DE69636193D1 - VERWENDUNG VON cGMP-PHOSPHODIESTERASE HEMMER ZUR BEHANDLUNG VON IMPOTENZ - Google Patents
VERWENDUNG VON cGMP-PHOSPHODIESTERASE HEMMER ZUR BEHANDLUNG VON IMPOTENZInfo
- Publication number
- DE69636193D1 DE69636193D1 DE69636193T DE69636193T DE69636193D1 DE 69636193 D1 DE69636193 D1 DE 69636193D1 DE 69636193 T DE69636193 T DE 69636193T DE 69636193 T DE69636193 T DE 69636193T DE 69636193 D1 DE69636193 D1 DE 69636193D1
- Authority
- DE
- Germany
- Prior art keywords
- impotence
- treatment
- phosphodiesterase inhibitors
- cgmp phosphodiesterase
- pyrazino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 201000001881 impotence Diseases 0.000 title abstract 2
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 title 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 title 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 title 1
- XZCSUPWHWMDLEC-LKNMKHRSSA-N (3s,6r,12ar)-6-(1,3-benzodioxol-5-yl)-2,3-dimethyl-6,7,12,12a-tetrahydro-3h-pyrazino[1,2-b]$b-carboline-1,4-quinone Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C(C4=CC=CC=C4N3)C[C@@H]3C(=O)N(C)[C@H](C(N32)=O)C)=C1 XZCSUPWHWMDLEC-LKNMKHRSSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- WOXKDUGGOYFFRN-IIBYNOLFSA-N tadalafil Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C(C4=CC=CC=C4N3)C[C@H]3N2C(=O)CN(C3=O)C)=C1 WOXKDUGGOYFFRN-IIBYNOLFSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Networks Using Active Elements (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Credit Cards Or The Like (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9514464.8A GB9514464D0 (en) | 1995-07-14 | 1995-07-14 | Medicaments |
GB9514464 | 1995-07-14 | ||
PCT/EP1996/003024 WO1997003675A1 (en) | 1995-07-14 | 1996-07-11 | Use of cgmp-phosphodiesterase inhibitors to treat impotence |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69636193D1 true DE69636193D1 (de) | 2006-07-06 |
DE69636193T2 DE69636193T2 (de) | 2007-04-26 |
Family
ID=10777695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69636193T Expired - Lifetime DE69636193T2 (de) | 1995-07-14 | 1996-07-11 | VERWENDUNG VON cGMP-PHOSPHODIESTERASE HEMMER ZUR BEHANDLUNG VON IMPOTENZ |
Country Status (25)
Country | Link |
---|---|
US (2) | US6140329A (de) |
EP (1) | EP0839040B1 (de) |
JP (1) | JP4169365B2 (de) |
CN (2) | CN1311828C (de) |
AT (1) | ATE327756T1 (de) |
AU (1) | AU704955B2 (de) |
BR (1) | BR9609758A (de) |
CA (1) | CA2226784C (de) |
CY (2) | CY2563B1 (de) |
CZ (1) | CZ289686B6 (de) |
DE (1) | DE69636193T2 (de) |
DK (1) | DK0839040T3 (de) |
ES (1) | ES2267111T3 (de) |
GB (1) | GB9514464D0 (de) |
HK (1) | HK1005363A1 (de) |
HU (1) | HU228369B1 (de) |
IL (1) | IL122870A (de) |
MX (2) | MXPA02009987A (de) |
NO (1) | NO314685B1 (de) |
PL (2) | PL185999B1 (de) |
PT (1) | PT839040E (de) |
RU (1) | RU2181288C2 (de) |
SI (1) | SI0839040T1 (de) |
SK (2) | SK284494B6 (de) |
WO (1) | WO1997003675A1 (de) |
Families Citing this family (101)
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CU23063A3 (es) | 1997-11-12 | 2005-07-19 | Bayer Ag | Imidazotriazinonas 2-fenil sustituidas como inhibidores de fosfodiesterasas |
WO1999043674A1 (fr) * | 1998-02-27 | 1999-09-02 | Kyowa Hakko Kogyo Co., Ltd. | Remedes contre les dysfonctionnements de l'erection |
AU4068599A (en) * | 1998-05-20 | 1999-12-06 | Schering Corporation | Combination of phentolamine and cyclic gmp phosphodiesterase inhibitors for the treatment of sexual dysfunction |
EP0967284A1 (de) * | 1998-05-28 | 1999-12-29 | Pfizer Limited | Phosphodiesterasen |
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US6326379B1 (en) | 1998-09-16 | 2001-12-04 | Bristol-Myers Squibb Co. | Fused pyridine inhibitors of cGMP phosphodiesterase |
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JP2000191518A (ja) * | 1998-10-19 | 2000-07-11 | Eisai Co Ltd | 溶解性の改善された口腔内速崩壊性錠剤 |
UA67802C2 (uk) | 1998-10-23 | 2004-07-15 | Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. | Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції |
CA2362918A1 (en) * | 1999-03-08 | 2000-09-14 | Elizabeth Stoner | Methods and compositions for treating erectile dysfunction |
NO20002097L (no) * | 1999-04-30 | 2001-10-26 | Lilly Icos Llc | Fremstillingsgjenstander |
US6943166B1 (en) * | 1999-04-30 | 2005-09-13 | Lilly Icos Llc. | Compositions comprising phosphodiesterase inhabitors for the treatment of sexual disfunction |
US6451807B1 (en) * | 1999-04-30 | 2002-09-17 | Lilly Icos, Llc. | Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor |
US6613768B1 (en) * | 1999-04-30 | 2003-09-02 | Lilly Icos Llc | Treatment of female arousal disorder |
US7182958B1 (en) * | 1999-08-03 | 2007-02-27 | Lilly Icos Llc. | β-carboline pharmaceutical compositions |
US6399826B1 (en) | 1999-08-11 | 2002-06-04 | Sepracor Inc. | Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain |
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US6436944B1 (en) * | 1999-09-30 | 2002-08-20 | Pfizer Inc. | Combination effective for the treatment of impotence |
DZ3218A1 (fr) | 1999-10-11 | 2001-04-19 | Pfizer | Pyrimidine-7-ones 5-(2-substitutees-5-heterocyclylsulphonylpyride-3-yl)-dihydropyrazolo[4,3-d] servant d'inhibiteurs de la phosphodiesterase |
UA74826C2 (en) | 2000-05-17 | 2006-02-15 | Ortho Mcneil Pharm Inc | ?-carboline derivatives as phosphodiesterase inhibitors |
UA72611C2 (uk) * | 2000-05-17 | 2005-03-15 | Орто-Макнейл Фармацевтикал, Інк. | Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази |
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JP2004533402A (ja) * | 2000-06-08 | 2004-11-04 | リリー アイコス リミテッド ライアビリティ カンパニー | Pdevインヒビターとしての四環系ジケトピペラジン化合物 |
JP4169149B2 (ja) * | 2000-06-23 | 2008-10-22 | リリー アイコス リミテッド ライアビリティ カンパニー | 化学的化合物 |
DE60112306T2 (de) | 2000-06-26 | 2006-01-12 | Lilly Icos Llc, Wilmington | Kondensierte pyrazindionderivate als pde5 inhibitore |
US7034027B2 (en) * | 2000-08-02 | 2006-04-25 | Lilly Icos Llc | Fused heterocyclic derivatives as phosphodiesterase inhibitors |
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WO2021245192A1 (en) | 2020-06-04 | 2021-12-09 | Topadur Pharma Ag | Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof |
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US3644384A (en) * | 1969-06-09 | 1972-02-22 | Sterling Drug Inc | Certain 2-(alpha-haloacetyl) - 1 2 3 4-tetrahydro - 9h - pyrido(3 4-b)indole-3-carboxylates and derivatives |
US3717638A (en) * | 1971-03-11 | 1973-02-20 | Sterling Drug Inc | 1,2,3,4,6,7,12,12A-OCTAHYDRO-2-PHENYLPYRAZINO[2',1':6,1]PYRIDO[3,4-b]INDOLES AND INTERMEDIATES THEREFOR |
US3917599A (en) * | 1973-03-30 | 1975-11-04 | Council Scient Ind Res | 2-Substituted-1,2,3,4,6,7,12,12A-octahydropyrazino(2{40 ,1{40 :6,1)pyrido(3,4-B)indoles |
GB1454171A (en) * | 1973-10-19 | 1976-10-27 | Council Scient Ind Res | Tetracyclic compounds |
US4188390A (en) * | 1977-11-05 | 1980-02-12 | Pfizer Inc. | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines |
US4656174A (en) * | 1982-07-24 | 1987-04-07 | Pfizer Inc. | Quinoline therapeutic agents |
IT1217190B (it) * | 1988-04-22 | 1990-03-14 | Recordati Chem Pharm | Composti utili per il trattamento e diagnosi di disfunzioni frettili |
EP0357122A3 (de) * | 1988-08-29 | 1991-10-23 | Duphar International Research B.V | Verwendung von Beta-Carbolinen und deren bio-isosterischen Benzofuran- und Benzothiophenanalogen zur Herstellung eines Arzneimittels mit cytostatischer Wirkung |
DE3830096A1 (de) * | 1988-09-03 | 1990-03-15 | Hoechst Ag | Piperazindione mit psychotroper wirkung |
FR2649613B1 (fr) * | 1989-07-11 | 1991-09-27 | Virag Ronald | Medicament vaso-actif |
JPH0344324A (ja) * | 1989-07-13 | 1991-02-26 | Kazuoki Tsuchiya | 性機能賦活剤 |
US5270323A (en) * | 1990-05-31 | 1993-12-14 | Pfizer Inc. | Method of treating impotence |
EP0459666B1 (de) * | 1990-05-31 | 1994-11-09 | Pfizer Inc. | Arzneimittel gegen Impotenz |
GB9012469D0 (en) * | 1990-06-05 | 1990-07-25 | Glaxo Group Ltd | Medicaments |
GB9013750D0 (en) * | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
GB9114760D0 (en) * | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
GB9311920D0 (en) * | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
GB9401090D0 (en) * | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
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