DE69630457T2 - Verbindungen zur immunotherapie und diagnose von tuberkulose - Google Patents

Verbindungen zur immunotherapie und diagnose von tuberkulose Download PDF

Info

Publication number
DE69630457T2
DE69630457T2 DE69630457T DE69630457T DE69630457T2 DE 69630457 T2 DE69630457 T2 DE 69630457T2 DE 69630457 T DE69630457 T DE 69630457T DE 69630457 T DE69630457 T DE 69630457T DE 69630457 T2 DE69630457 T2 DE 69630457T2
Authority
DE
Germany
Prior art keywords
seq
tuberculosis
ala
pro
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69630457T
Other languages
German (de)
English (en)
Other versions
DE69630457D1 (de
Inventor
G. Steven REED
A. Yasir SKEIKY
C. Davin DILLON
Antonio Campos-Neto
Raymond Houghton
H. Thomas VEDVICK
R. Daniel TWARDZIK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corixa Corp
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27541835&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69630457(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Corixa Corp filed Critical Corixa Corp
Publication of DE69630457D1 publication Critical patent/DE69630457D1/de
Application granted granted Critical
Publication of DE69630457T2 publication Critical patent/DE69630457T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69630457T 1995-09-01 1996-08-30 Verbindungen zur immunotherapie und diagnose von tuberkulose Expired - Lifetime DE69630457T2 (de)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US533634 1990-06-05
US52343695A 1995-09-01 1995-09-01
US523436 1995-09-01
US53363495A 1995-09-22 1995-09-22
US62087496A 1996-03-22 1996-03-22
US620874 1996-03-22
US65968396A 1996-06-05 1996-06-05
US659683 1996-06-05
US68057496A 1996-07-12 1996-07-12
US680574 1996-07-12
PCT/US1996/014674 WO1997009428A2 (en) 1995-09-01 1996-08-30 Compounds and methods for immunotherapy and diagnosis of tuberculosis

Publications (2)

Publication Number Publication Date
DE69630457D1 DE69630457D1 (de) 2003-11-27
DE69630457T2 true DE69630457T2 (de) 2004-11-25

Family

ID=27541835

Family Applications (4)

Application Number Title Priority Date Filing Date
DE69630457T Expired - Lifetime DE69630457T2 (de) 1995-09-01 1996-08-30 Verbindungen zur immunotherapie und diagnose von tuberkulose
DE69636487T Expired - Lifetime DE69636487T2 (de) 1995-09-01 1996-08-30 Zusammensetzungen zur Immuntherapie und Diagnose von Tuberculosis
DE69637879T Expired - Lifetime DE69637879D1 (de) 1995-09-01 1996-08-30 Verbindungen und Verfahren zur Immuntherapie und Diagnose von Tuberkulose
DE69636046T Expired - Lifetime DE69636046T2 (de) 1995-09-01 1996-08-30 Verbindungen und Verfahren zur Immuntherapie und Diagnose von Tuberkulose

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE69636487T Expired - Lifetime DE69636487T2 (de) 1995-09-01 1996-08-30 Zusammensetzungen zur Immuntherapie und Diagnose von Tuberculosis
DE69637879T Expired - Lifetime DE69637879D1 (de) 1995-09-01 1996-08-30 Verbindungen und Verfahren zur Immuntherapie und Diagnose von Tuberkulose
DE69636046T Expired - Lifetime DE69636046T2 (de) 1995-09-01 1996-08-30 Verbindungen und Verfahren zur Immuntherapie und Diagnose von Tuberkulose

Country Status (23)

Country Link
EP (5) EP1347055B1 (OSRAM)
JP (5) JP4382160B2 (OSRAM)
KR (1) KR100433750B1 (OSRAM)
CN (1) CN1117149C (OSRAM)
AT (5) ATE426025T1 (OSRAM)
AU (1) AU727602B2 (OSRAM)
BR (2) BR9610262B1 (OSRAM)
CA (3) CA2230885C (OSRAM)
CY (2) CY2570B1 (OSRAM)
CZ (3) CZ300953B6 (OSRAM)
DE (4) DE69630457T2 (OSRAM)
DK (4) DK1203817T3 (OSRAM)
ES (4) ES2262595T3 (OSRAM)
HU (2) HU225979B1 (OSRAM)
IL (1) IL123506A (OSRAM)
MX (1) MX9801638A (OSRAM)
NO (4) NO324372B1 (OSRAM)
NZ (1) NZ319377A (OSRAM)
PL (1) PL186774B1 (OSRAM)
PT (4) PT1203817E (OSRAM)
SI (1) SI0851927T1 (OSRAM)
TR (5) TR200806258T2 (OSRAM)
WO (1) WO1997009428A2 (OSRAM)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2501135Y2 (ja) 1989-06-10 1996-06-12 エヌティエヌ株式会社 摩擦式無段変速機
JP2501911B2 (ja) 1989-08-15 1996-05-29 日産自動車株式会社 トロイダル型無段変速機
US6641814B1 (en) 1997-04-02 2003-11-04 Statens Serum Institut Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis
US6991797B2 (en) 1993-07-02 2006-01-31 Statens Serum Institut M. tuberculosis antigens
US6458366B1 (en) 1995-09-01 2002-10-01 Corixa Corporation Compounds and methods for diagnosis of tuberculosis
US6290969B1 (en) 1995-09-01 2001-09-18 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
US6592877B1 (en) 1995-09-01 2003-07-15 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
TR199901569T2 (xx) * 1996-10-11 2000-12-21 Corixa Corporation T�berk�lozun te�hisi i�in bile�ikler ve y�ntemler.
US6544522B1 (en) * 1998-12-30 2003-04-08 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
US6350456B1 (en) 1997-03-13 2002-02-26 Corixa Corporation Compositions and methods for the prevention and treatment of M. tuberculosis infection
US6627198B2 (en) 1997-03-13 2003-09-30 Corixa Corporation Fusion proteins of Mycobacterium tuberculosis antigens and their uses
US6982085B2 (en) 1997-04-02 2006-01-03 Statens Serum Institut TB diagnostic based on antigens from M. tuberculosis
ATE370236T1 (de) * 1997-04-02 2007-09-15 Statens Seruminstitut Nukleinsäure- und polypeptidfragmente von m. tuberculosis
US7037510B2 (en) 1997-04-18 2006-05-02 Statens Serum Institut Hybrids of M. tuberculosis antigens
US6555653B2 (en) * 1997-05-20 2003-04-29 Corixa Corporation Compounds for diagnosis of tuberculosis and methods for their use
US6613881B1 (en) * 1997-05-20 2003-09-02 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
US6436409B1 (en) * 1997-07-16 2002-08-20 Institut Pasteur Polynucleotide functionally coding for the LHP protein from Mycobacterium tuberculosis, its biologically active derivative fragments, as well as methods using the same
EP1484405A1 (en) * 1997-11-10 2004-12-08 Statens Serum Institut Nucleic acid fragments and polypeptide fragments derived from M. Tuberculosis
CA2319380A1 (en) * 1997-11-10 1999-05-20 Statens Serum Institut Nucleic acid fragments and polypeptide fragments derived from m. tuberculosis
KR100692227B1 (ko) * 1998-04-07 2007-03-09 코릭사 코포레이션 마이코박테리움 튜베르쿨로시스 항원의 융합 단백질 및이의 용도
GB9808720D0 (en) * 1998-04-23 1998-06-24 Smithkline Beecham Biolog Novel compounds
CA2348475A1 (en) * 1998-11-04 2000-05-11 Isis Innovation Limited Tuberculosis diagnostic test
US6465633B1 (en) 1998-12-24 2002-10-15 Corixa Corporation Compositions and methods of their use in the treatment, prevention and diagnosis of tuberculosis
AU2594500A (en) * 1998-12-24 2000-07-31 Corixa Corporation Methods for using mycobacterium tuberculosis molecules as immunological adjuvants
US7932373B1 (en) * 1999-05-04 2011-04-26 University Of Medicine And Dentistry Of New Jersey Proteins expressed by mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines
US7009042B1 (en) * 1999-10-07 2006-03-07 Corixa Corporation Methods of using a Mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins
US6316205B1 (en) 2000-01-28 2001-11-13 Genelabs Diagnostics Pte Ltd. Assay devices and methods of analyte detection
AU2001241738A1 (en) 2000-02-25 2001-09-03 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
EP1542732B1 (en) 2000-06-20 2009-09-16 Corixa Corporation Fusion proteins of mycobacterium tuberculosis
WO2003070187A2 (en) 2002-02-15 2003-08-28 Corixa Corporation Fusion proteins of mycobacterium tuberculosis
ITRM20040091A1 (it) 2004-02-19 2004-05-19 Istituto Naz Per Le Malattie Test immunologico rapido per la diagnosi ed il monitoraggio dell'infezione tubercolare.
FI119445B (fi) * 2004-10-29 2008-11-14 Waertsilae Finland Oy Polttomoottorin polttoaineen syöttöjärjestelmän paineen värähtelyn vaimennin
JP4838259B2 (ja) 2004-11-16 2011-12-14 クルセル ホランド ベー ヴェー 組み換えウイルスベクターを含む多価ワクチン
ES2381492T3 (es) 2005-04-29 2012-05-28 Glaxosmithkline Biologicals Sa Procedimiento de prevención o tratamiento de infección por M. tuberculosis
FR2952058B1 (fr) 2009-10-29 2013-10-04 Centre Nat Rech Scient Procede de ligation native de polypeptides
WO2011092253A1 (en) 2010-01-27 2011-08-04 Glaxosmithkline Biologicals S.A. Modified tuberculosis antigens
SG190731A1 (en) 2010-12-14 2013-07-31 Glaxosmithkline Biolog Sa Mycobacterium antigenic composition
FR2971509B1 (fr) * 2011-02-16 2013-02-22 Centre Nat Rech Scient Procede de preparation de peptides par assemblage de multiples fragments peptidiques
CN103290030A (zh) * 2012-02-23 2013-09-11 上海交通大学 一种结核分枝杆菌标志物HtdY的重组蛋白及其制备方法和临床应用
NZ701324A (en) * 2012-05-04 2016-09-30 Pfizer Prostate-associated antigens and vaccine-based immunotherapy regimens
AU2015240516C1 (en) * 2014-04-04 2019-04-11 Vestaron Corporation Artificially activated peptides
GB201513176D0 (en) 2015-07-27 2015-09-09 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
FR3048286B1 (fr) * 2016-02-26 2021-01-22 Omunis Peptides immunogenes et leur utilisation
CN107304231B (zh) * 2016-04-18 2021-01-01 华中农业大学 一种结核分枝杆菌融合蛋白及应用
GB201614485D0 (en) 2016-08-25 2016-10-12 Univ Oxford Innovation Ltd Immunogenic composition

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2244539A1 (en) * 1973-07-13 1975-04-18 Mitsui Pharmaceuticals Tuberculin active proteins and peptides prepn - from tubercle bacillus
FR2265402A1 (en) * 1974-03-29 1975-10-24 Mitsui Pharmaceuticals Tuberculin active proteins and peptides prepn - from tubercle bacillus
US4876089A (en) * 1984-09-06 1989-10-24 Chiron Corporation Feline leukemia virus protein vaccines
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US4897268A (en) 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
FR2677365B1 (fr) * 1991-06-07 1995-08-04 Pasteur Institut Proteines de mycobacterium et applications.
US5330754A (en) * 1992-06-29 1994-07-19 Archana Kapoor Membrane-associated immunogens of mycobacteria
DK79893D0 (da) * 1993-07-02 1993-07-02 Statens Seruminstitut New vaccine
DK79793D0 (da) * 1993-07-02 1993-07-02 Statens Seruminstitut Diagnostic test

Also Published As

Publication number Publication date
DE69630457D1 (de) 2003-11-27
DK1203817T3 (da) 2006-08-14
EP1712628A2 (en) 2006-10-18
ES2324529T3 (es) 2009-08-10
JP2006149406A (ja) 2006-06-15
CN1200147A (zh) 1998-11-25
PL186774B1 (pl) 2004-02-27
ATE337399T1 (de) 2006-09-15
BR9612997B1 (pt) 2012-01-10
NO20070618L (no) 1998-04-27
PT1347055E (pt) 2009-06-19
PL325373A1 (en) 1998-07-20
CA2653566C (en) 2013-06-25
DE69636487T2 (de) 2007-05-03
CZ300953B6 (cs) 2009-09-23
JP4324596B2 (ja) 2009-09-02
HU227778B1 (en) 2012-02-28
EP1347055A2 (en) 2003-09-24
IL123506A (en) 2004-12-15
ES2210392T3 (es) 2004-07-01
KR19990044347A (ko) 1999-06-25
EP1203817B9 (en) 2006-08-16
NO20070619L (no) 1998-04-27
CZ62898A3 (cs) 1999-10-13
NO20070621L (no) 1998-04-27
EP1398379A2 (en) 2004-03-17
JP2007228972A (ja) 2007-09-13
ES2262595T3 (es) 2006-12-01
EP1398379B1 (en) 2006-08-23
DK0851927T3 (da) 2004-01-26
CA2230885A1 (en) 1997-03-13
NO336288B1 (no) 2015-07-13
EP1203817A3 (en) 2003-01-29
PT851927E (pt) 2004-03-31
TR200901109T1 (tr) 2012-02-21
BR9610262A (pt) 1999-07-06
JP2006187292A (ja) 2006-07-20
PT1398379E (pt) 2007-01-31
ES2271449T3 (es) 2007-04-16
EP1347055A3 (en) 2003-11-26
EP0851927B1 (en) 2003-10-22
EP0851927A2 (en) 1998-07-08
SI0851927T1 (en) 2004-02-29
BR9610262B1 (pt) 2013-11-26
CZ297406B6 (cs) 2006-12-13
PT1203817E (pt) 2006-08-31
JP4324597B2 (ja) 2009-09-02
ATE426025T1 (de) 2009-04-15
EP1203817B1 (en) 2006-04-12
EP1203817A2 (en) 2002-05-08
WO1997009428A2 (en) 1997-03-13
TR199800411T1 (xx) 1998-05-21
AU727602B2 (en) 2000-12-14
JP4324618B2 (ja) 2009-09-02
CZ300688B6 (cs) 2009-07-15
JP4382160B2 (ja) 2009-12-09
MX9801638A (es) 1998-05-31
ATE323165T1 (de) 2006-04-15
CA2684425A1 (en) 1997-03-13
EP1347055B1 (en) 2009-03-18
NO980883L (no) 1998-04-27
TR200806259T2 (tr) 2008-10-21
JP2009159982A (ja) 2009-07-23
WO1997009428A3 (en) 1997-07-17
DE69636046T2 (de) 2006-11-23
TR200403064T2 (tr) 2005-08-22
HU225979B1 (en) 2008-02-28
CN1117149C (zh) 2003-08-06
ATE252640T1 (de) 2003-11-15
NO324372B1 (no) 2007-10-01
EP1398379A3 (en) 2004-07-14
CA2653566A1 (en) 1997-03-13
DE69636487D1 (de) 2006-10-05
NO980883D0 (no) 1998-02-27
EP1712628A3 (en) 2007-05-23
CA2230885C (en) 2010-02-02
CY2612B2 (en) 2010-12-22
DK1347055T3 (da) 2009-06-29
AU7158696A (en) 1997-03-27
TR200806258T2 (tr) 2008-10-21
NZ319377A (en) 2000-01-28
IL123506A0 (en) 1998-10-30
DE69637879D1 (de) 2009-04-30
ATE513915T1 (de) 2011-07-15
HUP9900902A3 (en) 2001-03-28
DE69636046D1 (de) 2006-05-24
CY2570B1 (en) 2008-07-02
EP1712628B1 (en) 2011-06-22
DK1398379T3 (da) 2007-01-08
JP2001517069A (ja) 2001-10-02
KR100433750B1 (ko) 2004-09-01
HK1059282A1 (en) 2004-06-25
HUP9900902A2 (hu) 1999-07-28

Similar Documents

Publication Publication Date Title
DE69630457T2 (de) Verbindungen zur immunotherapie und diagnose von tuberkulose
DE69737125T3 (de) Streptococcus pneumoniae-Antigene und Impfstoffe
US7927609B2 (en) Compounds and methods for immunotherapy and diagnosis of tuberculosis
JP4162155B2 (ja) 結核の免疫治療および診断のための化合物およびそれらの使用方法
WO1997009428A9 (en) Compounds and methods for immunotherapy and diagnosis of tuberculosis
DE69628844T2 (de) Leishmania-antigene zur anwendung in der leishmaniasis therapie und diagnose
DE69838268T2 (de) Immonologisch aktiven, neuen Polypeptidefragmenten
AU1097795A (en) Abundant extracellular products and methods for their production and use
WO1995004145A1 (en) Novel b. burgdorferi polypeptides
NZ309945A (en) Abundant extracellular products and their use as vaccines
DE69838948T2 (de) Epitopen eines extrazellulären antigens
DE68928933T2 (de) Faser-hemagglutinin von b. pertussis
DE60035485T2 (de) IDENTIFIZIERUNG VON SPEZIFISCHEN DIFFERENZIELL EXPRIMIERTEN ANTIGENEN AUS MYCOBACTERIUM UND MEDIZINISCHE VERWENDUNG DER MYCOBAKTERIUMPROTEINE Rv0068 UND Rv3407
US6818223B2 (en) Abundant extracellular products and methods for their production and use
US6716591B1 (en) B. burgdorferi polypeptides
US7002002B2 (en) Abundant extracellular products and methods for their production and use
WO1996005223A1 (en) Abundant extracellular products and methods for their production and use
US20030152584A1 (en) Abundant extracellular products and methods for their production and use
HK1099338A (en) Compounds and methods for immunotherapy and diagnosis of tuberculosis
HK1059282B (en) Compounds for immunotherapy and diagnosis of tuberculosis

Legal Events

Date Code Title Description
8364 No opposition during term of opposition