CA2235967A1 - Diarylethylene metallocene derivatives, their processes of preparation and pharmaceutical compositions containing said derivatives - Google Patents
Diarylethylene metallocene derivatives, their processes of preparation and pharmaceutical compositions containing said derivativesInfo
- Publication number
- CA2235967A1 CA2235967A1 CA002235967A CA2235967A CA2235967A1 CA 2235967 A1 CA2235967 A1 CA 2235967A1 CA 002235967 A CA002235967 A CA 002235967A CA 2235967 A CA2235967 A CA 2235967A CA 2235967 A1 CA2235967 A1 CA 2235967A1
- Authority
- CA
- Canada
- Prior art keywords
- derivatives
- preparation
- processes
- pharmaceutical compositions
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Compounds of general Formula (I), (see fig I) wherein R3, R4, R5 and Z are as specifically defined, are provided herein, as well as their processes of preparation; and pharmaceutical compositions containing them. Thesederivatives are suitable for the preparation of antitumoral drugs for use, in particular, in the treatment of estrogen-dependent cancers.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR94/12151 | 1994-10-12 | ||
FR9412151A FR2725720B1 (en) | 1994-10-12 | 1994-10-12 | METALLOCENIC DIARYLETHYLENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES |
CA002202169A CA2202169A1 (en) | 1994-10-12 | 1995-10-11 | Metallocenic diarylethylene derivatives, methods for their preparation and pharmaceutical compositions containing same |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002202169A Division CA2202169A1 (en) | 1994-10-12 | 1995-10-11 | Metallocenic diarylethylene derivatives, methods for their preparation and pharmaceutical compositions containing same |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2235967A1 true CA2235967A1 (en) | 1996-04-25 |
CA2235967C CA2235967C (en) | 2001-12-18 |
Family
ID=25679228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002235967A Expired - Fee Related CA2235967C (en) | 1994-10-12 | 1995-10-11 | Diarylethylene metallocene derivatives, their processes of preparation and pharmaceutical compositions containing said derivatives |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2235967C (en) |
-
1995
- 1995-10-11 CA CA002235967A patent/CA2235967C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2235967C (en) | 2001-12-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |