PT93424A - Processo para a preparacao de uma composicao contendo d-cicloserina e d- -alanina para melhoria de memoria e de aprendizagem ou para tratamento de doencas psicoticas ou cognitivas - Google Patents
Processo para a preparacao de uma composicao contendo d-cicloserina e d- -alanina para melhoria de memoria e de aprendizagem ou para tratamento de doencas psicoticas ou cognitivasInfo
- Publication number
- PT93424A PT93424A PT93424A PT9342490A PT93424A PT 93424 A PT93424 A PT 93424A PT 93424 A PT93424 A PT 93424A PT 9342490 A PT9342490 A PT 9342490A PT 93424 A PT93424 A PT 93424A
- Authority
- PT
- Portugal
- Prior art keywords
- cycloserine
- memory
- treatment
- psychotic
- alaline
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Detergent Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32427989A | 1989-03-15 | 1989-03-15 | |
US07/473,241 US5061721A (en) | 1989-03-15 | 1990-02-06 | Composition containing d-cycloserine and d-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder |
Publications (2)
Publication Number | Publication Date |
---|---|
PT93424A true PT93424A (pt) | 1990-11-07 |
PT93424B PT93424B (pt) | 1996-08-30 |
Family
ID=26984373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT93424A PT93424B (pt) | 1989-03-15 | 1990-03-14 | Processo para a preparacao de uma composicao contendo d-cicloserina e d- -alanina para melhoria de memoria e de aprendizagem ou para tratamento de doencas psicoticas ou cognitivas |
Country Status (17)
Country | Link |
---|---|
US (1) | US5061721A (pt) |
EP (1) | EP0387867B1 (pt) |
JP (1) | JP2963720B2 (pt) |
KR (1) | KR900013961A (pt) |
AT (1) | ATE88890T1 (pt) |
AU (1) | AU624917B2 (pt) |
CA (1) | CA2010635C (pt) |
DE (1) | DE69001503T2 (pt) |
DK (1) | DK0387867T3 (pt) |
ES (1) | ES2055197T3 (pt) |
FI (1) | FI901289A0 (pt) |
GR (1) | GR3008225T3 (pt) |
IE (1) | IE64130B1 (pt) |
IL (1) | IL93562A (pt) |
NO (1) | NO901198L (pt) |
NZ (1) | NZ232809A (pt) |
PT (1) | PT93424B (pt) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5153193A (en) * | 1991-10-01 | 1992-10-06 | Hoechst-Roussel Pharmaceuticals Incorporated | Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs |
US5854217A (en) * | 1992-09-28 | 1998-12-29 | Bearsden Bio, Inc. | Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function |
JPH07505908A (ja) * | 1992-09-28 | 1995-06-29 | マックセチーニ、マリア ルイザ | Nmda受容体のアロステリックモジュレーター |
US5302609A (en) * | 1992-12-16 | 1994-04-12 | The Regents Of The University Of Michigan | Treatment of diabetic nephropathy |
US20040208875A1 (en) | 1995-03-15 | 2004-10-21 | Queen's University At Kingston | Method for treating amyloidosis |
EP1060750B1 (en) * | 1993-03-29 | 2005-12-07 | Queen's University At Kingston | Propane-1,3-disulfonic acid and its pharmaceutically acceptable salts for treating amyloidosis |
US5523323A (en) * | 1993-09-14 | 1996-06-04 | Maccecchini; Maria-Luisa | Use of partial agonists of the NMDA receptor to reduce opiate induced tolerance and dependence |
WO1996015788A1 (en) | 1994-11-23 | 1996-05-30 | G.D. Searle & Co. | Use of amino-isoxazolidone compounds for improvement of implicit memory |
ATE204852T1 (de) * | 1995-02-15 | 2001-09-15 | Bearsden Bio Inc | Alkylcarboxy-aminosäure modulatoren für den kainat-rezeptor |
US6172041B1 (en) | 1996-07-22 | 2001-01-09 | University Of Utah Research Foundation | Use of conantokins |
US6277825B1 (en) | 1996-07-22 | 2001-08-21 | University Of Utah Research Foundation | Use of conantokins for treating pain |
JP2001507924A (ja) | 1996-07-22 | 2001-06-19 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション | コナントキン類 |
RU2219924C2 (ru) | 1998-04-14 | 2003-12-27 | Дзе Дженерал Хоспитал Корпорейшн | Способ лечения нейропсихиатрических расстройств |
US6551993B1 (en) * | 1999-08-16 | 2003-04-22 | Thomas Jefferson University | Partial agonists at the glycine modulatory site of the NMDA receptor for treating cognitive dysfunction |
US6399574B1 (en) | 2000-03-22 | 2002-06-04 | University Of Utah Research Foundation | Use of conantokins |
US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
US20050096396A1 (en) * | 2002-03-28 | 2005-05-05 | Emory University | Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning |
AU2002311784B2 (en) * | 2001-03-29 | 2007-11-22 | Michael Davis | Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning |
CA2442798A1 (en) * | 2001-04-02 | 2002-10-10 | Panorama Research, Inc. | Antioxidant nitroxides and nitrones as therapeutic agents |
DE60229371D1 (de) * | 2001-05-02 | 2008-11-27 | Brni Neurosciences Inst | Kohlensäureanhydrase-aktivatoren zur verbesserung der lern- und gedächtnisleistung |
JP2005527525A (ja) * | 2002-03-15 | 2005-09-15 | ハー・ルンドベック・アクチエゼルスカベット | 神経学的及び精神医学的障害の治療にasc−1阻害剤を使用する方法 |
RS20050851A (sr) * | 2003-05-27 | 2008-04-04 | Forest Laboratories Inc., | Kombinacija antagonista nmda receptora i selektivnog inhibitora ponovnog preuzimanja serotonina za lečenje depresije i drugih poremećaja raspoloženja |
US7414076B2 (en) | 2003-06-23 | 2008-08-19 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
US7244764B2 (en) | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
US20070010573A1 (en) | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
WO2005014797A2 (en) * | 2003-08-08 | 2005-02-17 | The Burnham Institute | P16 mediated regulation of nmda receptors |
KR20070007276A (ko) | 2003-12-29 | 2007-01-15 | 제이슨 맥데빗 | 재발성 의학적 증상을 치료하기 위한 조성물 및 방법 |
TW200538181A (en) | 2004-05-18 | 2005-12-01 | Brni Neurosciences Inst | Treatment of depressive disorders |
US7619007B2 (en) * | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
CA2592320C (en) | 2004-12-22 | 2015-11-24 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
KR101406456B1 (ko) * | 2005-04-06 | 2014-06-20 | 아다마스 파마슈티칼스, 인코포레이티드 | Cns 장애의 치료를 위한 방법 및 조성물 |
TW200716088A (en) | 2005-04-15 | 2007-05-01 | Neurochem Int Ltd | Formulations and methods for treating amyloidosis |
CA2666246C (en) | 2006-10-12 | 2013-12-31 | Bellus Health (International) Limited | Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid |
US20100113453A1 (en) * | 2007-04-10 | 2010-05-06 | Mcdevitt Jason P | Sublingual Formulations of D-Cycloserine and Methods of Using Same |
EP2331571B1 (en) | 2008-09-18 | 2015-08-26 | Northwestern University | Nmda receptor modulators and uses thereof |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
TWI544923B (zh) * | 2009-12-29 | 2016-08-11 | 何應瑞 | 用於治療神經退化性疾病之醫藥組合物 |
KR101692275B1 (ko) | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | 2차 구조 안정화된 nmda 수용체 조절제 및 그의 용도 |
SG10201811584RA (en) | 2010-02-11 | 2019-01-30 | Univ Northwestern | Secondary Structure Stabilized NMDA Receptor Modulators And Uses Thereof |
JP5689026B2 (ja) * | 2010-06-17 | 2015-03-25 | 株式会社 資生堂 | 水中油型乳化皮膚化粧料 |
WO2012104852A1 (en) * | 2011-01-31 | 2012-08-09 | Serotech, Llc | Dosage regimen, medication dispensing package and uses thereof for the treatment of major depressive disorder |
US9737562B2 (en) | 2012-12-11 | 2017-08-22 | The Mclean Hospital Corporation | Xenon and/or argon treatment as an adjunct to psychotherapy for psychiatric disorders |
CA2898863A1 (en) | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
AU2014212485C1 (en) | 2013-01-29 | 2018-10-25 | Aptinyx, Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
HUE043843T2 (hu) | 2013-01-29 | 2019-09-30 | Aptinyx Inc | Spiro-laktám NMDA receptor modulátorok és azok alkalmazása |
AU2014212501A1 (en) | 2013-01-29 | 2015-07-30 | Aptinyx, Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
EA201591404A1 (ru) | 2013-01-29 | 2016-01-29 | Аптиникс Инк. | Спиролактамные модуляторы рецептора nmda и их применение |
US9877951B2 (en) | 2015-02-12 | 2018-01-30 | College Of William And Mary | Method for treating dementia |
CA3024606C (en) | 2016-05-19 | 2019-09-03 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
BR112019001926A2 (pt) | 2016-08-01 | 2019-08-06 | Aptinyx Inc | moduladores do receptor nmda espiro-lactama e bis-espiro-lactama e usos destes |
BR112019001768A2 (pt) | 2016-08-01 | 2019-06-11 | Aptinyx Inc | moduladores do receptor de spiro-lactamas nmda e usos dos mesmos |
CA3031534C (en) | 2016-08-01 | 2023-10-17 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
JP7032378B2 (ja) | 2016-08-01 | 2022-03-08 | アプティニックス インコーポレイテッド | スピロ-ラクタムnmda受容体修飾因子及びその使用 |
EP3490990B1 (en) | 2016-08-01 | 2023-12-06 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam nmda modulators and methods of using same |
EP3427729A1 (en) | 2017-07-13 | 2019-01-16 | Paris Sciences et Lettres - Quartier Latin | Probenecid for use in treating epileptic diseases, disorders or conditions |
WO2019152687A1 (en) | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
WO2020252384A1 (en) * | 2019-06-14 | 2020-12-17 | Vorsanger Gary | Treatment methods utilizing oxytocin receptor agonists |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3428730A (en) * | 1967-06-30 | 1969-02-18 | Hamao Umezawa | Antibacterial mixture of o-carbamyl-d-serine and d-4-amino-3-isoxazolidone |
US4031231A (en) * | 1974-06-13 | 1977-06-21 | Merck & Co., Inc. | Antibacterial composition comprising 3-fluoro-D-alanine or deutero analog in combination with auto-antagonist inhibitor |
US4904681A (en) * | 1987-12-01 | 1990-02-27 | G. D. Searle & Co. | D-cycloserine and its prodrugs as cognitive enhancers |
-
1990
- 1990-02-06 US US07/473,241 patent/US5061721A/en not_active Expired - Lifetime
- 1990-02-27 IL IL9356290A patent/IL93562A/en active IP Right Grant
- 1990-03-06 NZ NZ232809A patent/NZ232809A/en unknown
- 1990-03-06 AU AU50734/90A patent/AU624917B2/en not_active Ceased
- 1990-03-14 IE IE92190A patent/IE64130B1/en not_active IP Right Cessation
- 1990-03-14 JP JP2063937A patent/JP2963720B2/ja not_active Expired - Lifetime
- 1990-03-14 NO NO90901198A patent/NO901198L/no unknown
- 1990-03-14 CA CA002010635A patent/CA2010635C/en not_active Expired - Fee Related
- 1990-03-14 PT PT93424A patent/PT93424B/pt not_active IP Right Cessation
- 1990-03-15 AT AT90104875T patent/ATE88890T1/de not_active IP Right Cessation
- 1990-03-15 FI FI901289A patent/FI901289A0/fi not_active IP Right Cessation
- 1990-03-15 KR KR1019900003482A patent/KR900013961A/ko not_active Application Discontinuation
- 1990-03-15 DK DK90104875.1T patent/DK0387867T3/da active
- 1990-03-15 ES ES90104875T patent/ES2055197T3/es not_active Expired - Lifetime
- 1990-03-15 DE DE9090104875T patent/DE69001503T2/de not_active Expired - Fee Related
- 1990-03-15 EP EP90104875A patent/EP0387867B1/en not_active Expired - Lifetime
-
1993
- 1993-06-18 GR GR930400134T patent/GR3008225T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
IL93562A0 (en) | 1990-11-29 |
ES2055197T3 (es) | 1994-08-16 |
DE69001503T2 (de) | 1993-09-09 |
EP0387867A1 (en) | 1990-09-19 |
CA2010635C (en) | 2001-03-06 |
NO901198D0 (no) | 1990-03-14 |
ATE88890T1 (de) | 1993-05-15 |
DE69001503D1 (de) | 1993-06-09 |
IL93562A (en) | 1996-01-31 |
KR900013961A (ko) | 1990-10-22 |
US5061721A (en) | 1991-10-29 |
NO901198L (no) | 1990-09-17 |
EP0387867B1 (en) | 1993-05-05 |
JP2963720B2 (ja) | 1999-10-18 |
GR3008225T3 (pt) | 1993-09-30 |
JPH03148221A (ja) | 1991-06-25 |
IE900921L (en) | 1990-09-15 |
PT93424B (pt) | 1996-08-30 |
NZ232809A (en) | 1992-05-26 |
AU5073490A (en) | 1990-09-20 |
AU624917B2 (en) | 1992-06-25 |
DK0387867T3 (da) | 1993-06-01 |
FI901289A0 (fi) | 1990-03-15 |
IE64130B1 (en) | 1995-07-12 |
CA2010635A1 (en) | 1990-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG3A | Patent granted, date of granting |
Effective date: 19960502 |
|
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19971130 |