DE69502939T2 - Sublinguales oder bukkales arzneimittel - Google Patents

Sublinguales oder bukkales arzneimittel

Info

Publication number
DE69502939T2
DE69502939T2 DE69502939T DE69502939T DE69502939T2 DE 69502939 T2 DE69502939 T2 DE 69502939T2 DE 69502939 T DE69502939 T DE 69502939T DE 69502939 T DE69502939 T DE 69502939T DE 69502939 T2 DE69502939 T2 DE 69502939T2
Authority
DE
Germany
Prior art keywords
oxepino
dibenz
chloro
methyl
buccal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69502939T
Other languages
German (de)
English (en)
Other versions
DE69502939D1 (de
Inventor
Leonardus Delbressine
Johannes Wieringa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8216678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69502939(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of DE69502939D1 publication Critical patent/DE69502939D1/de
Publication of DE69502939T2 publication Critical patent/DE69502939T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69502939T 1994-03-02 1995-03-01 Sublinguales oder bukkales arzneimittel Expired - Lifetime DE69502939T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94200521 1994-03-02
PCT/EP1995/000765 WO1995023600A1 (en) 1994-03-02 1995-03-01 Sublingual or buccal pharmaceutical composition

Publications (2)

Publication Number Publication Date
DE69502939D1 DE69502939D1 (de) 1998-07-16
DE69502939T2 true DE69502939T2 (de) 1998-10-22

Family

ID=8216678

Family Applications (2)

Application Number Title Priority Date Filing Date
DE201012000050 Active DE122010000050I2 (de) 1994-03-02 1995-03-01 Sublinguales oder bukkales arzneimittel.
DE69502939T Expired - Lifetime DE69502939T2 (de) 1994-03-02 1995-03-01 Sublinguales oder bukkales arzneimittel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE201012000050 Active DE122010000050I2 (de) 1994-03-02 1995-03-01 Sublinguales oder bukkales arzneimittel.

Country Status (22)

Country Link
US (1) US5763476A (enExample)
EP (1) EP0746317B1 (enExample)
JP (2) JP4099224B2 (enExample)
KR (1) KR100330942B1 (enExample)
CN (1) CN1079670C (enExample)
AT (1) ATE167057T1 (enExample)
AU (1) AU692530B2 (enExample)
BR (2) BR9506924A (enExample)
CA (1) CA2182981C (enExample)
CZ (1) CZ284633B6 (enExample)
DE (2) DE122010000050I2 (enExample)
DK (1) DK0746317T3 (enExample)
ES (1) ES2118584T3 (enExample)
FI (1) FI117923B (enExample)
FR (1) FR10C0056I2 (enExample)
HU (1) HU225051B1 (enExample)
LU (1) LU91751I2 (enExample)
NO (2) NO308772B1 (enExample)
NZ (1) NZ282394A (enExample)
PL (1) PL180465B1 (enExample)
RU (1) RU2139051C1 (enExample)
WO (1) WO1995023600A1 (enExample)

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WO2005107808A2 (en) * 2004-05-11 2005-11-17 Pfizer Products Inc. Combination of atypical antipsychotics and 5-ht1b receptor antagonists
GB0416861D0 (en) * 2004-07-29 2004-09-01 Quadrant Drug Delivery Ltd Composition
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US7872147B2 (en) 2005-04-07 2011-01-18 N. V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
KR20070116973A (ko) 2005-04-07 2007-12-11 엔.브이.오가논 트랜스-5-클로로-2-메틸-2,3,3ａ,12ｂ-테트라히드로-1ｈ-디벤즈[2,3:6,7]옥세피노[4,5-ｃ]피롤의 제조용 중간체화합물
PE20061311A1 (es) * 2005-04-07 2007-02-09 Organon Nv Forma cristalina ortorrombica del maleato de asenapina en el tratamiento de esquizofrenia
US7741358B2 (en) * 2005-04-14 2010-06-22 N.V. Organon Crystal form of asenapine maleate
US7750167B2 (en) 2006-07-05 2010-07-06 N.V. Organon Process for the preparation of asenapine and intermediate products used in said process
US7875729B2 (en) 2007-01-05 2011-01-25 Synthon Bv Process for making asenapine
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WO2009156889A1 (en) * 2008-06-25 2009-12-30 Pfizer Inc. Diaryl compounds and uses thereof
WO2010127674A1 (en) * 2009-05-06 2010-11-11 Sunin K/S Transdermal compositions of asenapine for the treatment of psychiatric disorders
JP5801295B2 (ja) 2009-06-24 2015-10-28 メルク・シャープ・エンド・ドーム・ベー・フェー アセナピンを含有する注射可能な配合物およびそれを用いた処置方法
TW201118102A (en) 2009-07-29 2011-06-01 Organon Nv Hydroxyasenapine compounds, derivatives thereof and pharmaceutical compositions comprising same
US8779161B2 (en) 2010-06-18 2014-07-15 Dr. Reddy's Laboratories Limited Asenapine maleate
WO2012013766A1 (en) 2010-07-29 2012-02-02 Laboratorios Lesvi, S.L. Novel process for the preparation of asenapine
WO2012038975A2 (en) * 2010-09-22 2012-03-29 Msn Laboratories Limited Process for the preparation of (3ars,12brs)-5-chloro-2-methyl-2,3,3a12b-tetrahydro-1hdibenzo[2,3:6,7] oxepino [4,5-c]pyrrole maleate and it's pharmaceutical composition thereof
EA027840B1 (ru) 2010-11-15 2017-09-29 Эйджинбайо, Инк. Производные пиридазина, композиции и способы лечения когнитивного нарушения
WO2012066565A2 (en) 2010-11-16 2012-05-24 Cadila Healthcare Limited Asenapine maleate amorphous and crystalline form and process for preparation thereof
EP2468750A1 (en) 2010-12-13 2012-06-27 Chemo Ibérica, S.A. Polymorphic forms of asenapine maleate and processes for their preparation
WO2012123325A1 (en) 2011-03-11 2012-09-20 Medichem S.A. NEW CRYSTAL FORMS OF THE SALT OF TRANS-5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE WITH MALEIC ACID
EP2524919A1 (en) 2011-05-17 2012-11-21 Sandoz AG Novel crystalline salts of Asenapine with organic Di-acids and Tri-acids
JP6014656B2 (ja) 2011-05-18 2016-10-25 ラビラトリオス レスビ エス エレ 化合物の多形体
US9533994B2 (en) 2011-05-18 2017-01-03 Laboratorios Lesvi S.L. Monoclinic crystalline form of asenapine maleate with a specific particle size distribution
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US10195150B2 (en) 2012-12-20 2019-02-05 Kashiv Pharma, Llc Orally disintegrating tablet formulation for enhanced bioavailability
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Also Published As

Publication number Publication date
HU225051B1 (en) 2006-05-29
MX9603713A (es) 1997-12-31
FR10C0056I2 (enExample) 2011-11-25
KR100330942B1 (ko) 2002-11-16
FR10C0056I1 (enExample) 2011-01-28
NO963639L (no) 1996-10-30
ES2118584T3 (es) 1998-09-16
AU692530B2 (en) 1998-06-11
FI963398A0 (fi) 1996-08-30
NZ282394A (en) 1997-12-19
DE69502939D1 (de) 1998-07-16
JPH09509674A (ja) 1997-09-30
ATE167057T1 (de) 1998-06-15
CZ254196A3 (en) 1997-10-15
EP0746317A1 (en) 1996-12-11
HK1008417A1 (en) 1999-05-07
RU2139051C1 (ru) 1999-10-10
CA2182981A1 (en) 1995-09-08
FI117923B (fi) 2007-04-30
BR1100625A (pt) 1999-12-28
WO1995023600A1 (en) 1995-09-08
NO963639D0 (no) 1996-08-30
BR9506924A (pt) 1997-09-30
PL316080A1 (en) 1996-12-23
CA2182981C (en) 2006-10-17
HUT76319A (en) 1997-08-28
CN1143320A (zh) 1997-02-19
DK0746317T3 (da) 1999-03-22
AU1947895A (en) 1995-09-18
LU91751I2 (fr) 2011-01-04
DE122010000050I2 (de) 2011-07-21
NO2010024I1 (no) 2011-01-03
HU9602383D0 (en) 1996-10-28
CN1079670C (zh) 2002-02-27
NO308772B1 (no) 2000-10-30
DE122010000050I1 (de) 2011-05-05
PL180465B1 (pl) 2001-02-28
CZ284633B6 (cs) 1999-01-13
JP4616810B2 (ja) 2011-01-19
EP0746317B1 (en) 1998-06-10
JP4099224B2 (ja) 2008-06-11
JP2006342178A (ja) 2006-12-21
FI963398L (fi) 1996-08-30
US5763476A (en) 1998-06-09
NO2010024I2 (no) 2012-04-10

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