Verwendung zur Krebstherapie |
| US6432432B1 (en) | 1999-03-05 | 2002-08-13 | Arch Chemicals, Inc. | Chemical method of making a suspension, emulsion or dispersion of pyrithione particles |
| CO5180550A1 (es) | 1999-04-19 | 2002-07-30 | Smithkline Beecham Corp | Inhibidores de fab i |
| CO5370679A1 (es) | 1999-06-01 | 2004-02-27 | Smithkline Beecham Corp | Inhibidores fab 1 |
| PE20010635A1 (es) | 1999-10-08 | 2001-08-15 | Smithkline Beecham Corp | Inhibidores de fab i utiles para el tratamiento de infecciones bacterianas |
| US6762201B1 (en) | 1999-10-08 | 2004-07-13 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| US6730684B1 (en) | 1999-10-08 | 2004-05-04 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| ES2320984T3 (es) | 2001-04-06 | 2009-06-01 | Affinium Pharmaceuticals, Inc. | Inhibidores de fab i. |
| EP1348434A1 (de) * | 2002-03-27 | 2003-10-01 | Fujisawa Deutschland GmbH | Verwendung von Pyridylamiden als Inhibitoren von Angiogenese |
| DK1599468T3 (da) | 2003-01-14 | 2008-02-04 | Arena Pharm Inc | 1,2,3-trisubstituerede aryl- og heteroarylderivater som modulatorer af metabolisme og forebyggelse og behandling af forstyrrelser forbundet dermed såsom diabetes og hyperglykæmi |
| EP1768662A2 (de) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Immunstimulatoren kleiner moleküle und assays für deren nachweis |
| DOP2006000010A (es) | 2005-01-10 | 2006-07-31 | Arena Pharm Inc | Procedimiento para preparar eteres aromáticos |
| US20110045065A1 (en) * | 2005-07-11 | 2011-02-24 | Ashok Vasantray Vyas | Substance having antioxidant, geroprotective and anti-ischemic activity and method for the preparation thereof |
| US8067457B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
| US8067415B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
| EP2054422B1 (de) | 2006-07-20 | 2017-06-14 | Debiopharm International SA | Acrylamidderivate als fab-i-inhibitoren |
| WO2008026018A1 (en) | 2006-09-01 | 2008-03-06 | Topotarget Switzerland Sa | New method for the treatment of inflammatory diseases |
| US8263613B2 (en) | 2007-02-16 | 2012-09-11 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab I inhibitors |
| EP2098231A1 (de) | 2008-03-05 | 2009-09-09 | Topotarget Switzerland SA | Verwendung von NAD Synthesis Hemmern zur Behandlung von ischämischen Reperfusionsschäden |
| RU2529468C2 (ru) | 2008-06-24 | 2014-09-27 | Топотаргет А/С | Производные 1, 2-дигидроциклобутендиона в качестве ингибиторов фосфорибозилтрансферазы никотинамида |
| JP5688367B2 (ja) | 2008-08-29 | 2015-03-25 | トポターゲット・アクティーゼルスカブＴｏｐｏＴａｒｇｅｔ Ａ／Ｓ | 新規なウレアおよびチオウレア誘導体 |
| CN102421754B (zh) * | 2009-05-12 | 2013-11-27 | 北京世桥生物制药有限公司 | 丙烯酰胺类衍生物及其制备药物的用途 |
| WO2011006988A1 (en) | 2009-07-17 | 2011-01-20 | Topotarget A/S | Method for predicting the utility of administering nicotinic acid or a precursor or prodrug thereof to reduce the severity of side-effects of cancer treatment with nicotinamide phosphoribosyltransferase inhibitors |
| WO2011121055A1 (en) | 2010-03-31 | 2011-10-06 | Topotarget A/S | Pyridinyl derivatives comprising a cyanoguanidine or squaric acid moiety |
| TW201216963A (en) | 2010-09-03 | 2012-05-01 | Forma Therapeutics Inc | Novel compounds and compositions for the inhibition of NAMPT |
| JP6038792B2 (ja) | 2010-09-03 | 2016-12-07 | フォーマ ティーエム， エルエルシー． | 癌などの疾患の治療のためのｎａｍｐｔ阻害剤としての４−｛［（ピリジン−３−イル−メチル）アミノカルボニル］アミノ｝ベンゼン−スルホン誘導体 |
| RU2617988C2 (ru) | 2010-09-03 | 2017-05-02 | ФОРМА ТиЭм, ЭлЭлСИ | Новые соединения и композиции для ингибирования nampt |
| SG188548A1 (en) | 2010-09-22 | 2013-04-30 | Arena Pharm Inc | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| AU2011310592B2 (en) * | 2010-09-29 | 2015-01-22 | Intervet International B.V. | N-heteroaryl compounds |
| EP2640704A1 (de) | 2010-11-15 | 2013-09-25 | Abbvie Inc. | Nampt-inhibitoren |
| UY33726A (es) | 2010-11-15 | 2012-06-29 | Abbott Lab | Inhibidores de nampt y rock |
| RU2616612C2 (ru) * | 2011-05-04 | 2017-04-18 | ФОРМА ТиЭм, ЭлЭлСИ | Новые соединения и композиции для ингибирования nampt |
| JP5872027B2 (ja) | 2011-05-09 | 2016-03-01 | フォーマ ティーエム， エルエルシー． | ニコチンアミドホスホリボシルトランスフェラーゼ（ｎａｍｐｔ）を阻害するためのピペリジン誘導体および組成物 |
| EP2736887B1 (de) | 2011-07-29 | 2017-10-18 | Karyopharm Therapeutics, Inc. | Hydrazidhaltige kerntransportmodulatoren und verwendungen davon |
| US9096543B2 (en) * | 2012-05-09 | 2015-08-04 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| JP2015516436A (ja) | 2012-05-11 | 2015-06-11 | アッヴィ・インコーポレイテッド | Ｎａｍｐｔ阻害薬 |
| JP2015520752A (ja) | 2012-05-11 | 2015-07-23 | アッヴィ・インコーポレイテッド | Ｎａｍｐｔ阻害薬としてのピリダジンおよびピリジン誘導体 |
| US9193723B2 (en) | 2012-05-11 | 2015-11-24 | Abbvie Inc. | NAMPT inhibitors |
| CN104271572A (zh) | 2012-05-11 | 2015-01-07 | 艾伯维公司 | 用作nampt抑制剂的噻唑羧酰胺衍生物 |
| NZ702695A (en) | 2012-06-19 | 2015-10-30 | Debiopharm Int Sa | Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide |
| US9938258B2 (en) | 2012-11-29 | 2018-04-10 | Karyopharm Therapeutics Inc. | Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof |
| US10202366B2 (en) | 2013-03-15 | 2019-02-12 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using CRM1 inhibitors |
| EP3010892B8 (de) | 2013-06-21 | 2019-05-22 | Karyopharm Therapeutics Inc. | 1,2,4-triazole als nukleartransportmodulatoren und verwendungen davon |
| CN108440515B (zh) * | 2013-07-03 | 2022-05-03 | 卡尔约药物治疗公司 | 取代的苯并呋喃基和苯并噁唑基化合物及其用途 |
| WO2015042414A1 (en) | 2013-09-20 | 2015-03-26 | Karyopharm Therapeutics Inc. | Multicyclic compounds and methods of using same |
| CN105579449A (zh) * | 2013-10-09 | 2016-05-11 | 伊莱利利公司 | 新的用作nampt抑制剂的吡啶基氧基乙酰基四氢异喹啉化合物 |
| CA2954328A1 (en) | 2014-07-23 | 2016-01-28 | Aurigene Discovery Technologies Limited | 4,5-dihydroisoxazole derivatives as nampt inhibitors |
| CN111484483B (zh) | 2014-08-15 | 2023-05-26 | 卡尔约药物治疗公司 | 赛灵克斯的多晶型物 |
| EP3242666A1 (de) | 2015-01-06 | 2017-11-15 | Arena Pharmaceuticals, Inc. | Verfahren zur behandlung von erkrankungen im zusammenhang mit dem s1p1-rezeptor |
| CN104447483B (zh) * | 2015-01-13 | 2016-07-27 | 佛山市赛维斯医药科技有限公司 | 含苯胺和二烯金刚烷结构的化合物、其制备方法和用途 |
| CN104447486B (zh) * | 2015-01-13 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 二烯氟代金刚烷类化合物、其制备方法和用途 |
| CN104447484B (zh) * | 2015-01-13 | 2016-06-08 | 佛山市赛维斯医药科技有限公司 | 含烷氧苯基和二烯金刚烷结构的化合物、其制备方法和用途 |
| JP6838744B2 (ja) | 2015-06-22 | 2021-03-03 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Ｓ１Ｐ１レセプター関連障害における使用のための（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸（化合物１）の結晶性Ｌ−アルギニン塩 |
| EP3337797A1 (de) | 2015-08-18 | 2018-06-27 | Karyopharm Therapeutics, Inc. | (s,e) -3-(6-aminopyridin-3-yl ) -n-((5-(4-(3-fluor-3-methylpyrrolidin-1-carbonyl) ) phenyl) -7-(4-fluorphenyl) benzofuran-2-yl) methyl) acrylamid zur behandlung von krebs |
| TWI721016B (zh) * | 2015-09-15 | 2021-03-11 | 美商艾森伯利生物科學公司 | B型肝炎核心蛋白質調節劑 |
| WO2017117529A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| WO2017117447A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Multicyclic compounds and uses thereof |
| US10709706B2 (en) | 2015-12-31 | 2020-07-14 | Karopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US10751351B2 (en) | 2016-02-26 | 2020-08-25 | Debiopharm International S.A. | Medicament for treatment of diabetic foot infections |
| EP3279192A1 (de) * | 2016-08-05 | 2018-02-07 | Centre Hospitalier Universitaire Vaudois (CHUV) | Piperidinderivate zur verwendung in der behandlung von pankreaskrebs |
| WO2018086703A1 (en) | 2016-11-11 | 2018-05-17 | Bayer Pharma Aktiengesellschaft | Dihydropyridazinones substituted with phenylureas |
| US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
| CN107827897A (zh) * | 2017-10-23 | 2018-03-23 | 青岛大学 | 一种手性七元螺环吲哚酮类化合物的合成方法 |
| JP2021512103A (ja) | 2018-01-31 | 2021-05-13 | バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｎａｍｐｔ阻害剤を含む抗体薬物複合体（ａｄｃｓ） |
| CN108558840B (zh) * | 2018-06-04 | 2020-11-06 | 上海交通大学 | 水溶性氮杂α-萘黄酮类化合物及其制备方法和医药用途 |
| WO2021013693A1 (en) | 2019-07-23 | 2021-01-28 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (adcs) with nampt inhibitors |
| US20230023124A1 (en) | 2019-11-06 | 2023-01-26 | Remedy Plan, Inc. | Cancer treatments targeting cancer stem cells |
| JP2024518089A (ja) | 2021-05-13 | 2024-04-24 | リメディー プラン，インコーポレーテッド | Ｎａｍｐｔ阻害剤とその使用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4283541A (en) | 1980-05-27 | 1981-08-11 | Usv Pharmaceutical Corporation | Pyridylacyl-hydroxamates |
| NL8005133A (nl) | 1980-09-12 | 1982-04-01 | Duphar Int Res | Fenylpiperazinederivaten met antiagressieve werking. |
| US5326772A (en) | 1984-09-28 | 1994-07-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Diaryl compounds for their use |
| US4778796A (en) | 1985-07-19 | 1988-10-18 | Dainippon Pharmaceutical Co., Ltd. | ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same |
| DE3641822A1 (de) | 1986-12-06 | 1988-06-16 | Goedecke Ag | Verwendung von dihydrophenylaminosaeurederivaten und diese enthaltende arzneimittel zur immunmodulation und cytostase |
| JPS63179869A (ja) | 1987-01-20 | 1988-07-23 | Dainippon Pharmaceut Co Ltd | ピペリジン誘導体 |
| JP2832979B2 (ja) * | 1988-02-15 | 1998-12-09 | 武田薬品工業株式会社 | 不飽和カルボン酸アミド誘導体 |
| EP0401256B1 (de) | 1988-02-19 | 1993-05-26 | Byk Gulden Lomberg Chemische Fabrik GmbH | Optisch reines dexniguldipin und dessen derivate zur behandlung von tumorerkrankungen |
| EP0343307A1 (de) * | 1988-05-26 | 1989-11-29 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. | 4-Piperidinalkanamin-Derivate |
| IE903196A1 (en) | 1989-09-05 | 1991-03-13 | Searle & Co | Substituted n-benzylpiperidine amides |
| IE903957A1 (en) | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
| CA2080127A1 (en) | 1990-04-10 | 1991-10-11 | Peter Zimmermann | Pyridines as medicaments |
| AU7652391A (en) | 1990-04-10 | 1991-10-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel pyridine esters |
| US5260323A (en) | 1990-06-28 | 1993-11-09 | Hoechst Aktiengesellschaft | 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use |
| DE4020570A1 (de) | 1990-06-28 | 1992-01-02 | Hoechst Ag | 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung |
| DK0471236T3 (da) | 1990-07-30 | 1995-07-24 | Takeda Chemical Industries Ltd | Imidazopyridinderivater og deres anvendelse |
| EP0479601B1 (de) | 1990-10-05 | 1999-12-15 | Ajinomoto Co., Inc. | Piperidinderivate und ihre Verwendung als antiarrhythmische Wirkstoffe |
| FR2676053B1 (fr) | 1991-05-03 | 1993-08-27 | Sanofi Elf | Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| ATE152102T1 (de) | 1991-05-10 | 1997-05-15 | Takeda Chemical Industries Ltd | Pyridinderivate, deren herstellung und anwendung |
| US5208247A (en) | 1991-08-01 | 1993-05-04 | American Cyanamid Company | Pyridinium compounds which are useful as antagonists of platelet activating factor |
| CA2085954A1 (en) | 1991-12-24 | 1993-06-25 | Klaus Weidmann | Substituted pyridine n-oxides, processes for their preparation, and their use |
| US5622976A (en) | 1991-12-31 | 1997-04-22 | Fujisawa Pharmaceutical Co., Ltd. | Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity |
| FR2686084B1 (fr) | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
| GB9200535D0 (en) | 1992-01-10 | 1992-02-26 | Fujisawa Pharmaceutical Co | New compound |
| US5612336A (en) | 1992-07-13 | 1997-03-18 | Merck, Sharp & Dohme Ltd. | Heterocyclic amide derivatives as tachykinin antagonists |
| ATE210652T1 (de) | 1993-10-15 | 2001-12-15 | Schering Corp | Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen |
| NZ275646A (en) | 1993-10-15 | 1998-02-26 | Schering Corp | Tricyclic sulphonamide derivatives and medicaments |
| IL111235A (en) | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| EP0750496A1 (de) | 1994-03-14 | 1997-01-02 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Verwendung von lipoxygenase-hemmet als therapeutische und interventions- antikrebsmittel |
| US5712280A (en) | 1995-04-07 | 1998-01-27 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| IL117798A (en) | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| FR2738245B1 (fr) | 1995-08-28 | 1997-11-21 | Sanofi Sa | Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant |
| DE19624659A1 (de) * | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
| DE19624704A1 (de) * | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalkansäureamide |
| US6451816B1 (en) * | 1997-06-20 | 2002-09-17 | Klinge Pharma Gmbh | Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression |
| DE19624668A1 (de) | 1996-06-20 | 1998-02-19 | Klinge Co Chem Pharm Fab | Verwendung von Pyridylalkan-, Pyridylalken- bzw. Pyridylalkinsäureamiden |
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1996
- 1996-06-20 DE DE19624659A patent/DE19624659A1/de not_active Ceased
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1997
- 1997-06-19 ZA ZA9705437A patent/ZA975437B/xx unknown
- 1997-06-20 RU RU99101069/04A patent/RU2200734C2/ru not_active IP Right Cessation
- 1997-06-20 DE DE69715888T patent/DE69715888T2/de not_active Expired - Lifetime
- 1997-06-20 CN CNA2004100325866A patent/CN1546472A/zh active Pending
- 1997-06-20 CZ CZ19984093A patent/CZ291791B6/cs not_active IP Right Cessation
- 1997-06-20 IL IL12735297A patent/IL127352A/xx not_active IP Right Cessation
- 1997-06-20 CA CA002257448A patent/CA2257448C/en not_active Expired - Fee Related
- 1997-06-20 AU AU32625/97A patent/AU736206B2/en not_active Ceased
- 1997-06-20 HU HU9903766A patent/HU225715B1/hu not_active IP Right Cessation
- 1997-06-20 CN CNB971974241A patent/CN1152032C/zh not_active Expired - Fee Related
- 1997-06-20 WO PCT/EP1997/003245 patent/WO1997048696A1/en active IP Right Grant
- 1997-06-20 DK DK97928261T patent/DK0923570T3/da active
- 1997-06-20 AT AT97928261T patent/ATE224888T1/de active
- 1997-06-20 JP JP50231898A patent/JP4225572B2/ja not_active Expired - Fee Related
- 1997-06-20 EP EP97928261A patent/EP0923570B1/de not_active Expired - Lifetime
- 1997-06-20 BR BRPI9709823-0B1A patent/BR9709823B1/pt not_active IP Right Cessation
- 1997-06-20 ES ES97928261T patent/ES2179351T3/es not_active Expired - Lifetime
- 1997-06-20 TR TR1998/02651T patent/TR199802651T2/xx unknown
- 1997-06-20 PT PT97928261T patent/PT923570E/pt unknown
-
1999
- 1999-12-23 HK HK99106092A patent/HK1021974A1/xx not_active IP Right Cessation
-
2002
- 2002-08-05 US US10/213,952 patent/US7241745B2/en not_active Expired - Fee Related
-
2006
- 2006-12-07 US US11/635,157 patent/US20070219197A1/en not_active Abandoned
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2007
- 2007-02-26 US US11/678,980 patent/US20070142377A1/en not_active Abandoned
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| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: ASTELLAS PHARMA GMBH, 81673 MUENCHEN, DE |
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| 8327 | Change in the person/name/address of the patent owner |
Owner name: ASTELLAS DEUTSCHLAND GMBH, 81673 MUENCHEN, DE |