CN1079670C - 舌下或颊给药的药物组合物 - Google Patents

舌下或颊给药的药物组合物 Download PDF

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Publication number
CN1079670C
CN1079670C CN95191906A CN95191906A CN1079670C CN 1079670 C CN1079670 C CN 1079670C CN 95191906 A CN95191906 A CN 95191906A CN 95191906 A CN95191906 A CN 95191906A CN 1079670 C CN1079670 C CN 1079670C
Authority
CN
China
Prior art keywords
pharmaceutical composition
sublingual
dibenzo
tetrahydro
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN95191906A
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English (en)
Chinese (zh)
Other versions
CN1143320A (zh
Inventor
L·P·C·蒂尔雷斯
J·H·韦宁加
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme BV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8216678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1079670(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Publication of CN1143320A publication Critical patent/CN1143320A/zh
Application granted granted Critical
Publication of CN1079670C publication Critical patent/CN1079670C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN95191906A 1994-03-02 1995-03-01 舌下或颊给药的药物组合物 Expired - Lifetime CN1079670C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94200521 1994-03-02
EP94200521.6 1994-03-02

Publications (2)

Publication Number Publication Date
CN1143320A CN1143320A (zh) 1997-02-19
CN1079670C true CN1079670C (zh) 2002-02-27

Family

ID=8216678

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95191906A Expired - Lifetime CN1079670C (zh) 1994-03-02 1995-03-01 舌下或颊给药的药物组合物

Country Status (23)

Country Link
US (1) US5763476A (enExample)
EP (1) EP0746317B1 (enExample)
JP (2) JP4099224B2 (enExample)
KR (1) KR100330942B1 (enExample)
CN (1) CN1079670C (enExample)
AT (1) ATE167057T1 (enExample)
AU (1) AU692530B2 (enExample)
BR (2) BR9506924A (enExample)
CA (1) CA2182981C (enExample)
CZ (1) CZ284633B6 (enExample)
DE (2) DE122010000050I2 (enExample)
DK (1) DK0746317T3 (enExample)
ES (1) ES2118584T3 (enExample)
FI (1) FI117923B (enExample)
FR (1) FR10C0056I2 (enExample)
HK (1) HK1008417A1 (enExample)
HU (1) HU225051B1 (enExample)
LU (1) LU91751I2 (enExample)
NO (2) NO308772B1 (enExample)
NZ (1) NZ282394A (enExample)
PL (1) PL180465B1 (enExample)
RU (1) RU2139051C1 (enExample)
WO (1) WO1995023600A1 (enExample)

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US7872147B2 (en) 2005-04-07 2011-01-18 N. V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
AR056306A1 (es) * 2005-04-07 2007-10-03 Organon Nv FORMA CRISTALINA ORTORRoMBICA DEL MALEATO DE ASENAPINA , COMPOSICIONES FARMACÉUTICAS Y SU USO EN EL TRATAMIENTO DE TRASTORNOS MENTALES
ES2333980T3 (es) 2005-04-07 2010-03-03 N.V. Organon Compuestos intermediarios utiles en la preparacion de trans-5-cloro-2-metil-2,3,3a,12b-tetrahidro-1h-dibenzo(2,3:6,7)oxepino(4,5-c)pirrol.
US7741358B2 (en) * 2005-04-14 2010-06-22 N.V. Organon Crystal form of asenapine maleate
US7750167B2 (en) 2006-07-05 2010-07-06 N.V. Organon Process for the preparation of asenapine and intermediate products used in said process
US7875729B2 (en) 2007-01-05 2011-01-25 Synthon Bv Process for making asenapine
PE20091156A1 (es) * 2007-12-17 2009-09-03 Astrazeneca Ab Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
WO2009156889A1 (en) * 2008-06-25 2009-12-30 Pfizer Inc. Diaryl compounds and uses thereof
WO2010127674A1 (en) * 2009-05-06 2010-11-11 Sunin K/S Transdermal compositions of asenapine for the treatment of psychiatric disorders
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TW201118102A (en) 2009-07-29 2011-06-01 Organon Nv Hydroxyasenapine compounds, derivatives thereof and pharmaceutical compositions comprising same
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JP6014656B2 (ja) 2011-05-18 2016-10-25 ラビラトリオス レスビ エス エレ 化合物の多形体
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CN102657635B (zh) * 2012-05-04 2013-08-07 上海现代药物制剂工程研究中心有限公司 具有微孔的海绵状的阿塞那平舌下膜剂及其制备方法
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US4371516A (en) * 1976-10-06 1983-02-01 John Wyeth & Brother Limited Articles for carrying chemicals
EP0569096A1 (en) * 1992-05-08 1993-11-10 Akzo Nobel N.V. Depot preparation
EP0578823A1 (en) * 1991-04-08 1994-01-19 Sumitomo Pharmaceuticals Company, Limited Porous solid preparation containing physiologically active protein substance

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Patent Citations (3)

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US4371516A (en) * 1976-10-06 1983-02-01 John Wyeth & Brother Limited Articles for carrying chemicals
EP0578823A1 (en) * 1991-04-08 1994-01-19 Sumitomo Pharmaceuticals Company, Limited Porous solid preparation containing physiologically active protein substance
EP0569096A1 (en) * 1992-05-08 1993-11-10 Akzo Nobel N.V. Depot preparation

Also Published As

Publication number Publication date
FR10C0056I2 (enExample) 2011-11-25
ES2118584T3 (es) 1998-09-16
BR1100625A (pt) 1999-12-28
EP0746317A1 (en) 1996-12-11
NO2010024I1 (no) 2011-01-03
KR100330942B1 (ko) 2002-11-16
MX9603713A (es) 1997-12-31
CA2182981A1 (en) 1995-09-08
NO963639L (no) 1996-10-30
FI117923B (fi) 2007-04-30
JPH09509674A (ja) 1997-09-30
LU91751I2 (fr) 2011-01-04
WO1995023600A1 (en) 1995-09-08
EP0746317B1 (en) 1998-06-10
CA2182981C (en) 2006-10-17
DE69502939T2 (de) 1998-10-22
NO2010024I2 (no) 2012-04-10
JP4099224B2 (ja) 2008-06-11
DK0746317T3 (da) 1999-03-22
DE122010000050I1 (de) 2011-05-05
JP2006342178A (ja) 2006-12-21
HUT76319A (en) 1997-08-28
JP4616810B2 (ja) 2011-01-19
FI963398A0 (fi) 1996-08-30
HU225051B1 (en) 2006-05-29
DE69502939D1 (de) 1998-07-16
FR10C0056I1 (enExample) 2011-01-28
FI963398L (fi) 1996-08-30
CZ254196A3 (en) 1997-10-15
HU9602383D0 (en) 1996-10-28
NO963639D0 (no) 1996-08-30
ATE167057T1 (de) 1998-06-15
HK1008417A1 (en) 1999-05-07
NZ282394A (en) 1997-12-19
NO308772B1 (no) 2000-10-30
PL180465B1 (pl) 2001-02-28
DE122010000050I2 (de) 2011-07-21
CZ284633B6 (cs) 1999-01-13
RU2139051C1 (ru) 1999-10-10
US5763476A (en) 1998-06-09
AU1947895A (en) 1995-09-18
BR9506924A (pt) 1997-09-30
PL316080A1 (en) 1996-12-23
AU692530B2 (en) 1998-06-11
CN1143320A (zh) 1997-02-19

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