KR100330942B1 - 설하또는협측투여용약학조성물 - Google Patents

설하또는협측투여용약학조성물 Download PDF

Info

Publication number
KR100330942B1
KR100330942B1 KR1019960704774A KR19960704774A KR100330942B1 KR 100330942 B1 KR100330942 B1 KR 100330942B1 KR 1019960704774 A KR1019960704774 A KR 1019960704774A KR 19960704774 A KR19960704774 A KR 19960704774A KR 100330942 B1 KR100330942 B1 KR 100330942B1
Authority
KR
South Korea
Prior art keywords
sublingual
oxepino
tetrahydro
chloro
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1019960704774A
Other languages
English (en)
Korean (ko)
Inventor
페트루스 카를라 델브레씨네 레오나르두스
후베르투스 비에린가 요한네스
Original Assignee
악조 노벨 엔.브이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8216678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100330942(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 악조 노벨 엔.브이. filed Critical 악조 노벨 엔.브이.
Application granted granted Critical
Publication of KR100330942B1 publication Critical patent/KR100330942B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019960704774A 1994-03-02 1995-03-01 설하또는협측투여용약학조성물 Expired - Lifetime KR100330942B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94200521 1994-03-02
EP94200521.6 1994-03-02
PCT/EP1995/000765 WO1995023600A1 (en) 1994-03-02 1995-03-01 Sublingual or buccal pharmaceutical composition

Publications (1)

Publication Number Publication Date
KR100330942B1 true KR100330942B1 (ko) 2002-11-16

Family

ID=8216678

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960704774A Expired - Lifetime KR100330942B1 (ko) 1994-03-02 1995-03-01 설하또는협측투여용약학조성물

Country Status (23)

Country Link
US (1) US5763476A (enExample)
EP (1) EP0746317B1 (enExample)
JP (2) JP4099224B2 (enExample)
KR (1) KR100330942B1 (enExample)
CN (1) CN1079670C (enExample)
AT (1) ATE167057T1 (enExample)
AU (1) AU692530B2 (enExample)
BR (2) BR9506924A (enExample)
CA (1) CA2182981C (enExample)
CZ (1) CZ284633B6 (enExample)
DE (2) DE122010000050I2 (enExample)
DK (1) DK0746317T3 (enExample)
ES (1) ES2118584T3 (enExample)
FI (1) FI117923B (enExample)
FR (1) FR10C0056I2 (enExample)
HK (1) HK1008417A1 (enExample)
HU (1) HU225051B1 (enExample)
LU (1) LU91751I2 (enExample)
NO (2) NO308772B1 (enExample)
NZ (1) NZ282394A (enExample)
PL (1) PL180465B1 (enExample)
RU (1) RU2139051C1 (enExample)
WO (1) WO1995023600A1 (enExample)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2418499A (en) * 1997-12-19 1999-07-12 Akzo Nobel N.V. Org-5222 in the treatment of depression
WO2003068604A1 (en) * 2002-02-13 2003-08-21 Weibel Michael K Drug dose-form and method of manufacture
US7276246B2 (en) * 2003-05-09 2007-10-02 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US7306812B2 (en) 2003-05-09 2007-12-11 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
CN1791430A (zh) * 2003-05-16 2006-06-21 辉瑞产品公司 非典型抗精神病药物和gaba调节剂、抗惊厥药物或苯并二氮杂䓬类的治疗性组合
TWI327915B (en) * 2003-06-12 2010-08-01 Organon Nv Pharmaceutical composition comprising antipsychotic agent and use of the antipsychotic agent for treating patients with overweight
CN1905905B (zh) * 2003-09-22 2011-06-08 巴克斯特国际公司 用于药物制剂和医药产品最终灭菌的高压灭菌
BRPI0510942A (pt) * 2004-05-11 2007-07-17 Pfizer Prod Inc combinação de antipsicóticos atìpicos e antagonistas do receptor 5-ht1b
GB0416861D0 (en) * 2004-07-29 2004-09-01 Quadrant Drug Delivery Ltd Composition
MX2007004485A (es) * 2004-10-15 2007-06-13 Organon Nv Tratamiento de desordenes bipolares y sintomas asociados.
WO2006106136A1 (en) 2005-04-07 2006-10-12 N.V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
PL1917267T3 (pl) * 2005-04-07 2009-06-30 Merck Sharp & Dohme Postać krystaliczna maleinianu asenapiny
US7872147B2 (en) 2005-04-07 2011-01-18 N. V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
US7741358B2 (en) * 2005-04-14 2010-06-22 N.V. Organon Crystal form of asenapine maleate
US7750167B2 (en) 2006-07-05 2010-07-06 N.V. Organon Process for the preparation of asenapine and intermediate products used in said process
US7875729B2 (en) 2007-01-05 2011-01-25 Synthon Bv Process for making asenapine
PE20091156A1 (es) * 2007-12-17 2009-09-03 Astrazeneca Ab Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
WO2009156889A1 (en) * 2008-06-25 2009-12-30 Pfizer Inc. Diaryl compounds and uses thereof
WO2010127674A1 (en) * 2009-05-06 2010-11-11 Sunin K/S Transdermal compositions of asenapine for the treatment of psychiatric disorders
AU2010264670A1 (en) 2009-06-24 2012-01-19 Merck Sharp & Dohme B.V. Injectable formulations containing asenapine and method of treatment using same
TW201118102A (en) 2009-07-29 2011-06-01 Organon Nv Hydroxyasenapine compounds, derivatives thereof and pharmaceutical compositions comprising same
WO2011159903A2 (en) 2010-06-18 2011-12-22 Dr. Reddy's Laboratories Ltd. Asenapine maleate
CA2805542C (en) 2010-07-29 2017-12-12 Laboratorios Lesvi, S.L. Novel process for the preparation of asenapine
WO2012038975A2 (en) * 2010-09-22 2012-03-29 Msn Laboratories Limited Process for the preparation of (3ars,12brs)-5-chloro-2-methyl-2,3,3a12b-tetrahydro-1hdibenzo[2,3:6,7] oxepino [4,5-c]pyrrole maleate and it's pharmaceutical composition thereof
MX383953B (es) 2010-11-15 2025-03-14 Agenebio Inc Derivados de piridazina, composiciones y metodos para tratar deterioro cognitivo.
WO2012066565A2 (en) 2010-11-16 2012-05-24 Cadila Healthcare Limited Asenapine maleate amorphous and crystalline form and process for preparation thereof
EP2468750A1 (en) 2010-12-13 2012-06-27 Chemo Ibérica, S.A. Polymorphic forms of asenapine maleate and processes for their preparation
WO2012123325A1 (en) 2011-03-11 2012-09-20 Medichem S.A. NEW CRYSTAL FORMS OF THE SALT OF TRANS-5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE WITH MALEIC ACID
EP2524919A1 (en) 2011-05-17 2012-11-21 Sandoz AG Novel crystalline salts of Asenapine with organic Di-acids and Tri-acids
EP2709615A1 (en) 2011-05-18 2014-03-26 Laboratorios Lesvi, S.L. Monoclinic crystalline form of asenapine maleate with a specific particle size distribution
EP2709616B1 (en) * 2011-05-18 2018-01-24 Laboratorios Lesvi, S.L. Synthesis of a stable micronised monoclinic form of asenapine maleate
EP2572703A1 (en) 2011-09-21 2013-03-27 Hexal AG Compressed oral dosage form for asenapine maleate
WO2013041604A1 (en) 2011-09-21 2013-03-28 Sandoz Ag Crystal form of asenapine maleate
CN102657635B (zh) * 2012-05-04 2013-08-07 上海现代药物制剂工程研究中心有限公司 具有微孔的海绵状的阿塞那平舌下膜剂及其制备方法
ITMI20121810A1 (it) 2012-10-24 2014-04-25 Chemo Iberica Sa Poliformi di maleato di asenapina e processo per la loro preparazione
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
US9597291B2 (en) 2012-12-11 2017-03-21 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Orally disintegrating tablet containing asenapine
US10195150B2 (en) 2012-12-20 2019-02-05 Kashiv Pharma, Llc Orally disintegrating tablet formulation for enhanced bioavailability
CN103893139B (zh) * 2012-12-28 2018-06-08 石药集团中奇制药技术（石家庄）有限公司 一种阿塞那平组合物及其制备方法
CN103120688A (zh) * 2013-01-11 2013-05-29 盛世泰科生物医药技术(苏州)有限公司 一种闪释制剂的药物组合
US9545376B2 (en) 2013-01-23 2017-01-17 Arx, Llc Production of unit dose constructs
WO2014127786A1 (en) 2013-02-22 2014-08-28 Zentiva, K.S. Orally disintegrating pharmaceutical composition comprising asenapine
WO2014207664A2 (en) * 2013-06-28 2014-12-31 Alembic Pharmaceuticals Limited Stable pharmaceutical composition of asenapine
MX381561B (es) 2013-12-20 2025-03-12 Agenebio Inc Derivados de benzodiazepina, composiciones, y métodos para tratar el deterioro cognitivo.
US20170007537A1 (en) * 2014-02-18 2017-01-12 Hetero Research Foundation Pharmaceutical compositions of asenapine
KR20170012210A (ko) 2014-04-04 2017-02-02 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
TR201509009A1 (en) * 2014-12-11 2017-02-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi THIN FILM STRIP OF ASENAPINE
WO2016198113A1 (en) 2015-06-11 2016-12-15 Alrise Biosystems Gmbh Process for the preparation of drug loaded microparticles
US10815242B2 (en) 2015-06-19 2020-10-27 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
PL3838274T3 (pl) 2016-01-26 2024-04-02 Intra-Cellular Therapies, Inc. Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN
DK3407889T3 (da) 2016-03-25 2021-08-09 Intra Cellular Therapies Inc Organiske forbindelser og deres anvendelse til behandling og forebyggelse af lidelser i centralnervesystemet
US10085971B2 (en) 2016-08-22 2018-10-02 Navinta Iii Inc Pharmaceutical solution of asenapine for sublingual or buccal use
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11337932B2 (en) 2016-12-20 2022-05-24 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
CN110087640A (zh) 2016-12-20 2019-08-02 罗曼治疗系统股份公司 包含阿塞那平的透皮治疗系统
WO2018126140A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
WO2018126143A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
WO2018175969A1 (en) 2017-03-24 2018-09-27 Intra-Cellular Therapies, Inc. Novel compositions and methods
JP2020525545A (ja) 2017-06-26 2020-08-27 エルテーエス ローマン テラピー−ジステーメ アーゲー アセナピンおよびシリコーンアクリルハイブリッドポリマーを含有する経皮治療システム
US11980617B2 (en) 2018-03-16 2024-05-14 Intra-Cellular Therapies, Inc. Methods of treating acute depression and/or acute anxiety
WO2019183341A1 (en) 2018-03-23 2019-09-26 Intra-Cellular Therapies, Inc. Organic compounds
CA3104478A1 (en) 2018-06-19 2019-12-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN112704672A (zh) 2018-06-20 2021-04-27 罗曼治疗系统股份公司 含有阿塞那平的透皮治疗系统
US12329862B2 (en) 2018-06-20 2025-06-17 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
US12144808B2 (en) 2018-08-29 2024-11-19 Intra-Cellular Therapies, Inc. Compositions and methods
JP7546546B2 (ja) 2018-08-31 2024-09-06 イントラ－セルラー・セラピーズ・インコーポレイテッド 新規方法
AU2019331490B2 (en) 2018-08-31 2025-04-24 Intra-Cellular Therapies, Inc. Novel methods
EP4134101A1 (en) 2019-07-07 2023-02-15 Intra-Cellular Therapies, Inc. Deuterated lumateperone for the treatment of the bipolar ii disorder
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605526A (nl) * 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.
IE45770B1 (en) * 1976-10-06 1982-11-17 Wyeth John & Brother Ltd Pharmaceutical dosage forms
GB1548022A (en) * 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
FR2480283A1 (fr) * 1980-04-10 1981-10-16 Science Union & Cie Nouveaux derives tricycliques, leurs procedes de preparation et leur utilisation comme medicament
JPS5967218A (ja) * 1982-10-07 1984-04-16 Grelan Pharmaceut Co Ltd 軟質な口腔製剤
GB8613688D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
CA2027243A1 (en) * 1989-10-17 1991-04-18 Everett H. Ellinwood, Jr. Intraoral formulated trifluorobenzodiazepines and the use thereof
WO1992017209A1 (fr) * 1991-04-08 1992-10-15 Sumitomo Pharmaceuticals Company, Limited Preparation solide poreuse contenant une substance proteique physiologiquement active
ZA933134B (en) * 1992-05-08 1993-11-30 Akzo Nv Depot preparation
EP0569096A1 (en) * 1992-05-08 1993-11-10 Akzo Nobel N.V. Depot preparation

Also Published As

Publication number Publication date
HUT76319A (en) 1997-08-28
ES2118584T3 (es) 1998-09-16
DE122010000050I1 (de) 2011-05-05
NO963639L (no) 1996-10-30
FR10C0056I2 (enExample) 2011-11-25
JPH09509674A (ja) 1997-09-30
ATE167057T1 (de) 1998-06-15
AU1947895A (en) 1995-09-18
NZ282394A (en) 1997-12-19
JP4099224B2 (ja) 2008-06-11
DE69502939D1 (de) 1998-07-16
AU692530B2 (en) 1998-06-11
FI963398A0 (fi) 1996-08-30
JP4616810B2 (ja) 2011-01-19
HU9602383D0 (en) 1996-10-28
HU225051B1 (en) 2006-05-29
JP2006342178A (ja) 2006-12-21
LU91751I2 (fr) 2011-01-04
US5763476A (en) 1998-06-09
BR1100625A (pt) 1999-12-28
FI963398L (fi) 1996-08-30
DE122010000050I2 (de) 2011-07-21
FR10C0056I1 (enExample) 2011-01-28
PL180465B1 (pl) 2001-02-28
EP0746317A1 (en) 1996-12-11
CZ254196A3 (en) 1997-10-15
NO963639D0 (no) 1996-08-30
DK0746317T3 (da) 1999-03-22
WO1995023600A1 (en) 1995-09-08
FI117923B (fi) 2007-04-30
MX9603713A (es) 1997-12-31
CA2182981C (en) 2006-10-17
BR9506924A (pt) 1997-09-30
CN1143320A (zh) 1997-02-19
NO308772B1 (no) 2000-10-30
PL316080A1 (en) 1996-12-23
EP0746317B1 (en) 1998-06-10
CN1079670C (zh) 2002-02-27
NO2010024I2 (no) 2012-04-10
CZ284633B6 (cs) 1999-01-13
RU2139051C1 (ru) 1999-10-10
HK1008417A1 (en) 1999-05-07
NO2010024I1 (no) 2011-01-03
DE69502939T2 (de) 1998-10-22
CA2182981A1 (en) 1995-09-08

Similar Documents

Publication Publication Date Title
KR100330942B1 (ko) 설하또는협측투여용약학조성물
HK1008417B (en) Sublingual or buccal pharmaceutical composition
EP1246668B1 (en) An rapid acting freeze dired oral pharmaceutical composition for treating migraine
KR100292124B1 (ko) 온단세트론을포함하는경구조성물
US20020002172A1 (en) Pharmaceutical formulations
KR20140104986A (ko) 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법
EP1656102A2 (en) Compositions for delivering 5-ht agonists across the oral mucosa and methods of use thereof
JPH0812575A (ja) 口腔乾燥症治療剤
TWI343262B (en) Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist
US20150080442A1 (en) Transmucosal drug delivery system
WO2006017540A2 (en) Pilocarpine compositions and methods of use thereof
AU2004273574B2 (en) Buccal formulations of galanthamine and uses thereof
MXPA96003713A (en) Sublingual pharmaceutical composition or bu
CA2556450A1 (en) Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof
CA1328613C (en) Hypotensive agent comprising 4' ethyl-2-methyl-3-piperidinopropiophenone
KR20160105935A (ko) 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법
HK1080282B (en) Improved formulations containing substituted imidazole derivatives
HK1080282A1 (en) Improved formulations containing substituted imidazole derivatives

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 19960830

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20000224

Comment text: Request for Examination of Application

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20020307

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20020320

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20020321

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20050315

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 20060316

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 20070316

Start annual number: 6

End annual number: 6

PR1001 Payment of annual fee

Payment date: 20080320

Start annual number: 7

End annual number: 7

PR1001 Payment of annual fee

Payment date: 20090318

Start annual number: 8

End annual number: 8

PR1001 Payment of annual fee

Payment date: 20100309

Start annual number: 9

End annual number: 9

PR1001 Payment of annual fee

Payment date: 20110310

Start annual number: 10

End annual number: 10

PR1001 Payment of annual fee

Payment date: 20120228

Start annual number: 11

End annual number: 11

FPAY Annual fee payment

Payment date: 20130227

Year of fee payment: 12

PR1001 Payment of annual fee

Payment date: 20130227

Start annual number: 12

End annual number: 12

FPAY Annual fee payment

Payment date: 20140227

Year of fee payment: 13

PR1001 Payment of annual fee

Payment date: 20140227

Start annual number: 13

End annual number: 13

EXPY Expiration of term
PC1801 Expiration of term

Termination date: 20150901

Termination category: Expiration of duration