ATE299495T1 - Aryl-substituierte pyridylalkan-, alken-, und alkin- carboxamidderivate, verwendbar als zytostatische und immunosuppressive mittel - Google Patents
Aryl-substituierte pyridylalkan-, alken-, und alkin- carboxamidderivate, verwendbar als zytostatische und immunosuppressive mittelInfo
- Publication number
- ATE299495T1 ATE299495T1 AT98966352T AT98966352T ATE299495T1 AT E299495 T1 ATE299495 T1 AT E299495T1 AT 98966352 T AT98966352 T AT 98966352T AT 98966352 T AT98966352 T AT 98966352T AT E299495 T1 ATE299495 T1 AT E299495T1
- Authority
- AT
- Austria
- Prior art keywords
- alkene
- aryl
- alkine
- cytostatic
- immunosuppressive agents
- Prior art date
Links
- 150000001336 alkenes Chemical class 0.000 title abstract 2
- 239000000824 cytostatic agent Substances 0.000 title abstract 2
- 229940125721 immunosuppressive agent Drugs 0.000 title abstract 2
- 239000003018 immunosuppressive agent Substances 0.000 title abstract 2
- 150000001337 aliphatic alkines Chemical class 0.000 title 1
- 229940053202 antiepileptics carboxamide derivative Drugs 0.000 title 1
- 230000001085 cytostatic effect Effects 0.000 title 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 230000008105 immune reaction Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19756261A DE19756261A1 (de) | 1997-12-17 | 1997-12-17 | Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide |
| PCT/EP1998/008272 WO1999031064A1 (en) | 1997-12-17 | 1998-12-16 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic and immunosuppressive agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE299495T1 true ATE299495T1 (de) | 2005-07-15 |
Family
ID=7852345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98966352T ATE299495T1 (de) | 1997-12-17 | 1998-12-16 | Aryl-substituierte pyridylalkan-, alken-, und alkin- carboxamidderivate, verwendbar als zytostatische und immunosuppressive mittel |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7320993B1 (de) |
| EP (1) | EP1042291B1 (de) |
| JP (1) | JP4838934B2 (de) |
| AT (1) | ATE299495T1 (de) |
| AU (1) | AU2274099A (de) |
| DE (2) | DE19756261A1 (de) |
| ES (1) | ES2246073T3 (de) |
| PT (1) | PT1042291E (de) |
| WO (1) | WO1999031064A1 (de) |
| ZA (1) | ZA9811240B (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1031564A1 (de) | 1999-02-26 | 2000-08-30 | Klinge Pharma GmbH | Hemmer der Nicotinamidmonononukleotide-Bildung und deren Verwendung zur Krebstherapie |
| WO2003004010A1 (en) * | 2001-07-06 | 2003-01-16 | Poseidon Pharmaceuticals A/S | Carbonylamino derivatives useful for obtaining immune regulation |
| EP1348434A1 (de) * | 2002-03-27 | 2003-10-01 | Fujisawa Deutschland GmbH | Verwendung von Pyridylamiden als Inhibitoren von Angiogenese |
| US7754188B2 (en) | 2003-06-30 | 2010-07-13 | Merck Sharp & Dohme Corp. | Radiolabeled cannabinoid-1 receptor modulators |
| US7291744B2 (en) | 2003-11-13 | 2007-11-06 | Bristol-Myers Squibb Company | N-ureidoalkyl-amino compounds as modulators of chemokine receptor activity |
| EP1768662A2 (de) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Immunstimulatoren kleiner moleküle und assays für deren nachweis |
| US20080153917A1 (en) * | 2004-09-10 | 2008-06-26 | Ucb Pharma, S.A. | Sigma Receptor Ligands |
| EA200701745A1 (ru) | 2005-03-17 | 2008-06-30 | Пфайзер, Инк. | Циклопропанкарбоксамидные производные |
| ES2382876T3 (es) | 2005-05-31 | 2012-06-14 | Pfizer, Inc. | Compuestos de ariloxi-N-biciclometil-acetamida sustituidos como antagonistas de VR1 |
| EP2098231A1 (de) | 2008-03-05 | 2009-09-09 | Topotarget Switzerland SA | Verwendung von NAD Synthesis Hemmern zur Behandlung von ischämischen Reperfusionsschäden |
| WO2010066709A1 (en) * | 2008-12-09 | 2010-06-17 | Topotarget A/S | Novel pyridinyl acrylamide derivatives |
| FR2943675A1 (fr) * | 2009-03-24 | 2010-10-01 | Sanofi Aventis | Composes anticancereux, leur preparation et leur application en therapeutique |
| CA2764694A1 (en) * | 2009-06-09 | 2010-12-16 | Topotarget A/S | Pyridinyl derivatives asinhibitors of enzyme nicotinamide phosphoribosyltransferase |
| AR082886A1 (es) | 2010-09-03 | 2013-01-16 | Forma Therapeutics Inc | Compuestos y composiciones farmaceuticas que los contienen |
| AR082885A1 (es) | 2010-09-03 | 2013-01-16 | Genentech Inc | Compuestos y composiciones para la inhibicion de nampt |
| CN106986856A (zh) | 2010-09-03 | 2017-07-28 | 福马Tm有限责任公司 | 作为用于治疗疾病诸如癌症的nampt抑制剂的4‑{[(吡啶‑3‑基‑甲基)氨基羰基]氨基}苯‑砜衍生物 |
| EP2465498A1 (de) * | 2010-11-23 | 2012-06-20 | Faes Farma, S.A. | Diphenyl-Aminderivate Verwendungen, Verfahren zur Synthese und pharmazeutische Zusammensetzungen |
| JP5978293B2 (ja) | 2011-05-04 | 2016-08-24 | フォーマ ティーエム， エルエルシー． | Ｎａｍｐｔを阻害するための新規な化合物および組成物 |
| JP5872027B2 (ja) | 2011-05-09 | 2016-03-01 | フォーマ ティーエム， エルエルシー． | ニコチンアミドホスホリボシルトランスフェラーゼ（ｎａｍｐｔ）を阻害するためのピペリジン誘導体および組成物 |
| EP2721011B1 (de) * | 2011-06-20 | 2017-09-06 | Emory University | Prostaglandinrezeptor-ep2-antagonisten, derivate davon, zusammensetzungen damit und verwendungen davon |
| US8741250B2 (en) | 2011-08-05 | 2014-06-03 | The Curators Of The University Of Missouri | Hydroxylation of icosahedral boron compounds |
| US9382267B2 (en) * | 2011-11-30 | 2016-07-05 | The Curators Of The University Of Missouri | Small molecule inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) |
| WO2013082150A1 (en) * | 2011-11-30 | 2013-06-06 | The Curators Of The University Of Missouri | Small molecule inhibitors of nicotinamide phosphoribosyltransferase (nampt) |
| FR2996847B1 (fr) * | 2012-10-16 | 2014-12-05 | Centre Nat Rech Scient | Composes 3,4-bis(catechol)pyrrole-n-substitues, leur preparation et utilisation dans le traitement du cancer |
| ITRM20120555A1 (it) * | 2012-11-13 | 2014-05-14 | Aboca Spa Societa Agricola | Enteroclismi. |
| WO2015167825A1 (en) | 2014-04-29 | 2015-11-05 | Emory University | Prostaglandin receptor ep2 antagonists, derivatives, compositions, and uses related thereto |
| WO2019153007A2 (en) | 2018-02-05 | 2019-08-08 | The Boaro Of Trustees Of The University Of Illinois | Nicotinamide phosphoribosyltransferase inhibitors and methods for use of the same |
| WO2020191208A1 (en) | 2019-03-20 | 2020-09-24 | Emory University | Prostaglandin receptor ep2 antagonists, derivatives, and uses related thereto |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4283541A (en) * | 1980-05-27 | 1981-08-11 | Usv Pharmaceutical Corporation | Pyridylacyl-hydroxamates |
| NL8005133A (nl) | 1980-09-12 | 1982-04-01 | Duphar Int Res | Fenylpiperazinederivaten met antiagressieve werking. |
| JPS57136518A (en) | 1981-02-18 | 1982-08-23 | Eisai Co Ltd | Immunoregulator |
| US5326772A (en) | 1984-09-28 | 1994-07-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Diaryl compounds for their use |
| US4778796A (en) * | 1985-07-19 | 1988-10-18 | Dainippon Pharmaceutical Co., Ltd. | ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same |
| DE3641822A1 (de) * | 1986-12-06 | 1988-06-16 | Goedecke Ag | Verwendung von dihydrophenylaminosaeurederivaten und diese enthaltende arzneimittel zur immunmodulation und cytostase |
| JPS63179869A (ja) | 1987-01-20 | 1988-07-23 | Dainippon Pharmaceut Co Ltd | ピペリジン誘導体 |
| JP2832979B2 (ja) | 1988-02-15 | 1998-12-09 | 武田薬品工業株式会社 | 不飽和カルボン酸アミド誘導体 |
| AU638205B2 (en) | 1988-02-19 | 1993-06-24 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Optically pure r-(-)-niguldipine and its derivatives for treating tumorous diseases |
| EP0343307A1 (de) | 1988-05-26 | 1989-11-29 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. | 4-Piperidinalkanamin-Derivate |
| JP2730135B2 (ja) * | 1989-02-13 | 1998-03-25 | 武田薬品工業株式会社 | 酸アミド誘導体 |
| IE903196A1 (en) | 1989-09-05 | 1991-03-13 | Searle & Co | Substituted n-benzylpiperidine amides |
| FI97540C (fi) | 1989-11-06 | 1997-01-10 | Sanofi Sa | Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi |
| US5352684A (en) | 1990-04-10 | 1994-10-04 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyridines as medicaments |
| AU7652391A (en) | 1990-04-10 | 1991-10-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel pyridine esters |
| US5260323A (en) | 1990-06-28 | 1993-11-09 | Hoechst Aktiengesellschaft | 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use |
| DE4020570A1 (de) | 1990-06-28 | 1992-01-02 | Hoechst Ag | 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung |
| CA2048110C (en) * | 1990-07-30 | 2002-06-25 | Muneo Takatani | Imidazopyridine derivatives and their use |
| EP0479601B1 (de) | 1990-10-05 | 1999-12-15 | Ajinomoto Co., Inc. | Piperidinderivate und ihre Verwendung als antiarrhythmische Wirkstoffe |
| GB9025514D0 (en) * | 1990-11-23 | 1991-01-09 | Wellcome Found | Anti-inflammatory compounds |
| FR2676053B1 (fr) | 1991-05-03 | 1993-08-27 | Sanofi Elf | Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| EP0522606B1 (de) | 1991-05-10 | 1996-04-03 | Takeda Chemical Industries, Ltd. | Pyridinderivate, deren Herstellung und Anwendung |
| US5208247A (en) * | 1991-08-01 | 1993-05-04 | American Cyanamid Company | Pyridinium compounds which are useful as antagonists of platelet activating factor |
| CA2085954A1 (en) | 1991-12-24 | 1993-06-25 | Klaus Weidmann | Substituted pyridine n-oxides, processes for their preparation, and their use |
| GB9200535D0 (en) | 1992-01-10 | 1992-02-26 | Fujisawa Pharmaceutical Co | New compound |
| JP2875393B2 (ja) | 1993-10-15 | 1999-03-31 | シェーリング コーポレイション | Ｇ−タンパク質機能の阻害および増殖性疾患の治療に有用な三環式カルバメート化合物 |
| MY134819A (en) | 1993-10-15 | 2007-12-31 | Schering Corp | Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| EP0750496A1 (de) * | 1994-03-14 | 1997-01-02 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Verwendung von lipoxygenase-hemmet als therapeutische und interventions- antikrebsmittel |
| IL117798A (en) | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| FR2738245B1 (fr) | 1995-08-28 | 1997-11-21 | Sanofi Sa | Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant |
| DE19624668A1 (de) | 1996-06-20 | 1998-02-19 | Klinge Co Chem Pharm Fab | Verwendung von Pyridylalkan-, Pyridylalken- bzw. Pyridylalkinsäureamiden |
| DE19624704A1 (de) | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalkansäureamide |
| DE19624659A1 (de) * | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
| US5925527A (en) * | 1997-02-04 | 1999-07-20 | Trega Biosciences, Inc. | Tricyclic Tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries |
| WO1999005109A1 (en) * | 1997-07-25 | 1999-02-04 | Tsumura & Co. | PYRIDYLACRYLAMIDE DERIVATIVES AND NEPHRITIS REMEDIES AND TGF-β INHIBITORS CONTAINING THE SAME |
| EP1031564A1 (de) * | 1999-02-26 | 2000-08-30 | Klinge Pharma GmbH | Hemmer der Nicotinamidmonononukleotide-Bildung und deren Verwendung zur Krebstherapie |
-
1997
- 1997-12-17 DE DE19756261A patent/DE19756261A1/de not_active Ceased
-
1998
- 1998-12-08 ZA ZA9811240A patent/ZA9811240B/xx unknown
- 1998-12-16 DE DE69830855T patent/DE69830855T2/de not_active Expired - Lifetime
- 1998-12-16 WO PCT/EP1998/008272 patent/WO1999031064A1/en not_active Ceased
- 1998-12-16 AU AU22740/99A patent/AU2274099A/en not_active Abandoned
- 1998-12-16 ES ES98966352T patent/ES2246073T3/es not_active Expired - Lifetime
- 1998-12-16 JP JP2000538991A patent/JP4838934B2/ja not_active Expired - Fee Related
- 1998-12-16 EP EP98966352A patent/EP1042291B1/de not_active Expired - Lifetime
- 1998-12-16 AT AT98966352T patent/ATE299495T1/de active
- 1998-12-16 PT PT98966352T patent/PT1042291E/pt unknown
-
2000
- 2000-06-16 US US09/596,086 patent/US7320993B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2274099A (en) | 1999-07-05 |
| PT1042291E (pt) | 2005-11-30 |
| EP1042291B1 (de) | 2005-07-13 |
| US7320993B1 (en) | 2008-01-22 |
| EP1042291A1 (de) | 2000-10-11 |
| ZA9811240B (en) | 1999-06-08 |
| DE19756261A1 (de) | 1999-07-01 |
| JP2002508357A (ja) | 2002-03-19 |
| WO1999031064A1 (en) | 1999-06-24 |
| DE69830855D1 (de) | 2005-08-18 |
| ES2246073T3 (es) | 2006-02-01 |
| DE69830855T2 (de) | 2006-05-24 |
| JP4838934B2 (ja) | 2011-12-14 |
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