CL2011003082A1 - Compuestos derivados de [1,2,4]triazolo[1,5-a]piridina, inhibidores de jak2 o fak; composiciones farmaceuticas que los comprenden; y su uso para el tratamiento de una enfermedad hiperproliferativa. - Google Patents
Compuestos derivados de [1,2,4]triazolo[1,5-a]piridina, inhibidores de jak2 o fak; composiciones farmaceuticas que los comprenden; y su uso para el tratamiento de una enfermedad hiperproliferativa.Info
- Publication number
- CL2011003082A1 CL2011003082A1 CL2011003082A CL2011003082A CL2011003082A1 CL 2011003082 A1 CL2011003082 A1 CL 2011003082A1 CL 2011003082 A CL2011003082 A CL 2011003082A CL 2011003082 A CL2011003082 A CL 2011003082A CL 2011003082 A1 CL2011003082 A1 CL 2011003082A1
- Authority
- CL
- Chile
- Prior art keywords
- triazolo
- pyridine
- treatment
- jak2
- compounds derived
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
Compuestos derivados de n-fenil[1,2,4]triazolo[1,5-a]piridin-amina, moduladores de tirosina-cinasa como fak o jak; composición farmacéutica; y su uso para el tratamiento de una enfermedad hiperproliferativa, tal como cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18453309P | 2009-06-05 | 2009-06-05 | |
PCT/US2010/037363 WO2010141796A2 (en) | 2009-06-05 | 2010-06-04 | PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2011003082A1 true CL2011003082A1 (es) | 2012-06-08 |
Family
ID=42985748
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2011003082A CL2011003082A1 (es) | 2009-06-05 | 2011-12-05 | Compuestos derivados de [1,2,4]triazolo[1,5-a]piridina, inhibidores de jak2 o fak; composiciones farmaceuticas que los comprenden; y su uso para el tratamiento de una enfermedad hiperproliferativa. |
Country Status (14)
Country | Link |
---|---|
US (2) | US8501936B2 (es) |
EP (1) | EP2438066A2 (es) |
JP (1) | JP5684245B2 (es) |
KR (1) | KR20120044966A (es) |
CN (1) | CN102459258B (es) |
AU (1) | AU2010254806C1 (es) |
BR (1) | BRPI1009637A2 (es) |
CA (1) | CA2763900A1 (es) |
CL (1) | CL2011003082A1 (es) |
IL (1) | IL216609A0 (es) |
MX (1) | MX2011012961A (es) |
NZ (1) | NZ597140A (es) |
TW (1) | TWI500614B (es) |
WO (1) | WO2010141796A2 (es) |
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BRPI0910021A2 (pt) | 2008-06-20 | 2015-09-01 | Genentech Inc | "composto, composição farmacêutica, método para tratar ou atenuar a gravidade de uma doença ou condição responsiva à inibição da atividade jak2 quinas em um paciente, kit para o tratamento de uma doença ou distúrbio responsivo à inibição da jak quinase" |
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JO3030B1 (ar) | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
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JP6033230B2 (ja) * | 2010-12-06 | 2016-11-30 | セファロン、インク. | 狼瘡の処置のためのヤーヌスキナーゼ2(jak2)インヒビタ |
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US20160123982A1 (en) | 2013-02-04 | 2016-05-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for assaying jak2 activity in red blood cells and uses thereof |
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CN107759587B (zh) * | 2016-08-19 | 2021-01-26 | 中国医药研究开发中心有限公司 | [1,2,4]三唑并[1,5-a]吡啶类化合物及其制备方法和医药用途 |
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JP2010070503A (ja) | 2008-09-19 | 2010-04-02 | Daiichi Sankyo Co Ltd | 抗真菌作用2−アミノトリアゾロピリジン誘導体 |
WO2010057877A1 (en) | 2008-11-18 | 2010-05-27 | Cellzome Limited | 7-pyridinyl- or phenyl- substituted triazolo [1, 5 -a] pyridines as pi3k inhibitors |
AU2009328752B2 (en) | 2008-12-19 | 2015-07-16 | Leo Pharma A/S | Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases |
WO2010092015A1 (en) | 2009-02-10 | 2010-08-19 | Cellzome Limited | Urea triazololo [1, 5-a] pyridine derivatives as pi3k inhibitors |
EP2396324A1 (en) * | 2009-02-13 | 2011-12-21 | Fovea Pharmaceuticals | Ý1, 2, 4¨triazolo ý1, 5 -a¨pyridines as kinase inhibitors |
CA2784769A1 (en) * | 2010-01-15 | 2011-07-21 | Janssen Pharmaceuticals, Inc. | Novel substituted triazole derivatives as gamma secretase modulators |
-
2010
- 2010-06-04 BR BRPI1009637-0A patent/BRPI1009637A2/pt not_active IP Right Cessation
- 2010-06-04 MX MX2011012961A patent/MX2011012961A/es active IP Right Grant
- 2010-06-04 EP EP10724213A patent/EP2438066A2/en not_active Withdrawn
- 2010-06-04 NZ NZ597140A patent/NZ597140A/en unknown
- 2010-06-04 US US12/793,984 patent/US8501936B2/en active Active
- 2010-06-04 TW TW099118109A patent/TWI500614B/zh not_active IP Right Cessation
- 2010-06-04 AU AU2010254806A patent/AU2010254806C1/en not_active Ceased
- 2010-06-04 CA CA2763900A patent/CA2763900A1/en not_active Abandoned
- 2010-06-04 KR KR1020127000197A patent/KR20120044966A/ko active IP Right Grant
- 2010-06-04 WO PCT/US2010/037363 patent/WO2010141796A2/en active Application Filing
- 2010-06-04 CN CN201080024761.0A patent/CN102459258B/zh not_active Expired - Fee Related
- 2010-06-04 JP JP2012514166A patent/JP5684245B2/ja not_active Expired - Fee Related
-
2011
- 2011-11-24 IL IL216609A patent/IL216609A0/en unknown
- 2011-12-05 CL CL2011003082A patent/CL2011003082A1/es unknown
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2013
- 2013-06-18 US US13/920,153 patent/US8633173B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR20120044966A (ko) | 2012-05-08 |
MX2011012961A (es) | 2012-01-30 |
IL216609A0 (en) | 2012-02-29 |
TW201100421A (en) | 2011-01-01 |
JP5684245B2 (ja) | 2015-03-11 |
JP2012528886A (ja) | 2012-11-15 |
CN102459258A (zh) | 2012-05-16 |
CA2763900A1 (en) | 2010-12-09 |
US8633173B2 (en) | 2014-01-21 |
AU2010254806B2 (en) | 2016-02-04 |
US20130296312A1 (en) | 2013-11-07 |
US8501936B2 (en) | 2013-08-06 |
BRPI1009637A2 (pt) | 2019-04-30 |
WO2010141796A3 (en) | 2012-02-16 |
TWI500614B (zh) | 2015-09-21 |
AU2010254806A1 (en) | 2012-01-19 |
US20100311693A1 (en) | 2010-12-09 |
WO2010141796A2 (en) | 2010-12-09 |
EP2438066A2 (en) | 2012-04-11 |
NZ597140A (en) | 2014-01-31 |
CN102459258B (zh) | 2015-11-25 |
AU2010254806C1 (en) | 2016-07-07 |
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