DE60335123D1 - Pharmazeutische Zusammensetzungen, umfassend Komplexe von Phosphatderivaten von lipophilen Verbindungen - Google Patents

Pharmazeutische Zusammensetzungen, umfassend Komplexe von Phosphatderivaten von lipophilen Verbindungen

Info

Publication number
DE60335123D1
DE60335123D1 DE60335123T DE60335123T DE60335123D1 DE 60335123 D1 DE60335123 D1 DE 60335123D1 DE 60335123 T DE60335123 T DE 60335123T DE 60335123 T DE60335123 T DE 60335123T DE 60335123 D1 DE60335123 D1 DE 60335123D1
Authority
DE
Germany
Prior art keywords
complexes
pharmaceutical compositions
lipophilic compounds
phosphate derivatives
pharmacologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60335123T
Other languages
English (en)
Inventor
Simon Michael West
David Kannar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vital Health Sciences Pty Ltd
Original Assignee
Vital Health Sciences Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vital Health Sciences Pty Ltd filed Critical Vital Health Sciences Pty Ltd
Application granted granted Critical
Publication of DE60335123D1 publication Critical patent/DE60335123D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polishing Bodies And Polishing Tools (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60335123T 2002-08-09 2003-08-07 Pharmazeutische Zusammensetzungen, umfassend Komplexe von Phosphatderivaten von lipophilen Verbindungen Expired - Lifetime DE60335123D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2002950713A AU2002950713A0 (en) 2002-08-09 2002-08-09 Carrier
PCT/AU2003/000998 WO2004014432A1 (en) 2002-08-09 2003-08-07 Carrier

Publications (1)

Publication Number Publication Date
DE60335123D1 true DE60335123D1 (de) 2011-01-05

Family

ID=27809806

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60335123T Expired - Lifetime DE60335123D1 (de) 2002-08-09 2003-08-07 Pharmazeutische Zusammensetzungen, umfassend Komplexe von Phosphatderivaten von lipophilen Verbindungen

Country Status (12)

Country Link
US (1) US8841342B2 (de)
EP (1) EP1545621B1 (de)
JP (1) JP4652806B2 (de)
KR (1) KR20050047525A (de)
CN (1) CN1684709B (de)
AT (1) ATE489110T1 (de)
AU (4) AU2002950713A0 (de)
BR (1) BR0313575C1 (de)
CA (1) CA2495280C (de)
DE (1) DE60335123D1 (de)
MX (1) MXPA05001511A (de)
WO (1) WO2004014432A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040097472A1 (en) * 2000-11-14 2004-05-20 West Simon Michael Complexes of phosphate derivatives
AUPR549901A0 (en) 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
CA2453823C (en) * 2001-07-27 2010-12-21 Vital Health Sciences Pty Ltd Dermal therapy using phosphate derivatives of electron transfer agents
WO2003049774A1 (en) * 2001-12-13 2003-06-19 Vital Health Sciences Pty Ltd Transdermal transport of compounds
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
KR20050086954A (ko) * 2003-01-17 2005-08-30 바이탈 헬스 사이언시즈 피티와이 리미티드 항증식성 화합물
AU2003901815A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphate derivatives
AU2003901813A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Pharmaceutical derivatives
CA2557354C (en) * 2004-03-03 2013-05-07 Vital Health Sciences Pty Ltd. Alkaloid formulations
CA2575587C (en) * 2004-08-03 2014-06-17 Vital Health Sciences Pty Ltd Carrier for enteral administration
JP2008531602A (ja) * 2005-03-03 2008-08-14 バイタル ヘルス サイエンシズ プロプライアタリー リミティド 抗癌特性を有する化合物
AU2006257714B2 (en) * 2005-06-17 2011-07-21 Vital Health Sciences Pty Ltd A carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
US9168216B2 (en) * 2005-06-17 2015-10-27 Vital Health Sciences Pty. Ltd. Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
EP1973547A1 (de) * 2005-12-23 2008-10-01 Vital Health Sciences Pty Ltd. Verbindungen mit zytokin-modulierenden eigenschaften
KR101521989B1 (ko) 2007-03-02 2015-05-28 테이카 세이야쿠 가부시키가이샤 경피흡수 의약조성물, 의약조성물 저장유닛 및 이것을 이용하는 경피흡수제제
AU2010336018B2 (en) * 2009-12-23 2015-10-01 Phosphagenics Limited Carrier composition
RU2012133467A (ru) * 2010-02-05 2014-02-10 Фосфейдженикс Лимитед Композиция носителя
AU2011213557B2 (en) 2010-02-05 2015-05-07 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
BR112012024835A2 (pt) * 2010-03-30 2016-06-07 Phosphagenics Ltd adesivo de distribuição transdérmica
FR2969924B1 (fr) * 2010-12-30 2013-11-15 Lvmh Rech Composition comprenant un phosphate de tocopherol
WO2012122586A1 (en) 2011-03-15 2012-09-20 Phosphagenics Limited New composition
PT2782584T (pt) 2011-11-23 2021-09-02 Therapeuticsmd Inc Preparações e terapias de substituição para hormonoterapias naturais combinadas
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
AU2014386711B2 (en) * 2014-03-12 2020-04-30 Ego Pharmaceuticals Pty Ltd Compositions that assist skin healing and/or maintain skin health
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
BR112016029338A2 (pt) 2014-07-29 2017-08-22 Therapeuticsmd Inc creme transdérmico
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
EP3383371B1 (de) 2015-12-09 2024-05-01 Avecho Biotechnology Limited Pharmazeutische formulierung
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
CA3020153A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
CA3045702A1 (en) 2016-12-21 2018-06-28 Phosphagenics Limited Phosphorylation process of complex alcohols
CA3061607A1 (en) 2017-04-27 2018-11-01 Meltz, LLC Method for centrifugal extraction and apparatus suitable for carrying out this method

Family Cites Families (220)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2407823A (en) 1946-09-17 Antihemorrhagic esters and methods
US2667479A (en) 1951-01-30 1954-01-26 Merck & Co Inc Benzimidazole phosphate
GB778142A (en) 1953-11-20 1957-07-03 Leo Ab High-molecular weight derivatives of hydroxyl group-containing steroids and a method of producing them
US2913477A (en) 1957-03-22 1959-11-17 Merck & Co Inc Antihemorrhagic compounds and processes for preparing the same
US3127434A (en) 1959-10-20 1964-03-31 Hoffmann La Roche Dihydrovitamin k monophosphate compounds and preparation thereof
US3212901A (en) 1961-06-07 1965-10-19 Eastman Kodak Co Stabilized tocopherol concentrates and process for preparing the same
US3331896A (en) 1964-09-15 1967-07-18 Gen Aniline & Film Corp Method of preparing alkali soluble phosphate esters of hydroxylic organic compounds
JPS5315381Y1 (de) 1974-06-06 1978-04-22
DE2526938C2 (de) 1975-02-14 1982-04-22 F. Hoffmann-La Roche & Co. AG, 4002 Basel Vitaminpräparate
US4141938A (en) 1976-10-07 1979-02-27 Hoechst Aktiengesellschaft Production of acid orthophosphoric acid ester mixtures
US4444755A (en) 1978-01-23 1984-04-24 Efamol Limited Treatment for skin disorders
US4299906A (en) 1979-06-01 1981-11-10 American Hoechst Corporation Light-sensitive color proofing film with surfactant in a light-sensitive coating
SU925961A1 (ru) 1980-08-15 1982-05-07 Московский ордена Трудового Красного Знамени технологический институт пищевой промышленности Способ получени фосфорилированных глицеридов высших жирных кислот
JPS5944375B2 (ja) 1981-07-01 1984-10-29 日本鉱業株式会社 溶液中のカルシウムの選択的除去方法
US4369172A (en) 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
IT1157269B (it) 1982-03-19 1987-02-11 Seuref Ag Nuove formulazioni farmaceutiche contenenti il coenzima q10 adatte per la somministrazione topica
JPS58180410U (ja) 1982-05-28 1983-12-02 東芝プラント建設株式会社 下げ振り
JPS59157091U (ja) 1983-04-04 1984-10-22 日本建鐵株式会社 建具用パツキン
JPS60197621A (ja) 1984-03-19 1985-10-07 Hohnen Oil Co Ltd コレステロ−ル低下剤
CH661438A5 (it) 1984-04-09 1987-07-31 Seuref Ag Composizioni farmaceutiche ad azione antianossica e metabolica cerebrale.
US4603142A (en) 1984-06-01 1986-07-29 Wisconsin Alumni Research Foundation Cholesterol lowering method of use
EP0171009B1 (de) 1984-08-02 1991-05-22 HENKEL CORPORATION (a Delaware corp.) Reinigung von Tocopherolen durch Extraktion
JPS6191137A (ja) 1984-10-11 1986-05-09 Kao Corp 外用薬剤組成物
JPS6186940U (de) 1984-11-12 1986-06-07
JPS6191137U (de) 1984-11-19 1986-06-13
JP2540294B2 (ja) 1985-04-09 1996-10-02 花王株式会社 経皮吸収製剤
JPS6220822Y2 (de) 1985-04-17 1987-05-27
JPS62195393U (de) 1986-05-29 1987-12-11
JPH0781138B2 (ja) 1986-12-02 1995-08-30 株式会社資生堂 抗酸化剤
JPS6393791U (de) 1986-12-08 1988-06-17
DE3702766A1 (de) 1987-01-30 1988-08-11 Henkel Kgaa Verfahren zur herstellung und isolierung von monoalkylphosphorsaeureestern
JP3070744B2 (ja) 1987-04-10 2000-07-31 株式会社日立製作所 ベクトル処理装置
US4952495A (en) 1987-06-08 1990-08-28 Eastman Kodak Company Hydrolyzable compounds which release electron transfer agents and analytical use of same
PH25859A (en) 1988-01-11 1991-12-02 Takeda Chemical Industries Ltd Composition for treatment of ischemic disorder
US5446070A (en) 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5234957A (en) 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
DE3813624A1 (de) 1988-04-22 1989-11-02 Basf Ag Verfahren zur herstellung von d-(alpha)-tocopherol aus natuerlichen vorprodukten
CA2007643A1 (en) 1989-02-01 1990-08-01 Donald S. Karanewsky Combination of an hmg coa reductase inhibitor and a squalene synthetase inhibitor and method for lowering serum cholesterol using such combination
US6028105A (en) 1989-04-06 2000-02-22 Nigra; Thomas P. Topical drug delivery composition and method
US5053222A (en) 1989-06-07 1991-10-01 Shiseido Company Ltd. Hair cosmetic composition
US5094848A (en) 1989-06-30 1992-03-10 Neorx Corporation Cleavable diphosphate and amidated diphosphate linkers
DE3927113C2 (de) 1989-08-17 1993-11-25 Dolorgiet Gmbh & Co Kg Mittel zur Behandlung von schweren Schmerzzuständen und Verfahren zu ihrer Herstellung
JP2854631B2 (ja) 1989-11-21 1999-02-03 千寿製薬株式会社 糖尿病合併症および老化によって引き起こされる疾患の予防・治療剤
IT1236843B (it) 1989-11-22 1993-04-21 Simes Processo per la preparazione di 4-0-fosfati di dopamina o suoi derivati
JPH03206089A (ja) 1990-01-05 1991-09-09 Eisai Co Ltd 新規ビタミンｅ誘導体及びその製造方法
US5374645A (en) 1990-01-22 1994-12-20 Ciba-Geigy Corporation Transdermal administation of ionic pharmaceutically active agents via aqueous isopropanol
FR2657526B1 (fr) 1990-01-31 1994-10-28 Lvmh Rech Utilisation d'un phosphate d'alpha-tocopherol, ou de l'un de ses derives, pour la preparation de compositions cosmetiques, dermatologiques, ou pharmaceutiques; compositions ainsi obtenues.
US5041434A (en) 1991-08-17 1991-08-20 Virginia Lubkin Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
US5114957A (en) 1990-05-08 1992-05-19 Biodor U.S. Holding Tocopherol-based antiviral agents and method of using same
JPH05509296A (ja) 1990-05-21 1993-12-22 スミス・クライン・アンド・フレンチ・ラボラトリース・リミテッド 医薬用のフェノールおよびピリジノール誘導体
CA2067754C (en) 1990-08-24 2002-06-04 Gregor Cevc Preparation for the application of agents in mini-droplets
DE69024370T2 (de) 1990-10-26 1996-06-20 Senju Pharma Co Hautpräparat zur äusserlichen anwendung
SE9003665D0 (sv) 1990-11-16 1990-11-16 Kabivitrum Ab Morphine prodrugs
US5646190A (en) 1991-03-01 1997-07-08 Warner-Lambert Company Acne treating-wound healing compositions and methods for preparing and using same
US5643597A (en) 1991-08-01 1997-07-01 Lvmh Recherche Use of a tocopherol phosphate or one of its derivatives for the preparation of cosmetic or pharmaceutical compositions and compositions so obtained
FR2679904A1 (fr) 1991-08-01 1993-02-05 Lvmh Rech Utilisation d'un phosphate de tocopherol, ou de l'un de ses derives, pour la preparation de compositions cosmetiques, ou pharmaceutiques et compositions ainsi obtenues.
EP0535283A1 (de) 1991-10-02 1993-04-07 Merrell Dow Pharmaceuticals Inc. Tocopherol Analoge mit kardioprotektiver Wirkung
US5474891A (en) 1991-10-30 1995-12-12 Thomas Jefferson University Plasma-based platelet concentrate preparations with additive
EP0543417A1 (de) 1991-11-22 1993-05-26 Lipogenics, Incorporated Tocotrienole und Focotrienol-ähnliche Verbindungen und Verfahren zu ihrer Verwendung
US5282312A (en) 1991-12-31 1994-02-01 Tessera, Inc. Multi-layer circuit construction methods with customization features
WO1993015731A1 (en) 1992-02-14 1993-08-19 Robert Lamb Phosphate derivatives of vitamin e to protect cells from effects of aging and injury
JP3207494B2 (ja) 1992-04-02 2001-09-10 ロート製薬株式会社 水性懸濁製剤
JPH05286848A (ja) 1992-04-10 1993-11-02 Senju Pharmaceut Co Ltd 浴用剤
US5731299A (en) 1992-05-29 1998-03-24 The Procter & Gamble Company Phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
GB9212450D0 (en) 1992-06-11 1992-07-22 Indena Spa New derivatives of non-steroidal anti-inflammatory,analgesic and/or antipyretic substances,their use and pharmaceutical formulations containing them
US5741518A (en) 1992-08-03 1998-04-21 L'oreal Composition composed of an aqueous dispersion of stabilized vesicles of nonionic amphiphilic lipids
US5773457A (en) 1995-02-15 1998-06-30 Cesar Roberto Dias Nahoum Compositions
WO1994008599A1 (en) 1992-10-14 1994-04-28 The Regents Of The University Of Colorado Ion-pairing of drugs for improved efficacy and delivery
US5348357A (en) 1992-12-24 1994-09-20 General Motors Corporation Vehicle closure latch having plastic coated ratchet
US6384043B1 (en) 1993-02-01 2002-05-07 Gholam A. Peyman Methods of alleviating pain sensations of the denuded eye with opioid analgesics
TW252918B (de) 1993-03-31 1995-08-01 Senju Pharma Co
GB9318271D0 (en) 1993-09-03 1993-10-20 Scotia Holdings Plc Tocopherols
CA2129509A1 (en) 1993-09-10 1995-03-11 Kazumi Ogata Pharmaceutical composition for renal disorder and a dialysis solution for extracorporeal hemodialysis
AU7811094A (en) 1993-11-27 1995-06-13 Knoll Aktiengesellschaft Compositions comprising iminium ion scavengers and/or nitrite scavengers
JPH07196516A (ja) 1993-12-29 1995-08-01 Senju Pharmaceut Co Ltd 痔疾患治療剤
FR2715565B1 (fr) 1994-01-31 1996-03-15 Oreal Composition cosmétique ou dermatologique stabilisée contenant plusieurs précurseurs d'un même actif pour maximaliser sa libération, son utilisation.
EP0669132A1 (de) 1994-02-23 1995-08-30 van der Kraaij, Antonius Marinus Maria Kombinationspräparat von Vitamine E und Acetylsalicylate zur Behandlung und Prophylaxis des Atherosclerosis
CA2145229A1 (en) 1994-03-29 1995-09-30 Tetsuya Toge Suppressory compositions against hepatic metastases of tumors
US5554781A (en) 1994-03-30 1996-09-10 Reierson; Robert L. Monoalkyl phosphonic acid ester production process
JPH07277988A (ja) 1994-04-05 1995-10-24 Senju Pharmaceut Co Ltd 局所用掻痒除去、治療剤
TW287103B (de) 1994-04-22 1996-10-01 Senju Pharma Co
JP3362501B2 (ja) 1994-04-28 2003-01-07 千寿製薬株式会社 角膜障害治療剤
JP3396953B2 (ja) 1994-05-10 2003-04-14 千寿製薬株式会社 網膜疾患予防・治療剤
GB9409778D0 (en) 1994-05-16 1994-07-06 Dumex Ltd As Compositions
WO1995034303A1 (en) 1994-06-13 1995-12-21 Arcturus Pharmaceutical Corporation Method for the treatment, prevention or minimization of hair loss
US5589504A (en) 1994-07-26 1996-12-31 Cornell Research Foundation, Inc. Treatment of newborn jaundice
CA2152693A1 (en) 1994-08-05 1996-02-06 Kazumi Ogata Therapeutic composition for pancreatitis
IT1274734B (it) 1994-08-25 1997-07-24 Prospa Bv Composizioni farmaceutiche contenenti acidi grassi poliinsaturi, loro esteri o sali, unitamente a vitamine o provitamine antiossidanti
HU215966B (hu) 1994-11-21 1999-07-28 BIOGAL Gyógyszergyár Rt. Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum
US6407277B1 (en) 1994-12-09 2002-06-18 Kao Corporation Process for the preparation of phosphoric monoester
DE4444238A1 (de) 1994-12-13 1996-06-20 Beiersdorf Ag Kosmetische oder dermatologische Wirkstoffkombinationen aus Zimtsäurederivaten und Flavonglycosiden
SE9404568L (sv) 1994-12-30 1996-07-01 Perstorp Ab Användning av inositoltrisfosfat för beredning av läkemedel
AU4515996A (en) 1995-01-09 1996-07-31 Alpha-Therapeutics, Inc. Methods for increasing the bioavailability of biological active agents
FR2730928B1 (fr) 1995-02-23 1997-04-04 Oreal Composition a base de vesicules lipidiques a ph acide et son utilisation en application topique
JPH08231564A (ja) 1995-02-28 1996-09-10 Nippon Shokubai Co Ltd リン酸エステルおよびその製造方法並びにリン酸エステル重合体
GB9505025D0 (en) 1995-03-13 1995-05-03 Medical Res Council Chemical compounds
US6248779B1 (en) * 1995-04-21 2001-06-19 Sekisui Kagaku Kogyo Kabushiki Kaisha External preparations for treating dermatoses
US5665389A (en) 1995-05-24 1997-09-09 University Of Maryland At Baltimore Oral dosage composition for intestinal delivery and method of treating diabetes
US5607968A (en) 1995-06-07 1997-03-04 Avon Products, Inc. Topical alkyl-2-O-L-ascorbyl-phosphates
WO1997014705A1 (fr) 1995-10-17 1997-04-24 Showa Denko K.K. Phosphates de tocopherol tres purs, procedes de preparation, techniques d'analyse et produits cosmetiques correspondants
FR2741263B1 (fr) 1995-11-22 1997-12-26 Oreal Composition comprenant une dispersion aqueuse de vesicules lipidiques encapsulant un filtre uv a fonction acide et utilisations en application topique
CN1229114C (zh) 1996-03-27 2005-11-30 印斯拜尔药品股份有限公司 用三磷酸尿苷和相关化合物治疗纤毛运动障碍的方法
US6077828A (en) 1996-04-25 2000-06-20 Abbott Laboratories Method for the prevention and treatment of cachexia and anorexia
US5885595A (en) 1996-05-13 1999-03-23 Elizabeth Arden Co., Division Of Conopco, Inc. Cosmetic composition with a retinol fatty acid ester
JPH1045783A (ja) 1996-07-29 1998-02-17 Showa Denko Kk ヒドロキシクロマン誘導体リン酸エステルの製造方法
CA2209690A1 (en) 1996-07-31 1998-01-31 Sachiko Matsuura Therapeutic drug for acne vulgaris
JPH1067639A (ja) 1996-08-26 1998-03-10 Shiseido Co Ltd ビタミンｅ−ビタミンｃリン酸ジエステル／シクロデキストリン包接物及び該包接物を配合した皮膚外用剤
JPH10155429A (ja) 1996-11-27 1998-06-16 Showa Denko Kk 動物に対するビタミンｅ供給方法および動物用トコフェロールリン酸エステル又はその塩類組成物
US6022867A (en) 1996-11-27 2000-02-08 Showa Denko Kabushiki Kaisha Method of administering vitamin E to animals and compositions containing tocopheryl phosphates and salts thereof for animals
US6727280B2 (en) 1997-01-07 2004-04-27 Sonus Pharmaceuticals, Inc. Method for treating colorectal carcinoma using a taxane/tocopherol formulation
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US6932975B2 (en) 1997-01-29 2005-08-23 Kao Corporation Cosmetic composition comprising a phosphoric triester and a skin activating component
US5804168A (en) 1997-01-29 1998-09-08 Murad; Howard Pharmaceutical compositions and methods for protecting and treating sun damaged skin
CZ291842B6 (cs) 1997-03-13 2003-06-18 Hexal Ag Farmaceutická formulace
US7179486B1 (en) 1997-04-01 2007-02-20 Nostrum Pharmaceuticals, Inc. Process for preparing sustained release tablets
JP2926046B2 (ja) 1997-06-04 1999-07-28 株式会社太平洋 水安定型ｌ−アスコルビン酸誘導体とその製造方法及びこれを含有する美白化粧料組成物
US5928631A (en) 1997-06-09 1999-07-27 The Procter & Gamble Company Methods for controlling environmental odors on the body using compositions comprising uncomplexed cyclodextrins
US5906811A (en) 1997-06-27 1999-05-25 Thione International, Inc. Intra-oral antioxidant preparations
JPH1143436A (ja) 1997-07-25 1999-02-16 Showa Denko Kk 末梢血流障害予防・治療剤
US5776915A (en) 1997-08-12 1998-07-07 Clarion Pharmaceuticals Inc. Phosphocholines of retinoids
US6096326A (en) 1997-08-15 2000-08-01 Scandinavian-American Import/Export Corporation Skin care compositions and use
IT1294748B1 (it) 1997-09-17 1999-04-12 Permatec Tech Ag Formulazione per un dispositivo transdermico
JP3950216B2 (ja) 1997-12-26 2007-07-25 日本メナード化粧品株式会社 皮膚外用剤
JPH11199465A (ja) 1998-01-07 1999-07-27 Nonogawa Shoji Kk 皮膚外用剤
CA2319020A1 (en) 1998-02-03 1999-08-12 Senju Pharmaceutical Co., Ltd. Pharmaceutical compositions for prevention and treatment of neurodegenarative diseases
US6461623B2 (en) 1998-04-13 2002-10-08 Kao Corporation Cosmetic composition
US6254853B1 (en) 1998-05-08 2001-07-03 Vyrex Corporation Water soluble pro-drugs of propofol
JP4208209B2 (ja) 1998-06-22 2009-01-14 フジノン株式会社 コリメータレンズおよびこれを用いた光走査装置
US6121249A (en) 1998-07-01 2000-09-19 Donald L. Weissman Treatment and prevention of cardiovascular diseases with help of aspirin, antioxidants, niacin, and certain B vitamins
EP1094781B1 (de) 1998-07-07 2008-07-02 Transdermal Technologies Inc. Zusammensetzungen für die schnelle und nicht-irritierende transdermale verabreichung von pharmazeutika and verfahren zur formuliering davon und ihren verabreichung
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
US6770672B1 (en) 1998-09-23 2004-08-03 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
CA2345079C (en) 1998-09-23 2011-06-21 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
US6703384B2 (en) 1998-09-23 2004-03-09 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
US6153582A (en) 1998-11-05 2000-11-28 Bausch & Lomb Surgical, Inc. Defined serumfree medical solution for ophthalmology
IT1303787B1 (it) 1998-11-25 2001-02-23 Maria Rosa Gasco "nanosfere lipidiche solide atte ad una rapida internalizzazione nellecellule"
US6048891A (en) 1998-12-17 2000-04-11 Loma Linda University Medical Center Use of γ-tocopherol and its oxidative metabolite LLU-α in the treatment of natriuretic disease
AUPQ037499A0 (en) 1999-05-14 1999-06-10 Swig Pty Ltd Improved process for phosphorylation and compounds produced by this method
AUPP829399A0 (en) 1999-01-25 1999-02-18 Swig Pty Ltd Recovery for chroman derivatives
JP2000212082A (ja) 1999-01-26 2000-08-02 Showa Denko Kk 皮膚用剤
US6156354A (en) 1999-01-29 2000-12-05 Brandeis University Hyper-absorption of vitamin E dispersed in milks
DE19912798C1 (de) 1999-03-10 2000-02-17 Andreas Jordan Verfahren zur Kultivierung von Krebszellen aus Humangewebe und Vorrichtung zur Aufbereitung von Gewebeproben
AU3913800A (en) 1999-03-26 2000-10-16 Lipogenics, Inc. Novel antioxidant formulations and methods for using them
US6383471B1 (en) 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
MXPA01011597A (es) 1999-05-14 2002-06-04 Swig Pty Ltd Proceso mejorado para la fosforilacion y compuestos producidos mediante este proceso.
DE19923551A1 (de) 1999-05-21 2000-11-30 Lohmann Therapie Syst Lts Pharmazeutisches Präparat mit dem Wirkstoff Diamorphin und seine Verwendung in einem Verfahren zur Behandlung der Opiatsucht
US6184247B1 (en) 1999-05-21 2001-02-06 Amway Corporation Method of increasing cell renewal rate
AU5594700A (en) 1999-06-01 2000-12-18 Ocean Spray Cranberries, Inc. Cranberry seed oil extract and compositions containing components thereof
WO2000074684A1 (en) 1999-06-04 2000-12-14 The General Hospital Corporation Pharmaceutical formulations for treating postmenopausal and perimenopausal women, and their use
US6669951B2 (en) 1999-08-24 2003-12-30 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into epithelial tissues
WO2001015593A2 (en) 1999-09-02 2001-03-08 Drake Larson Compositions for reducing vascular plaque formation and methods of using same
GB9921960D0 (en) 1999-09-16 1999-11-17 Pharmacia & Upjohn Spa Formulations for parenteral use of estramustine phosphate and amino acids
JP2003513019A (ja) 1999-09-27 2003-04-08 ソーナス ファーマシューティカルス，インコーポレイテッド トコール可溶性治療剤の組成物
EP1265638A1 (de) 1999-11-12 2002-12-18 Pharmaderm Laboratories Ltd. Arzneizubereitungen zur transdermalen oder transmucosalen verabreichung von wirkstoffen
JP2001169731A (ja) 1999-12-17 2001-06-26 Showa Denko Kk 動物体の脂質代謝改善剤
EP1242431A1 (de) 1999-12-22 2002-09-25 Merck Frosst Canada & Co. Aromatische phosphonate als protein tyrosin phosphatase 1b (ptp-1b) inhibitoren
IT1317736B1 (it) 2000-01-26 2003-07-15 A C R Applied Coating Res S A Cerotto per la somministrazione locale e transdermica di principiattivi dotati di gruppi anionici ed elettronattrattori.
WO2001058889A1 (en) 2000-02-11 2001-08-16 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
US20030035812A1 (en) 2000-02-29 2003-02-20 Shinobu Ito Immune enhancement compositions and use thereof
US6346544B2 (en) 2000-03-02 2002-02-12 Oklahoma Medical Research Foundation Desmethyl tocopherols for protecting cardiovascular tissue
JP2001247585A (ja) 2000-03-03 2001-09-11 Nof Corp トコフェロール誘導体、その中間体、その製造方法及び用途
US6444220B2 (en) 2000-03-16 2002-09-03 Teresa S. Wiley Method and compositions for changing the contour of skin
AR027714A1 (es) 2000-03-24 2003-04-09 Baker Norton Pharma Uso de sales metalicas para estabilizar composiciones de taxanos.
US6361800B1 (en) 2000-04-13 2002-03-26 Cooper Concepts, Inc. Multi-vitamin and mineral supplement
US6485950B1 (en) 2000-07-14 2002-11-26 Council Of Scientific And Industrial Research Isozyme of autoclavable superoxide dismutase (SOD), a process for the identification and extraction of the SOD in cosmetic, food and pharmaceutical compositions
US6362234B1 (en) 2000-08-15 2002-03-26 Vyrex Corporation Water-soluble prodrugs of propofol for treatment of migrane
KR100365070B1 (ko) 2000-08-29 2002-12-16 주식회사 태평양 토코페롤 유도체 및 그의 제조방법
JP4818500B2 (ja) 2000-09-05 2011-11-16 株式会社ペンタプラストア トコトリエノール誘導体及びその製造方法
WO2002026238A1 (en) 2000-09-26 2002-04-04 Vital Health Sciences Pty Ltd. Phosphate derivative supplements
US20030206972A1 (en) 2000-10-13 2003-11-06 Babish John G. Compositions containing carotenoids and tocotrienols and having synergistic antioxidant effect
WO2002036736A2 (en) 2000-11-02 2002-05-10 The Regents Of The University Of California Alpha-tocopherol transfer protein knockout animals
AUPR549901A0 (en) 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
CA2426852C (en) 2000-11-14 2010-01-26 Vital Health Sciences Pty Ltd Formulation containing phosphate derivatives of electron transfer agents
US20040097472A1 (en) * 2000-11-14 2004-05-20 West Simon Michael Complexes of phosphate derivatives
AU2002228648A1 (en) 2000-11-16 2002-05-27 Pharmacia And Upjohn Company Combined therapy against tumors comprising estramustine phosphate and lhrh agonists or antagonists
US20020132845A1 (en) 2000-12-15 2002-09-19 Miller Guy Michael Compositions and methods for the prevention and treatment of tissue ischemia
US20020151467A1 (en) 2000-12-21 2002-10-17 Leung Frank K. Methods and compositions for oral insulin delivery
US20020131994A1 (en) 2001-01-10 2002-09-19 Schur Henry B. Non-irritating formulation for the transdermal delivery of substances
US6849271B2 (en) 2001-04-27 2005-02-01 Verion, Inc. Microcapsule matrix microspheres, absorption-enhancing pharmaceutical compositions and methods
KR100394770B1 (ko) 2001-06-05 2003-08-14 주식회사 태평양 토코페롤 유도체를 이용하여 나노유화입자를 안정화시키는방법 및 나노유화입자를 함유하는 피부 외용제 조성물
CA2453823C (en) * 2001-07-27 2010-12-21 Vital Health Sciences Pty Ltd Dermal therapy using phosphate derivatives of electron transfer agents
AUPR684801A0 (en) 2001-08-06 2001-08-30 Vital Health Sciences Pty Ltd Supplement therapy
EP1429739A1 (de) 2001-09-21 2004-06-23 Egalet A/S Polymer-freigabe-system
WO2003024430A1 (en) 2001-09-21 2003-03-27 Egalet A/S Morphine polymer release system
AU2002951045A0 (en) 2002-08-27 2002-09-12 Vital Health Sciences Pty Ltd Method of supplementing nascent endogenous storage forms
CA2458279A1 (en) 2001-09-26 2003-04-03 Vital Health Sciences Pty Ltd. Modulation of vitamin storage
JP4370451B2 (ja) 2001-09-28 2009-11-25 大塚製薬株式会社 医薬組成物
JP2003128531A (ja) * 2001-10-17 2003-05-08 Nonogawa Shoji Kk 皮膚外用剤
AU2002352726A1 (en) 2001-11-15 2003-06-10 Galileo Laboratories, Inc. Formulations and methods for treatment or amelioration of inflammatory conditions
WO2003049774A1 (en) 2001-12-13 2003-06-19 Vital Health Sciences Pty Ltd Transdermal transport of compounds
NZ533565A (en) 2001-12-19 2006-11-30 Res Dev Foundation Liposomal delivery of vitamin E based anti-cancer compounds
WO2003068209A1 (en) 2002-02-14 2003-08-21 Sonus Pharmaceuticals, Inc. Metformin salts of lipophilic acids
US7074825B2 (en) 2002-03-07 2006-07-11 Huanbiao Mo Composition and method for treating cancer
WO2003097714A1 (en) 2002-05-20 2003-11-27 Ranbaxy Laboratories Limited Fat binding using inter-polymer complex of glucosamine and polyacrylic acid
US20040018237A1 (en) 2002-05-31 2004-01-29 Perricone Nicholas V. Topical drug delivery using phosphatidylcholine
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
US20040067890A1 (en) 2002-10-04 2004-04-08 Gupta Shyam K. Ascorbic acid salts of organic bases with enhanced bioavailability for synergictic anti-aging and skin protective cosmetic compositions
US6645514B1 (en) * 2002-12-19 2003-11-11 Access Business Group International, Llc Increasing skin cell renewal with water-soluble Vitamin E
BR0317876A (pt) 2002-12-31 2005-12-06 Nicholas V Perricone Composições de liberação de droga tópica estáveis
KR20050086954A (ko) 2003-01-17 2005-08-30 바이탈 헬스 사이언시즈 피티와이 리미티드 항증식성 화합물
US7033998B2 (en) 2003-04-11 2006-04-25 All Natural Fmg, Inc. Alcohol-free transdermal insulin composition and processes for manufacture and use thereof
AU2003901815A0 (en) 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphate derivatives
AU2003901812A0 (en) 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphates of secondary alcohols
AU2003901813A0 (en) 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Pharmaceutical derivatives
JP2006199589A (ja) 2003-09-03 2006-08-03 Ltt Bio-Pharma Co Ltd 生理活性タンパク質またはペプチドを含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる外用剤
CA2557354C (en) 2004-03-03 2013-05-07 Vital Health Sciences Pty Ltd. Alkaloid formulations
CA2575587C (en) 2004-08-03 2014-06-17 Vital Health Sciences Pty Ltd Carrier for enteral administration
JP2008531602A (ja) 2005-03-03 2008-08-14 バイタル ヘルス サイエンシズ プロプライアタリー リミティド 抗癌特性を有する化合物
KR20070108383A (ko) 2005-03-03 2007-11-09 바이탈 헬스 사이언시즈 피티와이 리미티드 지질 저하성 화합물
US20090239827A1 (en) 2005-03-03 2009-09-24 Esra Ogru Compounds having lipid lowering properties
JP4270212B2 (ja) 2005-03-29 2009-05-27 セイコーエプソン株式会社 基板間隔調整装置、基板間隔調整方法、および液晶表示装置の製造方法
US9168216B2 (en) 2005-06-17 2015-10-27 Vital Health Sciences Pty. Ltd. Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
KR100764679B1 (ko) 2005-07-22 2007-10-09 익수제약 주식회사 파록세틴을 함유하는 경피투여용 패취제
US7446096B2 (en) 2005-12-19 2008-11-04 Industrial Technology Research Institute Glutathione based delivery system
EP1973547A1 (de) 2005-12-23 2008-10-01 Vital Health Sciences Pty Ltd. Verbindungen mit zytokin-modulierenden eigenschaften
WO2007123496A1 (en) 2006-04-25 2007-11-01 National University Of Singapore Method of zinc oxide film grown on the epitaxial lateral overgrowth gallium nitride template
JP5201858B2 (ja) 2007-03-26 2013-06-05 花王株式会社 遊離脂肪酸が低減された油脂の製造方法
FR2921259B1 (fr) 2007-09-26 2015-02-13 Lvmh Rech Utilisation cosmetique du phosphate de tocopherol comme agent anti-vieillissement de la peau
US20090297591A1 (en) 2008-05-30 2009-12-03 Orient Pharma Co., Ltd. Compositions And Methods For The Transdermal Delivery Of Pharmaceutical Compounds
JP5132700B2 (ja) 2010-02-22 2013-01-30 三菱電機株式会社 手乾燥装置

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