DE69001503T2 - D-cycloserin und d-alanin enthaltende mischung zur verbesserung des gedaechtnisses und des lernvermoegens oder zur behandlung von kognitiven und psychotischen erkrankungen. - Google Patents
D-cycloserin und d-alanin enthaltende mischung zur verbesserung des gedaechtnisses und des lernvermoegens oder zur behandlung von kognitiven und psychotischen erkrankungen.Info
- Publication number
- DE69001503T2 DE69001503T2 DE9090104875T DE69001503T DE69001503T2 DE 69001503 T2 DE69001503 T2 DE 69001503T2 DE 9090104875 T DE9090104875 T DE 9090104875T DE 69001503 T DE69001503 T DE 69001503T DE 69001503 T2 DE69001503 T2 DE 69001503T2
- Authority
- DE
- Germany
- Prior art keywords
- cycloserine
- alanine
- composition
- glycine
- ratio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 230000000699 topical effect Effects 0.000 description 1
- 229940125725 tranquilizer Drugs 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Detergent Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32427989A | 1989-03-15 | 1989-03-15 | |
| US07/473,241 US5061721A (en) | 1989-03-15 | 1990-02-06 | Composition containing d-cycloserine and d-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69001503D1 DE69001503D1 (de) | 1993-06-09 |
| DE69001503T2 true DE69001503T2 (de) | 1993-09-09 |
Family
ID=26984373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE9090104875T Expired - Fee Related DE69001503T2 (de) | 1989-03-15 | 1990-03-15 | D-cycloserin und d-alanin enthaltende mischung zur verbesserung des gedaechtnisses und des lernvermoegens oder zur behandlung von kognitiven und psychotischen erkrankungen. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5061721A (Direct) |
| EP (1) | EP0387867B1 (Direct) |
| JP (1) | JP2963720B2 (Direct) |
| KR (1) | KR900013961A (Direct) |
| AT (1) | ATE88890T1 (Direct) |
| AU (1) | AU624917B2 (Direct) |
| CA (1) | CA2010635C (Direct) |
| DE (1) | DE69001503T2 (Direct) |
| DK (1) | DK0387867T3 (Direct) |
| ES (1) | ES2055197T3 (Direct) |
| FI (1) | FI901289A7 (Direct) |
| GR (1) | GR3008225T3 (Direct) |
| IE (1) | IE64130B1 (Direct) |
| IL (1) | IL93562A (Direct) |
| NO (1) | NO901198L (Direct) |
| NZ (1) | NZ232809A (Direct) |
| PT (1) | PT93424B (Direct) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5153193A (en) * | 1991-10-01 | 1992-10-06 | Hoechst-Roussel Pharmaceuticals Incorporated | Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs |
| JPH07505908A (ja) * | 1992-09-28 | 1995-06-29 | マックセチーニ、マリア ルイザ | Ｎｍｄａ受容体のアロステリックモジュレーター |
| US5854217A (en) * | 1992-09-28 | 1998-12-29 | Bearsden Bio, Inc. | Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function |
| US5302609A (en) * | 1992-12-16 | 1994-04-12 | The Regents Of The University Of Michigan | Treatment of diabetic nephropathy |
| US20040208875A1 (en) | 1995-03-15 | 2004-10-21 | Queen's University At Kingston | Method for treating amyloidosis |
| ATE311864T1 (de) * | 1993-03-29 | 2005-12-15 | Propan-1,3-disulphonsäure und deren pharmazeutisch akzeptable salze zur behandlung von amyloidosis | |
| US5523323A (en) * | 1993-09-14 | 1996-06-04 | Maccecchini; Maria-Luisa | Use of partial agonists of the NMDA receptor to reduce opiate induced tolerance and dependence |
| WO1996015788A1 (en) * | 1994-11-23 | 1996-05-30 | G.D. Searle & Co. | Use of amino-isoxazolidone compounds for improvement of implicit memory |
| ATE204852T1 (de) * | 1995-02-15 | 2001-09-15 | Bearsden Bio Inc | Alkylcarboxy-aminosäure modulatoren für den kainat-rezeptor |
| JP2001507924A (ja) | 1996-07-22 | 2001-06-19 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション | コナントキン類 |
| US6277825B1 (en) | 1996-07-22 | 2001-08-21 | University Of Utah Research Foundation | Use of conantokins for treating pain |
| WO1998003189A1 (en) | 1996-07-22 | 1998-01-29 | Cognetix, Inc. | Use of conantokins |
| CA2601132C (en) * | 1998-04-14 | 2011-11-08 | The General Hospital Corporation | Use of n-methylglycine and pharmaceutical compositions comprising n-methylglycine for treating neuropsychiatric disorders |
| US6551993B1 (en) * | 1999-08-16 | 2003-04-22 | Thomas Jefferson University | Partial agonists at the glycine modulatory site of the NMDA receptor for treating cognitive dysfunction |
| US6399574B1 (en) | 2000-03-22 | 2002-06-04 | University Of Utah Research Foundation | Use of conantokins |
| US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
| AU2002311784B2 (en) * | 2001-03-29 | 2007-11-22 | Michael Davis | Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning |
| US20050096396A1 (en) * | 2002-03-28 | 2005-05-05 | Emory University | Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning |
| JP2004527520A (ja) * | 2001-04-02 | 2004-09-09 | パノラマ リサーチ，インコーポレイティド | 治療剤としての抗酸化ニトロキシドおよびニトロン |
| WO2002087423A2 (en) * | 2001-05-02 | 2002-11-07 | Blanchette Rockefeller Neurosciences Institute | Carbonic anhydrase activators for enhancing learning and memory |
| EP1487542A1 (en) * | 2002-03-15 | 2004-12-22 | H. Lundbeck A/S | Use of asc-1 inhibitors to treat neurological and psychiatric disorders |
| KR20070104480A (ko) * | 2003-05-27 | 2007-10-25 | 포레스트 래보러토리즈, 인코포레이티드 | 우울증 및 그 밖의 기분장애의 치료를 위한 ｎｍｄａ수용체 길항제 및 선택적 세로토닌 재흡수 억제제의 배합물 |
| US20070010573A1 (en) | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| US7244764B2 (en) | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| US7414076B2 (en) | 2003-06-23 | 2008-08-19 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| EP1660634A4 (en) * | 2003-08-08 | 2009-02-18 | Burnham Inst | P16-mediated regulation of NMDA receptors |
| CA2592631A1 (en) | 2003-12-29 | 2005-07-21 | Jason Mcdevitt | Compositions and methods to treat recurrent medical conditions |
| TW201207390A (en) | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Method for screening agent for antidepressant activity |
| US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| CA2592320C (en) | 2004-12-22 | 2015-11-24 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| MX2007012374A (es) * | 2005-04-06 | 2008-02-22 | Adamas Pharmaceuticals Inc | Metodos y composiciones para el tratamiento de condiciones relacionadas con cns. |
| TW200716088A (en) | 2005-04-15 | 2007-05-01 | Neurochem Int Ltd | Formulations and methods for treating amyloidosis |
| ES2533463T3 (es) | 2006-10-12 | 2015-04-10 | Bhi Limited Partnership | Métodos, compuestos, composiciones y vehículos para suministrar ácido 3-amino-1-propanosulfónico |
| US20100113453A1 (en) * | 2007-04-10 | 2010-05-06 | Mcdevitt Jason P | Sublingual Formulations of D-Cycloserine and Methods of Using Same |
| BRPI0918868B8 (pt) | 2008-09-18 | 2021-05-25 | Naurex Inc | compostos moduladores do receptor de nmda e composições compreendendo os mesmos |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
| TWI544923B (zh) * | 2009-12-29 | 2016-08-11 | 何應瑞 | 用於治療神經退化性疾病之醫藥組合物 |
| EP2542254B1 (en) | 2010-02-11 | 2018-09-26 | Northwestern University | Nmda receptor agonists and uses thereof |
| KR101692275B1 (ko) | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | ２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도 |
| JP5689026B2 (ja) * | 2010-06-17 | 2015-03-25 | 株式会社 資生堂 | 水中油型乳化皮膚化粧料 |
| EP2670409B1 (en) * | 2011-01-31 | 2018-04-18 | Serotech, LLC | Dosage regimen, medication dispensing package and uses thereof for the treatment of major depressive disorder |
| WO2014093277A1 (en) | 2012-12-11 | 2014-06-19 | The Mclean Hospital Corporation | Xenon and/or argon treatment as an adjunct to psychotherapy for psychiatric disorders |
| WO2014120789A1 (en) | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| MX2015009773A (es) | 2013-01-29 | 2016-08-05 | Aptinyx Inc | Moduladores de receptores nmda de espiro-lactama y sus usos. |
| LT3514158T (lt) | 2013-01-29 | 2023-02-10 | Aptinyx Inc. | Spirolaktaminiai nmda receptoriaus moduliatoriai ir jų panaudojimas |
| SG11201505862TA (en) | 2013-01-29 | 2015-08-28 | Naurex Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| PE20151427A1 (es) | 2013-01-29 | 2015-10-10 | Naurex Inc | Moduladores de receptores nmda de espiro-lactama y sus usos |
| US9877951B2 (en) | 2015-02-12 | 2018-01-30 | College Of William And Mary | Method for treating dementia |
| KR102128675B1 (ko) | 2016-05-19 | 2020-06-30 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조정제 및 그의 용도 |
| WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| IL286107B2 (en) | 2016-08-01 | 2024-09-01 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and usesthereof |
| AU2017306164B2 (en) | 2016-08-01 | 2021-10-21 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam NMDA modulators and methods of using same |
| WO2018026792A1 (en) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof |
| EP3490974B1 (en) | 2016-08-01 | 2023-12-06 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam nmda receptor modulators and uses thereof |
| SG10202101055VA (en) | 2016-08-01 | 2021-03-30 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| EP3427729A1 (en) | 2017-07-13 | 2019-01-16 | Paris Sciences et Lettres - Quartier Latin | Probenecid for use in treating epileptic diseases, disorders or conditions |
| JP7210599B2 (ja) | 2018-01-31 | 2023-01-23 | アプティニックス インコーポレイテッド | スピロラクタム系ｎｍｄａ受容体修飾因子およびその使用 |
| WO2020252384A1 (en) * | 2019-06-14 | 2020-12-17 | Vorsanger Gary | Treatment methods utilizing oxytocin receptor agonists |
| US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
| CN114786668B (zh) | 2019-11-27 | 2024-07-16 | 诺罗瑞韦有限公司 | 用于治疗抑郁症的环丝氨酸和锂的组合疗法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3428730A (en) * | 1967-06-30 | 1969-02-18 | Hamao Umezawa | Antibacterial mixture of o-carbamyl-d-serine and d-4-amino-3-isoxazolidone |
| US4031231A (en) * | 1974-06-13 | 1977-06-21 | Merck & Co., Inc. | Antibacterial composition comprising 3-fluoro-D-alanine or deutero analog in combination with auto-antagonist inhibitor |
| US4904681A (en) * | 1987-12-01 | 1990-02-27 | G. D. Searle & Co. | D-cycloserine and its prodrugs as cognitive enhancers |
-
1990
- 1990-02-06 US US07/473,241 patent/US5061721A/en not_active Expired - Lifetime
- 1990-02-27 IL IL9356290A patent/IL93562A/en active IP Right Grant
- 1990-03-06 NZ NZ232809A patent/NZ232809A/en unknown
- 1990-03-06 AU AU50734/90A patent/AU624917B2/en not_active Ceased
- 1990-03-14 PT PT93424A patent/PT93424B/pt not_active IP Right Cessation
- 1990-03-14 IE IE92190A patent/IE64130B1/en not_active IP Right Cessation
- 1990-03-14 CA CA002010635A patent/CA2010635C/en not_active Expired - Fee Related
- 1990-03-14 JP JP2063937A patent/JP2963720B2/ja not_active Expired - Lifetime
- 1990-03-14 NO NO90901198A patent/NO901198L/no unknown
- 1990-03-15 KR KR1019900003482A patent/KR900013961A/ko not_active Ceased
- 1990-03-15 EP EP90104875A patent/EP0387867B1/en not_active Expired - Lifetime
- 1990-03-15 ES ES90104875T patent/ES2055197T3/es not_active Expired - Lifetime
- 1990-03-15 FI FI901289A patent/FI901289A7/fi not_active IP Right Cessation
- 1990-03-15 AT AT90104875T patent/ATE88890T1/de not_active IP Right Cessation
- 1990-03-15 DE DE9090104875T patent/DE69001503T2/de not_active Expired - Fee Related
- 1990-03-15 DK DK90104875.1T patent/DK0387867T3/da active
-
1993
- 1993-06-18 GR GR930400134T patent/GR3008225T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3008225T3 (Direct) | 1993-09-30 |
| AU624917B2 (en) | 1992-06-25 |
| FI901289A7 (fi) | 1990-09-16 |
| NO901198D0 (no) | 1990-03-14 |
| IE900921L (en) | 1990-09-15 |
| CA2010635A1 (en) | 1990-09-15 |
| EP0387867B1 (en) | 1993-05-05 |
| IE64130B1 (en) | 1995-07-12 |
| CA2010635C (en) | 2001-03-06 |
| PT93424A (pt) | 1990-11-07 |
| ATE88890T1 (de) | 1993-05-15 |
| DE69001503D1 (de) | 1993-06-09 |
| NO901198L (no) | 1990-09-17 |
| JPH03148221A (ja) | 1991-06-25 |
| IL93562A (en) | 1996-01-31 |
| IL93562A0 (en) | 1990-11-29 |
| AU5073490A (en) | 1990-09-20 |
| JP2963720B2 (ja) | 1999-10-18 |
| FI901289A0 (fi) | 1990-03-15 |
| EP0387867A1 (en) | 1990-09-19 |
| KR900013961A (ko) | 1990-10-22 |
| US5061721A (en) | 1991-10-29 |
| ES2055197T3 (es) | 1994-08-16 |
| DK0387867T3 (da) | 1993-06-01 |
| NZ232809A (en) | 1992-05-26 |
| PT93424B (pt) | 1996-08-30 |
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