UY33535A - Derivados de 6,7-dihidro-3h-oxazolo[3,4]pirazin-5,8-diona - Google Patents

Derivados de 6,7-dihidro-3h-oxazolo[3,4]pirazin-5,8-diona

Info

Publication number
UY33535A
UY33535A UY0001033535A UY33535A UY33535A UY 33535 A UY33535 A UY 33535A UY 0001033535 A UY0001033535 A UY 0001033535A UY 33535 A UY33535 A UY 33535A UY 33535 A UY33535 A UY 33535A
Authority
UY
Uruguay
Prior art keywords
oxazolo
pde
pyrazin
dihydro
dione
Prior art date
Application number
UY0001033535A
Other languages
English (en)
Inventor
Artur Franz Keppler
Carlos Eduardo Da Costa Touzarim
Gilberto De Nucci
Marcio Enrique Zaim
Sergio Luiz Sacurai
Original Assignee
Biolab Sanus Farmaceutuca Limitada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biolab Sanus Farmaceutuca Limitada filed Critical Biolab Sanus Farmaceutuca Limitada
Publication of UY33535A publication Critical patent/UY33535A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D503/02—Preparation
    • C07D503/04—Preparation by forming the ring or condensed ring systems

Abstract

La presente invención describe una serie de derivados de 6,7-dihidro-3H-oxazolo[3,4-a]pirazin-5,8-diona, sus mezclas, sus sales farmacéuticamente aceptables, que son inhibidores de PDE-5, que poseen propiedades vasodilatadoras y efectos de relajación. En particular, el derivado (R)-3-(1, 3-benzodioxol-5-il)-1-(1 H-indol-3-il)-7-metil-6, 7-dihidro[1,3]oxazolo[3,4-a]pirazin-5,8-diona, su enantiómero (S)-3-(1 ,3-benzodioxol-5-il)-1 - (1 H-indol-3-il)-7-metil-6,7-dihidro[1,3]oxazolo[3,4-a]pirazin-5,8-diona.La presente invención describe, además, procesos para la preparación de dichos compuestos, composiciones farmacéuticas que los contienen, así como usos como inhibidores de la enzima fosfodiesterasa de tipo 5 (PDE-5) en el tratamiento de la disfunción eréctil y trastornos tratables con inhibidor de PDE-5.
UY0001033535A 2010-08-13 2011-07-27 Derivados de 6,7-dihidro-3h-oxazolo[3,4]pirazin-5,8-diona UY33535A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37348310P 2010-08-13 2010-08-13

Publications (1)

Publication Number Publication Date
UY33535A true UY33535A (es) 2011-12-01

Family

ID=45023415

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001033535A UY33535A (es) 2010-08-13 2011-07-27 Derivados de 6,7-dihidro-3h-oxazolo[3,4]pirazin-5,8-diona

Country Status (21)

Country Link
US (1) US8338432B2 (es)
EP (1) EP2603512B1 (es)
JP (1) JP5940535B2 (es)
KR (1) KR101871856B1 (es)
CN (1) CN103108878B (es)
AR (1) AR082661A1 (es)
BR (1) BR112013003225B1 (es)
CA (1) CA2807872C (es)
CL (1) CL2013000434A1 (es)
CO (1) CO6680703A2 (es)
DK (1) DK2603512T3 (es)
EC (1) ECSP13012486A (es)
ES (1) ES2565493T3 (es)
HK (1) HK1184786A1 (es)
HU (1) HUE027903T2 (es)
IL (1) IL224683A (es)
MX (1) MX347632B (es)
PL (1) PL2603512T3 (es)
RU (1) RU2581831C2 (es)
UY (1) UY33535A (es)
WO (1) WO2012019254A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY33535A (es) * 2010-08-13 2011-12-01 Biolab Sanus Farmaceutuca Limitada Derivados de 6,7-dihidro-3h-oxazolo[3,4]pirazin-5,8-diona
AR099523A1 (es) * 2014-02-24 2016-07-27 Biolab Sanus Farmacêutica Ltda Compuestos derivados de 6,7-dihidro-3h-oxazolo[3,4-a]pirazina-5,8-diona
EP3191099B1 (en) * 2014-09-12 2018-11-14 Biolab Sanus Farmacéutica Ltda Derivatives of pyridopyrimidines
JP2022540866A (ja) 2019-07-15 2022-09-20 バイオラブ・サヌス・ファーマセウティカ・エルティーディーエー． ３－（ベンゾ［ｄ］［１，３］ジオキサゾール－５－イル）－７－（１－ヒドロキシプロパン－２－イル）－１－（１Ｈ－インドール－３－イル）－６，７－ジヒドロ－３Ｈ－オキサゾール［３，４－ａ］ピラジン－５，８－ジオン化合物の立体異性体およびその抗腫瘍剤およびホスホジエステラーゼ酵素阻害剤としての使用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698560A (en) 1995-03-01 1997-12-16 Kyowa Hakko Kogyo Co., Ltd. Imidazoquinazoline derivatives
GB9514464D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Medicaments
DE60226970D1 (de) * 2001-06-05 2008-07-17 Lilly Icos Llc Pyrazinoä1',2':1,6ü-pyridoä3,4-bü indole-1,4-dionderivate
JP4339679B2 (ja) * 2001-06-21 2009-10-07 リリー アイコス リミテッド ライアビリティ カンパニー Ｐｄｅ５阻害剤としてのカルボリン誘導体
AR045950A1 (es) * 2003-10-09 2005-11-16 Speedel Experimenta Ag Compuestos derivados de piperazina, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos.
JP2007532526A (ja) 2004-04-07 2007-11-15 ファイザー・インク ピラゾロ［４，３−ｄ］ピリミジン類
RU2418590C2 (ru) * 2006-04-04 2011-05-20 Донг-А Фарматех Ко. Лтд. Средство для предупреждения и лечения гиперплазии предстательной железы, содержащее производное пиразолопиримидинона
BRPI0903803B1 (pt) * 2009-09-30 2019-07-09 Biolab Sanus Farmacêutica Ltda. Composto, processo de preparação, composição farmacêutica e uso dos compostos
UY33535A (es) * 2010-08-13 2011-12-01 Biolab Sanus Farmaceutuca Limitada Derivados de 6,7-dihidro-3h-oxazolo[3,4]pirazin-5,8-diona

Also Published As

Publication number Publication date
AR082661A1 (es) 2012-12-26
MX347632B (es) 2017-05-04
US20120040988A1 (en) 2012-02-16
ES2565493T3 (es) 2016-04-05
MX2013001692A (es) 2013-03-18
CL2013000434A1 (es) 2013-06-07
US8338432B2 (en) 2012-12-25
HUE027903T2 (hu) 2016-11-28
ECSP13012486A (es) 2013-04-30
CN103108878B (zh) 2016-01-27
BR112013003225B1 (pt) 2021-03-30
CA2807872C (en) 2018-07-24
RU2581831C2 (ru) 2016-04-20
JP2013533290A (ja) 2013-08-22
KR20130109110A (ko) 2013-10-07
EP2603512A4 (en) 2014-07-16
JP5940535B2 (ja) 2016-06-29
CO6680703A2 (es) 2013-05-31
BR112013003225A2 (pt) 2016-06-07
KR101871856B1 (ko) 2018-06-28
HK1184786A1 (zh) 2014-01-30
WO2012019254A1 (en) 2012-02-16
PL2603512T3 (pl) 2016-09-30
EP2603512B1 (en) 2015-12-30
IL224683A (en) 2016-03-31
CA2807872A1 (en) 2012-02-16
CN103108878A (zh) 2013-05-15
DK2603512T3 (en) 2016-04-04
RU2013110795A (ru) 2014-09-20
EP2603512A1 (en) 2013-06-19

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Effective date: 20210920